检索结果-南通市图书馆

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang zhiying chen Yinyi Xiong Qin Zhou Ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MOLECULAR DYNAMICS SIMULATION OF ENTROPY AND SURFACE TENSION FOR GRAIN BOUNDARY OF α-Fe

引用

Acta Mechanica Sinica 1991年第1期7卷 88-92页

作者： Ding Jiaqiang (1) chen zhiying (1) 1. Institute of Mechanics Chinese Academy of Sciences 100080 Beijing

The grain boundary is an interface and the surface tension is one of its important thermodynamic properties. In this paper, the surface tension of the Σ9 grain boundary for α-Fe at various temperatures and pressures is calculated by means of Computer Molecular Dynamics (CMD). The results agree satisfactorily with the experimental data. It. is shown that the contribution of entropy to surface tension of grain boundary can be ignored.

关键词： grain boundary entropy surface tension computer molecular dynamics simulation α-iron

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Molecular Dynamics Simulations on the Consolidation Process and Relaxed Structure of Nanocrystalline Alpha-Iron

引用

Chinese Physics Letters 1993年第2期10卷 103-106页

作者： chen zhiying YUAN Quan DING Jiaqiang Institute of Mechanics Academia SinicaBeijing 100080

The consolidation process of nanocrystallineα-Fe from single crystal grains is simulated and its relaxed atomic structure is obtained using molecular dynamics method.A uniaxial tensile“computer experiment”on this model nanocrystalline material proves that this“material”is mechanically stable and may be useful for the further studies on its mechanical and physical *** prepared nanocrystallineα-Fe consists of a crystalline component and a grain boundary *** result agrees with experimental facts *** calculated radial distribution function shows that the structure of the grain boundary component of nanocrystallineα-Fe appears to have an atomic distribution of short-range order.

关键词： grain distribution boundary

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chimeric antigen receptor （CAR）-modified natural killer cell-based immunotherapy and immunological synapse formation in cancer and HIV

引用

Protein & Cell 2017年第12期8卷 861-877页

作者： Dongfang Liu Shuo Tian Kai Zhang Wei Xiong Ndongala Michel Lubaki zhiying chen Weidong Han Center for Inflammation and Epigenetics Houston Methodist Research Institute Houston TX 77030 USA Department of Microbiology and Immunology WeUl Cornell Medical College Cornell University New York NY 10065 USA Institute of Basic Medicine College of Life Sciences Chinese PLA General Hospital Beijing 100853 China

Cytotoxic T lymphocytes （CTLs） and natural killer （NK） cells contribute to the body＇s immune defenses. Current chimeric antigen receptor （CAR）-modified T cell immunotherapy shows strong promise for treating var- ious cancers and infectious diseases. Although CAR- modified NK cell immunotherapy is rapidly gaining attention, its clinical applications are mainly focused on preclinical investigations using the NK92 cell line. Despite recent advances in CAR-modified T cell immunotherapy, cost and severe toxicity have hindered its widespread use. To alleviate these disadvantages of CAR-modified T cell immunotherapy, additional cyto- toxic cell-mediated immunotherapies are urgently nee- ded. The unique biology of NK cells allows them to serve as a safe, effective, alternative immunotherapeutic strategy to CAR-modified T cells in the clinic. While the fundamental mechanisms underlying the cytotoxicity and side effects of CAR-modified T and NK cell immunotherapies remain poorly understood, the for- mation of the immunological synapse （IS） between CAR- modified T or NK cells and their susceptible target cells is known to be essential. The role of the IS in CAR T and NK cell immunotherapies will allow scientists to harness the power of CAR-modified T and NK cells to treat can- cer and infectious diseases. In this review, we highlight the potential applications of CAR-modified NK cells to treat cancer and human immunodeficiency virus （HIV）, and discuss the challenges and possible future directions of CAR-modified NK cell immunotherapy, as well as the importance of understanding the molecular mechanisms of CAR-modified T cell- or NK cell-medi- ated cytotoxicity and side effects, with a focus on the CAR-modified NK cell IS.

关键词： natural killer cell chimeric antigenreceptor immunotherapy immunological synapse HIVcancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Purification characteristics and parameters optimization of anthocyanin extracted from blueberry

引用

International Journal of Agricultural and Biological Engineering 2015年第2期8卷 135-144页

作者： Zheng Xianzhe Zhang Zhaoguo Jin Changjiang Mu Yanqiu Liu chenghai chen zhiying Liu Haijun Lin Zhen College of Engineering Northeast Agricultural UniversityHarbin 150030China

To improve the yield and purity of anthocyanin extracted from blueberry,the characteristics and optimization for the separation and purification process of anthocyanin by AB-8 macroporous adsorbent resin was *** the absorption stage,the pH value has positive effect in ranges of 1.0-3.0 and the temperature rise has firstly negative then positive effect on adsorption rate of anthocyanin with adsorption *** the desorption stage,the ethanol concentration increase has firstly positive then steady effect and the temperature rise has positive and then negative effect on desorption rate of *** purification temperature may improve diffusion or induce degradation of ***-8 macroporous adsorbent resin is suitable to purify the anthocyanin from extract of powdered blueberries and the optimum parameters were obtained by using Design Expert software as adsorption time of 3 h,pH value of 1.0,adsorption temperature of 18℃ in absorption stage and desorption time of 30 min,ethanol concentration of 46.5%,desorption temperature of 22℃ in desorption stage with the highest absorption rate and desorption rate are 87.65% and 84.80%,respectively.

关键词： parameters optimization extraction purification adsorption desorption anthocyanin blueberry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The role of pathological tau in synaptic dysfunction in Alzheimer’s diseases

引用

Translational Neurodegeneration 2021年第4期10卷 584-594页

作者： Moxin Wu Manqing Zhang Xiaoping Yin Kai chen Zhijian Hu Qin Zhou Xianming Cao zhiying chen Dan Liu Department of Medical Laboratory Affiliated Hospital of Jiujiang UniversityJiujiang 332000China Jiujiang Clinical Precision Medicine Research Center Jiujiang 332000China Medical College of Jiujiang University Jiujiang 332000China Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiang 332000China Department of Dermatology Wuhan No.1 HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Medical Genetics Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Alzheimer's disease(AD)is a neurodegenerative disease characterized by progressive cognitive decline,accompanied by amyloid-β(Aβ)overload and hyperphosphorylated tau accumulation in the *** dysfunction,an important pathological hallmark in AD;is recognized as the main cause of the cognitive *** evidence suggests that synaptic dysfunction could be an early pathological event in *** tau,which is detached from axonal microtubules and mislocalized into pre-and postsynaptic neuronal compartments,is suggested to induce synaptic dysfunction in several ways,including reducing mobility and release of presynaptic vesicles,decreasing glutamatergic receptors,impairing the maturation of dendritic spines at postsynaptic terminals,disrupting mitochondrial transport and function in synapses,and promoting the phagocytosis of synapses by ***,we review the current understanding of how pathological tau mediates synaptic dysfunction and contributes to cognitive decline in *** propose that elucidating the mechanism by which pathological tau impairs synaptic function is essential for exploring novel therapeutic strategies for AD.

关键词： Pathological tau Synaptic dysfunction Synaptic plasticity Alzheimer's disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of the antioxidant activity of blueberry ethanol extracts under microwave extraction

引用

International Journal of Agricultural and Biological Engineering 2022年第4期15卷 205-213页

作者： chenghai Liu Xinglong Zhao Zhen Wang Xianzhe Zheng Liangliang Xue Chai Liu zhiying chen Bingfang Zhang College of Engineering Northeast Agricultural UniversityHarbin 150030China Heilongjiang Plant Quarantine and Plant Protection Station Harbin 150090China

Blueberry extract contains diversiform monomers of anthocyanins, whose antioxidant activity determines the functionality of anthocyanidins and the efficacy of extraction technology. The evaluation of the antioxidant activity of anthocyanidins of blueberry ethanol extracts (BEE) was investigated by considering the monomers' identification and thermal degradation in microwave-assisted extraction (MAE). Thirteen monomers of anthocyanins were identified from the extracts of blueberry under MAE, where the highest content was for cyanidin glycosides, and the lowest content was for the malvidin glycosides. The onset temperatures of degradation for anthocyanidins monomers in BEE were 41.07°C-48.50°C, and the glycoside contents of delphinidin, cyanidin, petunidin, peonidin, peonidin, and malvidin, in turn, decreased obviously. The degradation of anthocyanidins with extraction temperature improved, other than weakened, its antioxidant activities in BEE under MAE. The research results may provide valuable guidance for the antioxidant application of extracts from blueberries.

关键词： blueberry anthocyanins microwave-assisted extraction extracts monomer antioxidant activity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dislocations in the Crystallites of Nanocrystalline α-Fe—A Molecular Dynamics Study

引用

Journal of Materials Science & Technology 1996年第6期12卷 476-478页

作者： zhiying chen and Jiaqans DING (Lab. on Non-linear Mechanics of Continuous Media, Institute of Mechanics, Chinese Academy of Sciences,Beijing 100080, China)(To whom correspondence should be addressed) Lab. on Non-linear Mechanics of Continuous Media Institute of Mechanics Chinese Academy of Sciences Beijing 100080 China

Molecular dynamics simulations are carried out in order to Study the atomic structure of crystalline component of nanocrystalline α-Fe when it is consolidated from small grains. A two-dimensional computational block is used to simulate the consolidation process. All the preset dislocations in the original grains glide out of them in the consolidation process, but new dislocations can generate when the grain size is large enough. It shows that dislocations exist in the consolidated material rather than in the original grains. Whether dislocations exist in the crystalline component of the resultant model nano-material depends upon grain size. The critical value of grain size for dislocation generation appears to be about 9 nm. This result agrees with experiments qualitatively.

关键词： Fe A Molecular Dynamics Study Dislocations in the Crystallites of Nanocrystalline

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

航空发动机滑油监视与诊断系统软件研制

引用

推进技术 1998年第5期19卷 52-54页

作者：陈志英北京航空航天大学动力系

介绍了发动机滑油监视系统的功能和监测参数，并讲述了软件系统总体设计方案，给出了软件系统流程图，论述了软件各功能模块的内容和特点，本软件系统ＥＯＭＳ在厦门航空公司应用表明，该软件系统具有实用性等特点。

关键词：航空发动机滑油监控系统诊断系统软件

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于粗糙集神经网络和振动信号的高压断路器机械故障诊断

引用

电工技术学报 2020年第S01期35卷 277-283页

作者：林琳陈志英厦门理工学院福建省高电压技术重点实验室厦门361024 厦门理工学院电气工程与自动化学院厦门361024

为了准确检测出高压断路器的机械故障类型,该文提出一种基于本征模态边际谱能量与粗糙集神经网络相结合的高压断路器振动信号故障诊断方法。首先将断路器的振动信号经过经验模态分解(EMD),得到若干个本征模态函数(IMF),对各个IMF分量进... 详细信息

为了准确检测出高压断路器的机械故障类型,该文提出一种基于本征模态边际谱能量与粗糙集神经网络相结合的高压断路器振动信号故障诊断方法。首先将断路器的振动信号经过经验模态分解(EMD),得到若干个本征模态函数(IMF),对各个IMF分量进行希尔伯特(Hilbert)变换得到Hilbert边际谱,求取Hilbert边际谱的二次方得到Hilbert边际谱能量作为特征向量。基于粗糙集理论对特征向量进行属性约简分析,从而建立简单明了的决策表,根据决策表规则建立径向基函数(RBF)神经网络故障模型。实验结果表明,该方法能有效对高压断路器的机械故障类型进行分类。

关键词：高压断路器本征模态边际谱能量粗糙集神经网络振动信号故障诊断

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：