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New Theory on Three Major Literary Debates at the Beginning of Founding Nation

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学术界 2010年第5期 279-280页

作者： liu zhihua Department of Chinese Language and Literature of Fudan University Department of Chinese Language and Literature of Putian University

Differential expression analysis of matrix metallo-proteinase 20(MMP20) in human esophageal cancer

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Chinese Science Bulletin 2001年第12期46卷 1009-1012,1057页

作者： YANG Cuihong liu zhihua WANG Qun LUO Aiping SUN Yuntian ZHANG Xun WANG Xiuqin ZHOU Chuannong WU Min National Key Laboratory of Molecular Oncology Cancer InstituteChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China Department of Pathology Cancer InstituteChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China

The aim of this study was to investigate the different expressions of MMP20 in the process of esophageal cancer. RT-PCR, immunohistochemistry and Western blot were employed to detect the mRNA expression and protein expression of MMP20. Compared with the corresponding normal esophagus tissues, results showed the common trend of the dramatical overexpression of MMP20 in the esophageal cancer tissues. The analysis of MMP20 expression in different clinical early stages of esophageal cancer by RT-PCR indicated that MMP20 was much more overexpressed in the esophageal cancer with invasion than in the early stages. This suggested that MMP20 might play an important role in the progression of esophageal cancer. It probably plays a critical role in tumor invasion.

关键词： esophageal cancer MMP20 RT-PCR Western blot.

Phosphoproteomics reveals therapeutic targets of esophageal squamous cell carcinoma

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3390-3392页

作者： Yi Li Bin Yang Yanchun Ma Xiaojun Peng Zhiyu Wang Bin Sheng Zichao Wei Yongping Cui zhihua liu State Key Lab of Molecular Oncology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Pathology Key Laboratory of Cellular Physiology(Shanxi Medical University)Ministry of EducationTaiyuan 030001 ShanxiChina Department of Tumor Surgery Shanxi Cancer HospitalTaiyuan 030013 ShanxiChina Department of Bioinformatics Jingjie PTM Biolab Co.LtdHangzhou 310018China

Dear Editor,Esophageal squamous cell carcinoma(ESCC)is one of the most aggressive squamous cell carcinomas and highly prevalent in *** incidence of ESCC is affected by environmental factors(alcohol consumption,tobacco use,etc.)and genetic factors,both result in tumorigenesis by altering proteomic,posttranslational modification(PTM)and metabolic characterization of esophageal epithelial ***,large-scale investigations of ESCC have been performed,focusing on the discovery of new driver ***,the mechanisms underlying ESCC development remain unclear,and comprehensive protein profiling of ESCC is necessary to understand its underlying *** far,the approaches to the treatment of ESCC patients mainly include endoscopic therapy,surgery and ***,most patients especially with poor prognosis ESCC still lack effective targeted treatment.

关键词： esophageal squamous surgery

RPS15 interacted with IGF2BP1 to promote esophageal squamous cell carcinoma development via recognizing m^(6)A modification

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3400-3414页

作者： Yahui Zhao Yang Li Rui Zhu Riyue Feng Heyang Cui Xiao Yu Furong Huang Ruixiang Zhang Xiankai Chen Lei Li Yinghui Chen Yuhao liu Jinhua Wang Guanhua Du zhihua liu State Key Laboratory of Molecular Oncology National Cancer CenterNational Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Oncology Cancer InstitutePeking University Shenzhen HospitalShenzhen Peking University-Hong Kong University of Science and Technology(PKU-HKUST)Medical CenterShenzhen 518035China Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518116China School of Life Sciences Tsinghua UniversityBeijing 100084China Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China

Increased rates of ribosome biogenesis have been recognized as hallmarks of many cancers and are associated with poor *** a CRISPR synergistic activation mediator(SAM)system library targeting 89 ribosomal proteins(RPs)to screen for the most oncogenic functional RPs in human esophageal squamous cell carcinoma(ESCC),we found that high expression of RPS15 correlates with malignant phenotype and poor prognosis of ESCC.

关键词： esophageal squamous prognosis

Gut dysbiosis impairs intestinal renewal and lipid absorption in Scarb2 deficiency-associated neurodegeneration

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Protein & Cell 2024年第11期15卷 818-839页

作者： Yinghui Li Xingchen liu Xue Sun Hui Li Shige Wang Wotu Tian Chen Xiang Xuyuan Zhang Jiajia Zheng Haifang Wang Liguo Zhang Li Cao Catherine C.L.Wong zhihua liu Institute for Immunology and School of Basic Medicine Tsinghua UniversityBeijing 100084China Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Institute of Biophysics University of Chinese Academy of SciencesBeijing 100049China Tsinghua-Peking Center for Life Sciences Tsinghua UniversityBeijing 100084China First School of Clinical Medicine Peking University First HospitalPeking UniversityBeijing 100034China School of Pharmacy University of Wisconsin-MadisonMadisonWI 53705United States Department of Neurology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China Department of Laboratory Medicine Peking University Third HospitalBeijing100191China Clinical Stem Cell Research Center Peking University Third HospitalBeijing 100191China Department of Medical Research Center State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Tsinghua University-Peking University Joint Center for Life Sciences Peking UniversityBeijing 100084China

Scavenger receptor class B,member 2(SCARB2)is linked to Gaucher disease and Parkinson’s *** in the SCARB2 gene causes progressive myoclonus epilepsy(PME),a rare group of inherited neurodegenerative diseases characterized by *** found that Scarb2 deficiency in mice leads to age-dependent dietary lipid malabsorption,accompanied with vitamin E *** investigation revealed that Scarb2 deficiency is associated with gut dysbiosis and an altered bile acid pool,leading to hyperactivation of FXR in *** of FXR impairs epithelium renewal and lipid *** with SCARB2 mutations have a severe reduction in their vitamin E levels and cannot absorb dietary vitamin ***,inhibiting FXR or supplementing vitamin E ameliorates the neuromotor impairment and neuropathy in Scarb2 knockout *** data indicate that gastrointestinal dysfunction is associated with SCARB2 deficiency-related neurodegeneration,and SCARB2-associated neurodegeneration can be improved by addressing the nutrition deficits and gastrointestinal issues.

关键词： gut dysbiosis intestinal renewal neuron disease

Severe Global Environmental Issues Caused by Canada’s Record-Breaking Wildfires in 2023

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Advances in Atmospheric Sciences 2024年第4期41卷 565-571页

作者： Zhe WANG Zifa WANG Zhiyin ZOU Xueshun CHEN Huangjian WU Wending WANG Hang SU Fang LI Wenru XU zhihua liu Jiaojun ZHU State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Institute of Applied Ecology Chinese Academy of SciencesShenyang 110016China

Due to the record-breaking wildfires that occurred in Canada in 2023,unprecedented quantities of air pollutants and greenhouse gases were released into the *** wildfires had emitted more than 1.3 Pg CO_(2)and 0.14 Pg CO_(2)equivalent of other greenhouse gases(GHG)including CH4 and N_(2)O as of 31 *** wildfire-related GHG emissions constituted more than doubled Canada’s planned cumulative anthropogenic emissions reductions in 10 years,which represents a significant challenge to climate mitigation *** model simulations showed that the Canadian wildfires impacted not only the local air quality but also that of most areas in the northern hemisphere due to long-range transport,causing severe PM_(2.5)pollution in the northeastern United States and increasing daily mean PM_(2.5)concentration in northwestern China by up to 2μg *** observed maximum daily mean PM_(2.5)concentration in New York City reached 148.3μg m-3,which was their worst air quality in more than 50 years,nearly 10 times that of the air quality guideline(i.e.,15μg m-3)issued by the World Health Organization(WHO).Aside from the direct emissions from forest fires,the peat fires beneath the surface might smolder for several months or even longer and release substantial amounts of CO_(2).The substantial amounts of greenhouse gases from forest and peat fires might contribute to the positive feedback to the climate,potentially accelerating global *** better understand the comprehensive environmental effects of wildfires and their interactions with the climate system,more detailed research based on advanced observations and Earth System Models is essential.

关键词： Canada forest fire greenhouse gases PM_(2.5) transboundary air pollution

Immune-tumor interaction dictates spatially directed evolution of esophageal squamous cell carcinoma

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National Science Review 2024年第5期11卷 170-185页

作者： Yong Zhou Shanlan Mo Heyang Cui Ruifang Sun Weimin Zhang Xiaofei Zhuang Enwei Xu Hongyi Li Yikun Cheng Yongsheng Meng Meilin liu Ting Yan Huijuan liu Ling Zhang Bin Yang Yanfeng Xi Shubin Wang Xiaolong Cheng Shuai Cheng Li zhihua liu Qimin Zhan Zheng Hu Yongping Cui Cancer Institute Department of Pathology Peking University Shenzhen Hospital Shenzhen Peking University-the Hong Kong University of Science and Technology(PKU-HKUST) Medical Center Institute of Cancer ResearchShenzhen Bay Laboratory Key Laboratory of Cellular Physiology of the Ministry of Education Department of Pathology Shanxi Medical University City University of Hong Kong Shenzhen Research Institute CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of Sciences Department of Surgery Faculty of Medicine The Chinese University of Hong Kong Department of Tumor Biobank Shanxi Province Cancer HospitalShanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical SciencesCancer Hospital Affiliated to Shanxi Medical University Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of Molecular Oncology Peking University Cancer Hospital & Institute Research Unit of Molecular Cancer Research Chinese Academy of Medical Sciences Department of Thoracic Surgery Shanxi Province Cancer HospitalShanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical SciencesCancer Hospital Affiliated to Shanxi Medical University Department of Pathology Shanxi Province Cancer HospitalShanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical SciencesCancer Hospital Affiliated to Shanxi Medical University College of Letters & Science University of California Berkeley State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Esophageal squamous cell carcinoma（ESCC） is a poor-prognostic cancer type with extensive intra-and inter-patient heterogeneity in both genomic variations and tumor microenvironment（TME）. However, the patterns and drivers of spatial genomic and microenvironmental heterogeneity of ESCC remain largely unknown. Here, we generated a spatial multi-omic atlas by whole-exome, transcriptome, and methylome sequencing of 507 tumor samples from 103 patients. We identified a novel tumor suppressor PREX2,accounting for 22% of ESCCs with frequent somatic mutations or hyper-methylation, which promoted migration and invasion of ESCC cells in vitro. Analysis of the TME and quantification of subclonal expansion indicated that ESCCs undergo spatially directed evolution, where subclones mostly originated from the tumor center but had a biased clonal expansion to the upper direction of the ***, we found upper regions of ESCCs often underwent stronger immunoediting with increased selective fitness, suggesting more stringent immune selection. In addition, distinct TMEs were associated with variable genomic and clinical outcomes. Among them, hot TME was associated with high immune evasion and subclonal heterogeneity. We also found that immunoediting, instead of CD8+T cell abundance, acts as an independent prognostic factor of ESCCs. Importantly, we found significant heterogeneity in previously considered potential therapeutic targets, as well as BRCAness characteristics in a subset of patients, emphasizing the importance of focusing on heterogeneity in ESCC targeted ***, these findings provide novel insights into the mechanisms of the spatial evolution of ESCC and inform precision therapeutic strategies.

关键词： squamous cell carcinoma heterogeneity multi-omics evolution tumor microenvironment

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表面印迹交替层状组装薄膜

高分子学报 2011年第9期21卷 950-955页

作者：刘志华张希光化学转换与功能材料重点实验室中国科学院理化技术研究所北京100190 有机光电子与分子工程教育部重点实验室清华大学化学系北京100084 中国科学院研究生院北京100049

在简要概述非常规交替层状组装这一进展后,重点总结了如何利用非常规交替层状组装以实现表面印迹膜的制备.模板分子与聚电解质在溶液中组装形成超分子复合物,然后以此超分子复合物为构筑基元,与感光性高分子,如重氮树脂,通过常规交替层... 详细信息

在简要概述非常规交替层状组装这一进展后,重点总结了如何利用非常规交替层状组装以实现表面印迹膜的制备.模板分子与聚电解质在溶液中组装形成超分子复合物,然后以此超分子复合物为构筑基元,与感光性高分子,如重氮树脂,通过常规交替层状组装形成聚合物多层膜.利用聚合物多层膜之间的光化学反应形成稳定的多层膜,然后去除模板分子得到分子印迹交替组装薄膜.该研究表明不同的分子间相互作用均可用于分子印迹交替组装薄膜的制备,并且通过引入多点相互作用可以提高其选择性.以此为基础,交替层状组装分子印迹薄膜分别与微接触印刷和膜分离技术相结合,制备了具有正电荷选择性的印章材料和电荷选择性的膜分离材料,从而提供一种新的制备表面分子印迹材料的方法.

关键词：非常规交替层状组装分子印迹

A Real-world Prospective Study of Mother-to-child Transmission of HBV in China Using a Mobile Health Application (Shield 01)

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Journal of Clinical and Translational Hepatology 2020年第1期8卷 1-8页

作者： Xueru Yin Guorong Han Hua Zhang MeiWang Wenjun Zhang Yunfei Gao Mei Zhong Xiaolan Wang Xiaozhu Zhong Guojun Shen Chuangguo Yang Huiyuan liu Zhihong liu Po-Lin Chan Marc Bulterys Fuqiang Cui Hui Zhuang zhihua liu Jinlin Hou Department of Infectious Diseases Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Gynecology and Obstetrics The Second Affiliated Hospital of the Southeast UniversityNanjingJiangsuChina Department of Obstetrics and Gynecology Beijing Youan HospitalCapital Medical UniversityBeijingChina Department of Obstetrics and Gynecology The Fifth Medical CentreChinese People’s Liberation Army General HospitalBeijingChina Department of Obstetrics and Gynecology The Fifth Affiliated Hospital of Southern Medical UniversityGuangzhouGuangdongChina Department of Obstetrics and Gynecology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Obstetrics Jiujiang Maternal and Child Care CenterJiujiangJiangxiChina Department of Infectious Diseases Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Infectious Diseases Third People’s Hospital of JiujiangJiujiangJiangxiChina Department of Infectious Diseases The Third Affiliated Hospital of Southern Medical universityGuangzhouGuangdongChina Department of Severe Liver Diseases Guangzhou Eighth People’s HospitalGuangzhouGuangdongChina World Health Organization/Western Pacific Regional Office(WPRO) ManilaPhilippines Global Hepatitis Programme World Health OrganizationGenevaSwitzerland School of Public Health Peking UniversityBeijingChina Department of Microbiology and Center of Infectious Diseases School of Basic Medical SciencesPeking University Health Science CenterBeijingChina

Background and Aims:The World Health Organization(WHO)Western Pacific Region set a target of eliminating mother-to-child transmission(MTCT)of hepatitis B virus(HBV)by *** assess the feasibility of this target in China,we carried out an epidemiological study to investigate the status quo of MTCT in the real-world ***:One thousand and eight hepatitis B surface antigen-positive preg-nant women were enrolled at 10 ***-laxis was administered to *** addition,mothers with HBV DNA level>2,000,000 IU/mL were advised to initiate antiviral therapy during late pregnancy.A health application called SHIELD was used to manage the ***:Nine hundred and five of the enrolled mothers,with 924 infants,completed the ***-dose hepatitis B vaccine and hepatitis B immunoglobulin were received by 99.7%and 99.7%of infants,respectively,within 24 h after *** ;were 446 mothers who received antiviral therapy,including 72.3%of the mothers with HBV DNA level>2,000,000 IU/mL and 21.0%of the mothers with HBV DNA level<2,000,000 IU/*** infants were infected with *** overall rate of MTCT was 0.9%.Birth defects were rare(0.5%among in-fants with maternal antiviral exposure versus 0.7%among infants without exposure;p=1.00).Conclusions:The MTCT rate was lower than the WHO Western Pacific Region elimina-tion MTCT target in this real-world study,indicating that a comprehensive management composed of immunoprophy-laxis to infants and antiviral prophylaxis to mothers may be a feasible strategy to achieve the 2030 WHO elimination goal.

关键词： Mother-to-child transmission Hepatitis B virus Antiviral therapy Immunoprophylaxis Shield Project