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The Analysis of the Correlation between SPT and CPT Based on CNN-GA and Liquefaction Discrimination Research

Computer Modeling in Engineering & Sciences 2024年第2期138卷 1159-1182页

作者： Ruihan Bai Feng Shen Zihao Zhao zhiping zhang Qisi Yu Key Laboratory of the Ministry of Education for Geomechanics and Embankment Engineering College of Civil and Transportation EngineeringHohai UniversityNanjing210098China School of Civil Engineering Suzhou University of Science and TechnologySuzhou215011China School of Civil Engineering Shenyang Jianzhu UniversityShenyang110168China College of Civil Engineering Tongji UniversityShanghai200092China

The objective of this study is to investigate themethods for soil liquefaction discrimination. Typically, predicting soilliquefaction potential involves conducting the standard penetration test (SPT), which requires field testing and canbe time-consuming and labor-intensive. In contrast, the cone penetration test (CPT) provides a more convenientmethod and offers detailed and continuous information about soil layers. In this study, the feature matrix based onCPT data is proposed to predict the standard penetration test blow count N. The featurematrix comprises the CPTcharacteristic parameters at specific depths, such as tip resistance qc, sleeve resistance f s, and depth H. To fuse thefeatures on the matrix, the convolutional neural network (CNN) is employed for feature extraction. Additionally,Genetic Algorithm (GA) is utilized to obtain the best combination of convolutional kernels and the number ofneurons. The study evaluated the robustness of the proposed model using multiple engineering field data *** demonstrated that the proposed model outperformed conventional methods in predicting N values forvarious soil categories, including sandy silt, silty sand, and clayey silt. Finally, the proposed model was employedfor liquefaction discrimination. The liquefaction discrimination based on the predicted N values was comparedwith the measured N values, and the results showed that the discrimination results were in 75% agreement. Thestudy has important practical application value for foundation liquefaction engineering. Also, the novel methodadopted in this research provides new ideas and methods for research in related fields, which is of great academicsignificance.

关键词： CNN liquefaction discrimination SPT CPT

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Radiation-based immunogenic vaccine combined with a macrophage“checkpoint inhibitor”for boosting innate and adaptive immunity against metastatic colon cancers

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2247-2262页

作者： Hongbo Xu Xianya Qin Yuanyuan Guo Siyu Zhao Xingxing Feng Runzan zhang Tianyi Tian Li Kong Conglian Yang zhiping zhang Tongji School of Pharmacy Huazhong University of Science and TechnologyWuhan 430030China Hubei Engineering Research Center for Novel Drug Delivery System Wuhan 430030China Wuhan Liyuan Hospital of Tongji School of Pharmacy Huazhong University of Science and TechnologyWuhan 430077China

Immunogenic dying tumor cells hold promising prospects as cancer vaccines to activate systemic immunity against both primary and metastatic ***,X-ray-induced dying tumor cells are rich in highly immunogenic tumor-associated antigens and self-generated dsDNA as potent ***,we found that the X-ray induction process can result in the excessive exposure of phosphatidylserine in cancer vaccines,which can specifically bind with the MerTK receptor on macrophages,acting as a“checkpoint”to facilitate immune silence in the tumor ***,we developed a novel strategy combining X-ray-induced cancer vaccines with UNC2250,a macrophage MerTK“checkpoint inhibitor,”for treating peritoneal carcinomatosis in colon *** incorporating UNC2250 into the treatment regimen,immunosuppressive efferocytosis of macrophages,which relies on MerTK-directed recognition of phosphatidylserine on vaccines,was effectively ***,the immune analysis revealed that this combination strategy promoted the maturation of dendritic cells and M1-like repolarization of macrophages,thereby simultaneously eliciting robust adaptive and innate *** innovative approach utilizing X-ray-induced vaccines combined with a checkpoint inhibitor may provide valuable insights for developing effective cancer vaccines and immunotherapies targeting colon cancer.

关键词： Immunogenic cell death Cancer vaccine X-ray Efferocytosis Macrophage STING Adaptive immunity Innate immunity

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CCL9/CCR1 axis-driven chemotactic nanovesicles for attenuating metastasis of SMAD4-deficient colorectal cancer by trapping TGF-β

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3711-3729页

作者： Boning Niu Tianyi Tian Lu Wang Yinmei Tian Tian Tian Yuanyuan Guo Hu Zhou zhiping zhang Tongji School of Pharmacy Huazhong University of Science and TechnologyWuhan 430030China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pharmacy Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Pharmaceutical Sciences Fujian Provincial Key Laboratory of Innovative Drug Target ResearchHigh Throughput Drug Screening PlatformXiamen UniversityXiamen 361102China National Engineering Research Center for Nanomedicine Huazhong University of Science and TechnologyWuhan 430030China Hubei Engineering Research Centre for Novel Drug Delivery System Huazhong University of Science and TechnologyWuhan 430030China

SMAD4 deficiency in colorectal cancer(CRC)is highly correlated with liver metastasis and high mortality,yet there are few effective precision therapies ***,we show that CCR1^(+)-granulocytic myeloid-derived suppressor cells(G-MDSCs)are highly infiltrated in SMAD4-deficient CRC via CCL15/CCR1 and CCL9/CCR1 axis in clinical specimens and mouse models,*** excessive TGF-β,secreted by tumor-infiltrated CCR1^(+)-G-MDSCs,suppresses the immune response of cytotoxic T lymphocytes(CTLs),thus facilitating ***,we develop engineered nanovesicles displaying CCR1 and TGFBR2 molecules(C/T-NVs)to chemotactically target the tumor driven by CCL9/CCR1 axis and trap TGF-βthrough TGF-β-TGFBR2 specific *** C/T-NVs counteract CCR1^(+)-G-MDSC infiltration through competitive responding CCL9/CCR1 axis.C/T-NVs-induced intratumoral TGF-βexhaustion alleviates the TGF-β-suppressed immune response of ***,C/T-NVs attenuate liver metastasis of SMAD4-deficient *** further exploration,high expression of programmed cell death ligand-1(PD-L1)is observed in clinical specimens of SMAD4-deficient *** C/T-NVs with anti-PD-L1 antibody(aPD-L1)induces tertiary lymphoid structure formation with sustained activation of CTLs,CXCL13^(+)-CD4^(+)T,CXCR5^(+)-CD20^(+)B cells,and enhanced secretion of cytotoxic cytokine interleukin-21 and IFN-γaround tumors,thus eradicating metastatic *** strategy elicits pleiotropic antimetastatic immunity,paving the way for nanovesicle-mediated precision immunotherapy in SMAD4-deficient CRC.

关键词： SMAD4-deficient CRC Metastasis G-MDSCs TGF-β CCR1 TGFBR2

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Genetic and immunologic characteristics of colorectal cancer patients with KRAS mutations and predictive significance of tumor immune microenvironment in adjuvant chemotherapy

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Genes & Diseases 2024年第3期11卷 43-46页

作者： Zhengqi Wen Wenliang Li Chengmin Shi Junrui Ma Sihui Zhao Ruize Zhou Xihong Liu Rong Yang zhiping zhang Hushan zhang Bo Li Department of Oncology The First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China The Third Affliated Hospital of Kunming Medical University(Yunnan Cancer Center) KunmingYunnan 650021China Gastrointestinal and Hernia Surgery The First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China School of Nursing Yunnan University of Chinese MedicineKunmingYunnan 650022China Department of General Surgery The First People's Hospital of Yunnan ProvinceKunmingYunnan 650000China Department of General Surgery The Affiliated Hospital of Yunnan UniversityYunnan 650011China Medical Department 3D Medicines Inc.Shanghai 201114China Zhaotong Health Vocational College ZhaotongYunnan 657000China

Colorectal cancer(CRC)is one of the most common cancers around the world,and it is one of the leading causes of cancer-related death.1 Although anti-EGFR therapy and immune checkpoint inhibitor(ICl)therapy are becoming more and more important for colorectal therapy,however,clinical outcomes of current treatments for metastatic CRC,especially with ICls,have been shown to be affected by the status of ***,KRAS mutation status detection has become a very important diagnostic factor for managing metastatic CRC patients.

关键词： KRAS colorectal patients

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Amelioration of habitat since the early Holocene contributed to the origin of agriculture in the farming-pastoral zone of northern China

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Science China Earth Sciences 2024年第8期67卷 2535-2546页

作者： Xin JIA zhiping zhang Yonggang SUN Runqi JIANG Shuangwen YI Wei CHEN Jue SUN Guoqiang LI Shuzhi WANG Enrui LI Xiaonong HU Qingchun BAO Harry F.LEE Huayu LU Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing 210023China Schlool of History and Culture Chifeng UniversityChifeng 024000China School of Geography and Ocean Science Nanjing UniversityNanjing 210023China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Institute of Archaeology Chinese Academy of Social SciencesBeijing 100710China Ulanqab Museum Ulanqab 012000China The Institute of Cultural Relics and Archaeology Hohhot 010011China Department of Geography and Resource Management The Chinese University of Hong KongHong Kong 999077China Key Laboratory of Virtual Geographic Environment(Ministry of Education of PRC) Nanjing Normal UniversityNanjing 210023China School of Geography Nanjing Normal UniversityNanjing 210023China Institute of Environmental Archaeology Nanjing Normal UniversityNanjing 210023China

The origin of agriculture in the farming-pastoral zone of northern China remains in *** central region of the Inner Mongolia Plateau is located in the core area of the farming-pastoral zone;thus,it is a critical region for exploring the origin of the dryland farming system in northern *** study selected the Yumin Site and Banan Site,which belong to the Yumin Culture-the beginning of Neolithic culture in Inner Mongolia-as the research *** on the quartz optically stimulated luminescence(OSL)dating on the sedimentary sections from the Yumin site(YM)and Banan site(BN1 and BN2),the Holocene chronology framework of each section was *** that,by identifying carbonized grains in the Yumin site and the multi-proxy analysis of each section,we investigated the relationship between the origin of agriculture and climate change in this *** results revealed that the timing of the origin of agriculture recorded in the Yumin site lagged behind the timing of a significant increase of precipitation during the early Holocene but coincided with the timing of a significant increase of vegetation around 8.4 *** phenomenon was further confirmed by the published high-resolution paleoenvironmental records from the surrounding area of the Yumin *** propose that with the gradual amelioration of hydrothermal conditions since the beginning of the Holocene,the regional ecosystem had been improved,resulting in the gradual conversion of the land surface from infertile sand to organic-rich soil,providing an appropriate environmental foundation for the origin of dryland farming in northern China around 8.4 *** study highlighted that the“accumulative environmental effects”during the early Holocene played a vital role in the origin of agriculture in northern China and provided a reference for agricultural management in the context of future climate change.

关键词： Origin of agriculture Accumulative environmental effects Yumin Culture Northern China Holocene

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情感现象的本质及其构成环节

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江海学刊 2024年第1期 24-33页

作者：张志平上海师范大学哲学系

人在情感中绽放自身存在,并通过情感意识到自身存在是否具有完善性。在汉语中,无论是“情”还是“感”,其含义都既具有适用于万物的普遍性,也有仅适用于生命存在,特别是人之存在的特殊性。其中,“情”着眼于存在者的具体存在状态,“感... 详细信息

人在情感中绽放自身存在,并通过情感意识到自身存在是否具有完善性。在汉语中,无论是“情”还是“感”,其含义都既具有适用于万物的普遍性,也有仅适用于生命存在,特别是人之存在的特殊性。其中,“情”着眼于存在者的具体存在状态,“感”着眼于存在者之间的交互影响。从本质上讲,情感现象涉及意识自我与他者的存在利益关系,这种关系又体现为力量性、价值性和圆满性三个方面。从现象上看,作为关系的情感现象有感觉—理解关系、感受关系和感情关系三个构成环节。感情在时间上具有三维性,它既是对积极感受的召回和不断生成,也是对消极感受的消除和不断避免。作为动能,感情不仅为意识自我确定价值方向,还促使意识自我不断采取行动。单纯的感情有可能陷入盲目性和片面性,因此需要理智介入。但理智也有“智慧”“死板”和“聪狡”之分。情感是衡量人之一切作为的意义与价值的“硬通货”。无论是社会发展还是技术进步,都应以塑造和谐良性的万物关系,创建人人都能体验到自身存在完善性的健全情感空间为旨归。

关键词：情感关系构成环节动力学控制

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常减压蒸馏装置节能与优化改造

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石油与天然气化工 2024年第2期53卷 139-144页

作者：章志平程才智武汉金中工程技术有限公司

目的解决某石化企业常减压蒸馏装置生产能耗高、产品结构不合理等问题。方法采取优化换热网络、优化设备操作参数、提高加热炉余热回收率、提高装置处理能力及更换高效塔分离元件等方式对装置进行节能及优化改造。结果改造完成后,装置... 详细信息

目的解决某石化企业常减压蒸馏装置生产能耗高、产品结构不合理等问题。方法采取优化换热网络、优化设备操作参数、提高加热炉余热回收率、提高装置处理能力及更换高效塔分离元件等方式对装置进行节能及优化改造。结果改造完成后,装置能耗降低了1.23 kg标油/t原油,高附加值的航煤组分及润滑油加氢改质料等产品收率共计提高了2.3%,综合创效6600万元/年。结论采用板式换热器及组合式空气预热器,优化中段回流取热负荷分配比例及顺序,调整装置蒸汽产、用量等是装置节能的有效手段,CTST立体传质塔盘及高效、低压降规整填料等的应用解决了产品结构不合理问题。

关键词：常减压蒸馏装置炼油厂节能优化

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水轮机调节系统与轴系耦合模型对系统参数的敏感性分析

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振动与冲击 2024年第8期43卷 78-88页

作者：章志平张送校杨雄秦程孙洁冯陈张玉全江西洪屏抽水蓄能有限公司江西宜春336000 河海大学水利水电学院南京210098 河海大学能源与电气学院南京210098

抽水蓄能电站频繁地暂态过程对轴系振动有重要影响,建立一个能够反映水电机组暂态响应的调节系统与轴系的耦合模型对于研究抽水蓄能电站的安全运行至关重要。以拉日朗日公式推导的扭矩方程为纽带,构建了水轮发电机组调节系统与考虑多振... 详细信息

抽水蓄能电站频繁地暂态过程对轴系振动有重要影响,建立一个能够反映水电机组暂态响应的调节系统与轴系的耦合模型对于研究抽水蓄能电站的安全运行至关重要。以拉日朗日公式推导的扭矩方程为纽带,构建了水轮发电机组调节系统与考虑多振动诱发因素的轴系系统的瞬态耦合模型。计算了甩不同负荷下轴系的动态响应过程,分析了发电机偏心质量以及发电机励磁电流对轴系暂态过程的影响。研究发现,甩去的负荷越多,轴系在动态响应的过程中振动越剧烈,甩30%负荷,甩60%负荷,以及甩100%负荷后,发电机转子在x方向上的振幅较甩负荷前分别增加了68.7%,109.3%,以及126.3%。发电机的偏心质量越大,水轮发电机组轴系在动态响应过程中的幅值越高,系统越不稳定,而励磁电流越大,轴系在响应过程中的幅值越小,越有利于系统稳定运行。本文的目的是为水轮发电机组调速系统-轴系系统瞬态耦合模型的建立提供一种方法,探讨和评价甩负荷下瞬态耦合模型的参数敏感性,保障机组暂态下的安全稳定运行。

关键词：抽水蓄能电站调节系统轴系动态响应励磁电流甩负荷

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二氢槲皮素生物合成研究进展

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中国生物工程杂志 2024年第9期44卷 126-140页

作者：廖凯张智萍丁笠陈玥柔张新跃扬州大学生物科学与技术学院扬州225009

二氢槲皮素(dihydroquercetin,DHQ),又名花旗松素,是一种天然二氢黄酮类化合物,因其具有高效抗氧化活性而受到密切关注,被广泛应用于医药、食品和保健品等领域。DHQ的传统生产方式是从植物组织中提取,但受制于原材料来源、生产工艺等因... 详细信息

二氢槲皮素(dihydroquercetin,DHQ),又名花旗松素,是一种天然二氢黄酮类化合物,因其具有高效抗氧化活性而受到密切关注,被广泛应用于医药、食品和保健品等领域。DHQ的传统生产方式是从植物组织中提取,但受制于原材料来源、生产工艺等因素,传统方法在制备DHQ上面临挑战。而以生物合成法为代表的新生产方式将是解决这一问题的关键。有鉴于此,全面总结了DHQ的主要生物合成途径,综述了近年来有关DHQ生物合成研究进展,以期为DHQ的应用开发以及其他类似天然产物的生物合成提供参考。

关键词：二氢槲皮素代谢途径制备方式生物合成生物活性

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混合所有制改革与劳动投资效率——源自沪深A股国有上市公司的经验证据

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东岳论丛 2024年第8期45卷 116-127,192页

作者：付光新蒋守芬张志平山东大学商学院山东威海264209

劳动力投资的有效配置是企业实现高质量发展的关键。本文以2007—2020年沪深A股国有上市公司为样本,检验混合所有制改革对劳动投资效率的影响及其作用机制。研究发现混合所有制改革能显著提高国有上市公司的劳动投资效率,强化监督和抑... 详细信息

劳动力投资的有效配置是企业实现高质量发展的关键。本文以2007—2020年沪深A股国有上市公司为样本,检验混合所有制改革对劳动投资效率的影响及其作用机制。研究发现混合所有制改革能显著提高国有上市公司的劳动投资效率,强化监督和抑制预算软约束是混合所有制改革提高劳动投资效率的重要作用机制。进一步研究发现,混改对投资过度和投资不足的劳动投资效率均具有改善作用;在地方国企、信息透明度低、竞争性行业和市场化程度低的企业中,混改对劳动投资效率的提升作用更大。研究结论为国有企业混合所有制改革后果的研究提供了新证据,同时也对政府监管部门相关政策制定和混合所有制改革的持续推进提供一定的借鉴意义。

关键词：混合所有制改革劳动投资效率国有上市公司全面深化改革

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