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Development of a new cerebral ischemia reperfusion model of Mongolian gerbils and standardized evaluation system

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Animal Models and Experimental Medicine 2024年第1期7卷 48-55页

作者： Ying Wu Caijiao Hu zhihui li Feiyang li Jianyi Lv Meng Guo Xin liu Changlong li Xueyun Huo Zhenwen Chen lifeng Yang Xiaoyan Du School of Basic Medical Sciences Capital Medical UniversityBeijingChina Laboratory for Clinical Medicine Capital Medical UniversityBeijingChina College of Veterinary Medicine China Agricultural UniversityBeijingChina

Background:The Mongolian gerbil is an excellent laboratory animal for preparing the cerebral ischemia model due to its inherent deficiency in the circle of ***,the low incidence and unpredictability of symptoms are caused by numerous complex variant types of the ***,the lack of an evaluation system for the cer-ebral ischemia/reperfusion(I/R)model of gerbils has shackled the application of this ***:We created a symptom-oriented principle and detailed neurobehavioral scoring *** different time points of reperfusion,we analyzed the alteration in locomotion by rotarod test and grip force score,infarct volume by triphenyltetrazo-lium chloride(TTC)staining,neuron loss using Nissl staining,and histological charac-teristics using hematoxylin-eosin(H&E)***:With a successful model rate of 56%,32 of the 57 gerbils operated by our method harbored typical features of cerebral I/R injury,and the mortality rate in the male gerbils was significantly higher than that in the female *** suc-cessfully prepared I/R gerbils demonstrated a significant reduction in motility and grip strength at 1 day after reperfusion;formed obvious infarction;exhibited typi-cal pathological features,such as tissue edema,neuronal atrophy and death,and vacuolated structures;and were partially recovered with the extension of reperfu-sion ***:This study developed a new method for the unilateral common carotid artery ligation I/R model of gerbil and established a standardized evaluation system for this model,which could provide a new cerebral I/R model of gerbils with more practical applications.

关键词： ischemia/reperfusion Mongolian gerbil standardized model system unilateral carotid occlusion

Simultaneous microwave characterization of wafer-level optoelectronic transceiver chips based on photonic sampling and mapping

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Science China(Information Sciences) 2024年第2期67卷 337-338页

作者： Yutong HE Xinhai ZOU Ying XU zhihui li Naidi CUI Junbo FENG Yali ZHANG Zhiyao ZHANG Shangjian ZHANG Yong liU Ninghua ZHU Research Center for Microwave Photonics State Key Laboratory of Electronic Thin Films and Integrated DevicesSchool of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of China Chongqing United Microelectronics Center (CUMEC) Xiongan Institute of Innovation Chinese Academy of Sciences

Photonic integrated circuits(PICs) promise future parallelism growths of high-performance communication, computation, and offer unprecedented bandwidth scalability with reduced power consumption as a viable replacement for an electrical wire with an optoelectronic transceiver consisting of a transmitter and a receiver integrated on the same wafer.

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Systematic Cloud-Based Optimization: Twin-Fold Moth Flame Algorithm for VM Deployment and Load-Balancing

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Intelligent Automation & Soft Computing 2024年第3期39卷 477-510页

作者： Umer Nauman Yuhong Zhang zhihui li Tong Zhen Information Science and Engineering College Henan University of TechnologyZhengzhou450001China School of Artificial Intelligence and Big Data Henan University of TechnologyZhengzhou450001China Key Laboratory of Grain Information Processing and Control Ministry of EducationHenan University of TechnologyZhengzhou450001China

Cloud computing has gained significant recognition due to its ability to provide a broad range of online services and ***,existing commercial cloud computing models demonstrate an appropriate design by concentrating computational assets,such as preservation and server infrastructure,in a limited number of large-scale worldwide data *** the deployment of virtual machines(VMs)is crucial in this scenario to ensure system dependability,performance,and minimal latency.A significant barrier in the present scenario is the load distribution,particularly when striving for improved energy consumption in a hypothetical grid computing *** design employs load-balancing techniques to allocate different user workloads across several virtual *** address this challenge,we propose using the twin-fold moth flame technique,which serves as a very effective optimization *** intentionally designed the twin-fold moth flame method to consider various restrictions,including energy efficiency,lifespan analysis,and resource *** provides a thorough approach to evaluating total costs in the cloud computing *** assessing the efficacy of our suggested strategy,the study will analyze significant metrics such as energy efficiency,lifespan analysis,and resource *** investigation aims to enhance cloud computing techniques by developing a new optimization algorithm that considers multiple factors for effective virtual machine placement and load *** proposed work demonstrates notable improvements of 12.15%,10.68%,8.70%,13.29%,18.46%,and 33.39%for 40 count data of nodes using the artificial bee colony-bat algorithm,ant colony optimization,crow search algorithm,krill herd,whale optimization genetic algorithm,and improved Lévy-based whale optimization algorithm,respectively.

关键词： Optimizing cloud computing deployment of virtual machines load-balancing twin-fold moth flame algorithm grid computing computational resource distribution data virtualization

Associations between parental adherence to healthy lifestyles and cognitive performance in offspring:A prospective cohort study in China

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Chinese Medical Journal 2024年第6期137卷 683-693页

作者： Rongxia Lv Yuhui Huang Siyi Huang Shiyi Wu Siwen Wang Guangyu Hu Yanan Ma Peige Song Jorge E.Chavarro S.V.Subramanian Chunling Lu zhihui li Changzheng Yuan School of Public Health the Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310058China Department of Nutrition Harvard T.H.Chan School of Public HealthBostonMA 02115USA Institute of Medical Information/Center for Health Policy and Management Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Biostatistics and Epidemiology School of Public HealthChina Medical UniversityShenyangLiaoning 110122China Department of Social and Behavioral Sciences Harvard T.H.Chan School of Public HealthBostonMA 02115USA Division of Global Health Equity Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA Department of Global Health and Social Medicine Harvard Medical SchoolBostonMA 02115USA Vanke School of Public Health Tsinghua UniversityBeijing 100084China Department of Global Health and Population Harvard T.H.Chan School of Public HealthBostonMA 02115USA

Background:Previous studies have reported associations of specific maternal and paternal lifestyle factors with offspring’s cognitive development during early *** study aimed to investigate the prospective associations between overall parental lifestyle and offspring’s cognitive performance during adolescence and young adulthood in ***:We included 2531 adolescents aged 10-15 years at baseline in 2010 from the China Family Panel Studies.A healthy parental lifestyle score(ranged 0-5)was constructed based on the following five modifiable lifestyle factors:Smoking,drinking,exercise,sleep,and *** estimating equation models were used to examine the association between baseline parental healthy lifestyle scores and offspring’s fluid and crystallized intelligence in subsequent years(2012,2014,2016,and 2018).Results:Offspring in the top tertile of parental healthy lifestyle scores performed better in overall fluid intelligence(multivariable-adjusted β=0.53,95%confidence interval[CI]:0.29-0.77)and overall crystallized intelligence(multivariable-adjusted β=0.35,95%CI:0.16-0.54)than those in the bottom tertile of parental healthy lifestyle *** results were similar after further adjustment for the offspring’s healthy lifestyle scores and persisted across the subgroups of parental socioeconomic ***,maternal and paternal healthy lifestyle scores were independently associated with better offspring’s cognitive performance,with significant contribution observed for paternal never-smoking,weekly exercise,and diversified *** both parents and offspring adhered to a healthier lifestyle,we observed the highest level of the offspring’s overall crystallized ***:Our study indicates that parental adherence to a healthier lifestyle is associated with significantly better offspring’s cognitive performance during adolescence and early adulthood,regardless of socioeconomic *** findings highlight the poten

关键词： Cohort study Parental healthy lifestyle Offspring Cognitive performance Intelligence Adolescence

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真空羽流中相变过程DSMC仿真方法研究

力学学报 2024年第5期56卷 1356-1365页

作者：李中华李志辉吴俊林中国空气动力研究与发展中心超高速空气动力研究所四川绵阳621000 中国空气动力研究与发展中心飞行器流体物理全国重点实验室四川绵阳621000 国家计算流体力学实验室北京100191

真空燃气羽流快速膨胀过程中,其中的H_(2)O和CO_(2)等组元容易发生凝结相变现象.为了研究真空羽流中水蒸气的相变产物冰晶对羽流红外信号、侵蚀等污染效应的影响,开展羽流中相变过程的数值模拟方法研究.基于稀薄两相羽流双向耦合DSMC方... 详细信息

真空燃气羽流快速膨胀过程中,其中的H_(2)O和CO_(2)等组元容易发生凝结相变现象.为了研究真空羽流中水蒸气的相变产物冰晶对羽流红外信号、侵蚀等污染效应的影响,开展羽流中相变过程的数值模拟方法研究.基于稀薄两相羽流双向耦合DSMC方法,采用经典成核理论和液滴生长理论,建立了真空羽流的相变过程的数值仿真方法.对水蒸气在拉法尔喷管中自凝结试验的仿真.通过与试验结果的对比,对经典成核理论进行了修正,对成核率给出了10^(3)的修正因子,可以得到与试验符合的仿真结果,表明对成核理论修正后,可以应用到稀薄流动的数值模拟中.对某发动机真空羽流相变流场的仿真,在核心区得到与CFD相近的结果.仿真结果表明,在羽流流场中,由于相变,存在较多的冰晶颗粒,在计算条件下,羽流核心区冰晶数密度最大达到10^(15) m^(-3)的量级,冰晶直径在约10^(-8) m的量级.在真空环境下,随着羽流向倒流区无限制膨胀,倒流区流场内也会出现一定数量的冰晶颗粒,数密度从10^(7)~10^(10)m^(-3)的量级,直径在5.0×10^(-10)m的量级.颗粒在空间的数密度、尺寸等分布与气相分布存在差异,需要开展相关污染效应的影响研究.

关键词：真空羽流相变成核直接模拟蒙特卡罗数值仿真

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带有状态/输入量化的无人艇航向跟踪控制

中国舰船研究 2024年第1期19卷 111-118页

作者：李伟王雨宁君李志慧大连海事大学航海学院辽宁大连116026 吉林师范大学信息技术学院吉林四平136000

[目的]针对水面无人艇(USV)的海上通信受限的问题,提出一种带有状态/输入量化的USV航向跟踪控制方法。[方法]基于反步法设计系统控制律,结合动态面技术降低虚拟控制律的计算量膨胀问题。对于控制系统中存在的不确定项及外界干扰,利用扩... 详细信息

[目的]针对水面无人艇(USV)的海上通信受限的问题,提出一种带有状态/输入量化的USV航向跟踪控制方法。[方法]基于反步法设计系统控制律,结合动态面技术降低虚拟控制律的计算量膨胀问题。对于控制系统中存在的不确定项及外界干扰,利用扩张状态观测器(ESO)进行估计。采用均匀量化器分别对控制系统中的状态变量和控制输入进行量化,且量化后的状态反馈信息仅用于跟踪控制。利用量化状态递归设计基于ESO的USV航向控制器,证明闭环控制系统中量化变量和非量化变量间误差的有界性。[结果]基于李雅普诺夫稳定性理论,提出了量化误差考量及闭环系统稳定性判定方法,严格证明了所设计的带有状态量化和输入量化的USV航向跟踪控制系统的稳定性,仿真实验验证了该控制策略的有效性。[结论]结果表明,所提方法可为USV航向跟踪控制提供借鉴。

关键词：无人艇状态量化和输入量化量化反馈控制扩张状态观测器量化误差

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程序性死亡受体1联合BeGEV方案序贯自体造血干细胞移植治疗肺复发霍奇金淋巴瘤1例并文献复习

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白血病．淋巴瘤 2024年第3期33卷 174-177页

作者：李智慧李丽王彦丽临沂市中心医院血液科临沂276400

目的探讨程序性死亡受体1联合BeGEV方案序贯自体造血干细胞移植(ASCT)治疗肺复发霍奇金淋巴瘤(HL)患者的临床效果。方法回顾性分析2020年10月临沂市中心医院收治的1例局限期HL患者1年内结外复发的临床资料,并复习相关文献。结果患者,女... 详细信息

目的探讨程序性死亡受体1联合BeGEV方案序贯自体造血干细胞移植(ASCT)治疗肺复发霍奇金淋巴瘤(HL)患者的临床效果。方法回顾性分析2020年10月临沂市中心医院收治的1例局限期HL患者1年内结外复发的临床资料,并复习相关文献。结果患者,女性,40岁,因发现左侧颈部肿物,行淋巴结全切术,经病理诊断为经典霍奇金淋巴瘤(cHL),采用ABVD方案4个疗程联合放疗进行治疗。患者1年内出现肺复发,经程序性死亡受体1联合BeGEV方案序贯ASCT治疗,随访1年无复发。结论HL治愈率高,但部分患者呈复发难治病程,挽救性化疗序贯ASCT可获得较好的临床疗效。

关键词：霍奇金淋巴瘤复发自体干细胞移植 PD-1

商品房预售与商业银行的信用风险承担--来自我国地方性银行的经验证据

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国际金融研究 2024年第7期 62-72页

作者：李志辉朱明皓南开大学经济学院

促进房地产市场平稳发展已成为我国防范化解重大经济金融风险工作的重要任务。本文以2009—2022年国内43家上市地方性商业银行为研究样本,从预售交易比例与预售交易门槛两个方面度量各城市商品房预售交易水平,探究商业银行所在城市的商... 详细信息

促进房地产市场平稳发展已成为我国防范化解重大经济金融风险工作的重要任务。本文以2009—2022年国内43家上市地方性商业银行为研究样本,从预售交易比例与预售交易门槛两个方面度量各城市商品房预售交易水平,探究商业银行所在城市的商品房预售交易对其信用风险承担的影响。研究发现:商品房预售交易会提高房地产企业贷款、建筑企业贷款与个人购房贷款的违约率,导致当地银行的风险承担水平上升。该结论经过一系列稳健性检验后依然成立。在影响渠道方面,商品房预售交易通过提高房地产企业杠杆率、恶化建筑企业资金周转率以及降低期房竣工率来影响信贷资产质量,提升银行风险承担水平。进一步分析发现:银行加强对房地产企业信贷业务的风险管理可以有效缓解商品房预售交易对其风险承担的不利影响。同时,政府主导的预售资金提取监管与合理的房价水平均能够减弱商品房预售交易带来的信用风险。本文的研究结论可为商业银行与监管部门防范房地产金融风险提供参考。

关键词：商品房预售预售资金监管房地产企业房地产金融风险

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高频下功率模块有机硅凝胶封装材料中电树枝生长及自愈特性

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中国电机工程学报 2024年第10期44卷 4134-4144,I0033页

作者：王健陈晨闫豪生李志辉王伟邹亮张黎李庆民新能源电力系统国家重点实验室(华北电力大学) 北京市昌平区102206 山东大学电气工程学院山东省济南市250061

有机硅凝胶因其良好的电、热及机械性能,被广泛应用于多能变换装备中功率模块的封装绝缘,电树枝是由于局部放电而产生的树枝状放电通道,是功率模块封装绝缘系统较为常见的失效形式。基于此,该文搭建高频正弦电压激励下有机硅凝胶中电树... 详细信息

有机硅凝胶因其良好的电、热及机械性能,被广泛应用于多能变换装备中功率模块的封装绝缘,电树枝是由于局部放电而产生的树枝状放电通道,是功率模块封装绝缘系统较为常见的失效形式。基于此,该文搭建高频正弦电压激励下有机硅凝胶中电树枝生长实验平台,开展不同频率下的电树枝生长实验,探究高频下有机硅凝胶中电树枝的起始及传播机制,分析频率对电树枝特性的影响机理;进一步开展不同温度以及组分配比下的电树枝自愈实验,研究有机硅凝胶中电树枝自愈行为及其影响机制。实验结果表明,随着频率的升高,硅凝胶中电树枝形态将更加复杂,起树电压也会随之下降,18kHz下起树电压较8kHz下降了约17%。分析认为,麦克斯韦应力是导致高频下电树枝起始的主要原因,而有机硅凝胶中电树枝的传播特性也有别于传统固体电介质。针对自愈特性,温度升高有利于电树枝的自愈,但在100℃下将会抑制自愈,分析得到温度通过影响气体状态来影响自愈的不同阶段。同时,组分配比不同也会影响硅凝胶的形态及电树枝特性。

关键词：有机硅凝胶电树枝自愈特性功率模块