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Tonghua Liu:A life dedicated to clinical pathology

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Protein & Cell 2019年第12期10卷 857-860页

作者： Lin Dong Tanping Fu Junyi Pang zhiyong liang Wenli Duan Peking Union Medical College Hospital Beijing 100730China

Professor Tonghua Liu(刘彤华)was an academician of the Chinese Academy of Engineering,a renowned medical scientist,pathologist,medical educator and professor of the Pathology Department in Peking Union Medical College Hospital(PUMCH)(Fig.1).She passed away from illness on July 8th,2018 at *** was 89(PUMCH,2018).*** was born on November 13th,1929 in Wuxi,Jiangsu *** studied at the Medical School of Saint John's University in Shanghai from 1947 to 1953(Fang et al.,2009).

关键词： Province life Jiangsu

Transient response of carbon nanotube integrated circuits

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Nano Research 2015年第3期8卷 1005-1016页

作者： Panpan Zhang Yingjun Yang Tian Pei Chenguang Qiu Li Ding Shibo liang zhiyong Zhang Lianmao Peng ing 100871 China

The speed of frequency response of all published carbon nanotube （CNT） integrated circuits （ICs） is far from that predicted. The transient response of CNT ICs is explored systematically through the combination of experimental and simulation methods. Complementary field-effect-transistor （FET） based inverters were fabricated on a single semiconducting CNT, and the dynamic response measurement indicates that it can only work at an unexpectedly low speed, i.e. with a large propagation delay of 30 }_ts. Owing to the larger output resistance of CNT FETs, the existence of parasitic capacitances should induce much larger resistive-capacitive （RC） delay than that in Si ICs. Through detailed analysis combining simulation and experimental measurements, several kinds of parasitic capacitances dragging down the actual speed of CNT FET ICs are identified one by one, and each of them limits the speed at different levels through RC delay. It is found that the parasitic capacitance from the measurement system is the dominant one, and the large RC delay lowers the speed of CNT FETs logic circuits to only several kHz which is similar to the experimental results. Various optimized schemes are suggested and demonstrated to minimize the effect of parasitic capacitances, and thus improve the speed of CNT ICs.

关键词： type keywordscarbon nanotube field-effect-transistors (CNTFETs) transient response parasitic capacitance propagation delay digital circuits

Dynamics of non-metal-regulated FeCo bimetal microenvironment on oxygen reduction reaction activity and intrinsic mechanism

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Nano Research 2023年第2期16卷 2199-2208页

作者： Hong Cui Tong Liu Yunjian Chen Pengyue Shan Qi Jiang Xue Bai Yazhou Wang zhiyong liang Rong Feng Qin Kang Hongkuan Yuan School of Mechanical Engineering Shaanxi University of TechnologyHanzhong 723001China Shaanxi Key Laboratory of Industrial Automation Shaanxi University of TechnologyHanzhong 723001China School of Physical Science and Technology Southwest UniversityChongqing 400715China

The change in the coordination environment of the active sites of a fuel cell cathode catalyst provides a new modulation strategy for stimulating the catalyst’s oxygen reduction reaction *** thermodynamic and electronic properties of the FeCoN5A and FeCoN6A catalyst structures with nonmetallic A-doped(A=B,N,O,P,and S)coordination were calculated and analyzed based on density functional *** modulation order of G*OH by different A-doped FeCo bimetal pairs(BMPs)was as follows:S>P>O>N/C>*** was a dynamic distribution of charges in the coordination environment during the adsorption of OH,which resulted in inversely proportional relationship with the charge transfer between the adsorbate OH,active site,first coordination layer,and second coordination layer in *** of the orbital energy levels of neighboring nonmetal atoms were constructed based on the p-electron number and electronegativity of the doped nonmetal *** change of the orbital energy levels of the first coordination atom during the adsorption process caused the structure to exhibit different adsorption *** study provides new insights on the non-metallic modulation of the M-N-C coordination environment to improve the oxygen reduction reaction activity.

关键词： dynamic distribution of charges coordination environment charge transfer orbital energy levels

How Does Korean Shipbuilding Realize Successful Transformation？

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中国船检 2011年第4期 114-115页

作者： liang zhiyong

Korea shipbuilding industry virtually started at 1970s,which overtook Japan to be world No.1 shipbuilding country a he beginning of the new century,Since then,while continuing to improve its building capacity,Korea shipbuilding industry focusas on pushing ahead with intensive development pattems,resulting in changing from big to strong.

关键词：韩国集约发展海洋工程设备造船业

Numerical Simulation of the Thin Film Coating Flow in Two-Dimension

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Open Journal of Fluid Dynamics 2017年第3期7卷 330-339页

作者： zhiyong liang Hui Zhou College of Science Donghua University Shanghai China

Thin film coating is a process of making liquid film cover and deposit base body surface by the way of dipping, spraying, sliding or spin coating, which is a kind of modern surface engineering. It plays an important role in the actual processing, such as improving the surface properties, fine processing, and new surface properties. Analysis of the influence of substrating morphology and fluid flow properties itself on coating fluid motion has an important significance to optimize the thin film coating and improve the quality of the final film. The influence from uneven substrate surface’s geometry configuration on internal motion of the flow field in slip-coating is analyzed by using the FLUENT software as a calculation platform. A two-dimension model of slip coating under isosceles triangle and isosceles trapezoid substrate was established, and thin film coating fluid motions under different configuration parameters were simulated. It is pointed out that the key factor determining the turbulence generation and evolution is the parameter of substrating surface nature. The effects of the change of Reynolds number on turbulent appearance and action area are studied. The velocity contours of fluid field on different substrate surfaces are shown, and the impact of substrate geometry on the backwater region is analyzed.

关键词： Numerical Simulation Thin Film Slip-Coating Surface Engineering Fluid Mechanics

Fast Target Tracking Based on Improved Deep Sort and YOLOv3 Fusion Algorithm

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国际计算机前沿大会会议论文集 2021年第1期 360-369页

作者： Yanqing Wang zhiyong liang Xinyu Cheng Nanjing Xiaozhuang University Nanjing 211171China

Aiming at fast moving targets, such as ships, high-speed vehicles andathletes, this paper discusses a series of target detection algorithms based on neuralnetwork, YOLOv3 and background modeling. Compared KCF tracking with SSDtracking, Gaussian filter was applied to remove noise from pictures, and edgepreserving filter was used to preserve edge features. Moreover, the algorithmcombining deepsort tracking algorithm with YOLOv3 detection algorithm canimprove the accuracy of YOLOv3 target detection, solve the problem of targetloss during target tracking, adjust the frame size in real time, and improve the fitwith the target position. Experiments show that the proposed algorithm based ondetection before tracking has strong learning ability and robustness to unknownenvironment.

关键词： Target detection Target tracking YOLOv3 Kalman filter

Genomic characterization reveals distinctmutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract

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Cancer Communications 2022年第12期42卷 1367-1386页

作者： Huanwen Wu Zicheng Yu Yueping Liu Lei Guo lianghong Teng Lingchuan Guo Li liang Jing Wang Jie Gao Ruiyu Li Ling Yang Xiu Nie Dan Su zhiyong liang Department of Pathology State Key Laboratory of Complex Severe and Rare DiseasesMolecular Pathology Research CenterPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730P.R.China Geneplus-Beijing Beijing 102200P.R.China Department of Pathology The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebei 050011P.R.China Department of Pathology Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China Department of Pathology Xuanwu HospitalCapital Medical UniversityBeijing 100053P.R.China Department of Pathology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215000P.R.China Department of Pathology Southern Medical UniversityGuangzhouGuangdong 510515P.R.China Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022P.R.China Department of Pathology The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhouZhejiang 310022P.R.China

Background:Neuroendocrine carcinomas of the gastrointestinal tract(GINECs)remain a disease of grim prognosis with limited therapeutic *** molecular characteristics are still *** study aimed to explore the underlying genetic basis and heterogeneity of ***:Comprehensive genomic analysis using whole-exome sequencing was performed on 143 formalin-fixed,paraffin-embedded samples of surgically resected GI-NEC with a thorough histological *** signatures,somatic mutations,and copy number aberrations were analyzed and compared across anatomic locations and histological *** analysis was conducted to identify the independent ***:In total,143GI-NECswere examined:the stomach,87 cases(60.8%);the esophagus,29 cases(20.3%);the colorectum,20 cases(14.0%);and the small intestine,7 cases(4.9%).Eighty-three(58.0%)and 60(42.0%)cases were subclassified into small cell and large cell subtypes,***-NECs showed distinct genetic alterations from their lung counterparts and non-neuroendocrine carcinomas in the same *** heterogeneity of mutational signatures,somatic mutations,and copy number variations was revealed across anatomic locations rather than histological *** for tumor protein p53(TP53)and retinoblastoma 1(RB1),the most frequently mutated genes in the stomach,esophagus,colorectum,and small intestine were low-density lipoprotein receptor-related protein 1B(LRP1B),notch receptor 1(NOTCH1),adenomatosis polyposis coli(APC),catenin beta 1(CTNNB1),*** in the WNT-β-catenin,NOTCH and erythroblastic leukemia viral oncogene B(ERBB)pathwayswere prevalently identified in gastric,esophageal,and colorectalNECs,***,104(72.7%)GI-NECs harbored putative clinically relevant alterations,and non-gastric location and RB1 bi-allelic inactivation with copy number alterations were identified as two independent poor prognostic ***,we found th

关键词： Neuroendocrine carcinomas Gastrointestinal tract Genomic characterization Heterogeneity Therapeutic implications

Cellular crosstalk of regulatory T cells in pancreatic ductal adenocarcinoma

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Journal of Pancreatology 2024年第2期7卷 131-140页

作者： Xuqing Shi Hangqi Liu zhiyong liang Department of Pathology State Key Laboratory of Complex Severe and Rare DiseaseMolecular Pathology Research CenterPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Pancreatic ductal adenocarcinoma(PDAC)is one of the most lethal solid tumors and is characterized by dense desmoplasia and immune *** T cells(Tregs)are critical components of the immune tumor microenvironment(TIME)of ***-induced immune evasion presents a significant hurdle in enhancing the efficacy of conventional and emerging therapeutic ***,Treg deficiency alone led to inconsistent *** unveil the underlying potential reasons for these results and to determine the role of Tregs in other therapeutic strategies,in-depth insights into the crosstalk between Tregs and other cells in PDAC are indispensable and currently ***,in this review,we comprehensively delineate the direct and indirect interplay between Tregs and various cellular constituents ranging from cancer cells and immune cells to stromal cells in PDAC in an attempt to uncover potential leads for the development of Treg-associated therapies.

关键词： Cancer-associated fibroblasts Cellular crosstalk Myeloid cells Pancreatic ductal adenocarcinoma Regulatory T cells

Surveying method of points on axis of cyllindrical pipe

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Geodesy and Geodynamics 2012年第1期3卷 27-33页

作者： Xu Jinjun Wang Haicheng Luo Yuzhen liang zhiyong School of Geodesy and Geomatics Wuhan University Wuhan 430079 China Hebei Investigation and Design Institute of Water Conservancy and Hydropower Tianjing 300250 China

To determine axes line of pipe or structural building which has a round normal section is recurrent in actual building works. The verticality measurement of chimney, TV tower and the deflection measurement of pipe are important to find out the deviation from design in construction, installation and completion. This pa- per discussed the measurement technique and data processing method for axes line of round normal section based on reflectorless distance measure. Simulation and practical results showed its feasibility and high effi- ciency.

关键词： reflectorless measurement round cross section ellipse centric point axes line