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实施性研究利益相关方偏好评估

协和医学杂志 2024年第6期15卷 1447-1455页

作者：卯润蔡毅媛杨程茗彭井兰宁芷晴刘思源徐东贵州医科大学公共卫生与健康学院流行病与卫生统计学系Acacia基层医疗卫生实验室贵阳561113 贵州医科大学公共卫生与健康学院环境污染与疾病监控教育部重点实验室贵阳561113 南方医科大学卫生管理学院卫生管理学系Acacia实施科学实验室广州510515 南方医科大学公共卫生学院广州510515 南方医科大学皮肤病医院全球健康研究院广州510091 南方医科大学世界卫生组织研究中心广州510515

针对健康服务问题开展实施性研究过程中,服务供需双方(即利益相关方)对循证实践内容和实施策略的偏好直接影响实施的成败。目前,存在多种偏好评估方法,其各具特点,且适用场景不同,为研究者选择适宜的方法带来挑战。本文对常用偏好评估... 详细信息

针对健康服务问题开展实施性研究过程中,服务供需双方(即利益相关方)对循证实践内容和实施策略的偏好直接影响实施的成败。目前,存在多种偏好评估方法,其各具特点,且适用场景不同,为研究者选择适宜的方法带来挑战。本文对常用偏好评估方法的起源、特点及应用场景进行阐述,以期为国内学者选择适宜的偏好评估方法提供参考。

关键词：实施性研究循证实践偏好评估应用场景

CsOH catalyzed aerobic oxidative synthesis of p-quinols from multi-alkyl phenols under mild conditions

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Science China Chemistry 2015年第8期58卷 1334-1339页

作者： Yu-Feng Liang Kai Wu zhiqing Liu Xiaoyang Wang Yujie Liang Chenjiang Liu ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University The Key Laboratory of Oil and Gas Fine Chemicals Ministry of Education & Xinjiang Uygur Autonomous Region Xinjiang University

p-Quinols are ubiquitous structural motifs of various natural products and pharmaceutical compounds,and versatile building blocks in synthetic *** reported methods for the synthesis of p-quinol require stoichiometric amounts of *** oxygen is considered as an ideal oxidant due to its natural,inexpensive,and environmentally friendly *** the ongoing research of C–H bond hydroxylation,we found that multi-alkyl phenols could react with molecular oxygen under mild ***,we describe an efficient oxidative de-aromatization of multi-alkyl phenols to p-quinols.1 atm of molecular oxygen was used as the *** multi-alkyl phenols could react smoothly at room *** labeling experiment was also performed,and the result proved that the oxygen atom in the produced hydroxyl group is from molecular oxygen.

关键词： p-quinol molecular oxygen de-aromatization carbanion cesium hydroxide

Current Status of the Research on Coal Geology in China

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Acta Geologica Sinica(English Edition) 2016年第4期90卷 1284-1297页

作者： WANG Tong WANG Qingwei SHAO Longyi XIA Yucheng FU Xuehai ning Shuzheng XIE zhiqing JIANG Tao China National Administration of Coal Geology Beijing 100039China College of Resources and Environment North China University of Water Resources and Electric PowerZhengzhou 450046China College of Geoscience and Surveying Engineering China University of Mining and Technology(Beijing)Beijing 100083China Xi'an University of Science and Technology Xi'an 710054China China University of Mining and Technology Xuzhou 221008China

Coal is the main energy in China, which has already played and will continue to play an important role in the national economy. Coal geology, as a practical science, has an access to gradual development with the growth and prosperity of China. From the meaning of the coalfield geology, this paper introduces the research progress and status of coalfield geology, including the research on coal basin, stratigraphy of coal-bearing stratigraphic sequences, coal-forming process, structural geology of coalfields, and exploration and development status of coal resources. The paper specially focuses on coal-forming process, including coal formation in terrestrial facies and transgressive / regression events, and introduces new technology which has been applied to research progress in structural geology of coalfield. This paper puts forward a new comprehensive exploration system for coal exploration and reviews regional coal geological exploration results in recent years, such as coal-poor regions of seven provinces in southern China and the coal resources area in northwest China, which will be an important coal-producing area in the future .

关键词： coal resource distribution exploration and exploitation new thought

Tauroursodeoxycholic acid(TUDCA) inhibits influenza A viral infection by disrupting viral proton channel M2

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Science Bulletin 2019年第3期64卷 180-188页

作者： ning Li Yanxu Zhang Shuangxiu Wu Ruodan Xu zhiqing Li Jindong Zhu Hongliang Wang Xiao Li Mingyao Tian Huijun Lu ningyi Jin Chengyu Jiang State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Peking Union Medical College Tsinghua University China Academy of Chinese Medicine Sciences Interdisciplinary Nanoscience Center (iNANO) Department of Engineering Aarhus University Genetic Engineering Laboratory Institute of Military Veterinary Academy of Military Medical Sciences

Influenza is a persistent threat to human health and there is a continuing requirement for updating antiinfluenza strategies. Initiated by observations of different endoplasmic reticulum(ER) responses of host to seasonal H1N1 and highly pathogenic avian influenza(HPAI) A H5N1 infections, we identified an alternative antiviral role of tauroursodeoxycholic acid(TUDCA), a clinically available ER stress inhibitor, both in vitro and in vivo. Rather than modulating ER stress in host cells, TUDCA abolished the proton conductivity of viral M2 by disrupting its oligomeric states, which induces inefficient viral infection. We also showed that M2 penetrated cells, whose intracellular uptake depended on its proton channel activity,an effect observed in both TUDCA and M2 inhibitor amantadine. The identification and application of TUDCA as an inhibitor of M2 proton channel will expand our understanding of IAV biology and complement current anti-IAV arsenals.

关键词： Influenza TUDCA M2 proton channel Virus entry Cell-penetrating peptide Oligomerization inhibitor

Hippo pathway-manipulating neutrophil-mimic hybrid nanoparticles for cardiac ischemic injury via modulation of local immunity and cardiac regeneration

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Acta Pharmaceutica Sinica B 2023年第12期13卷 4999-5015页

作者： Qiaozi Wang Yanan Song Jinfeng Gao Qiyu Li Jing Chen Yifang Xie Zhengmin Wang Haipeng Tan Hongbo Yang ning Zhang Juying Qian zhiqing Pang Zheyong Huang Junbo Ge Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghai 200032China Institute of Biomedical Sciences Fudan UniversityShanghai 200032China School of Pharmacy Fudan UniversityKey Laboratory of Smart Drug DeliveryMinistry of EducationShanghai 201203China National Clinical Research Center for Interventional Medicine Shanghai 200032China

The promise of regeneration therapy for restoration of damaged myocardium after cardiac ischemic injury relies on targeted delivery of proliferative molecules into cardiomyocytes whose healing benefits are still limited owing to severe immune microenvironment due to local high concentration of proinflammatory *** therapeutic strategies are therefore in urgent need to both modulate local immunity and deliver proliferative ***,we addressed this unmet need by developing neutrophil-mimic nanoparticles NM@miR,fabricated by coating hybrid neutrophil membranes with artificial lipids onto mesoporous silica nanoparticles(MSNs)loaded with *** hybrid membrane could endow nanoparticles with strong capacity to migrate into infammatory sites and neutralize proinfammatory cytokines and increase the delivery efficiency of microRNA-1Ob into adult mammalian cardiomyocytes(CMs)by fusing with cell membranes and leading to the release of MSNs-miR into *** NM@miR administration,this nanoparticle could home to the injured myocardium,restore the local immunity,and efficiently deliver microRNA-1Ob to cardiomyocytes,which could reduce the activation of Hippo-YAP pathway mediated by excessive cytokines and exert the best proliferative effect of *** combination therapy could finally improve cardiac function and mitigate ventricular ***,this work offers a combination strategy of immunity modulation and proliferative molecule delivery to boost cardiac regeneration after injury.

关键词： Myocardial infarction Cardiac regeneration Biomimetic nanoparticles Neutrophils Immunity restoration MicroRNA Hippo pathway Membrane fusion

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机场登机口优化调度算法及实证

南京航空航天大学学报 2007年第6期39卷 819-823页

作者：王志清商红岩宁宣熙南京航空航天大学经济与管理学院南京210016

在图论的基础上建立了旅客登机口优化安排的网络模型,给出了它的优化算法。考虑到在登机口调度的实际运作中存在着飞机停场的时间限制、"航班对"的限制和机型与登机口的匹配等限制,提出了该理论模型在使用中的实用算法,并用首都机场18... 详细信息

在图论的基础上建立了旅客登机口优化安排的网络模型,给出了它的优化算法。考虑到在登机口调度的实际运作中存在着飞机停场的时间限制、"航班对"的限制和机型与登机口的匹配等限制,提出了该理论模型在使用中的实用算法,并用首都机场18个登机口优化安排334个航班的例子证实了这种算法在缩短旅客步行距离和提高设施利用率方面的显著效果。该算法也可以用于到港飞机停靠廊桥的优化安排,以减少旅客从廊桥到行李房步行的总距离。

关键词：登机口调度优化调度网络模型机场规划

Mismatched donor cell infusion-related syndrome following microtransplant in patients with acute myeloid leukemia

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Chinese Medical Journal 2023年第7期136卷 815-821页

作者： Bo Cai Xiaoyan Zou Xin ning Tieqiang Liu Bingxia Li Yaqing Lei Jianhui Qiao Kaixun Hu Yangyang Lei zhiqing Liu Bo Yao Huisheng Ai Yi Wang Changlin Yu Mei Guo Department of Hematology The Fifth Medical CenterChinese PLA General HospitalBeijing 100071China

Background:Immunotherapies such as adoptive immune cell infusion and immune-modulating agents are widely used for cancer treatment,and the concomitant symptoms,including cytokine release syndrome(CRS)or immune-related adverse events(irAEs),are frequently ***,clinical manifestations induced by mismatched donor granulocyte colony-stimulating factor mobilized peripheral blood mononuclear cell(GPBMC)infusion in patients receiving microtransplant(MST)have not yet been well ***:We analyzed 88 cycles of mismatched GPBMC infusion in patients with acute myeloid leukemia receiving MST and 54 cycles of chemotherapy without GPBMC infusion as a *** symptoms and their correlation with clinical features,laboratory findings,and clinical response were ***:Fever(58.0%[51/88])and chills(43.2%[38/88])were the significant early-onset symptoms after GPBMC *** possessing less human leukocyte antigen-matching loci with the donor or those with unrelated donors experienced more chills(3[2–5]loci vs.5[3–5]loci,P=0.043 and 66.7%[12/18]vs.37.1%[26/70],P=0.024).On the other hand,those with decreased CD4^(+)/CD8^(+)T-cell ratio developed more fever(0.8[0.7–1.2]vs.1.4[1.1–2.2],P=0.007).Multivariable analysis demonstrated that younger patients experienced more fever(odds ratio[OR]=0.963,95%confidence interval[CI]:0.932–0.995,P=0.022),while patients with younger donors experienced more chills(OR=0.915,95%CI:0.859–0.975,P=0.006).Elevated ultra-sensitive C-reactive protein levels in the absence of cytokine storm were observed following GPBMC infusion,which indicated mild and transient inflammatory *** no predictive value of infusion-related syndrome to leukemia burden change was found,the proportion of host pre-treatment activated T cells was positively correlated with leukemia ***:Mismatched GPBMC infusion in MST induced unique infusion-related symptoms and laboratory changes,which were associated with

关键词： Microtransplant Immunotherapy Adoptive immune cell infusion Adverse events Acute myeloid leukemia

冲击荷载作用下含黏结界面混凝土破坏特征与应力应变分析

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上海交通大学学报 2022年第9期56卷 1208-1217页

作者：赵洪谢友均龙广成李宁张嘉伟程智清中南大学土木工程学院长沙410075 湖南工学院材料科学与工程学院湖南衡阳421002 西南交通大学牵引动力国家重点实验室成都610031

为研究冲击荷载下板式无砟轨道结构蒸养混凝土与自密实混凝土层间界面的破坏行为,利用分离式霍普金森杆(SHPB)对含黏结界面混凝土进行冲击试验,并就其破坏特征和应力应变全曲线特性以及损伤本构方程进行探讨.结果表明:含黏结界面混凝土... 详细信息

为研究冲击荷载下板式无砟轨道结构蒸养混凝土与自密实混凝土层间界面的破坏行为,利用分离式霍普金森杆(SHPB)对含黏结界面混凝土进行冲击试验,并就其破坏特征和应力应变全曲线特性以及损伤本构方程进行探讨.结果表明:含黏结界面混凝土在动态冲击荷载作用下存在界面脱黏分离和整体破碎两种失效模式.界面脱黏分离失效模式下,随着应变率的增加,含黏结界面混凝土的动态抗压强度、强度动态提高因子(DIF)、峰值应变、冲击韧性均增加,具有明显的应变率敏感性;整体破碎失效模式下,界面脱黏变形和破碎变形同时存在,随着应变率的增加,裂纹向界面区域累积、拓展,界面起到了能量缓冲的作用,此时含黏结界面混凝土动态抗压强度、DIF基本不变,而峰值应变和冲击韧性增加.所建立的基于Weibull分布的本构模型与试验结果吻合较好,尤其对峰前应力应变曲线有很好的匹配性.

关键词：分离式霍普金森压杆试验层间界面冲击韧性应力应变曲线本构模型

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用于施工进度优化的VNS-CRO混合算法

江苏大学学报（自然科学版） 2016年第1期37卷 115-120,124页

作者：蒋宇一邵志清蔡宁张欢欢华东理工大学信息科学与工程学院上海200237 上海嘉定交通发展集团有限公司上海201899

针对现有研究中忽略施工任务分包资源系统异构的问题,结合建筑信息模型技术与异构环境下任务调度理论,提出变邻域搜索-化学反应混合优化算法,实现了对异构资源环境下道路施工进度计划任务调度与分包的优化.该算法在有向无环图模型与异... 详细信息

针对现有研究中忽略施工任务分包资源系统异构的问题,结合建筑信息模型技术与异构环境下任务调度理论,提出变邻域搜索-化学反应混合优化算法,实现了对异构资源环境下道路施工进度计划任务调度与分包的优化.该算法在有向无环图模型与异构资源系统模型的基础上,融合了约束关键路径重排序策略,并在初始化与优化构造超级分子阶段,设计应用了一种平衡邻域结构的变邻域搜索方法,强化了算法的整体优化能力.模拟试验使用上海市陈翔路工程的实际工程数据,试验结果验证了所提出算法优化的有效性与鲁棒性及其相对其他算法的优势.

关键词：施工进度优化建筑信息模型变邻域搜索方法化学反应优化算法异构资源系统