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Pre-mating nitenpyram exposure in male mice leads to depression-like behavior in offspring by affecting tryptophan metabolism in gut microbiota

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Journal of Environmental Sciences 2024年第3期137卷 120-130页

作者： Sen Yan Wei Sun Sinuo Tian Zhiyuan Meng Jinling Diao zhiqiang zhou Li Li Wentao Zhu Innovation Center of Pesticide Research Department of Applied ChemistryCollege of ScienceChina Agricultural UniversityBeijing 100193China College of Plant Protection/Joint International Research Laboratory of Agriculture&Agri-Product Safety Yangzhou UniversityYangzhou 225009China College of Plant Protection Shanxi Agricultural UniversityTaiyuan 030031China

Several studies have confirmed that the health status of the paternal affects the health of the offspring,however,it remains unknown whether paternal exposure to pesticides affect the offspring ***,we used untargeted metabolomics and 16S rRNA sequencing technology,combined with tail suspension test and RT-qPCR to explore the effects of paternal exposure to nitenpyram on the neurotoxicity of *** results found that the paternal exposure to nitenpyram led to the offspring’s depressive-like behaviors,accompanied by the reduction of tryptophan content and the disorder of microbial abundance in the gut of the ***,we determined the expression of tryptophan metabolism-related genes tryptophanase(tnaA)and tryptophan hydroxylase 1(TpH1)in gut bacteria and colonic *** found that tryptophan is metabolized to indoles rather than being absorbed into colonocytes,which coursed the reduce of tryptophan availability after nitenpyram *** conclusion,our study deepens our understanding of the intergenerational toxic effects of pesticides.

关键词： Nitenpyram Depressive-like behaviors Gut microbiota Tryptophan metabolism

Beware of the serious harm of veterinary drug poisoning:a case report

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World Journal of Emergency Medicine 2024年第2期15卷 153-155页

作者： Ping Dai Jin Sun Tongyue Zhang zhiqiang zhou Zixi Wen Tianzi Jian Aerbusili Genjiafu Baotian Kan Xiangdong Jian Department of Poisoning and Occupational Diseases Emergency MedicineQilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012China Emergency Department Affiliated the Jianhu Clinical Medical College of Yangzhou UniversityYancheng 224700China Department of Occupational and Environmental Health School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China School of Nursing and Rehabilitation Cheeloo College of MedicineShandong UniversityNursing Theory&Practice Innovation Research Center of Shandong UniversityJinan 250012China Department of Geriatric Medicine Qilu HospitalNursing Theory Innovation and Research Center of Shandong UniversityCheeloo College of MedicineShandong UniversityJinan 250012China

Veterinary drugs are substances(including pharmaceutical feed additives)used to prevent,treat,and diagnose diseases or regulate the physiological functions of *** drug poisoning in humans is relatively rare both in China and the rest of the ***,we report a case of death from veterinary drug poisoning from ***-closantel is a broad-spectrum antiparasitic drug,which has high efficacy against a variety of trematodes and nematodes.

关键词： drug drugs diseases

近断层砂化白云岩隧洞突水涌砂演化过程及防突岩盘安全厚度研究

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岩石力学与工程学报 2024年第3期43卷 639-652页

作者：张延杰董家兴周志强周伦顺米健刘登学云南省滇中引水工程有限公司云南昆明650000 昆明理工大学国土资源工程学院云南昆明650093 昆明理工大学电力工程学院云南昆明650500 云南省水利水电勘测设计研究院云南昆明650021 长江科学院水利部岩土力学与工程重点实验室湖北武汉430010

滇中引水工程砂化白云岩隧洞突水涌砂灾害频发,严重制约工程进度并威胁着施工安全。通过施工跟踪、砂化白云岩隧洞突水涌砂案例统计、理论分析等手段,总结富水洞段突水涌砂的成灾条件及灾变特征;基于小扑隧洞典型近断层段的突水涌砂灾... 详细信息

滇中引水工程砂化白云岩隧洞突水涌砂灾害频发,严重制约工程进度并威胁着施工安全。通过施工跟踪、砂化白云岩隧洞突水涌砂案例统计、理论分析等手段,总结富水洞段突水涌砂的成灾条件及灾变特征;基于小扑隧洞典型近断层段的突水涌砂灾害原型,采用FLAC3D模拟突水涌砂过程渗流场、应力场、位移场的演化,确定突水涌砂灾害的防突岩盘安全厚度临界判据,并建立系统、可行的灾害防控体系。研究结果表明:(1)突水涌砂通常发生在断层发育的富水强烈、剧烈砂化洞段;(2)突水涌砂灾变演化过程中,强烈、剧烈砂化白云岩孔隙水压力均存在漏斗效应,剧烈砂化白云岩渗流量变化与强烈砂化白云岩相比存在时滞性,并且剧烈砂化白云岩的渗流量明显比强烈砂化白云岩小;(3)强烈砂化白云岩隧洞开挖至距离断层4 m时,隧洞围岩应力出现突变现象,剧烈砂化白云岩隧洞开挖至距离断层8~9 m时,呈现出明显的拉应力区域;(4)强烈砂化洞段拱顶最大沉降于开挖至距离断层1 m时出现,而剧烈砂化洞段位移场演化无明显规律;(5)确定了富水砂化白云岩隧洞防突岩盘安全厚度临界判据,通过工程实例计算得到的最小安全厚度与实际工程预留接近。结合综合超前地质预报、富水砂化白云岩隧洞突水涌砂演化过程建立的隧洞施工期突水涌砂防控体系,可为富水砂化白云岩地下工程易发频发的突水涌砂灾害防控提供借鉴。

关键词：隧道工程富水砂化白云岩工程原型流固耦合演化过程防突岩盘安全厚度

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基于矢量量化IFTS的网络流量预测模型

计算机应用与软件 2024年第1期41卷 71-77,88页

作者：周志强杨雪青河南农业职业学院河南郑州451450

针对传统网络流量预测模型存在的局限性,提出一种基于矢量量化直觉模糊时间序列的网络流量预测模型。利用模糊直觉推理有效地表述了网络流量数据中存在的高度模糊性以及不确定性,利用直觉模糊时间序列矢量距离作为评估标准,并且通过坐... 详细信息

针对传统网络流量预测模型存在的局限性,提出一种基于矢量量化直觉模糊时间序列的网络流量预测模型。利用模糊直觉推理有效地表述了网络流量数据中存在的高度模糊性以及不确定性,利用直觉模糊时间序列矢量距离作为评估标准,并且通过坐标平移与质心进行匹配,提升不同时间序列段的分类能力,从而有效地建立网络流量预测模型。通过实验分析可知,提出的预测模型能够提升预测精度并且减少计算复杂度,另外该算法有能力长期预测多个输出。

关键词：直觉模糊时间序列矢量量化网络流量长期预测

镁含量对超高强铝合金屈服强度淬火敏感性的影响

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中国有色金属学报 2024年第5期34卷 1519-1528页

作者：刘安民刘胜胆杨梦楚张梦晗周爱华周智强中南大学材料科学与工程学院长沙410083 中南大学有色金属材料科学与工程教育部重点实验室长沙410083 云南爱家铝业有限公司曲靖655335

通过浸入式末端淬火、室温拉伸测试、电导率测试、相图和连续冷却转变曲线计算、扫描电镜、电子背散射衍射和透射电镜等方法,研究了Mg含量(1%、2%、3%,质量分数)对Al-9Zn-xMg-1Cu合金屈服强度淬火敏感性的影响。结果表明:Mg含量越高,合... 详细信息

通过浸入式末端淬火、室温拉伸测试、电导率测试、相图和连续冷却转变曲线计算、扫描电镜、电子背散射衍射和透射电镜等方法,研究了Mg含量(1%、2%、3%,质量分数)对Al-9Zn-xMg-1Cu合金屈服强度淬火敏感性的影响。结果表明:Mg含量越高,合金屈服强度随着淬火速率减小而下降的比率越高,即淬火敏感性越高。合金中的淬火诱导相均为η相和T相,Mg含量升高提高了这些相析出的临界淬火速率,同时增加了它们的数量和尺寸。结合电导率和淬火诱导相面积分数结果,从淬火诱导相的析出驱动力和非均匀形核位点数量差异的角度,探讨了Mg含量影响合金淬火敏感性的机理。

关键词： Al-Zn-Mg-Cu合金 Mg含量屈服强度淬火敏感性

温度和应变幅对亚稳奥氏体不锈钢S321低周疲劳行为的影响

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同济大学学报（自然科学版） 2024年第4期52卷 604-610页

作者：何国球黎若芸周志强廖逸平刘胤孚同济大学材料科学与工程学院上海201800

在室温和650℃的环境下对S321、S321H不锈钢进行了0.5%、0.7%、0.9%应变幅下的低周疲劳试验,并在室温下对S321和S321H开展了多个寿命点的疲劳加载历史试验,结合X射线衍射定量分析测算形变诱发马氏体的含量。结果表明:形变诱发马氏体的... 详细信息

在室温和650℃的环境下对S321、S321H不锈钢进行了0.5%、0.7%、0.9%应变幅下的低周疲劳试验,并在室温下对S321和S321H开展了多个寿命点的疲劳加载历史试验,结合X射线衍射定量分析测算形变诱发马氏体的含量。结果表明:形变诱发马氏体的生成会导致奥氏体钢持续循环硬化,室温下合金在初次硬化后继续二次硬化,而在650℃下没有形变诱发马氏体生成,合金在初次硬化后进入循环稳定阶段。循环过程中,碳含量越低,形变诱发马氏体含量越多,合金的循环硬化程度更高。两种温度下,两种材料的疲劳寿命在低应变幅下都相差不大,应变幅越大,两种材料的疲劳寿命相差越大,因此,可以考虑服役条件为低应变幅时使用S321不锈钢代替S321H不锈钢。

关键词：低周疲劳行为 S321不锈钢 S321H不锈钢形变诱发马氏体碳含量温度

Fast Laplace transform methods for the PDE system of Parisian and Parasian option pricing

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Science China Mathematics 2022年第6期65卷 1229-1246页

作者： Jingtang Ma zhiqiang zhou School of Economic Mathematics Southwestern University of Finance and EconomicsChengdu 611130China School of Mathematics and Finance Xiangnan UniversityChenzhou 423000China

This paper develops a fast Laplace transform method for solving the complex PDE system arising from Parisian and Parasian option *** value functions of the options are governed by a system of partial differential equations(PDEs)of two and three *** the Laplace transform to the PDEs with respect to the calendar time to maturity leads to a coupled system consisting of an ordinary differential equation(ODE)and a 2-dimensional partial differential equation(2d-PDE).The solution to this ODE is found analytically on a specific parabola contour that is used in the fast Laplace inversion,whereas the solution to the 2d-PDE is approximated by solving 1-dimensional integro-differential *** Laplace inversion is realized by the fast contour integral *** results confirm that the Laplace transform methods have the exponential convergence rates and are more efficient than the implicit finite difference methods,Monte Carlo methods and moving window methods.

关键词： Parisian option Parasian option coupled PDE Laplace transform method convergence rate

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基于生物炭技术的园林废弃物处理途径研究

山东林业科技 2024年第2期54卷 22-29页

作者：焦冉周志强华侨大学/建筑学院福建厦门361000

以园林废弃物资源化利用为出发点,划分了园林废弃物的种类并总结了其现有的资源化途径。重点探讨了园林废弃物生物质制备生物炭的技术,及其作为一种新的资源化利用方法的可行性和价值。研究将园林废弃物转化为生物炭的技术,对于应对气... 详细信息

以园林废弃物资源化利用为出发点,划分了园林废弃物的种类并总结了其现有的资源化途径。重点探讨了园林废弃物生物质制备生物炭的技术,及其作为一种新的资源化利用方法的可行性和价值。研究将园林废弃物转化为生物炭的技术,对于应对气候变化并实现“双碳”战略具有重要意义。

关键词：园林废弃物生物炭资源化利用碳中和

Simulation of non-Newtonian (Power-law) fluid flow past a row of square cylinders

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Science China(Physics,Mechanics & Astronomy) 2011年第4期54卷 703-710页

作者： zhou zhiqiang PENG Jie Department of Engineering Mechanics Tsinghua University Beijing 100084 China

The power-law fluid flow past a row of uniform placed square cylinders is investigated using the Lattice Boltzmann method (LBM).The flow is assumed to be two-dimensional and *** relaxation time is assumed to be shear-dependent and determined by using a variable parameter related to the local shear *** effects of both shear-thinning/shear-thickening property and the cylinder spacing on the confluence of the jets are mainly *** bifurcation diagrams of the flow are obtained,which include confluences of double and quadruple *** results show that both the first and second pitchfork bifurcations are advanced due to the effect of the shear-thinning property,and postponed due to the shear-thickening property.

关键词： power-law fluid pitchfork bifurcation Lattice Boltzmann method