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二胺型苯并噁嗪改性双酚A环氧树脂及其玻璃纤维复合材料性能研究

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复合材料科学与工程 2024年第6期 29-33,59页

作者：程圣谢志辉何伟韩张跃梁智明黄泽张伟冉起超东方电气集团东方电机有限公司德阳618000 四川大学高分子科学与工程学院成都610065

为了延长环氧树脂漆的适用期,提高其耐热性,使用苯并噁嗪树脂对其进行共混改性。以溶液共混方式制备了环氧树脂漆(EP)与苯并噁嗪树脂(BZ)的共混树脂体系(E/B-x),讨论了BZ的加入对共混树脂的黏度、流变特性、凝胶化活化能、固化行为、表... 详细信息

为了延长环氧树脂漆的适用期,提高其耐热性,使用苯并噁嗪树脂对其进行共混改性。以溶液共混方式制备了环氧树脂漆(EP)与苯并噁嗪树脂(BZ)的共混树脂体系(E/B-x),讨论了BZ的加入对共混树脂的黏度、流变特性、凝胶化活化能、固化行为、表面特性及玻布增强复合材料的耐热性、力学性能的影响。结果表明:BZ的加入使共混树脂的黏度明显降低,凝胶温度及凝胶活化能增加,迟滞了EP的固化反应,延长了其适用期;少量BZ的加入不会改变EP的玻璃化转变温度(Tg),当BZ加入量达到40份时,与EP复合材料相比,E/B-40复合材料的干态和湿态Tg分别提高了12.6%和11.7%;随BZ加入量的增加,复合材料的弯曲强度先下降后上升,E/B-40复合材料的弯曲强度和弯曲模量可达569 MPa和27.9 GPa,与EP复合材料相当。

关键词：环氧树脂苯并噁嗪共聚湿态玻璃化转变温度复合材料

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Influence of asymmetric tidal mixing on sediment dynamics in a partially mixed estuary

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Acta Oceanologica Sinica 2023年第9期42卷 1-15页

作者： Zhongyong Yang zhiming liang Yufeng Ren Daobin Ji Hualong Luan Changwen Li Yujie Cui Andreas Lorke College of Hydraulic and Environmental Engineering China Three Gorges UniversityYichang 443002China Hubei Field Observation and Scientific Research Stations for Water Ecosystem in Three Gorges Reservoir China Three Gorges UniversityYichang 443002China Hubei Key Laboratory of Intelligent Yangtze and Hydroelectric Science China Yangtze Power Co.Ltd.Yichang 443000China River Research Department Changjiang River Scientific Research InstituteWuhan 430010China Institute for Environmental Sciences University of Koblenz-LandauLandau 76829Germany

To investigate the influence of asymmetric tidal mixing(ATM) on sediment dynamics in tidal estuaries, we developed a vertically one-dimensional idealized analytical model, in which the M_2 tidal flow, residual flow and suspended sediment concentration(SSC) are described. Model solutions are obtained in terms of tidallyaveraged, and tidally-varying components(M_2 and M_4) of both hydrodynamics and sediment dynamics. The effect of ATM was considered with a time-varying eddy viscosity and time-varying eddy diffusivity of SSC. For the first time, an analytical solution for SSC variation driven by varying diffusivity could be derived. The model was applied to York River Estuary, where higher(or lower) eddy diffusivity was observed during flood(or ebb) in a previous study. The model results agreed well with the observation in both hydrodynamics and sediment dynamics. The vertical sediment distribution under the influence of ATM was analyzed in terms of the phase lag of the M_2 component of SSC relative to tidal flow. The phase lag increases significantly in estuaries with typical ATM(higher diffusivity during flood and lower diffusivity during ebb) for the case of seaward-directed net bottom shear stress(e.g., strong river discharge). In contrary, the phase lag is reduced by ATM, if the tidally-averaged bottom shear stress is landward(e.g., strong horizontal density gradient). The dynamics of sediment transport was analyzed as a function of ATM phase lag to identify the time of highest sediment diffusivity, as well as a function of the residual flow, to evaluate the relative importance of seaward and landward residual flows. In estuaries with relative strong fresh water discharge or weak tidal forcing(in case of flood season or neap tide), the near bottom SSC could be higher during ebb than during flood, since the bottom shear stress is higher during ebb due to seaward residual flow. However, landward net sediment transport can be expected in these estuaries in case of a

关键词： idealized model asymmetric sediment diffusivity vertical sediment phase lag sediment transport

Spatiotemporal Characteristics of Typical Ecosystem Services and Their Spatial Responses to Driving Factors in Ecologically Fragile Areas in Upper Yellow River,China

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Chinese Geographical Science 2024年第4期34卷 674-688页

作者： liang Gui FANG Fengman LIN Yuesheng ZHANG zhiming School of Geography and Tourism Anhui Normal UniversityWuhu 241003China Key Laboratory of Earth Surface Processes and Regional Response in the Yangtze Huaihe River Basin Anhui Normal UniversityWuhu 241003China

The identification of dominant driving factors for different ecosystem services(ESs)is crucial for ecological conservation and sustainable ***,the spatial heterogeneity of the dominant driving factors affecting various ESs has not been adequately elucidated,particularly in ecologically fragile *** study employed the integrated valuation of ESs and trade-offs(InVEST)model to evaluate four ESs,namely,water yield(WY),soil conservation(SC),habitat quality(HQ),and carbon storage(CS),and then to identify the dominant driving factors of spatiotemporal differentiation of ES and further to characterize the spatial heterogeneity characteristics of the dominant driving factors in the eco-fragile areas of the upper Yellow River,China from 2000 to *** results demonstrated that WY exhibited northeast-high and northwest-low patterns in the upper Yellow River region,while high values of SC and CS were distributed in central forested areas and a high value of HQ was distributed in vast grassland *** CS,WY,and SC exhibited decreasing trends over *** most critical factors affecting WY,SC,HQ,and CS were the actual evapotranspiration,precipitation,slope,and normalized difference vegetation index,*** addition,the effects of different factors on various ESs exhibited spatial *** results could provide spatial decision support for eco-protection and rehabilitation in ecologically fragile areas.

关键词： integrated valuation of ecosystem services and trade-offs(InVEST)model geographically weighted regression(GWR) natural factor spatial heterogeneity Lanxi urban agglomeration upper Yellow River China

Fabrication of pollution-free coal gangue-based catalytic material utilizing ferrous chloride as activator for efficient peroxymonosulfate activation

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International Journal of Coal Science & Technology 2024年第1期11卷 103-118页

作者： zhiming Sun Xinlin Wang Shaoran Jia Jialin liang Xiaotian Ning Chunquan Li School of Chemical and Environmental Engineering China University of Mining and Technology(Beijing)Beijing100083China Key Laboratory of Coal Processing and Efficient Utilization (China University of Mining and Technology)Ministry of EducationXuzhou221116China

Novel coal gangue-based persulfate catalyst(CG-FeCl_(2))was successfully synthesized by the means of calcinating under nitrogen atmosphere with the addition of ferrous chloride tetrahydrate(FeCl_(2)·_(4)H_(2)O).The phase transformation of the prepared materials and gas products during the heating process are thoroughly *** is suggested that ferrous chloride participated in the phase transformation and formed Si-O-Fe *** the main gaseous products are H_(2)O,H_(2),and HCl during the heating ***,the ability of CG-FeCl_(2) to activate peroxymonosulfate(PMS)for catalytic degradation of polycyclic aromatic hydrocarbons(PAHs)and phenol was deeply *** than 95%of naphthyl,phenanthrene and phenol were removed under optimizied *** addition,1O_(2),·OH,and SO_(4)·−were involved in the CG-FeCl_(2)/PMS system from the free radical scavenging experiment,where 1O_(2) played a major role during the oxidation ***,CG-FeCl_(2)/PMS system exhibited superior stability in a relatively wide pH range and the presence of common anion from related degradation ***,the novel CG-FeCl_(2) is an efficient and environmentally friendly catalyst,displaying potential application prospect in the field of PAHs and phenol-contaminated wastewater treatment.

关键词： Coal gangue Persulfate activation Advanced oxidation processes Polycyclic aromatic hydrocarbons Phenol Ferrous chloride

Research progress of CO_(2) capture and mineralization based on natural minerals

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1208-1227页

作者： Chenguang Qian Chunquan Li Peng Huang Jialin liang Xin Zhang Jifa Wang Jianbing Wang zhiming Sun School of Chemical and Environmental Engineering China University of Mining and Technology(Beijing)Beijing 100083China Shanghai Construction Building Material Technology Group Shanghai 200080China

Natural minerals,such as kaolinite,halloysite,montmorillonite,attapulgite,bentonite,sepiolite,forsterite,and wollastonite,have considerable potential for use in CO_(2) capture and mineralization due to their abundant reserves,low cost,excellent mechanical prop-erties,and chemical *** the past decades,various methods,such as those involving heat,acid,alkali,organic amine,amino sil-ane,and ionic liquid,have been employed to enhance the CO_(2) capture performance of natural minerals to attain high specific surface area,a large number of pore structures,and rich active *** research on CO_(2) capture by natural minerals will focus on the full utiliza-tion of the properties of natural minerals,adoption of suitable modification methods,and preparation of composite materials with high specific surface area and rich active *** addition,we provide a summary of the principle and technical route of direct and indirect mineralization of CO_(2) by natural *** process uses minerals with high calcium and magnesium contents,such as forsterite(Mg_(2)SiO_(4)),serpentine[Mg_(3)Si_(2)O(OH)_(4)],and wollastonite(CaSiO_(3)).The research status of indirect mineralization of CO_(2) using hydro-chloric acid,acetic acid,molten salt,and ammonium salt as media is also introduced in *** recovery of additives and high-value-added products during the mineralization process to increase economic benefits is another focus of future research on CO_(2) mineralization by natural minerals.

关键词： natural mineral carbon dioxide capture modification composite material carbon dioxide mineralization

Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance specific cytotoxic activity against HIV Envt cells in vivo

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Virologica Sinica 2023年第2期38卷 285-295页

作者： Hanyu Pan Xinyi Yang Jing Wang Huitong liang Zhengtao Jiang Lin Zhao Yanan Wang zhiming liang Xiaoting Shen Qinru Lin Yue liang Jinglong Yang Panpan Lu Yuqi Zhu Min Li Pengfei Wang Jianqing Xu Hongzhou Lu Huanzhang Zhu State Key Laboratory of Genetic Engineering And Key Laboratory of Medical Molecular Virology of Ministry of Education/HealthSchool of Life SciencesFudan UniversityShanghai200438China Shanghai Institute of Infectious Disease and Biosecurity School of Life SciencesFudan UniversityShanghai200438China Department of Infectious Disease Key Laboratory of Medical Molecular Virology of Ministry of Education/HealthSchool of Basic Medical Sciences and Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Scientific Research Center Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Department of Infectious Diseases and Immunology Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Department of Infectious Diseases and Nursing Research Institution National Clinical Research Center for Infectious DiseasesThe Third People's Hospital of ShenzhenShenzhen518112China

HIV-specific chimeric antigen receptor(CAR)T-cells have been developed to target HIV-1 infected CD4t T-cells that express HIV Env ***,T cell exhaustion and the patient-specific autologous paradigm of CAR-T cell hurdled clinical ***,we created HIV-specific CAR-T cells using human peripheral blood mononuclear cells and a 3BNC117-E27(3BE)CAR construct that enabled the expression of programmed cell death protein(PD-1)-blocking scFv E27 and the single-chain variable fragment of the HIV-1-specific broadly neutralizing antibody 3BNC117 to target native HIV *** with T cells expressing 3BNC117-CAR alone,3BE CAR-T cells showed greater cytotoxic activity against HIV Envt cells with stronger proliferation capability,higher killing efficiency,and enhanced cytokine secretion in the presence of HIV Env-expressing ***,we manufactured TCR-deficient 3BE CAR-T cells through gene editing and demonstrated that these CAR-T cells could effectively kill HIV Env^(+) cells in vivo without the occurrence of severe graft-versus-host disease(GvHD)in NSG *** data suggest that we have provided a feasible approach to the generation of“off-theshelf”anti-HIV CAR-T cells in combination with PD-1 checkpoint blockade immunotherapy,which can be a powerful therapeutic candidate for the functional cure of HIV.

关键词： Anti-HIV CAR-T PD-1 blocking TCR disruption Cellular immunotherapy

Unveiling the chemistry behind the electrolytic production of hydrogen peroxide by oxygenated carbon

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Journal of Energy Chemistry 2024年第9期96卷 49-58页

作者： Pan Xiang Kunshang Yang Qihao Yang Yang Gao Wenwen Xu Zhiyi Lu liang Chen zhiming Wang Ziqi Tian Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054SichuanChina Key Laboratory of Advanced Fuel Cells and Electrolyzers Technology of Zhejiang Province Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201ZhejiangChina Institute for Advanced Study Chengdu UniversityChengdu 610106SichuanChina

Oxygenated carbon materials exhibit outstanding electrocatalytic performance in the production of hydrogen peroxide(H2O2)through a two-electron oxygen reduction *** nature of the active functional group and underlying reaction mechanism,however,remain ***,a comprehensive workflow was established to identify the active sites from the numerous possible *** common hydroxyl group at the notched edge demonstrates a key role in the two-electron *** local chemical environment weakens the binding of OOH intermediate to substrate while enhancing interaction with solution,thereby promoting the H_(2)O_(2)*** increasing pH,the intramolecular hydrogen bond between OOH intermediate and hydroxyl decreases,facilitating OOH ***,the rise in selectivity with increasing potential stems from the suppression of the four-electron *** active site was further validated through *** by theoretical understanding,optimal performance was achieved with high selectivity(>95%)and current density(2.06 mA/cm^(2))in experiment.

关键词： First-principles calculation Oxygen reductionreaction Hydrogen peroxide production Fixed-potential method Oxygenated carbon materials

IMAGGS: a radiogenomic framework for identifying multi-way associations in breast cancer subtypes

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Journal of Genetics and Genomics 2024年第4期51卷 443-453页

作者： Shuyu liang Sicheng Xu Shichong Zhou Cai Chang zhiming Shao Yuanyuan Wang Sheng Chen Yunxia Huang Yi Guo Department of Electronic Engineering School of Information Science and TechnologyFudan UniversityShanghai 200433China The Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention(MICCAI)of Shanghai Shanghai 200032China Shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200433China Department of Ultrasound Fudan University Shanghai Cancer CenterDepartment of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Breast Surgery Fudan University Shanghai Cancer CenterDepartment of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China

Investigating correlations between radiomic and genomic profiling in breast cancer(BC)molecular subtypes is crucial for understanding disease mechanisms and providing personalized *** present a well-designed radiogenomic framework image–gene–gene set(IMAGGS),which detects multi-way associations in BC subtypes by integrating radiomic and genomic *** dataset consists of 721 patients,each of whom has 12 ultrasound(US)images captured from different angles and gene mutation *** better characterize tumor traits,12 multi-angle US images are fused using two distinct ***,we analyze complex many-to-many associations between phenotypic and genotypic features using a machine learning algorithm,deviating from the prevalent one-to-one relationship pattern observed in previous *** radiomic and genomic features are screened using these *** addition,gene set enrichment analysis is performed to investigate the joint effects of gene sets and delve deeper into the biological functions of BC *** further validate the feasibility of IMAGGS in a glioblastoma multiforme dataset to demonstrate the scalability of IMAGGS across different modalities and *** together,IMAGGS provides a comprehensive characterization for diseases by associating imaging,genes,and gene sets,paving the way for biological interpretation of radiomics and development of targeted therapy.

关键词： IMAGGS Radiogenomic framework "lmage-gene-geneset"associations Molecular subtypes Breast cancer

Neutralization of five SARS-CoV-2 variants of concern by convalescent and BBIBP-CorV vaccinee serum

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Virologica Sinica 2022年第6期37卷 831-841页

作者： Yuqi Zhu Xinyi Yang Jingna Xun Jun Liu Qing Wen Yixiao Lin Xiaoting Shen Jun Chen Songhua Yuan Xiaying Zhao Jing Wang Hanyu Pan Jinlong Yang zhiming liang Yue liang Qinru Lin Huitong liang Min Li Jianping Liu Yinzhong Shen Xiaoyan Zhang Pengfei Wang Daru Lu Chunhua Yin Jianqing Xu Shibo Jiang Hongzhou Lu Huanzhang Zhu State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology Ministry of EducationInstitute of GeneticsSchool of Life SciencesFudan UniversityShanghai200438China Scientific Research Center Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Fubio(Suzhou)Biomedical Technology Co. LtdSuzou215300China Department of Infectious Diseases and Immunology Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesFudan UniversityShanghai200032China Department of Infectious Diseases and Nursing Research Institution National Clinical Research Center for Infectious DiseasesThe Third People's Hospital of ShenzhenShenzhen518112China

The prevalence of SARS-CoV-2 variants of concern(VOCs) is still escalating throughout the world. However, the level of neutralization of the inactivated viral vaccine recipients’ sera and convalescent sera against all VOCs,including B.1.1.7(Alpha), B.1.351(Beta), P.1(Gamma), B.1.617.2(Delta), and B.1.1.529(Omicron) remains to be lack of comparative analysis. Therefore, we constructed pseudoviruses of five VOCs using a lentiviral-based system and analyzed their viral infectivity and neutralization resistance to convalescent and BBIBP-CorV vaccinee serum at different times. Our results show that, compared with the wild-type strain(WT), five VOC pseudoviruses showed higher infection, of which B.1.617.2 and B.1.1.529 variant pseudoviruses exhibited higher infection rates than wild-type or other VOC strains, respectively. Sera from 10 vaccinated individuals at the 1, 3and 5-month post second dose or from 10 convalescent at 14 and 200 days after discharge retained neutralizing activity against all strains but exhibited decreased neutralization activity significantly against the five VOC variant pseudoviruses over time compared to WT. Notably, 100%(30/30) of the vaccinee serum samples showed more than a 2.5-fold reduction in neutralizing activity against B.1.1.529, and 90%(18/20) of the convalescent serum samples showed more than 2.5-fold reduction in neutralization against B.1.1.529. These findings demonstrate the reduced protection against the VOCs in vaccinated and convalescent individuals over time, indicating that it is necessary to have a booster shot and develop new vaccines capable of eliciting broad neutralization antibodies.

关键词： SARS-CoV-2 Variants of concern(VOCs) Convalescent BBIBP-CorV vaccine Neutralization