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艾迪注射液联合XELOX化疗方案治疗晚期结直肠癌患者的效果

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中国民康医学 2024年第10期36卷 123-125页

作者：崔志强陈琼闫志兴驻马店桐安肿瘤医院肿瘤科河南驻马店463000

目的:观察艾迪注射液联合XELOX(卡培他滨+奥沙利铂)化疗方案治疗晚期结直肠癌患者的效果。方法:选取2022年1月至2023年6月该院收治的76例晚期结直肠癌患者进行前瞻性研究,按随机数字表法将其分为对照组与研究组各38例。对照组采用XELOX... 详细信息

目的:观察艾迪注射液联合XELOX(卡培他滨+奥沙利铂)化疗方案治疗晚期结直肠癌患者的效果。方法:选取2022年1月至2023年6月该院收治的76例晚期结直肠癌患者进行前瞻性研究,按随机数字表法将其分为对照组与研究组各38例。对照组采用XELOX化疗方案治疗,研究组在对照组基础上联合艾迪注射液治疗。比较两组临床疗效,治疗前后卡氏功能状态(KPS)评分、肿瘤标志物[糖类抗原72-4(CA72-4)、癌胚抗原(CEA)、糖类抗原242(CA242)]水平,以及不良反应发生率。结果:研究组疾病控制率为63.16%(24/38),高于对照组的39.47%(15/38),差异有统计学意义(P<0.05);治疗后,两组KPS评分均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组CA72-4、CEA、CA242水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率为18.42%,低于对照组的42.11%,差异有统计学意义(P<0.05)。结论:艾迪注射液联合XELOX化疗方案治疗晚期结直肠癌患者可提高疾病控制率和KPS评分,降低肿瘤标志物水平和不良反应发生率,其效果优于单纯XELOX化疗方案治疗。

关键词：艾迪注射液 XELOX化疗方案晚期结直肠癌肿瘤标志物不良反应

康莱特注射液联合化疗在晚期肺癌患者中的应用效果

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中国民康医学 2024年第7期36卷 119-121,125页

作者：崔志强陈琼闫志兴驻马店桐安肿瘤医院肿瘤科河南驻马店463000

目的:观察康莱特注射液联合化疗在晚期肺癌患者中的应用效果。方法:选取2019年10月至2022年10月该院收治的86例晚期肺癌患者进行前瞻性研究,按随机数字表法将其分为观察组和对照组各43例。对照组予以化疗,观察组在对照组基础上联合康莱... 详细信息

目的:观察康莱特注射液联合化疗在晚期肺癌患者中的应用效果。方法:选取2019年10月至2022年10月该院收治的86例晚期肺癌患者进行前瞻性研究,按随机数字表法将其分为观察组和对照组各43例。对照组予以化疗,观察组在对照组基础上联合康莱特注射液治疗,比较两组客观缓解率(ORR)、治疗前后肿瘤标志物[神经元特异性烯醇化酶(NSE)、糖类抗原125(CA125)、癌胚抗原(CEA)]水平、肺功能指标[最大通气量(MVV)、用力肺活量(FVC)、第1秒用力呼气容积(FEVl)]水平、视觉模拟评分法(VAS)评分和治疗期间不良反应发生率。结果:观察组ORR为67.44%(29/43),高于对照组的44.19%(19/43),差异有统计学意义(P<0.05);治疗后,观察组NSE、CA125、CEA水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组MVV、FVC、FEV1水平均高于对照组,差异有统计学意义(P<0.05);治疗后,两组VAS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为9.30%(4/43),低于对照组的25.58%(11/43),差异有统计学意义(P<0.05)。结论:康莱特注射液联合化疗应用于晚期肺癌患者可提高ORR和肺功能指标水平,降低肿瘤标志物水平、VAS评分和不良反应发生率,效果优于单纯化疗。

关键词：晚期肺癌化疗康莱特注射液肿瘤标志物疼痛肺功能

Probabilistic modeling of multifunction radars with autoregressive kernel mixture network

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Defence Technology（防务技术） 2024年第5期35卷 275-288页

作者： Hancong Feng Kaili.Jiang zhixing Zhou Yuxin Zhao Kailun Tian Haixin yan Bin Tang School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

The task of modeling and analyzing intercepted multifunction radars(MFRs)pulse trains is vital for cognitive electronic reconnaissance.Existing methodologies predominantly rely on prior information or heavily constrained models,posing challenges for non-cooperative applications.This paper introduces a novel approach to model MFRs using a Bayesian network,where the conditional probability density function is approximated by an autoregressive kernel mixture network(ARKMN).Utilizing the estimated probability density function,a dynamic programming algorithm is proposed for denoising and detecting change points in the intercepted MFRs pulse trains.Simulation results affirm the proposed method's efficacy in modeling MFRs,outperforming the state-of-the-art in pulse train denoising and change point detection.

关键词： Probabilistic forecasting Multifunction radar Unsupervised learning Change point detection Outlier detection

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Boosting the performance of LiNi_(0.90)Co_(0.06)Mn_(0.04)O_(2) electrode by uniform Li_(3)PO_(4) coating via atomic layer deposition

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Chinese Chemical Letters 2024年第5期35卷 499-503页

作者： Mingjiao Lu zhixing Wang Gui Luo Huajun Guo Xinhai Li Guochun yan Qihou Li Xianglin Li Ding Wang Jiexi Wang School of Metallurgy and Environment Central South UniversityChangsha 410083China BASF ShanShan Battery Materials Co. Ltd.Changsha 410006China Engineering Research Center of the Ministry of Education for Advanced Battery Materials Central South UniversityChangsha 410083China Hunan Provincial Key Laboratory of Nonferrous Value-Added Metallurgy Central South UniversityChangsha 410083China School of Physics and Chemistry Hunan First Normal UniversityChangsha 410205China National and Local Joint Engineering Laboratory for Lithium-ion Batteries and Materials Preparation Technology Key Laboratory of Advanced Battery Materials of Yunnan ProvinceFaculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming 650093China

Ultra-high nickel material is considered to be a promising cathode material.However,with the increase of nickel content,the interfacial side reactions between the cathode and electrolyte become increasingly serious.Herein,an atomically controllable ionic conductor Li_(3)PO_(4)(LPO)coating is deposited on the LiNi_(0.90)Co_(0.06)Mn_(0.04)O_(2)(NCM9064)based electrode by the atomic layer deposition method.The results shows that the LPO coating is uniformly and densely covered on the surface of secondary particles of NCM9064,helping to prevent the direct contact between the electrolyte and cathode during the chargingdischarging process.In addition,the coating layer is electrochemically stable.As a result,the interfacial side reactions during the long cycle are effectively suppressed,and the solid electrolyte interphase layer at the interface is stabilized.The electrode with 20 layers of LPO deposition(ALD-LPO-20)exhibits an excellent capacity retention of 81%after 200 cycles in 2.8-4.3 V at 25℃,which is 18%higher than the unmodified material(ALD-LPO-0).Besides,the moderate LPO coating improves the rate capability and high temperature cycling performance of NCM9064.This study provides a method for the modification of ultra-high nickel cathode materials and corresponding electrodes.

关键词： Ultra-high nickel material LiNi_(0.90)Co_(0.06)Mn_(0.04)O_(2) Atomic layer deposition Li_(3)PO_(4) Ionic conductor

24 Model在道路运输事故成因中的应用

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汽车安全与节能学报 2024年第2期15卷 185-192页

作者：刘晓露梁志星吴君安严玉琼张苏福州大学环境与安全工程学院福州350116 福州海盈港务有限公司福州350015

为预防道路运输事故,基于事故致因“2-4”(24 Model)模型,对2015—2021年发生的215起道路运输事故的行为原因进行研究。从个人层面和组织层面分析导致事故发生的直接原因、间接原因、根本原因及其根源原因。结果表明:发生频次最多的不... 详细信息

为预防道路运输事故,基于事故致因“2-4”(24 Model)模型,对2015—2021年发生的215起道路运输事故的行为原因进行研究。从个人层面和组织层面分析导致事故发生的直接原因、间接原因、根本原因及其根源原因。结果表明:发生频次最多的不安全动作是驾驶员超速行驶(占10.67%);22.33%的道路运输事故存在管理者违章安排无资质员工上岗作业;管理者和领导者对57.67%的道路运输事故的发生有重要影响;由人为因素产生的不安全物态占比达71.53%;驾驶员、车辆安全生产管理制度欠缺或执行不到位在根本原因中尤为突出(占20.92%)。基于此,提出道路运输事故预防对策并构建出道路运输系统各因素关系图。

关键词：汽车主动安全道路运输事故事故致因 “2-4”模型(24 Model) 对策

一种基于内置变压器的高增益双向DC-DC变换器

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电源学报 2020年第3期18卷 4-12页

作者：严志星曾君赖臻刘俊峰华南理工大学电力学院广州510640 华南理工大学自动化科学与工程学院广州510640

提出一种应用在储能系统的双向DC-DC变换器,其具有电压增益高、电压应力小和软开关范围宽的优势。通过将内置变压器集成在飞跨电容结构和2个交错的Buck/Boost结构中,可以同时实现电压增益高和电压应力小。内置变压器结构的特点是磁芯中... 详细信息

提出一种应用在储能系统的双向DC-DC变换器,其具有电压增益高、电压应力小和软开关范围宽的优势。通过将内置变压器集成在飞跨电容结构和2个交错的Buck/Boost结构中,可以同时实现电压增益高和电压应力小。内置变压器结构的特点是磁芯中的磁通可以相互抵消,避免了磁饱和,从而有效地减小磁性器件的体积。通过采用交错的结构,低压侧的电流纹波明显减少;通过调节占空比,实现变压器原、副两边的电压匹配,从而减少环流;同时,通过采用移相控制,可以单调地调节传输功率;合理设置参数后,所有MOSFET可以实现宽范围的软开关。详细给出了工作原理和稳态分析,并设计了额定功率为1 kW的实验样机,以验证所述变换器的可行性。样机的效率在升压模式和降压模式下是相似的,这表明该变换器的效率是不受功率传输的方向影响的;在低压侧电压变化时,该变换器的效率变化不大。因此,所提变换器适用于需要高电压增益、宽电压侧电压范围的储能系统。

关键词：双向DC-DC变换器内置变压器交错技术高电压增益软开关

乳酸菌发酵乳蛋白水解物对RAW264.7细胞氧化损伤的保护作用

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食品与发酵工业 2024年第3期50卷 86-92页

作者：候智兴李恒蒋敏钱建瑛闫建国卢俭许正宏史劲松江南大学生命科学与健康工程学院江苏无锡214122 宁夏塞尚乳业有限公司宁夏银川750001 粮食发酵与食品生物制造国家工程研究中心江苏无锡214122

利用乳酸菌发酵乳蛋白水解物(milk protein hydrolysates,MPH)有助于提高乳酸菌水解蛋白的能力,促进功能成分的产生与挖掘。基于不同乳酸菌发酵MPH上清液的体外自由基清除能力和铁离子还原力综合评价,筛选获得一株抗氧化活性较强的鼠李... 详细信息

利用乳酸菌发酵乳蛋白水解物(milk protein hydrolysates,MPH)有助于提高乳酸菌水解蛋白的能力,促进功能成分的产生与挖掘。基于不同乳酸菌发酵MPH上清液的体外自由基清除能力和铁离子还原力综合评价,筛选获得一株抗氧化活性较强的鼠李糖乳酪杆菌(Lacticaseibacillus rhamnosus)ST(LST)。LST发酵MPH所得上清液产物(FPS)中,游离氨基酸总量比MPH提高了66.98%,分子质量低于180 Da组分增加8.66%。在H_(2)O_(2)诱导的RAW 264.7细胞氧化损伤模型中,FPS能显著提高细胞存活率,上调核因子E2相关因子2(nuclear factor E2-related factor 2,Nrf2)、超氧化物歧化酶1(superoxide dismutase 1,SOD1)、血红素加氧酶-1(heme oxygenase-1,HO-1)和谷胱甘肽过氧化酶1(glutathione peroxidase 1,GPX1)等抗氧化基因的转录水平。由此表明,鼠李糖乳酪杆菌LST发酵MPH可以有效缓解细胞氧化损伤,具有进一步应用于抗氧化食品开发的潜力。

关键词：乳酸菌乳蛋白水解物氧化损伤抗氧化

Two-dimensional Modeling of the Tearing-mode-governed Magnetic Reconnection in the Large-scale Current Sheet above the Two-ribbon Flare

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Research in Astronomy and Astrophysics 2022年第8期22卷 125-139页

作者： Yining Zhang Jing Ye zhixing Mei yan Li Jun Lin Yunnan Observatories Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Center for Astronomical Mega-Science Chinese Academy of SciencesBeijing 100101China

We attempt to model magnetic reconnection during the two-ribbon flare in a gravitationally stratified solar atmosphere with the Lundquist number of S=10~6 using 2 D simulations.We found that the tearing mode instability leads to inhomogeneous turbulence inside the reconnecting current sheet(CS)and invokes the fast phase of reconnection.Fast reconnection brings an extra dissipation of magnetic field which enhances the reconnection rate in an apparent way.The energy spectrum in the CS shows a power law pattern and the dynamics of plasmoids govern the associated spectral index.We noticed that the energy dissipation occurs at a scale l_(ko)of 100-200 km,and the associated CS thickness ranges from 1500 to 2500 km,which follows the Taylor scale l_(T)=l_(ko)S_(1/6).The termination shock(TS)appears in the turbulent region above flare loops,which is an important contributor to heating flare loops.Substantial magnetic energy is converted into both kinetic and thermal energies via TS,and the cumulative heating rate is greater than the rate of the kinetic energy transfer.In addition,the turbulence is somehow amplified by TS,in which the amplitude is related to the local geometry of the TS.

关键词： magnetic reconnection magnetohydrodynamics(MHD) Sun:flares turbulence

Free-standing ultrathick LiMn_(2)O_(4)@single-wall carbon nanotubes electrode with high areal capacity

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Journal of Energy Chemistry 2022年第10期31卷 452-459,I0012页

作者： Yuntao Guo Xinhai Li zhixing Wang Jiexi Wang Huajun Guo Guochun yan School of Metallurgy and Environment Central South UniversityChangsha 410083HunanChina Engineering Research Center of the Ministry of Education for Advanced Battery Materials Central South UniversityChangsha 410083HunanChina Hunan Provincial Key Laboratory of Nonferrous Value-added Metallurgy Central South UniversityChangsha 410083HunanChina

The ever-increasing demands for advanced lithium-ion batteries with high energy density have greatly stimulated the pursuit of thick electrodes with high active material loading.However,it is not feasible to prepare thick electrodes with traditional coating methods due to mechanical instability.Herein,using single-wall carbon nanotubes(SWCNT)as conductive carbon and binder,free-standing LiMn_(2)O_(4) thick electrodes(F-LMO)with ultrahigh-mass loading up to~190 mg cm^(-2)were prepared by vacuum filtration combined with freeze-drying.The thick electrodes with~30 mg cm^(-2)mass loading achieved a high specific capacity of 106.7 mAh g^(-1)with a good capacity retention of 94%over 50 cycles at 0.5 C,which was superior to the traditional coating electrodes(~20 mg cm^(-2))of 99.3 mAh g^(-1)with 95%because of the enhanced electronic conductivity originated from SWCNT.In addition,the high active material ratio of 97.5 wt%,near-theoretical reversible capacity,and high mass loading gave ultrathick F-LMO electrodes(600μm)of~190 mg cm^(-2)with a remarkable areal capacity of 20 mAh cm^(-2).Moreover,the concentration polarization that occurred in the thick F-LMO electrodes under high current density was discussed via electrochemical stimulation.

关键词： Thick electrodes Free-standing High areal capacity Concentration polarization