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A Hyper-Heuristic Framework for Lifetime Maximization in Wireless Sensor Networks With A Mobile Sink

IEEE/CAA Journal of Automatica Sinica 2020年第1期7卷 223-236页

作者： Jinghui Zhong zhixing huang Liang Feng Wan Du Ying Li School of Computer Science and Engineering South China University of TechnologyGuangzhou 510006China College of Computer Science Chongqing UniversityChongqing 400044China Department of Computer Science and Engineering School of EngineeringThe University of CaliforniaMerced USA Binxun Technology Co. LtdShenzhen 518000China

Maximizing the lifetime of wireless sensor networks(WSNs) is an important and challenging research problem. Properly scheduling the movements of mobile sinks to balance the energy consumption of wireless sensor network is one of the most effective approaches to prolong the lifetime of wireless sensor networks. However, the existing mobile sink scheduling methods either require a great amount of computational time or lack effectiveness in finding high-quality scheduling solutions. To address the above issues, this paper proposes a novel hyperheuristic framework, which can automatically construct high-level heuristics to schedule the sink movements and prolong the network lifetime. In the proposed framework, a set of low-level heuristics are defined as building blocks to construct high-level heuristics and a set of random networks with different features are designed for training. Further, a genetic programming algorithm is adopted to automatically evolve promising high-level heuristics based on the building blocks and the training networks. By using the genetic programming to evolve more effective heuristics and applying these heuristics in a greedy scheme, our proposed hyper-heuristic framework can prolong the network lifetime competitively with other methods, with small time consumption. A series of comprehensive experiments, including both static and dynamic networks,are designed. The simulation results have demonstrated that the proposed method can offer a very promising performance in terms of network lifetime and response time.

关键词： Index Terms—Genetic programming hyper-heuristics static and dynamic networks wireless sensor networks(WSNs).

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Late-stage azolation of benzylic C‒H bonds enabled by electrooxidation

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Science China Chemistry 2021年第5期64卷 800-807页

作者： Zhixiong Ruan zhixing huang Zhongnan Xu Shaogao Zeng Pengju Feng Ping-Hua Sun Key Laboratory of Molecular Target&Clinical Pharmacology and the State Key Laboratory of Respiratory Disease School of Pharmaceutical Sciences&the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education College of PharmacyJinan UniversityGuangzhou 510632China Department of Chemistry Jinan UniversityGuangzhou 510632China

The installation of azoles via C–H/N–H cross-coupling is significantly underdeveloped,particularly in benzylic C–H azolation due to the requirement for external chemical oxidants and the challenge in controlling the site-and chemo-selectivity.Herein,a late-stage azolation of benzylic C‒H bonds enabled by electrooxidation is described,which proceeds in an undivided cell under mild,catalyst-and chemical-oxidant-free reaction conditions.The strategy empowers the C‒H azolation on primary,secondary,and even challenging tertiary benzylic positions selectively.The remarkable synthetic utility of our approach is highlighted by its easy scalability without overoxidation of products and ample scope with valuable functional groups.The approach can be directly used to install benzyl and azole motifs on highly functionalized drug molecules.

关键词： electrooxidation azolation external oxidant-free cross-dehydrogenative coupling late-stage functionalization

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Direct Electrochemical Synthesis of Sulfur-Containing Triazolium Inner Salts

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Chinese Journal of Chemistry 2021年第4期39卷 942-946页

作者： Yueheng Li zhixing huang Guangquan Mo Wei Jiang Chengwei Zheng Pengju Feng Zhixiong Ruan Key Laboratory of Molecular Target&Clinical Pharmacology and the State Key Laboratory of Respiratory Disease School of Pharmaceutical Sciences&the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhouGuangdong 511436China Department of Chemistry Jinan UniversityGuangzhouGuangdong 510632China

Main observation and conclusion The electrochemical thiocyanation/cyclization of aldehyde hydrazones was developed under external oxidant-free and catalyst-free conditions.In contrast to previous thiocyanation,this electrosynthetic approach enabled a cascade C-H thiocyanation/cyclization through a mild,direct electrolysis manner in an undivided cell without the additive of halogens and stoichiometric oxidants.In this protocol,commercially available and inexpensive sodium thiocyanate was used,which played a dual role as a thiocyanation reagent and electrolyte.This strategy provides expedient access to functionalized sulfur-containing triazolium inner salts with ample scope and diverse functional group tolerance.Based on the findings of mechanistic studies,a reaction mechanism was proposed.

关键词： Electrochemistry Thiocyanation Cyclization Aldehyde Hydrazone Triazolium

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Cold acclimation improves photosynthesis by regulating the ascorbate–glutathione cycle in chloroplasts of Kandelia obovata

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Journal of Forestry Research 2019年第3期30卷 755-765页

作者： Weicheng Liu Chunfang Zheng Jinong Chen Jianbiao Qiu zhixing huang Qi Wang Yong Ye Zhejiang Key Laboratory of Exploitation and Preservation of Coastal Bio-resource Zhejiang Mariculture Research Institute325005 WenzhouPeople’s Republic of China College of Life and Environmental Science Wenzhou University325035 WenzhouPeople’s Republic of China Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystem College of the Environment and EcologyXiamen University361005 XiamenPeople’s Republic of China

As the most northerly mangrove species in China, Kandelia obovata may undergo extreme cold event stress. Enhancing the cold tolerance of this species is crucial to its successful afforestation. This study aimed to determine the resistance of K. obovata seedlings to low temperature stress by cold acclimation and to explain the mechanisms for alleviating cold injury. To understand these mechanisms, seedlings that were acclimatized and not acclimatized were exposed to 5℃/- 2℃(day/night)for 48 h.Results showed that low temperature stress reduced leaf photosynthesis of non-acclimatized seedlings by inducing oxidative stress and structural damage to chloroplasts. These phenomena were shown by increasing levels of malondialdehyde (MDA), O2-and H2O2, as well as decreasing enzyme activities in the ascorbate–glutathione (AsA-GSH) cycle. However, cold-acclimatized seedlings had improved photosynthetic rates and efficiency of photosystem II (PSII) under low temperature stress. Compared with non-acclimatized seedlings, leaves of coldacclimatized seedlings under low temperature stress for 48 h exhibited higher anti-oxidative enzyme activities, lower levels of O2^- and H2O2, less damage to chloroplast structure, and removed 33.7% of MDA at low temperature stress for 48 h. The data indicate that cold acclimation enhances photosynthetic capacity by effectively regulating activation in the PSII electron transport and the AsA–GSH cycle to scavenge excess ROS in chloroplasts, while the latter is more important.

关键词： Ascorbate–glutathione cycle Cold acclimation Kandelia obovata Photosynthesis

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基于YOLOv5s的自动扶梯乘客异常行为实时检测算法

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激光与光电子学进展 2024年第8期61卷 201-208页

作者：王源鹏万海斌黄凯迟兆展张金旗黄智星广西大学计算机与电子信息学院广西南宁530004 广西大学机械工程学院广西南宁530004

为了实时检测乘客的异常行为,提出一种基于YOLOv5s算法的轻量化自动扶梯乘客异常行为实时检测算法YOLO-STE。首先在主干网络中引入轻量化ShuffleNetV2网络,以减少主干网络的参数量和计算量;其次在骨干网络的最后一层引入基于Transforme... 详细信息

为了实时检测乘客的异常行为,提出一种基于YOLOv5s算法的轻量化自动扶梯乘客异常行为实时检测算法YOLO-STE。首先在主干网络中引入轻量化ShuffleNetV2网络,以减少主干网络的参数量和计算量;其次在骨干网络的最后一层引入基于Transformer编码的C3TR模块,以更好地提取丰富的全局信息和融合不同尺度的特征;最后在YOLOv5s的特征融合网络中嵌入SE(Squeeze-and-excitation)注意力机制,以更好地关注主要信息,从而提高模型精度。自建数据集并进行实验,实验结果表明,相比于原YOLOv5s,改进算法的全类平均精度值(mAP)高出1.9百分点,达到了96.1%,模型大小减少了70.8%。并且在Jetson Nano硬件上部署测试所得,改进后的算法前传耗时比原YOLOv5s模型缩短了39.9%。通过对比改进前后的算法,后者能更好地实现对自动扶梯乘客异常行为的实时检测,从而可以更好地保障乘客乘梯安全。

关键词：目标检测轻量化 YOLOv5s ShuffleNetV2 C3TR模块注意力机制

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基于细观力学的多相耐火材料压缩状态损伤表征

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粉末冶金材料科学与工程 2024年第2期29卷 93-100页

作者：黄志兴王志刚刘昌明李贤军武汉科技大学省部共建耐火材料与冶金国家重点实验室武汉430081 武汉科技大学冶金装备及其控制教育部重点实验室武汉430081 武汉科技大学机械自动化学院武汉430081

针对多相复合耐火材料压缩状态下的非线性力学行为,在细观损伤力学的基础上,对改进的广义自洽模型进行逆向求解,研究多相耐火材料受到压缩载荷时的损伤行为,提出一种能表征多相耐火材料在压缩载荷下非线性损伤行为的方法。以AMC(aluminu... 详细信息

针对多相复合耐火材料压缩状态下的非线性力学行为,在细观损伤力学的基础上,对改进的广义自洽模型进行逆向求解,研究多相耐火材料受到压缩载荷时的损伤行为,提出一种能表征多相耐火材料在压缩载荷下非线性损伤行为的方法。以AMC(aluminum-magnesium-carbon)多相耐火材料为例,利用该方法对其在受压状态下的力学行为进行表征。结果显示,表征结果和实验值吻合较好,为多相复合耐火材料的损伤表征提供了一种思路和理论基础。

关键词：细观损伤力学多相耐火材料损伤表征广义自洽模型非线性力学行为

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Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis

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Signal Transduction and Targeted Therapy 2024年第2期9卷 738-750页

作者： Yun Zhang Lijun Du Chenxi Wang Zhangsheng Jiang Qingchi Duan Yiping Li Zhijun Xie zhixing He Yi Sun Lin huang Liwei Lu Chengping Wen Key Laboratory of Chinese medicine rheumatology of Zhejiang Province Research Institute of Chinese Medical Clinical Foundation and ImmunologyCollege of Basic Medical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China Department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong KongHong KongChina Chongqing International Institute for Immunology Chongqing 400038China

Systemic lupus erythematosus(SLE),a severe autoimmune disorder,is characterized by systemic inflammatory response,autoantibody accumulation and damage to organs.The dysregulation of double-negative(DN)T cells is considered as a crucial commander during SLE.Neddylation,a significant type of protein post-translational modification(PTM),has been well-proved to regulate T cell-mediated immune response.However,the function of neddylation in SLE is still unknown.Here,we reported that neddylation inactivation with MLN4924,a specific inhibitor of NEDD8-activating enzyme E1(NAE1),or genetic abrogation of Ube2m in T cells decreased DN T cell accumulation and attenuated murine lupus development.Further investigations revealed that inactivation of neddylation blocked Bim ubiquitination degradation and maintained Bim level in DN T cells,contributing to the apoptosis of the accumulated DN T cells in lupus mice.Then double knockout(KO)lupus-prone mice(Ube2m-/-Bim-/-lpr)were generated and results showed that loss of Bim reduced Ube2m deficiency-induced apoptosis in DN T cells and reversed the alleviated lupus progression.Our findings identified that neddylation inactivation promoted Bim-mediated DN T cell apoptosis and attenuated lupus progression.Clinically,we also found that in SLE patients,the proportion of DN T cells was raised and their apoptosis was reduced.Moreover,compared to healthy groups,SLE patients exhibited decreased Bim levels and elevated Cullin1 neddylation levels.Meantime,the inhibition of neddylation induced Bim-dependent apoptosis of DN T cells isolated from SLE patients.Altogether,our findings provide the direct evidence about the function of neddylation during lupus,suggesting a promising therapeutic approach for this disease.

关键词： inactivation double finding

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小坪矿区铅锌矿资源勘察及成矿规律探析

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江西建材 2023年第4期 102-103,108页

作者：黄志星福建省地质调查研究院福建福州350013

文中结合实际情况,通过对区域地质、地球物理化学、地层岩性、构造及构造角砾岩发育特征、地球物理特征等进行综合分析,对小坪矿区铅锌研究成矿规律进行归纳,通过成矿规律特征的分析,对找矿标志矿化特征等进行总结,为后续铅锌矿的地质... 详细信息

文中结合实际情况,通过对区域地质、地球物理化学、地层岩性、构造及构造角砾岩发育特征、地球物理特征等进行综合分析,对小坪矿区铅锌研究成矿规律进行归纳,通过成矿规律特征的分析,对找矿标志矿化特征等进行总结,为后续铅锌矿的地质找矿以及成矿研究提供参考。

关键词：铅锌矿地层岩性矿产地质资源勘察成矿规律

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THE DETERMINATION OF THE FLELD PARAMETERS OF SADDLE DEFLECTION YOKE WITH A FERROMAGNETIC SHIELD

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Journal of Electronics(China) 1988年第1期5卷 7-15页

作者：谢志行黄达诠沈庆垓 Department of Radio Engineering Zhejiang University

The analysis and computation of the field distribution of the saddle deflection coil with aferromagnetic shield by the boundary element method are described,and the limitations of the modelproposed by D.M.Fye（1979）is pointed out.The Green’s function is expanded by the Maclaurin series,andthe analytical forms of the field parameters B0,B2,and B4 are given.The results obtained agree well with theexperimentally measured values.

关键词： Electron optics Defletion yoke Field computation BEM

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基于永磁无刷电机的电动仿真目标动力系统设计

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车辆与动力技术 2023年第3期 41-46页

作者：苏亮裴长江黄智兴中信机电制造公司科研设计院侯马043007

永磁无刷电机电动机的两后胎单独推动,这种类型的仿真目标底盘对比传统的燃油仿真底盘目标而言,可控性好,数字化与无人化研发周期短,而且永磁无刷电机底盘运行情况下的传动效率和运行成本较普通汽车底盘具备更为明显的优点.文中根据现... 详细信息

永磁无刷电机电动机的两后胎单独推动,这种类型的仿真目标底盘对比传统的燃油仿真底盘目标而言,可控性好,数字化与无人化研发周期短,而且永磁无刷电机底盘运行情况下的传动效率和运行成本较普通汽车底盘具备更为明显的优点.文中根据现阶段新能源底盘领域的迅猛发展,研究了轮式电动底盘驱动系统,阐述了永磁无刷电机电动机有关理论基础,根据研究的方法,开展认证.在实验过程中首先确保主要参数配对,且合乎车辆动态性能规定,提出了一种外转子永磁直流无刷电机,磁石的构造,车轮尺寸配置、永磁铁氧体和驱动电源的选用及其主要参数配对的最优方案,并构建数字模型测试.

关键词：电动仿真目标驱动电机设计电流预测控制

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