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Defect detection and repair algorithm for structures generated by topology optimization based on 3D hierarchical fully convolutional network

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Biomimetic Intelligence & Robotics 2024年第2期4卷 24-31页

作者： zhiyu Wan Hai Lan Sichao Lin Houde dai School of Advanced Manufacturing Fuzhou UniversityJinjiang 362251China Quanzhou Institute of Equipment Manufacturing Haixi InstitutesChinese Academy of SciencesJinjiang 362216China Fujian Key Laboratory of Special Intelligent Equipment Safety Measurement and Control Fujian Special Equipment Inspection and Research InstituteFuzhou 350008China

Customized 3D-printed structural parts are widely used in surgical *** satisfy the mechanical properties and kinematic functions of these structural parts,a topology optimization technique is adopted to obtain the optimal structural layout while meeting the constraints and ***,topology optimization currently faces some practical challenges that must be addressed,such as ensuring that structures do not have significant defects when converted to additive manufacturing *** address this problem,we designed a 3D hierarchical fully convolutional network(FCN)to predict the precise position of the defective *** on the prediction results,an effective repair strategy is adopted to repair the defective structure.A series of experiments is conducted to demonstrate the effectiveness of our *** to the 2D fully convolutional network and the rule-based detection method,our approach can accurately capture most defect structures and achieve 89.88%precision and 95.59%***,we investigate the impact of different ways to increase the receptive field of our model,as well as the trade-off between different defect-repairing *** results of the experiment demonstrate that the hierarchical structure,which increases the receptive field,can substantially improve the defect detection *** the best of our knowledge,this paper is the first to investigate 3D defect prediction and repair for topology optimization in conjunction with deep learning algorithms,providing practical tools and new perspectives for the subsequent development of topology optimization techniques.

关键词： Topology optimization Additive manufacturing Deep learning 3D semantic segmentation Defect detection

The critical role of BTRC in hepatic steatosis as an ATGL E3 ligase

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Journal of Molecular Cell Biology 2023年第10期15卷 54-64页

作者： Weiwei Qi Zhenzhen Fang Chuanghua Luo Honghai Hong Yanlan Long zhiyu dai Junxi Liu Yongcheng Zeng Ti Zhou Yong Xia Xia Yang Guoquan Gao Department of Biochemistry Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Department of Clinical Laboratory The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510006China Department of Internal Medicine University of Arizona College of MedicinePhoenixAZ 85004USA Guangdong Engineering&Technology Research Center for Gene Manipulation and Biomacromolecular Products Sun Yat-sen UniversityGuangzhou 510080China Guangdong Province Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Key Laboratory of Tropical Disease Control Ministry of EducationSun Yat-sen UniversityGuangzhou 510080China

Non-alcoholic fatty liver disease(NAFLD),characterized by hepatic steatosis,is one of the commonest causes of liver *** triglyceride lipase(ATGL)is closely related to lipid turnover and hepatic steatosis as the speed-limited triacylglycerol lipase in liver ***,the expression and regulation of ATGL in NAFLD remain ***,our results showed that ATGL protein levels were decreased in the liver tissues of high-fat diet(HFD)-fed mice,naturally obese mice,and cholangioma/hepatic carcinoma patients with hepatic steatosis,as well as in the oleic acid-induced hepatic steatosis cell model,while ATGL mRNA levels were not *** protein was mainly degraded through the proteasome pathway in ***-transducin repeat containing(BTRC)was upregulated and negatively correlated with the decreased ATGL level in these hepatic steatosis ***,BTRC was identified as the E3 ligase for ATGL through predominant ubiquitination at the lysine 135 ***,adenovirus-mediated knockdown of BTRC ameliorated steatosis in HFD-fed mouse livers and oleic acid-treated liver cells via upregulating the ATGL *** together,BTRC plays a crucial role in hepatic steatosis as a new ATGL E3 ligase and may serve as a potential therapeutic target for treating NAFLD.

关键词： adipose triglyceride lipase(ATGL) beta-transducin repeat containing(BTRC) non-alcoholic fatty liver disease(NAFLD) obesity proteasomal degradation

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考虑密度影响的砂土静止土压力系数研究

岩石力学与工程学报 2021年第8期40卷 1664-1671页

作者：蔡正银朱洵代志宇南京水利科学研究院岩土工程研究所江苏南京210024

静止土压力系数是支挡结构设计与分析中非常重要的参数,其值决定了作用于结构上初始水平土压力的大小。以福建标准砂为研究对象,开展均质砂土地基离心模型试验,研究砂土静止土压力系数随初始相对密度的变化规律;进行砂土在不同初始相对... 详细信息

静止土压力系数是支挡结构设计与分析中非常重要的参数,其值决定了作用于结构上初始水平土压力的大小。以福建标准砂为研究对象,开展均质砂土地基离心模型试验,研究砂土静止土压力系数随初始相对密度的变化规律;进行砂土在不同初始相对密度下的三轴固结排水试验,获得砂土峰值强度随初始相对密度的变化规律;综合离心模型试验和三轴试验结果提出可反应砂土静止土压力系数-峰值摩擦角关系的“南水公式”,即K_(0)=sinφ′-0.16 。为了验证南水公式的正确性,提出可描述砂土细观受力特征的颗粒微结构概化模型,通过推导得到砂土静止土压力系数与其微结构颗粒接触角及摩擦偏移角之间的关系,初步探讨初始相对密度对砂土内部传力机制的影响,指出随着砂土相对密度的增加颗粒微结构存在由高阶环状单元结构向低阶稳定单元结构转化的可能,而低阶稳定单元结构的双重支撑作用将促进颗粒竖向应力向侧向的传递。研究成果对完善砂土土压力理论具有一定的参考价值。

关键词：土力学砂土相对密度静止土压力离心模型试验南水公式

Intracellular PEDF contributes to triglyceride degradation

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Intracellular PEDF contributes to triglyceride degradation

利用核桃壳制备高比表面积活性炭电极材料的研究

第11届全国脂质与脂蛋白学术会议

作者： zhiyu dai Cen Li Weiwei Qi Juling Lu Yuling Mao Xia Yang Guoquan Gao Department of Biochemistry Zhongshan Medical SchoolSun Yat-sen University

Baekgroup/Aims:Pigment epithelium-derived factor(PEDF) is well known as a secreted glycoprotein with anti-angiogenic activity,but its role in liver lipid regulation is largely *** present study is to demonstrate that cytoplasmic PEDF associates with adipose triglyceride lipase(ATGL) and G/G switch gene 2(G0S2) to regulate triglyceride (TG) degradation. Methods:The expression pattern of hepatic PEDF mRNA and protein,TG and FFA level were investigated in progressing obesity mice induced by high fat ***

关键词： ATGL G0S2 Triglyceride hepatocyte lipid droplet

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材料导报 2016年第2期30卷 24-27,33页

作者：郭晖张记升朱天星代治宇河南理工大学材料科学与工程学院焦作454003 河南理工大学万方科技学院焦作454000 焦作大学化工与环境工程学院焦作454000

以核桃壳为原料，采用KOH活化法制备活性炭，并将其用作超级电容器电极材料。利用N2吸附和扫描电镜（SEM）表征活性炭的孔结构及表面形貌，系统研究碱炭比（KOH与核桃壳炭化料的质量比）对活性炭孔结构的影响，并采用恒流充放电及循环... 详细信息

以核桃壳为原料，采用KOH活化法制备活性炭，并将其用作超级电容器电极材料。利用N2吸附和扫描电镜（SEM）表征活性炭的孔结构及表面形貌，系统研究碱炭比（KOH与核桃壳炭化料的质量比）对活性炭孔结构的影响，并采用恒流充放电及循环伏安等测定核桃壳活性炭电极材料在3mol／LKOH电解液中的电化学性能。结果表明，随着碱炭比的增大，活性炭的比表面积、总孔容及中孔比例先逐渐增大后稍有减小。当活化温度为800℃，活化时间为1h，碱炭比为4时，可制备出比表面积为2404m^2／g，总孔容为1．344cm^3／g，中孔比例为28．6％，孔径分布在0．7～3．0nm之间的高比表面积活性炭。该活性炭用作超级电容器电极材料具有良好的大电流放电特性和优异的循环性能，电流密度由50mA／g提高到5000mA／g时，其比电容由340F／g降低到288F／g，经1000次循环后，比电容保持率为93．4％。

关键词：核桃壳活性炭超级电容器电极材料

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离心模型试验中界面土压力盒标定方法研究

水利学报 2020年第6期51卷 695-704页

作者：蔡正银代志宇徐光明任国锋南京水利科学研究院岩土工程研究所江苏南京210024

在离心模型试验中,准确量测结构面上土压力的首要条件是采用合理的方法对界面土压力盒进行标定。本文首先使用砂雨法制备砂土土样,并考虑了出砂口尺寸和落距对制样结果的影响;然后在考虑温度变化,传感器上覆砂层厚度和砂颗粒粒径变化的... 详细信息

在离心模型试验中,准确量测结构面上土压力的首要条件是采用合理的方法对界面土压力盒进行标定。本文首先使用砂雨法制备砂土土样,并考虑了出砂口尺寸和落距对制样结果的影响;然后在考虑温度变化,传感器上覆砂层厚度和砂颗粒粒径变化的情况下对BW-3型界面土压力盒分别进行了标定试验;最后将标定结果应用于相对密度为0.9的砂土静止侧压力系数测量当中。结果发现:40℃和20℃的温度变化对传感器测量结果的影响不大;砂标试验时,随着传感器上覆砂层厚度的增加,传感器输出电压的非线性趋势逐渐明显,土压力盒的标定系数逐渐增大;当采用不同颗粒粒径的砂对传感器进行标定时,标定系数与颗粒粒径的变化呈正相关趋势;通过测量不同土样的静止侧压力系数发现,土样K0值随着砂颗粒粒径的增加而逐渐减小,与Jaky公式计算结果对比证实了仅考虑有效内摩擦角计算土样K0值是不准确的。

关键词：离心模型试验土压力盒标定土压力

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浅析极域电子教室在机房教学和管理中的应用

无线互联科技 2016年第19期13卷 131-132页

作者：戴智育南京市广播电视大学江苏南京210002

高校人才培养方案中关于通过计算机仿真软件的学习内容比重较大,为了更好地利用计算机技术进行辅助教学,提高机房教学的质量,虚拟化电子教室成为多媒体教学的重要途径。文章分析了极域电子教室在日常教学和机房管理工作中的应用,通过对... 详细信息

高校人才培养方案中关于通过计算机仿真软件的学习内容比重较大,为了更好地利用计算机技术进行辅助教学,提高机房教学的质量,虚拟化电子教室成为多媒体教学的重要途径。文章分析了极域电子教室在日常教学和机房管理工作中的应用,通过对广播教学、文件分发、学生演示等方面进行阐述,同时针对其在使用中的不足之处给出了个人观点。

关键词：计算机教学电子教室机房管理

应对可转移多黏菌素耐药性--饲料添加剂来源的白屈菜红碱具有双重效应

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Engineering 2024年第1期32卷 163-173页

作者： Huangwei Song Xueyang Wang Muchen Zhang zhiyu Zou Siyuan Yang Tian Yi Jianfeng Wang Dejun Liu Yingbo Shen Chongshan dai Zhihai Liu Timothy R.Walsh Jianzhong Shen Congming Wu Yang Wang National Key Laboratory of Veterinary Public Health and Safety College ofVeterinary MedicineChina Agricultural UniversityBeijing 100193China Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510642China State Key Laboratory for Zoonotic Diseases Key Laboratory of Zoonosis ResearchMinistry of EducationInstitute of ZoonosisCollege of Veterinary MedicineJilin UniversityChangchun 130015China College of Chemistry and Pharmaceutical Sciences Qingdao Agricultural University.Qingdao 266109China Ineos-Oxford Institute of Antimicrobial Research Department of BiologyUniversity of OxfordOxford OX13SZUK

The emergence and spread of the mobile colistin-resistance gene,mcr-1,and its variants pose achallenge to the use of colistin,a last-resort antibiotic used to treat severe infections caused by extensively drug-resistant(XDR)Gram-negative *** adjuvants are a promising strategy to enhance the efficacy of colistin against colistin-resistant pathogens;however,few studies have considered the effects of adjuvants on limiting resistance-gene *** found that chelerythrine(4 mg·L^(-1))derived from Macleaya cordata extract,which is used as an animal feed additive,reduced the minimal inhibitory concentration(MIC)of colistin against an mcr-1 positive Escherichia coli(***)strain by 16-fold(from 2.000 to 0.125 mg·L^(-1)).eliminated approximately 10^(4) colony-forming units(CFUs)of an mcr-1-carrying strain in a murine intestinal infection model,and inhibited the conjugation of an mcr-1-bearing plasmid in vitro(by>100-fold)and in a mouse model(by up to 5-fold).A detailed analysis revealed that chelery-thrine binds to phospholipids on bacterial membranes and increases cytoplasmic membrane fluidity,thereby impairing respiration,disrupting proton motive force(PMF),generating reactive oxygen species(ROS),and decreasing intracellular adenosine triphosphate(ATP)levels,which subsequently downregu-lates mcr-1 and conjugation-associated *** dual effects of chelerythrine can expand the use of antibiotic adjuvants and may provide a new strategy for circumventing mobile colistin resistance.

关键词： Chelerythrine Antibiotic adjuvant Conjugation inhibitor Colistin mcr-1 Dual effects

模态测试不确定性影响因素分析及传感器布置应用

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湖南大学学报（自然科学版） 2024年第7期51卷 62-71页

作者：王志宇陈华钊施袁锋张惊朝戴靠山四川大学建筑与环境学院四川成都610065 深地科学与工程教育部重点实验室(四川大学) 四川成都610065 中国建筑第八工程局有限公司四川成都610093

模态测试结果的准确性会受测试数据采集、数据处理、建模假设和参数估计等不确定性因素的影响.为研究模态测试中模态参数的不确定性水平及不同影响因素对其的影响规律,本文采用状态空间模型和费希尔信息矩阵的快速模态参数不确定性分析... 详细信息

模态测试结果的准确性会受测试数据采集、数据处理、建模假设和参数估计等不确定性因素的影响.为研究模态测试中模态参数的不确定性水平及不同影响因素对其的影响规律,本文采用状态空间模型和费希尔信息矩阵的快速模态参数不确定性分析方法,探讨包括振动信号的采样时长、采样频率、采样信噪比和结构的阻尼比等多种因素对模态参数不确定性水平的影响,同时提出利用模态参数不确定性水平来优化传感器布置策略的实用性建议.结果表明:模态参数的不确定性水平随采样时长、采样频率、信噪比和传感器数量的增加而降低,随结构阻尼比的增大而升高;对于均匀分布结构,多数传感器布置在结构顶部和中上部,少数布置在中下部时,模态参数的整体不确定性水平较低,是一种相对较优的传感器布置方案.

关键词：模态测试不确定性分析费希尔信息矩阵状态空间方法

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