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Real-time monitoring of tumor vascular disruption induced by radiofrequency assisted gadofullerene

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Science China Materials 2018年第8期61卷 1101-1111页

作者： Ruijun Deng yuqing Wang Mingming Zhen Xue Li Toujun ZOU Jie Li Tong yu yue Zhou zhigao Lu Hui Xu Chunying Shu Chunru Wang Beijing National Laboratory for Molecular Sciences Key Laboratory of Molecular Nanostructure and NanotechnologyCAS Research / Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049Chin CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and TechnologyBeijing 100190China

The anti-vascular therapy has been extensively studied for high performance tumor therapy by suppressing the tumor angiogenesis or cutting off the existing tumor vasculature. We have previously reported a novel anti-tumor treatment technique using radiofrequency （RF）-assisted ga- dofullerene nanocrystals （GFNCs） to selectively disrupt the tumor vasculature. In this work, we further revealed the changes on morphology and functionality of the tumor vas-culature during the high-performance RF-assisted GFNCs treatment in vivo. Here, a dearly evident mechanism of this technique in tumor vascular disruption was elucidated. Based on the H22 tumor bearing mice with dorsal skin flap chamber （DSFC） mode] and the dynamic contrast enhanced magnetic resonance imaging （DCE-MRI） technique, it was revealed that the GFNCs would selectively inset in the gaps of tumor vas-culature due to the innately incomplete structures and unique microenvironment of tumor vasculature,＇ and they damaged the surrounding endothelia cells excited by the RF to induce a phase transition accompanying with size expansion. Soon afterwards, the blood flow of the tumor blood vessels was permanently shut off, causing the entire tumor vascular net- work to collapse within 24 h after the treatment. The RF-as- sistant GFNCs technique was proved to aim at the tumor vasculatnre precisely, and was harmless to the normal vascu- lature. The current studies provide a rational explanation on the high efficiency anticancer activity of the RF-assisted GFNCs treatment, suggesting a novel technique with potent clinical application.

关键词： gadofullerene radiofrequency dorsal skin flap chamber dynamic contrast enhanced magnetic resonance imaging tumor vasculaturegadofullerene radiofrequency dorsal skin flap chamber dynamic contrast enhanced magnetic resonance imaging tumor vasculature

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盾尾密封对盾构周边渗流场及正面稳定的影响

同济大学学报（自然科学版） 2008年第2期36卷 172-177,192页

作者：廖少明余炎程致高同济大学地下建筑与工程系上海200092 浙江舟山连岛工程建设指挥部浙江舟山316000

基于地下渗流基本方程,采用有限差分法对江底隧道盾构施工中产生的周边渗透力进行了分析,并推导了渗流条件下盾构正面稳定的判别公式.分析表明:隧道开挖后,隧道周边土层的孔隙水压力将重新分布,开挖面附近孔隙水压力等值线呈楔形体,隧... 详细信息

基于地下渗流基本方程,采用有限差分法对江底隧道盾构施工中产生的周边渗透力进行了分析,并推导了渗流条件下盾构正面稳定的判别公式.分析表明:隧道开挖后,隧道周边土层的孔隙水压力将重新分布,开挖面附近孔隙水压力等值线呈楔形体,隧道开挖面上孔隙水压力变化达到最大;而开挖面附近的总水头等值线围绕开挖面呈环形分布,渗透力的最大值出现在开挖面上及盾尾透水处.土中渗透力使隧道开挖面稳定性系数减小,但盾构压力舱内的泥水压力有利于隧道正面的稳定.分析还表明,如果盾构掘进过程中盾尾有透水现象,则整个盾构机将处于水头产生较大变化的范围之内,会导致极其严重的后果.

关键词：江底盾构隧道砂性土正面稳定性渗流作用有限差分法

Influence of Be-Doping on Electronic Structure and Optical Properties of ZnO

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Journal of Semiconductors 2008年第12期29卷 2316-2321页

作者：郑勇平陈志高卢宇吴青云翁臻臻黄志高福建师范大学物理系福州350007 中国科学院福建物质结构研究所福州350002

The electronic structure and optical properties of Zn1-x BexO alloys were studied using first principle calculation based on density functional theory （DTF）. The results indicate that the band gap of Zn1-x BexO alloys increases as Be composition increases. The major reason is that the valence band maximum （VBM） of O2p has no obvious shift while the conduction band minimum （CBM） of Zn4s shifts to higher energy as x composition increases. Calculated results of the imaginary part of the dielectric function reveal that the peak heights at 2.0 and 6.76eV decrease as x composition increases, which is attributed to the decrease of the Zn3d states after Be substitutes for Zn. Due to the increasing transition probability from VBM of O2p to CBM of Be2s in wurtzite structure BeO,the peak height at 9.9eV is enhanced and its position shifts toward higher energy.

关键词： ZnO Be electronic structure optical properties first principles

康柏西普治疗糖尿病合并CRVO-ME高反射点的临床观察

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山东大学耳鼻喉眼学报 2024年第3期38卷 55-60+87页

作者：鲍莹刘志高姜鹏飞崔文轩郑晓霞杨梦瑶司明威王玉王红山东大学齐鲁医院眼科济南爱尔眼科医院烟台毓璜顶医院眼科济南市第二人民医院

目的观察康柏西普治疗糖尿病合并非缺血型视网膜中央静脉阻塞伴黄斑水肿(central retinal vein occlusion-macular edema, CRVO-ME)患者视网膜层间高反射点(hyperreflective dots, HRD)的变化。方法选取非缺血型CRVO-ME患者80例80眼... 详细信息

目的观察康柏西普治疗糖尿病合并非缺血型视网膜中央静脉阻塞伴黄斑水肿(central retinal vein occlusion-macular edema, CRVO-ME)患者视网膜层间高反射点(hyperreflective dots, HRD)的变化。方法选取非缺血型CRVO-ME患者80例80眼，根据有无糖尿病分为糖尿病组40例(40眼)、非糖尿病组40例(40眼),对比分析两组患者玻璃体腔注射康柏西普(intravitreal injection of conbercept, IVC)治疗前及治疗后1、3、6个月的最佳矫正视力(best-corrected visual acuity, BCVA)、黄斑中心凹厚度(central macular thickness, CMT)、视网膜内外层HRD数量。结果 IVC治疗后3、6个月时，非糖尿病组BCVA较糖尿病组明显提高(F=4.106,P=0.046;F=10.474,P=0.002);IVC治疗后6个月时，CMT明显降低(F=10.688,P=0.002)。两组IVC治疗前后视网膜内层HRD数量差异无统计学意义(F=1.608,P=0.209),视网膜外层HRD数量差异有统计学意义(F=4.290,P=0.042)。结论 IVC对非缺血型CRVO-ME疗效明显。视网膜外层HRD可以作为监测炎症反应、评估预后的影像学指标。糖尿病组患者发生非缺血型CRVO-ME后，远期治疗效果较非糖尿病组差，因此，更要重视糖尿病患者的长期随访观察，避免严重并发症的发生。

关键词：糖尿病非缺血型视网膜中央静脉阻塞玻璃体腔注射黄斑水肿高反射点

Process optimization of rare earth and aluminum leaching from weathered crust elution-deposited rare earth ore with compound ammonium salts

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Journal of Rare Earths 2016年第4期34卷 413-419页

作者：何正艳张臻悦余军霞徐志高池汝安 School of Minerals Processing and Bioengineering Central South University Key Laboratory for Green Chemical Process of Ministry of Education Wuhan Institute of Technology

In order to intensify the leaching process of rare earth（RE） and reduce the impurities in the leachate, ammonium chloride（NH4Cl） and ammonium nitrate（NH4NO3） were mixed as a compound leaching agent to treat the weathered crust elution-deposited RE ore. Effects of molar ratio of NH~＋_4Cl and NH_4NO_3, ammonium（NH_4） concentration, leaching agent pH and flow rate on the leaching process of RE were studied and evaluated by the chromatographic plate theory. Leaching process of the main impurity aluminium（Al） was also discussed in detail. Results showed that a higher initial ammonium concentration in a certain range could enhance the mass transfer process of RE and Al by providing a driving force to overcome the resistance of diffusion. pH almost had no effects on the mass transfer efficiency of RE and Al in the range of 4 to 8. The relationship between the flow rate and height equivalent to a theoretical plate（HETP） could fit well with the Van Deemter equation, and the flow rate at the lowest HETP was determined. The optimum conditions of column leaching for RE and Al were 1：1（molar ratio） of NH_4Cl and NH_4NO_3, 0.2 mol/L of ammonium concentration, pH 4–8 of leaching agent and 0.5 mL /min of flow rate. Under this condition, the mass transfer efficiency of RE was improved, but no change was observed for Al compared with the most widely used ammonium sulfate. Moreover, the significant difference value（around 20 mL） of retention volume at the peak concentration between RE and Al provided a possibility for their separation. It suggested the potential application of the novel compound leaching agent（NH_4Cl/NH_4NO_3）. It was found that the relative concentration of RE in the leachate could be easily obtained by monitoring the pH of leachate.

关键词： weathered crust elution-deposited rare earth ore aluminum leaching process mass transfer ammonium chloride ammonium nitrate

基于显著性先验的自适应空可变图像去模糊方法

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华中科技大学学报（自然科学版） 2021年第9期49卷 30-35,46页

作者：时愈严嘉倩黄志高华夏武汉工程大学电气信息学院湖北武汉430205 武汉工程大学光学信息与模式识别湖北省重点实验室湖北武汉430205 武汉工程大学湖北省视频图像与高清投影研究中心湖北武汉430205

针对图像分块不够合理导致的模糊核估计不精确或计算量较大等问题,提出了一种从单幅空间可变模糊图像中自适应估计清晰图像的方法.首先,采用四叉树分解将空可变模糊图像进行自适应划分,按照模糊核的相似程度确保划分的不同图像块具有不... 详细信息

针对图像分块不够合理导致的模糊核估计不精确或计算量较大等问题,提出了一种从单幅空间可变模糊图像中自适应估计清晰图像的方法.首先,采用四叉树分解将空可变模糊图像进行自适应划分,按照模糊核的相似程度确保划分的不同图像块具有不同的模糊核.然后,对于每一个图像块,施加了一种显著性值先验来恢复潜在清晰图像,提取人眼感兴趣的重要部分能够更精确地估计模糊核,并且可以保留更多的图像细节.最后,采用加权窗函数对尺寸大小不同的相邻图像块进行拼接,得到去模糊后的复原图像.实验结果表明:在对空不变和空可变的模糊图像进行去模糊后,与目前的经典方法相比,提出的方法可以得到较好的图像恢复结果.

关键词：图像分块自适应去模糊四叉树分解显著性图加权窗函数

Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020

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Science China(Life Sciences) 2021年第5期64卷 752-765页

作者： Encheng Sun Zhenjiang Zhang Zilong Wang Xijun He Xianfeng Zhang Lulu Wang Wenqing Wang Lianyu Huang Fei Xi Haoyue Huangfu Ghebremedhin Tsegay Hong Huo Jianhong Sun Zhijun Tian Wei Xia Xuewu yu Fang Li Renqiang Liu yuntao Guan Dongming Zhao zhigao Bu State Key Laboratory of Veterinary Biotechnology National High Containment Facilities for Animal Diseases Control and PreventionHarbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069China College of Animal Science and Technology Inner Mongolia University for NationalitiesTongliao 028000China

African swine fever virus(ASFV)has been circulating in China for more than two years,and it is not clear whether the biological properties of the virus have ***,we report on our surveillance of ASFVs in seven provinces of China,from June to December,2020.A total of 22 viruses were isolated and characterized as genotype II ASFVs,with mutations,deletions,insertions,or short-fragment replacement occurring in all isolates compared with Pig/HLJ/2018(HLJ/18),the earliest isolate in *** isolates had four different types of natural mutations or deletion in the EP402R gene and displayed a nonhemadsorbing(non-HAD)*** isolates were tested for virulence in pigs;two were found to be as highly lethal as HLJ/***,two non-HAD isolates showed lower virulence but were highly transmissible;infection with 106 TCID50 dose was partially lethal and caused acute or sub-acute disease,whereas 103 TCID50 dose caused non-lethal,sub-acute or chronic disease,and persistent *** emergence of lower virulent natural mutants brings greater difficulty to the early diagnosis of ASF and creates new challenges for ASFV control.

关键词： African swine fever virus natural mutant non-hemadsorbing lower virulent

明初下西洋使团中的医者——从新出张仕琦墓志谈起

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中国国家博物馆馆刊 2020年第10期 132-140页

作者：虞金永王志高南京师范大学文博系南京210097

新获《故承事郎齐庵张仕琦墓志铭》详细记载了明代南京名医张仕琦的家世及生平事迹,其中关于其祖父张寿观永乐时期以太医院医士身份"护市蕃使者"下西洋经历的记载,对明初下西洋历史事件的研究具有重要的学术价值,可补史阙。"市蕃使者"... 详细信息

新获《故承事郎齐庵张仕琦墓志铭》详细记载了明代南京名医张仕琦的家世及生平事迹,其中关于其祖父张寿观永乐时期以太医院医士身份"护市蕃使者"下西洋经历的记载,对明初下西洋历史事件的研究具有重要的学术价值,可补史阙。"市蕃使者"可解读为来华贸易的贡使或明廷派遣到外蕃开展贸易活动的使臣,以后者的可能性为大。通过对相关史籍及碑刻资料的考析可知,明初下西洋庞大使团中的医务人员有医官(御医)、医士、民医之别,其中的医官(御医)多隶属于太医院,医士则是有官方背景的普通医务人员,亦有因下西洋有功由民医转为官医者。他们之间既有身份的差异,也应该存在一定的医务分工,以承担不同的职责。

关键词：张仕琦墓志张寿观下西洋医士市蕃使者

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无封底嵌岩钢板桩围堰嵌固深度研究

桥梁建设 2023年第6期53卷 103-110页

作者：黄宇费志高康啊真张东明金可中交中南工程局有限公司湖南长沙410116 中交一公局厦门工程有限公司福建厦门361021 西南交通大学桥梁工程系四川成都610031 成都大学建筑与土木工程学院四川成都610106

为确定深水条件下无封底嵌岩钢板桩围堰在硬岩中的合理嵌固深度,以东江北干流特大桥76号墩承台围堰施工为背景,建立钢板桩-回填土-硬岩相互作用三维有限元模型,分析嵌固深度0~2.4 m对钢板桩等效应力、变形以及引孔槽口硬岩等效应力分布... 详细信息

为确定深水条件下无封底嵌岩钢板桩围堰在硬岩中的合理嵌固深度,以东江北干流特大桥76号墩承台围堰施工为背景,建立钢板桩-回填土-硬岩相互作用三维有限元模型,分析嵌固深度0~2.4 m对钢板桩等效应力、变形以及引孔槽口硬岩等效应力分布的影响。结果表明:嵌固深度对钢板桩的等效应力及变形影响较小。引孔槽口硬岩顶部区域沿水平方向存在规律性、间歇性的应力集中区,是可能发生引孔槽口硬岩踢脚破坏的薄弱区域。不同嵌固深度下,引孔槽口硬岩等效应力沿水平及竖直方向的分布规律高度相似。相较于嵌固深度0 m,嵌固深度1.5 m的引孔槽口硬岩应力集中区最大应力显著降低约14%,有利于引孔槽口硬岩的稳定性;当嵌固深度增加到1.5 m以上时,继续增加嵌固深度不会降低引孔槽口硬岩的等效应力,无法进一步提高引孔槽口硬岩的稳定性。

关键词：围堰钢板桩嵌固深度等效应力变形稳定性有限元法