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KNO_(3)介稳区宽度的研究及初级成核动力学计算

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无机盐工业 2024年第9期56卷 67-74页

作者：邹洋陆志艳胡志林孙泽华东理工大学资源与环境工程学院上海200237 上海锅炉厂有限公司上海200245 青海民族大学青海西宁810007

为研究KNO_(3)在KNO_(3)-NaNO_(3)-H_(2)O中的冷却结晶过程,采用静态平衡法测量293.15~341.38 K下KNO_(3)在该体系中的溶解度,通过Apelblat方程和Van’t Hoff方程得到了溶解度与温度的关系,并计算了KNO_(3)的溶解焓和溶解熵。采用超声... 详细信息

为研究KNO_(3)在KNO_(3)-NaNO_(3)-H_(2)O中的冷却结晶过程,采用静态平衡法测量293.15~341.38 K下KNO_(3)在该体系中的溶解度,通过Apelblat方程和Van’t Hoff方程得到了溶解度与温度的关系,并计算了KNO_(3)的溶解焓和溶解熵。采用超声波法研究了298.03~332.30 K下NaNO_(3)含量、搅拌速率和冷却速率对KNO_(3)介稳区宽度的影响。实验结果表明,当体系中存在NaNO_(3)时介稳区宽度变窄但影响有限。KNO_(3)介稳区宽度随搅拌速率的增加而变窄,随冷却速率增加而变宽。以KNO_(3)溶解度和溶解焓数据为基础,研究了KNO_(3)的初级成核动力学,采用自洽Nývlt型方程得到成核级数m小于3,KNO_(3)为瞬时成核,且随着饱和温度的升高,成核速率呈先增大后减小的趋势;在经典三维成核理论中,随着饱和温度的升高,成核更容易发生,当饱和温度达到一定程度后,固-液界面能γ趋于稳定。以农用硝酸钾为原料,通过冷却结晶得到高纯度KNO_(3)产品,当饱和KNO_(3)溶液由343.15 K降至298.15 K、搅拌速率为300 r/min、冷却速率为25 K/h时,添加晶种后,溶液中Na^(+)含量仅为0.0011%。

关键词：硝酸钾硝酸钠介稳区成核动力学工业结晶

白细胞介素-6参与卒中后抑郁发病的机制探讨

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神经疾病与精神卫生 2024年第8期24卷 533-538页

作者：胡志林葛朝明兰州大学第二医院神经内科 730000

卒中后抑郁(PSD)是脑卒中的常见并发症之一,其病理生理机制尚未完全阐明。目前,寻找与PSD相关的血清学标志物和新型抗抑郁药的作用靶点成为一大研究热点。白细胞介素-6(IL-6)因其在体内具有广泛的生物学功能和明确的促炎作用,与PSD的发... 详细信息

卒中后抑郁(PSD)是脑卒中的常见并发症之一,其病理生理机制尚未完全阐明。目前,寻找与PSD相关的血清学标志物和新型抗抑郁药的作用靶点成为一大研究热点。白细胞介素-6(IL-6)因其在体内具有广泛的生物学功能和明确的促炎作用,与PSD的发生密切相关。本文通过综述IL-6与PSD发病机制之间的关系,旨在探讨其作为潜在治疗靶点的可能性。

关键词：白细胞介素-6 卒中卒中后抑郁作用机制综述

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基于深度学习的男装款式图制版要素识别

染整技术 2024年第9期46卷 66-72,115页

作者：胡志霖陈敏之浙江理工大学服装学院浙江杭州311100 浙江理工大学国际时装技术学院浙江杭州311100

探讨在传统服装制版领域中如何应用深度学习技术,以替代传统制版师在款式图中进行尺寸评价关键点和部件类别信息提取的人工思维过程,从而提高服装结构设计的效率和质量。首先,对经典服装款式图的构成要素进行了分析,以及探讨了制版师在... 详细信息

探讨在传统服装制版领域中如何应用深度学习技术,以替代传统制版师在款式图中进行尺寸评价关键点和部件类别信息提取的人工思维过程,从而提高服装结构设计的效率和质量。首先,对经典服装款式图的构成要素进行了分析,以及探讨了制版师在款式图分析中提取关键信息的思维模式。其次,介绍了基于Hourglass和YOLOv5款式图识别模型的设计和实现过程。对包含15个服装尺寸测量关键点的数据集和包含15种常见男装部件的数据集进行了预处理、标注和数据增强等,共涵盖2000张男装款式图。对这两个数据集进行训练,迭代了多个模型,并对模型的性能指标进行了测试、评估和分析。深度学习技术成功实现了对款式图中关键信息的自动提取,有效替代了传统制版师的人工判读过程,从而提高了设计效率和质量。未来的研究方向包括扩大数据集规模、丰富标签类别、探索更复杂的模型结构,并考虑其他领域的应用,如女装、童装款式图识别等。

关键词：深度学习款式图信息识别制版流程优化 Hourglass YOLOv5

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Regulation of T cell immunity by cellular metabolism

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Frontiers of Medicine 2018年第4期12卷 463-472页

作者： zhilin hu Qiang Zou Bing Su Shanghai Institute of Immunology Department of Immunology and Microbiology Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

T cells are an important adaptive immune response arm that mediates cell-mediated immunity. T cell metabolism plays a central role in T cell activation, proliferation, differentiation, and effector function. Specific metabolic programs are tightly controlled to mediate T cell immune responses, and alterations in T cell metabolism may result in many immunological disorders. In this review, we will summarize the main T cell metabolic pathways and the important factors participating in T cell metabolic programming during T cell homeostasis, differentiation, and function.

关键词： T cell immunity metabolic pathways nutrient uptake metabolic checkpoints

Effect of agonist on gamma-aminobutyric acid B receptor subunit expression in the hippocampus of epileptic rats

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Neural Regeneration Research 2009年第8期4卷 577-582页

作者： Jihong Tang Shiyao Bao Siming hu zhilin Zhang Department of Neurology Children's Hospital Affiliated to Soochow University Suzhou 215003 Jiangsu Province China

BACKGROUND： An amino acid imbalance has been considered to be responsible for epilepsy pathogenesis. Gamma-aminobutyric acid-B receptor （GABABR） inhibits voltage-sensitive calcium ion channels and GABA or glutamic acid （Glu） neurotransmitter release, which promotes or inhibits onset and development of epilepsy. OBJECTIVE： To explore the effect of baclofen on GBRla and GBR2 mRNA expression in the hippocampus of epileptic rats following kainic acid （KA） induction, and to study the adaptability of GABABR subunits. DESIGN, TIME AND SETTING： A randomized, controlled, animal experiment based on molecular biology was performed at the Laboratory Research Center of Second Hospital Affiliated to Soochow University from November 2005 to March 2006. MATERIALS： KA was provided by Sigma, USA. In situ hybridization detection kit of GBRla and GBR2 was provided by Wuhan Boster Biological Technology, China. GABABR agonist （baclofen） was provided by Sigma, USA. METHODS： Forty-four epileptic rats were randomly allocated to epileptic （n = 28） and drug intervention （n = 16） groups. The epileptic group was further divided into post-epileptic subgroups at different time points： 6, 12 hours, 1, 3, 7, 15, and 30 days （n = 4）. The drug intervention group was further divided into intervention controls subgroups at various time points： 6 hours, 1 day, and 3 days （n = 4）. Four additional rats were considered the normal control group and not modeled, but were injected with saline in the hippocampal CA3 region. MAIN OUTCOME MEASURES： GBRla and GBR mRNA expression was detected in the right hippocampal CA1, CA3, and dentate gyrus （DG） areas of the control, epileptic, and interference groups at various time intervals according to in situ hybridization results. RESULTS：（1） During the early stage of epilepsy （6 and 12 hours）, GBRla and GBR2 mRNA expression was decreased, and expression was less than the control group at one day after KA induction （P 〈 0.05）. mRNA expression was increased in the DG, bu

关键词： temporal lobe epilepsy GABAB receptor hippocampus baclofen in situ hybridization

基于MA2C方法优化和Sumo仿真实时推演的信号控制策略研究

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软件 2024年第8期45卷 48-50页

作者：高万宝陈泽熙王飞飏胡智淋合肥革绿信息科技有限公司安徽合肥230039 安徽大学安徽合肥230039

当前,交管部门多依赖人工经验解决城市交通车流拥堵问题,然而此种方法缺乏数学理论支持与实践验证,并且无法从全局性和整体性的角度提供最优方案。本文基于Sumo交通仿真,采用MA2C多智能体强化学习模型,制定具有针对性的信号灯配时强化... 详细信息

当前,交管部门多依赖人工经验解决城市交通车流拥堵问题,然而此种方法缺乏数学理论支持与实践验证,并且无法从全局性和整体性的角度提供最优方案。本文基于Sumo交通仿真,采用MA2C多智能体强化学习模型,制定具有针对性的信号灯配时强化学习规则,经多轮训练,获得对应车流运输效率最高的信号灯配时。同时,将Sumo仿真建模和数据处理过程进行了代码化与模块化,以提升运转效率,最终实现交通信号灯配时优化与过程的全自动化。

关键词：城市交叉口交通仿真信号优化强化学习 MA2C

Uncovering hidden nodes and hidden links in complex dynamic networks

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 51-63页

作者： Zhaoyang Zhang Xinyu Wang Haihong Li Yang Chen zhilin Qu Yuanyuan Mi Gang hu Department of Physics School of Physical Science and TechnologyNingbo UniversityNingbo 315211China School of Science Beijing University of Posts and TelecommunicationsBeijing 100876China Department of Medicine David Geffen School of MedicineUniversity of CaliforniaLos Angeles 90095USA Brainnetome Center and National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China Department of Psychology Tsinghua UniversityBeijing 100084China Department of Physics Beijing Normal UniversityBeijing 100875China

Inferring network structures from available data has attracted much interest in network science;however,in many realistic networks,only some of the nodes are perceptible while others are hidden,making it a challenging *** this work,we develop a method for reconstructing the network with hidden nodes and links,taking account of fast-varying noise and time-delay *** calculating the correlations of available data with different derivative orders for multiple pairs of accessible nodes,analyzing and integrating the relationships between different correlations,and defining diverse hidden-node-related reconstruction motifs,we can effectively identify the hidden nodes and hidden links in the network.

关键词： networks and genealogical trees stochastic analysis methods time series analysis

SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function

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SENP3 senses oxidative stress to facilitate STING-dependent ...

Spatial continuous modeling of early Cenozoic carbon cycle and climate

第十四届全国免疫学学术大会

作者： zhilin hu Xiao-Lu Teng Liufu Deng Zhengting Wang Qiang Zou shanghai institute of immunology

STING-dependent cytosolic DNA sensing in dendritic cells(DCs) initiates antitumor immune responses, but how STING signaling is metabolically regulated in the tumor microenvironment remains unknown. Here, we show that oxidative stress is required for STING-induced DC antitumor function through a process that directs SUMO-specific protease 3(SENP3) activity. DC-specific deletion of Senp3 drives tumor progression by blunting STING-dependent type-I interferon(IFN) signaling in DCs and dampening antitumor immune responses. DC-derived reactive oxygen species(ROS) trigger SENP3 accumulation and the SENP3-IFI204 interaction, thereby catalyzing IFI204 deSUMOylation and boosting STING signaling activation in mice. Consistently, SENP3 senses ROS to facilitate STING-dependent DC activity in tissue samples from colorectal cancer patients. Our Results reveal that oxidative stress as a metabolic regulator promotes STING-mediated DC antitumor immune responses and highlights SENP3 as an overflow valve for STING signaling induction in the metabolically abnormal tumor microenvironment.

关键词： SENP3 Dendritic cells STING ROS Tumor immunity

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National Science Review 2024年第4期11卷 30-32页

作者： Yonggang Liu Jian Zhang Haoyue Zuo zhilin He Jiaqi Guo Qifan Lin Haonan Yu Jiawenjing Lan Jing Han Zhihong Song Zihan Yin Liang Zhao Yongyun hu Zhengtang Guo Laboratory for Climate and Ocean-Atmosphere Studies Department of Atmospheric and Oceanic Sciences School of Physics Peking University Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of Sciences State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences

The partial pressure of atmospheric CO2（pCO2） is determined by the carbon cycle that involves climate, biogeochemistry, and plate tectonics. In this cycle,atmospheric CO2is converted into organic carbon and carbonates by biological activities and silicate weathering, and buried as sediments. The sediments on the ocean floor are subducted into the Earth’s interior, and subsequently converted back into CO2and outgassed into the atmosphere.

关键词： ATMOSPHERIC CO2