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International Understanding 2022年第3期 21-21页

作者： liu zhihua Beijing Peaceland Foundation

Secretary General liu zhihua introduced that the Foundation is purchasing a vessel and planning to upgrade it with medical aid equipment for humanitarian aid *** to liu,under the support and guidance of China NGO Netw... 详细信息

关键词： Peace Secretary Human

Zero-Hopf bifurcation for an infection-age structured epidemic model with a nonlinear incidence rate

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Science China Mathematics 2017年第8期60卷 1371-1398页

作者： liu zhihua YUAN Rong School of Mathematical Sciences Beijing Normal University

An infection-age structured epidemic model with a nonlinear incidence rate is *** formulate the model as an abstract non-densely defined Cauchy problem and derive the condition which guarantees the existence and uniqueness for positive age-dependent equilibrium of the *** analyzing the associated characteristic transcendental equation and applying the normal form theory presented recently for non-densely defined semilinear equations,we show that the SIR(susceptible-infected-recovered)epidemic model undergoes Zero-Hopf bifurcation at the positive equilibrium which is the main result of this paper.

关键词： infection-age structured epidemic non-densely defined stability normal form zero-Hopf bifurcation

Reflections on the withdrawal of medical articles and the development of writing and publishing standards

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Cancer Biology & Medicine 2022年第9期19卷 1283-1289页

作者： Lidong Wang zhihua liu Research Integrity Construction Office(RICO) National Natural Science Foundation of ChinaBeijing 100085China The Supervisory Committee National Natural Science Foundation of ChinaBeijing 100085China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

In recent years,the withdrawal of several batches of articles from international academic journals has negatively affected Chinese *** Chinese government,the scientific community,and many scientific researchers have made substantial efforts to rectify this *** Editorial reviews the mass withdrawal events as a whole;identifies their causes;and systematically investigates China’s policy adjustments,institutional arrangements,and regulatory mechanisms in *** hope that,in addition to reminding authors to pay greater attention to avoiding withdrawals,this Editorial will provide guidance to help them conduct scientific research and present their achievements in a more standardized manner.

关键词： withdrawal arrangement batch

LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation

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Protein & Cell 2017年第1期8卷 55-66页

作者： Ruiqing Yan zhihua liu Key Laboratory of Infection and Immunity of CAS Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China CAS Center for Excellence in Biomacromolecules Chinese Academy of Sciences Beijing 100101 China

The innate immune system is critical for clearing infection, and is tightly regulated to avert excessive tissue damage. Nod1/2-Rip2 signaling, which is essential for initiating the innate immune response to bacterial infection and ER stress, is subject to many regulatory mechanisms. In this study, we found that LRRK2, encoded by a gene implicated in Crohn＇s disease, leprosy and familial Parkinson＇s disease, modulates the strength of Nod1/2-Rip2 signaling by enhancing Rip2 phosphorylation. LRRK2 deficiency markedly reduces cytokine production in macrophages upon Nod2 activation by muramyl dipeptide （MDP）, Nod1 activation by D-gamma-Glu-meso-diaminopimelic acid （iE-DAP） or ER stress. Our biochemical study shows that the presence of LRRK2 is necessary for optimal phosphorylation of Rip2 upon NOd2 activation. Therefore, this study reveals that LRRK2 is a new positive regulator of Rip2 and promotes inflammatory cytokine induction through the Nod1/2-Rip2 pathway.

关键词： LRRK2 Nod2 Rip2 NF-κB activation Inflammation

Microbes and host dance in harmony or disarray？

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Protein & Cell 2018年第5期9卷 395-396页

作者： zhihua liu CAS Key Laboratory of Infection and Immunity CAS Center for Excellence in Biomacromolecules Institute of Biophysics hinese Academy of Sciences Beijing 100101 China

We are not alone. Trillion of microbes （bacteria, fungi, virus and protozoa） take residence on and in our bodies. Despite their large number, their roles in our health had been largely ignored until recently. Advances in sequencing technologies have helped us to realize the diversity and dynamics of microbes associated with our bodies. A number of interna- tional microbiome consortium programs have suggested connections between dysbiosis and a range of human dis- eases, including metabolic syndrome, autoimmune diseases, autism and many others. Furthermore, use of antibiotics has been found to reduce the efficacy of cancer immunotherapies. Currently, the microbiome is attracting enormous research interest internationally and has become a frontier in life sciences.

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An Industrial Intrusion Detection Method Based on Hybrid Convolutional Neural Networks with Improved TCN

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Computers, Materials & Continua 2024年第1期78卷 411-433页

作者： zhihua liu Shengquan liu Jian Zhang College of Computer Science and Technology Xinjiang UniversityXinjiang Uygur Autonomous RegoinUrumqi830000China

Network intrusion detection systems(NIDS)based on deep learning have continued to make significant ***,the following challenges remain:on the one hand,simply applying only Temporal Convolutional Networks(TCNs)can lead to models that ignore the impact of network traffic features at different scales on the detection *** the other hand,some intrusion detection methods considermulti-scale information of traffic data,but considering only forward network traffic information can lead to deficiencies in capturing multi-scale temporal *** address both of these issues,we propose a hybrid Convolutional Neural Network that supports a multi-output strategy(BONUS)for industrial internet intrusion ***,we create a multiscale Temporal Convolutional Network by stacking TCN of different scales to capture the multiscale information of network ***,we propose a bi-directional structure and dynamically set the weights to fuse the forward and backward contextual information of network traffic at each scale to enhance the model’s performance in capturing the multi-scale temporal features of network *** addition,we introduce a gated network for each of the two branches in the proposed method to assist the model in learning the feature representation of each *** experiments reveal the effectiveness of the proposed approach on two publicly available traffic intrusion detection datasets named UNSW-NB15 and NSL-KDD with F1 score of 85.03% and 99.31%,respectively,which also validates the effectiveness of enhancing the model’s ability to capture multi-scale temporal features of traffic data on detection performance.

关键词： Intrusion detection industrial internet channel spatial attention multiscale features dynamic fusion multi-output learning strategy

Reflection on micro RNAs in cancer: the next decade

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Science Bulletin 2015年第24期60卷 2142-2144页

作者： Gang Ma zhihua liu Department of Gastrointestinal Cancer Biology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy The State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

When researchers find molecules or pathways that are critical for development and homeostasis of cells,tumors always hijacked them for their own ***,it is not surprising that dysregulation of micro RNAs in almost all ... 详细信息

关键词：下线服务迁移

Paneth cells: the hub for sensing and regulating intestinal flora

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Science China(Life Sciences) 2016年第5期59卷 463-467页

作者： Zheng Zhang zhihua liu Department of Gastroenterology the Affiliated Yixing Hospital of Jiangsu University CAS Key Laboratory of Infection and Immunity Institute of Biophysics Chinese Academy of Sciences

The complex interplay between symbiotic bacteria and host immunity plays a key role in shaping intestinal homeostasis and maintaining host health. Paneth cells, as one of the major producers of antimicrobial peptides in the intestine under steady-state conditions, play a vital role in regulating intestinal flora. Many studies on inflammatory bowel disease(IBD)-associated genes have put Paneth cells at the center of IBD pathogenesis. In this perspective, we focus on mechanistic studies of different cellular processes in Paneth cells that are regulated by various IBD-associated susceptibility genes, and we discuss the hypothesis that Paneth cells function as the central hub for sensing and regulating intestinal flora in the maintenance of intestinal homeostasis.

关键词： inflammatory bowel disease Paneth cell commensal bacteria intestinal homeostasis

Study of Hollow Cathode Arc Welding Technology for Ti Alloys

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Journal of Materials Science & Technology 2001年第1期17卷 183-184页

作者： zhihua liu Qing ZHAO Deqing LI Aerospace Research institute of Materials&Processing Technology Beijing 100076China

In this paper, technology margin experiment of hollow cathode fusion arc welding (FAW) and penetrating arc welding (PAW) is presented in detail. The advantages of PAW. compared with FAW, are better weld formation, narrower welds, as well as a larger welding technology margin. Technological experiment and hydraulic test for the Ti alloy pressure vessels with PAW are described. Also, the weld formation control on Ti alloys is preliminarily analyzed. Finally, conclusions are addressed.

关键词： Welding Technology arc welding welding technology formation control pressure vessels hollow cathode Ti alloy

Targeting Aberrant Histone Posttranscription Modification Machinery in Esophageal Squamous Cell Carcinoma:Current Findings and Challenges

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Research 2023年第1期2022卷 27-29页

作者： Gang Ma Tongyang Gong zhihua liu Department of Gastric Surgery Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China State Key Lab of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Esophageal squamous cell carcinoma(ESCC)is an aggressive malignancy,but the survival rates of patients with ESCC have not improved as yet largely because the available targeted therapies are *** posttranscription modification(PTM)is a critical epigenetic *** deregulations in histone PTM machinery have been identified to promote malignant phenotypes of ESCC,providing druggable targets in treating ***,we briefly describe current progress and challenges ahead in this field.

关键词： Carcinoma Esophageal regulations