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EZH2-dependent myelination following sciatic nerve injury

Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu Li Mu Xi Xu Tianyi Huang Ying wang Siyuan Xu Yiting wang Wencong wang zhiping wang Hongkui wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

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Interval analysis method and convex models for impulsive response of structures with uncertain-but-bounded external loads

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Acta Mechanica Sinica 2006年第3期22卷 265-276页

作者： zhiping Qiu Xiaojun wang Institute of Solid Mechanics Beijing University of Aeronautics and Astronautics Beijing 100083 China

Two non-probabilistic, set-theoretical methods for determining the maximum and minimum impulsive responses of structures to uncertain-but-bounded impulses are presented. They are, respectively, based on the theories of interval mathematics and convex models. The uncertain-but-bounded impulses are assumed to be a convex set, hyper-rectangle or ellipsoid. For the two non-probabilistic methods, less prior information is required about the uncertain nature of impulses than the probabilistic model. Comparisons between the interval analysis method and the convex model, which are developed as an anti-optimization problem of finding the least favorable impulsive response and the most favorable impulsive response, are made through mathematical analyses and numerical calculations. The results of this study indicate that under the condition of the interval vector being determined from an ellipsoid containing the uncertain impulses, the width of the impulsive responses predicted by the interval analysis method is larger than that by the convex model; under the condition of the ellipsoid being determined from an interval vector containing the uncertain impulses, the width of the interval impulsive responses obtained by the interval analysis method is smaller than that by the convex model.

关键词： Impulsive response Interval analysis method Convex model Uncertain-but-bounded impulse

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Self-heating Probe Instrument and Method for Measuring High Temperature Melting Volume Change Rate of Material

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Chinese Journal of Mechanical Engineering 2013年第2期26卷 371-376页

作者： wang Junwei wang zhiping LU Yang CHENG Bo College of Materials Science and Engineering Lanzhou University of Technology State Key Laboratory of Gansu Advanced Non-ferrous Metal Materials Lanzhou University of Technology Renewable Energy Laboratory Lanzhou University of Technology

The castings defects are affected by the melting volume change rate of material. The change rate has an important effect on running safety of the high temperature thermal storage chamber, too. But the characteristics of existing measuring installations are complex structure, troublesome operation and low precision. In order to measure the melting volume change rate of material accurately and conveniently, a self-designed measuring instrument, self-heating probe instrument, and measuring method are described. Temperature in heating cavity is controlled by PID temperature controller; melting volume change rate υ and molten density are calculated based on the melt volume which is measured by the instrument. Positive and negative υ represent expansion and shrinkage of the sample volume after melting, respectively. Taking eutectic LiF＋CaF2 for example, its melting volume change rate and melting density at 1 123 K are -20.6% and 2 651 kg/m–3 measured by this instrument, which is only 0.71% smaller than literature value. Density and melting volume change rate of industry pure aluminum at 973 K and analysis pure NaCl at 1 123 K are detected by the instrument too. The measure results are agreed with report values. Measuring error sources are analyzed and several improving measures are proposed. In theory, the measuring errors of the change rate and molten density which are measured by the self-designed instrument is nearly 1/20-1/50 of that measured by the refitted mandril thermal expansion instrument. The self-designed instrument and method have the advantages of simple structure, being easy to operate, extensive applicability for material, relatively high accuracy, and most importantly, temperature and sample vapor pressure have little effect on the measurement accuracy. The presented instrument and method solve the problems of complicated structure and procedures, and large measuring errors for the samples with high vapor pressure by existing installations.

关键词： high temperature volume expansion rate molten density measuring instrument measuring method

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Thermal Contact Resistance between Aero Engine Compressor Blade and Flexible Fixture

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Journal of Thermal Science 2021年第2期30卷 530-539页

作者： DAI Shijie wang Dong ZHANG Huibo LI Shibo wang zhiping State Key Laboratory of Reliability and Intelligence of Electrical Equipment Hebei University of TechnologyTianjin 300130China School of Mechanical Engineering Hebei University of TechnologyTianjin 300130China Tianjin City Civil Aircraft Airworthiness and Repair Key Laboratory Civil Aviation University of ChinaTianjin 300300China

In the process of two-pass micro plasma arc welding of titanium alloy sheet,based on the thermal contact resistance theory,a three-dimensional transient heat transfer finite element model of contact heat transfer between titanium alloy sheet and flexible fixture was *** effects of contact upper surface temperature,micro-contact thermal resistance,micro-gap thermal resistance,DC and pulse welding on thermal contact resistance were investigated,and the simulation and experimental results were *** results show that the thermal contact resistance increases as the temperature increases when the temperature of the contact upper surface (titanium alloy sheet) is in the range of 290-350 *** effect of micro-contact thermal resistance on the thermal contact resistance is 26.1%-46.3% larger than the micro-gap thermal *** thermal contact resistance of pulse welding is 3.1%-3.5% larger than DC *** error of simulation and experimental results of weld pool depth is 8.6%,which verifies the reliability of the model.

关键词： titanium alloy micro plasma arc welding thermal contact resistance micro-contact thermal resistance micro-gap thermal resistance finite element model

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PARALLEL COMPUTING FOR STATIC RESPONSE ANALYSIS OF STRUCTURES WITH UNCERTAIN-BUT-BOUNDED PARAMETERS

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Acta Mechanica Solida Sinica 2008年第5期21卷 472-482页

作者： zhiping Qiu Xiaojun wang Xu Zhang Institute of Solid Mechanics Beijing University of Aeronautics and Astronautics Beijing 100083 China

The vertex solution for estimation on the static displacement bounds of structures with uncertain-but-bounded parameters is studied in this paper. For the linear static problem, when there are uncertain interval parameters in the stiffness matrix and the vector of applied forces, the static response may be an interval. Based on the interval operations, the interval solution obtained by the vertex solution is more accurate and more credible than other methods （such as the perturbation method）. However, the vertex solution method by traditional serial computing usually needs large computational efforts, especially for large structures. In order to avoid its disadvantages of large calculation and much runtime, its parallel computing which can be used in large-scale computing is presented in this paper. Two kinds of parallel computing algorithms are proposed based on the vertex solution. The parallel computing will solve many interval problems which cannot be resolved by traditional interval analysis methods.

关键词： vertex solution interval analysis UBB parallel computing

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Rare earth effect on the microstructure and tribological properties of FeNiCr coatings

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Rare Metals 2010年第3期29卷 270-275页

作者： LIANG Bunu ZHANG Zhenyu wang zhiping CHEN Baiming Mechanical Engineering Department Lanzhou Polytechnical College Lanzhou 730050 China State Key Laboratory of New Nonferrous Metal Materials Lanzhou University of Technology Lanzhou 730050 China

FeNiCr alloys with various amounts of La2O3 powders were thermally sprayed onto steel *** probe microscopy analysis （EPMA）,X-ray photoelectron spectroscopy （XPS）,and an Optimol SRV oscillating friction and wear tester in a ball-on-disc contact configuration were employed to investigate the properties of the sprayed *** results show that rare earth can refine the microstructure effectively and make the element distribution uniform,which leads to the improvement in the properties of the ***,the wear rate of the FeNiCr alloy with 1.5% La2O3 is smaller than those of the other ***,the rare earth can reduce the friction coefficient and act as a self-lubricant in the oxide debris layer formed on the worn surface in *** wear mechanism of the coatings is oxidation wear,and a large amount of counterpart material is transferred to the coatings.

关键词： coatings rare earth oxides thermal spray microstructure tribological property

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Optical bistability and multistability via atomic coherence in the quasi-Λ-type atomic system

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Science China(Physics,Mechanics & Astronomy) 2009年第4期52卷 524-528页

作者： CHEN AiXi wang zhiping CHEN DeHai Department of Applied Physics East China Jiaotong UniversityNanchang 330013China

The steady-state optical bistability(OB) and optical multistability(OM) behavior in the quasi——type atomic system driven by a probe field and a coherent coupling field inside a unidirectional ring cavity are shown,and the effects of coupling-field detuning and coupling-field intensity on the OB and OM behavior are investigated. The transition from OB to OM or vice versa is found by varying the detuning of the coherent coupling field or by adjusting the intensity of the coupling field. The influence of the atomic cooperation parameter on the OM behavior is also discussed.

关键词： optical bistability detuning intensity multistability

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An 80–83 GHz CMOS DCO based on Di CAD technique for size, linearity and noise optimization

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Science China(Information Sciences) 2017年第8期60卷 80-82页

作者： zhiping wang Haikun JIA Lixue KUANG Baoyong CHI Institute of Microelectronics Tsinghua University Tsinghua National Laboratory for Information Science and Technology

Dear editor,It becomes practical to implement competitive mm-wave circuits in advanced deep-submicron CMOS process,with the scaling CMOS technology and innovative circuit *** various mm-wave circuit blocks,the oscillator draws special attention since mm-wave signal sources are demanded in almost all mm-wave electrical ***,big challenges still exist to implement a

关键词： DCO as CAD An 80 GHz CMOS DCO based on Di CAD technique for size CMOS for on

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Fouling corrosion in aluminum heat exchangers

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Chinese Journal of Aeronautics 2015年第3期28卷 954-960页

作者： Su Jingxin Ma Minyu wang Tianjing Guo Xiaomei Hou Liguo wang zhiping Tianjin Key Laboratory for Civil Aircraft Airworthiness and Maintenance Civil Aviation University of China Aircraft Maintenance and Engineering Corporation Beijing Capital International Airport

Abstract Fouling deposits on aluminum heat exchanger reduce the heat transfer efficiency and cause corrosion to the apparatus. This study focuses on the corrosive behavior of aluminum cou- pons covered with a layer of artificial fouling in a humid atmosphere by their weight loss, Tafel plots, electrochemical impedance spectroscopy （EIS）, and scanning electron microscope （SEM） observations. The results reveal that chloride is one of the major elements found in the fouling which damages the passive film and initiates corrosion. The galvanic corrosion between the metal and the adjacent carbon particles accelerates the corrosive process. Furthermore, the black carbon favors the moisture uptake, and gives the dissolved oxygen greater chance to migrate through the fouling layer and form a continuous diffusive path. The corrosion rate decreasing over time is conformed to electrochemistry measurements and can be verified by Faraday＇s law. The EIS results indicate that the mechanism of corrosion can be interpreted by the pitting corrosion evolution mechanism, and that pitting was observed on the coupons by SEM after corrosive exposure.

关键词： Aluminum EIS Heat exchanger Pitting corrosion Tafel plots

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Theoretical and metrical standardization of strain rate sensitivity index

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Science China(Technological Sciences) 2007年第6期50卷 714-735页

作者： SONG YuQuan GUAN zhiping LI ZhiGang wang MingHui Superplastic and Plastic Research Institute Jilin University Changchun 130022 China Superplastic and Plastic Research Institute Jilin University Changchun 130022 China Superplastic and Plastic Research Institute Jilin University Changchun 130022 China Superplastic and Plastic Research Institute Jilin University Changchun 130022 China

Strain rate sensitivity index m is one of the vital mechanical parameters for deter- mining material superplasticity. In this paper, the existing formulae for measuring m value are reviewed, and it is found that the m values can be classified into three classes: mi under constant length, mv under constant velocity, and mP under con- stant load. The constraint equation of the generalized m value is established ac- cording to the tensile constitutive equation and the basis theory for plastic me- chanics. Based on three typical deformation paths, the m value is redefined. Fur- thermore, from the formula of generalized m value, the formulae for measuring mi, mv and mP are theoretically deduced. The precise methods with numerical simula- tion are presented. The results prove that the m value is a non-constant and its dependence on ε changes with the deformation path. Under different deformation paths, the m values calculated from the same formula are different. Using different formulae, the m values under the same deformation path are also different. There- fore, deformation path and corresponding formula should be given during the measurement of the m value. Moreover, it is explained theoretically and experi- mentally that why the mv value under constant velocity is sometimes negative but the mP value under constant load is sometimes lager than 1. The aim of the analysis and measurement of the m value is to facilitate the study on the relationship be- tween macroscopical mechanical laws and microscopic physical mechanisms during superplastic deformation.

关键词： superplasticity, strain rate sensitivity index, tensile deformation

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