检索结果-南通市图书馆

维普期刊数据库博看期刊

A Mechanical Single-molecule Potentiometer Based on Foldamer

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2021年第2期37卷 335-336页

作者： zhao zhikai WANG Qingling XIANG Dong Tianjin Key Laboratory of Micro-scale Optical Information Science and Technology Institute of Modern OpticsNankai UniversityTianjin300350P.R.China

Molecular potentiometers that can indicate displacement-conductance relationship and predict the molecular conductance are of significant importance towards the real application of molecule-based devices but rarely developed so *** this end,Li et *** a single-molecule potentiometer based on ortho-pentaphenylene *** demonstrated that these pseudoelastic molecules can be stretched and compressed by the mechanical force of the Au electrode along with a dramatically variable conductance by up to two orders of magnitude,demonstrating the great potential as angstrom-scale single-molecule *** work has been published in Nature Communications,2021.

关键词： electrode displacement potential

Time-lapse changes of in vivo injured neuronal substructures in the central nervous system after low energy two-photon nanosurgery

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第5期12卷 751-756页

作者： zhikai zhao Shuangxi Chen Yunhao Luo Jing Li Smaranda Badea Chaoran Ren Wutian Wu Guangdong-Hong Kong-Macao Institute of CNS Regeneration Jinan University Guangzhou Guangdong Province China School of Biomedical Sciences Division of Anatomy The University of Hong Kong Pokfulam Hong Kong Special Administrative Region China Guangdong Engineering Research Center of Stem Cell Storage and Clinical Application Saliai Stem Cell Science and Technology Guangzhou Guangdong Province China State Key Laboratory of Brain and Cognitive Sciences The University of Hong Kong Pokfulam Hong Kong Special Administrative Region China

There is currently very little research regarding the dynamics of the subcellular degenerative events that occur in the central nervous system in response to injury. To date, multi-photon excitation has been primarily used for imaging applications; however, it has been recently used to selectively disrupt neural structures in living animals. However, understanding the complicated processes and the essential underlying molecular pathways involved in these dynamic events is necessary for studying the underlying process that promotes neuronal regeneration. In this study, we introduced a novel method allowing in vivo use of low energy（less than 30 m W） two-photon nanosurgery to selectively disrupt individual dendrites, axons, and dendritic spines in the murine brain and spinal cord to accurately monitor the time-lapse changes in the injured neuronal structures. Individual axons, dendrites, and dendritic spines in the brain and spinal cord were successfully ablated and in vivo imaging revealed the time-lapse alterations in these structures in response to the two-photon nanosurgery induced lesion. The energy（less than 30 m W） used in this study was very low and caused no observable additional damage in the neuronal sub-structures that occur frequently, especially in dendritic spines, with current commonly used methods using high energy levels. In addition, our approach includes the option of monitoring the time-varying dynamics to control the degree of lesion. The method presented here may be used to provide new insight into the growth of axons and dendrites in response to acute injury.

关键词： nerve regeneration dendrite dendritic spine axon spinal cord two-photon nanosurgery single-synapse resolution neural regeneration

Prestin-Mediated Frequency Selectivity Does not Cover Ultrahigh Frequencies in Mice

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2022年第7期38卷 769-784页

作者： Jie Li Shuang Liu Chenmeng Song Tong Zhu zhikai zhao Wenzhi Sun Yi Wang Lei Song Wei Xiong School of Life Sciences Tsinghua UniversityBeijing 100084China IDG/MeGovern Institute for Brain Research at Tsinghua University Tsinghua UniversityBeijing 100084China Chinese Institute for Brain Research Beijing 102206China School of Basic Medical Sciences Capital Medical UniversityBeijing 100069China Department of Otolaryngology Head and Neck SurgeryShanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Ear Institute Shanghai Jiao Tong University School of MedicineShanghai 200092China Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases Shanghai 20001lChina

In mammals,the piezoelectric protein,Prestin,endows the outer hair cells(OHCs)with electromotility(eM),which confers the capacity to change cellular length in response to alterations in membrane *** with basilarmembrane resonance and possible stereociliary motility,Prestin-based OHC eM lays the foundation for enhancing cochlear sensitivity and frequency ***,it remains debatable whether Prestin contributes to ultrahigh-frequency hearing due to the intrinsic nature of the cel's low-pass *** low-pass_property of mouse OHC eM is based on the finding that eM magnitude dissipates within the frequency bandwidth of human *** this study,we examined the role of Prestin in sensing broad-range frequencies(4-80 kHz)in mice that use ultrasonic hearing and vocalization(to>100 kHz)for social *** audiometric measurements in mice showed that ablation of Prestin did not abolish hearing at frequencies>40 *** associative behavior tests confirmed that Prestin-knockout mice can learn ultrahigh-frequency sound-coupled tasks,similar to control *** vivo cochlear Ca2+imaging experiments demonstrated that without Prestin,the OHCs still exhibit ultrahigh-frequency transduction,which in contrast,can be abolished by a universal cation channel blocker,*** vivo salicylate treatment disrupts hearing at frequencies40 *** findings demonstrate that cochlear OHCs are the target cells that support ultrahigh-frequency transduction,which does not require Prestin.

关键词： Prestin PIEZO2 Ultrahigh-frequency hearing Electromotility Outer hair cells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于XML的参数化虚拟场景建模技术

计算机工程 2006年第22期32卷 215-217,271页

作者：陆亚萍刘厚泉赵志凯中国矿业大学计算机科学与技术学院徐州221008

针对VRML虚拟场景建模可定制性差和开发效率低的缺陷,提出一种基于XML的参数化虚拟场景建模技术,增强了VRML场景建模的可定制性,提高了开发效率,并对大场景采用区域划分的方法,提高了大场景的绘制速度,在虚拟城市的构建项目中得到了较... 详细信息

针对VRML虚拟场景建模可定制性差和开发效率低的缺陷,提出一种基于XML的参数化虚拟场景建模技术,增强了VRML场景建模的可定制性,提高了开发效率,并对大场景采用区域划分的方法,提高了大场景的绘制速度,在虚拟城市的构建项目中得到了较好的应用。

关键词：虚拟现实虚拟现实建模语言参数化场景建模 XML

在线全文

学校读者我要写书评

暂无评论

煤矿物联网研究现状及发展趋势

工矿自动化 2015年第5期41卷 1-5页

作者：丁恩杰赵志凯中国矿业大学物联网(感知矿山)研究中心江苏徐州221008 矿山互联网应用技术国家地方联合工程实验室江苏徐州221008

阐述了国内外煤矿物联网的一些概念及发展历史,分别从系统架构、感知层、传输层、应用层及工程应用方面总结了国内外煤矿物联网研究现状;指出目前煤矿物联网研究存在的主要问题为缺乏低功耗智能传感器及装置、矿井环境能量捕获技术、数... 详细信息

阐述了国内外煤矿物联网的一些概念及发展历史,分别从系统架构、感知层、传输层、应用层及工程应用方面总结了国内外煤矿物联网研究现状;指出目前煤矿物联网研究存在的主要问题为缺乏低功耗智能传感器及装置、矿井环境能量捕获技术、数据与网络安全方法、公共服务平台以及煤矿物联网相关标准;从嵌入式智能信息传感技术、基于大数据的矿山安全生产云服务平台、安全性方面探讨了煤矿物联网可能的发展方向。

关键词：煤矿物联网感知矿山智能传感器能量捕获云平台物联网安全

在线全文

学校读者我要写书评

暂无评论

时间序列多尺度异常检测方法

计算机工程与应用 2018年第20期54卷 122-127页

作者：陈波刘厚泉赵志凯中国矿业大学计算机科学与技术学院江苏徐州221116 中国矿业大学信息与控制工程学院物联网感知矿山研究中心江苏徐州221008

针对时间序列异常模式检测大多采用线性模式分割方式的局限性,研究了在Haar小波变换多尺度特征的基础上,结合时间序列模式分割技术,提出一种时间序列多尺度异常检测方法。该方法首先通过小波变换压缩时间序列,把时间序列分解在不同的尺... 详细信息

针对时间序列异常模式检测大多采用线性模式分割方式的局限性,研究了在Haar小波变换多尺度特征的基础上,结合时间序列模式分割技术,提出一种时间序列多尺度异常检测方法。该方法首先通过小波变换压缩时间序列,把时间序列分解在不同的尺度上;再利用二次回归模型将分解后的时间序列分割成可变长度的模式序列,计算模式异常值;最后重构原时间序列,检测原时间序列中的异常模式。实验结果表明,该方法可以有效地检测异常,而且可以从不同分解级数的压缩时间序列中检测多尺度异常模式。

关键词：时间序列小波变换二次回归模型多尺度异常模式

Aurora B promotes the CENP-T–CENP-W interaction to guide accurate chromosome segregation in mitosis

在线全文

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2024年第2期16卷 11-23页

作者： Wei Liu Zhen Dou Chunyue Wang Gangyin zhao Fengge Wu Chunli Wang Felix Aikhionbare Mingliang Ye Divine Mensah Sedzro Zhenye Yang Chuanhai Fu zhikai Wang Xinjiao Gao Xuebiao Yao Xiaoyu Song Xing Liu MOE Key Laboratory for Cellular Dynamics Center for Advanced Interdisciplinary Science and Biomedicine of IHMUniversity of Science and Technology of China School of Life SciencesHefei 230027China Keck Center for Cellular Dynamics and Organoids Plasticity AtlantaGA 30310USA Anhui Key Laboratory for Cellular Dynamics and Chemical Biology Hefei National Research Center for Interdisciplinary Sciences at the MicroscaleHefei 230026China National Chromatographic Research and Analysis Center Chinese Academy of SciencesDalian 116023China

Accurate chromosome segregation in mitosis depends on kinetochores that connect centromeric chromatin to spindle *** are captured by individual microtubules via a kinetochore constitutive centromere-associated network(CCAN)during chromosome *** contains 16 subunits,including CENP-W and ***,the molecular recognition and mitotic regulation of the CCAN assembly remain ***,we revealed that CENP-W binds to the histone fold domain and an uncharacterized N-terminal region of *** B phosphorylates CENP-W at threonine 60,which enhances the interaction between CENP-W and CENP-T to ensure robust metaphase chromosome alignment and accurate chromosome segregation in *** findings delineate a conserved signaling cascade that integrates protein phosphorylation with CCAN integrity for the maintenance of genomic stability.

关键词： mitosis kinetochore Aurora B CENP-T CENP-W phosphorylation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于DBN-ELM的入侵检测研究

计算机工程 2018年第9期44卷 153-158页

作者：魏思政刘厚泉赵志凯中国矿业大学计算机科学与技术学院江苏徐州221116 中国矿业大学物联网感知矿山研究中心江苏徐州221008

为了有效解决海量复杂数据的入侵检测分类问题,基于深度信念网络(DBN)和极限学习机(ELM),提出一种新的入侵检测方法。使用DBN对大量复杂无标签的原始数据进行特征提取,得到高度抽象的重要特征,再用ELM完成最终的分类工作。结合DBN自动... 详细信息

为了有效解决海量复杂数据的入侵检测分类问题,基于深度信念网络(DBN)和极限学习机(ELM),提出一种新的入侵检测方法。使用DBN对大量复杂无标签的原始数据进行特征提取,得到高度抽象的重要特征,再用ELM完成最终的分类工作。结合DBN自动提取特征的能力和ELM快速学习且泛化性好的优势,提高入侵检测识别率和运行效率。实验结果表明,与原始的DBN、ELM以及DBN-SVM方法相比,该方法具有更优的精确度和运行效率。

关键词：深度学习深度信念网络极限学习机混合模型入侵检测无监督

在线全文

学校读者我要写书评

暂无评论

一种基于SVR的定位误差修正算法

计算机应用研究 2017年第8期34卷 2515-2517,2524页

作者：郭建刘全景赵志凯中国矿业大学信息与电气工程学院江苏徐州221008 中国矿业大学物联网(感知矿山)研究中心江苏徐州221008

针对井下无线信号传播环境发生改变需要重新采集RSS(received signal strength)指纹数据的问题,提出一种基于支持向量回归(SVR)的定位误差修正算法。该算法在离线阶段利用支持向量回归机,建立待训练点的RSS值和定位结果与定位误差之间... 详细信息

针对井下无线信号传播环境发生改变需要重新采集RSS(received signal strength)指纹数据的问题,提出一种基于支持向量回归(SVR)的定位误差修正算法。该算法在离线阶段利用支持向量回归机,建立待训练点的RSS值和定位结果与定位误差之间的非线性关系,在线阶段利用该模型计算RSS样本的定位误差,并修正定位结果。实验结果表明,在离线训练点数量增加前后,该修正算法比指纹匹配算法的定位误差分别减少了22%与38%。

关键词：无线传播环境 RSS指纹数据支持向量回归机定位误差