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Prevalence and Genomic Characterization of Multidrug-Resistant Salmonella enterica Serovar Kentucky Sequence Type 198 Circulating—Beijing Municipality,China,2016–2023

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China CDC weekly 2024年第33期6卷 825-833页

作者： Mei Qu Ying Huang Bing lyu xin Zhang Yi Tian Zhaomin Feng zhiyong Gao Daitao Zhang Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning Beijing Center for Disease Prevention and ControlBeijingChina

Introduction Highly fluoroquinolone-resistant Salmonella enterica serovar Kentucky(***)of sequence type(ST)198 has emerged as a global multidrug-resistant(MDR)clone,posing a threat to public *** Whole genome sequencing and antibiotic susceptibility testing was used to characterize the population structure and evolutionary history of 54 *** isolates recovered from food and human clinical cases in Beijing from 2016 to *** All 54 *** ST198 isolates exhibited resistance to quinolones,carrying point mutations in the quinolone resistance-determining regions(gyrA_S83F and parC_S80I).Resistance to other antibiotics(folate pathway inhibitors,cephems,aminoglycosides,phenicols,rifamycin,fosfomycin,macrolides,and tetracyclines),mediated by the sul1,sul2,dfrA14,blaCTX-M,blaTEM-1B,aac(3)-Id,aadA2,aadA7,aph(3')-I,aph(3'')-Ib,rmtB,floR,arr-2,fosA,mph(A),and tet(A)genes,was also observed in different *** Beijing *** ST198 evolutionary tree was divided into clades 198.2-1 and 198.2-2,which were further differentiated into three subclades:198.2-2A,198.2-2B,and *** with the extended-spectrumβ-lactamase-encoding gene blaCTX-M-14b in 198.2-1,the co-existence of blaCTX-M-55 and blaTEM-1B,as well as chromosomally located qnrS1,was detected in most 198.2-2 isolates,which showed more complex MDR *** ST198 outbreak isolates derived from two predominant clonal sources:198.2-1 with cgST236434 and 198.2-2A with *** The *** population in Beijing is genetically diverse,consisting of multiple co-circulating lineages that have persisted since *** surveillance of food and humans will aid in implementing measures to prevent and control the spread of AMR.

关键词： Kentucky predominant Whole

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Impact of early refined nursing program on prognosis of middleaged and elderly patients with cognitive dysfunction combined with cerebral infarction

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World Journal of Psychiatry 2024年第7期14卷 1034-1042页

作者： Hui-Lian Xiong zhi-xin Li xin Lu Yan-Hua Lu Ping Zhong Ganzhou City Central Blood Station Ganzhou 341000Jiangxi ProvinceChina Department of Rehabilitation Medicine Ganzhou People's HospitalGanzhou 341000Jiangxi ProvinceChina

BACKGROUND Cerebral infarction is a local or extensive necrosis of brain ***,the corresponding neurological deficits *** incidence of cerebrovascular diseases in China is increasing *** the onset of cerebrovascular disease,the most common sequelae include movement disorders,language disorders,and cognitive *** To investigate the effect of early refined nursing program on the prognosis of middle-aged and elderly patients with cerebral infarction combined with cognitive *** A retrospective study was conducted to divide 60 patients with cerebral infarction and cognitive impairment into an experimental group(n=32)and a control group(n=28).The experimental group received early intensive care every day,and the control group received daily routine *** scores of the Mini-Mental State Examination(MMSE)and the Trail Making Test(TMT),as well as the latency and amplitude of the event-related potential P300,were used as main indicators to evaluate changes in cognitive function,and changes in BDNF,TGF-β,and GDNF expression were used as secondary *** Both groups experienced notable enhancements in MMSE scores,with the experi-mental group demonstrating higher scores than the control group(experimental:28.75±2.31;control:25.84±2.87).Moreover,reductions in TMT-A and TMT-B scores were observed in both groups(experimental:TMT-A 52.36±6.18,TMT-B 98.47±10.23;control:TMT-A 61.48±7.92,TMT-B 112.63±12.55),with the experimental group displaying lower scores.P300 Latency decreased(experimental:270.63 ms±14.28 ms;control:285.72 ms±16.45 ms),while amplitude increased(experimental:7.82μV±1.05μV;control:6.35μV±0.98μV)significantly in both groups,with superior outcomes in the experimental ***,the levels of the growth factors BDNF,TGF-β1,and GDNF surged(experimental:BDNF 48.37 ng/mL±5.62 ng/mL,TGF-β152.14 pg/mL±4.28 pg/mL,GDNF 34.76 ng/mL±3.89 ng/mL;control:BDNF 42.58 ng/mL±4.73 ng/mL,TGF-β146.23 pg/m

关键词： Early refined nursing program Cerebral infraction Cognitive impairment Psychiatry Trajectory test

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Cutting performance of saw blades with microtextured rougher and finisher sawteeth

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Advances in Manufacturing 2024年第2期12卷 317-334页

作者： Yang Lu Jian-xin Deng zhi-Hui Zhang Jia-xing Wu Ran Wang Yi-Chen Bao Key Laboratory of High Efficiency and Clean Mechanical Manufacture of MOE School of Mechanical EngineeringShandong UniversityJinan250061People’s Republic of China

The problems of severe sawtooth wear,harsh sawing noise,and low surface quality during the processing of circular saw blades need to be *** improve the cutting performance of TiC-based cermet saw blades,microtextures parallel to the cutting edge were fabricated on rough and fine sawteeth by laser *** cutting tests were performed on a sawing platform under lubricated *** of the sawing arc length and working sawtooth cutting force variations were developed for sawing steel pipes,and the accuracy of the sawing force model was verified *** results indicate that the variations in the sawing force are proportional to the sawing arc *** circular saw blades with microtextures that did not penetrate the sawtooth rake face exhibited the lowest cutting force,sawing noise,and highest machined surface ***,the worn-out distance of the rougher and finisher sawteeth was reduced by approximately 7.4%and 44.1%,respectively,compared with conventional circular saw *** main failure modes of sawteeth were tip wear,rake face adhesion,and oxidative *** addition,the mechanism by which the textures improve the cutting and wear properties of TiC-based circular saw blades was *** study provided a significant concept for enhancing the cutting performance of circular saw blades and improving the machined surface quality.

关键词： Circular saw blades Micro textures Cutting performance Wear performance

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Pre-combustion mercury removal with co-production of hydrogen via coal electrolysis

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Journal of Environmental Sciences 2024年第2期136卷 382-389页

作者： Xiang lyu Runming Tao Tianyu Zhang Chemical and Biomolecular Engineering Department Ohio University165 Stocker CenterAthensOH45701USA Electrification and Energy Infrastructures Division Oak Ridge National LaboratoryOak RidgeTN37831USA Beijing Key Lab for Source Control Technology of Water Pollution College of Environmental Science and EngineeringBeijing Forestry UniversityBeijing 100083China Engineering Research Center for Water Pollution Source Control&Eco-remediation College of Environmental Science and EngineeringBeijing Forestry UniversityBeijing 100083China

Pre-combustion mercury removal via coal electrolysis was performed and investigated on a bench-scale coal electrolytic cell(CEC)systemically,and factorial design was used to determine the effect of different operating conditions(coal particle size,operating temperature,operating cell voltage,and flow rate of slurry)on the percentage of mercury removal,percentage of ash removal,and dry heating value *** results showed that the operating cell voltage,as well as the interaction between operating cell voltage and coal particle size,are significant factors in the percentage of mercury *** is no significant factor in the percentage of ash removal and the dry heating value change,but the coal could be purified while keeping the dry heating value almost constant after electrolysis.A co-product of hydrogen could be produced during coal electrolysis with 50%lower energy consumption compared with water ***,a mechanism for mercury removal in coal was *** facts indicate that coal electrolysis is a promising method for precombustion mercury removal.

关键词： Pre-combustion mercury removal Coal electrolysis Ash removal Dry heating value Hydrogen production

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Challenges and opportunities in rare cancer research in China

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Science China(Life Sciences) 2024年第2期67卷 274-285页

作者： Jianxin Xue Qunyan lyu Division of Thoracic Tumor Multimodality Treatment Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China National Natural Science Foundation of China Beijing 100085China

Cancer is one of the major public health challenges in *** cancers collectively account for a considerable proportion of all *** lack of awareness of rare cancers among healthcare professionals and the general public,the typically complex and delayed diagnosis,and limited access to clinical trials are key *** years have witnessed an increase in funding for research related to rare cancers in *** this review,we provide a comprehensive overview of rare cancers and summarize the status of research on rare cancers in China and overseas,including the trends of funding and *** also highlight the challenges and perspectives regarding rare cancers in China.

关键词： rare cancers basic research clinical research preclinical model funding scheme

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Homer1a reduces inflammatory response after retinal ischemia/reperfusion injury

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Neural Regeneration Research 2024年第7期19卷 1608-1617页

作者： Yanan Dou Xiaowei Fei xin He Yu Huan Jialiang Wei Xiuquan Wu Weihao lyu Zhou Fei Xia Li Fei Fei Department of Neurosurgery Xijing HospitalAir Force Military Medical UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology Xijing HospitalAir Force Military Medical UniversityXi’anShaanxi ProvinceChina

Elevated intraocular pressure(IOP)is one of the causes of retinal ischemia/reperfusion injury,which results in NRP3 inflammasome activation and leads to visual *** is repo rted to play a protective role in neuroinflammation in the ***,the effects of Homerla on NLRP3inflammasomes in retinal ischemia/reperfusion injury caused by elevated IOP remain *** our study,animal models we re constructed using C57BL/6J and Homer1^(flox/-)/Homerla^(+/-)/Nestin-Cre^(+/-)mice with elevated IOP-induced retinal ischemia/repe rfusion *** in vitro expe riments,the oxygen-glucose deprivation/repe rfusion injury model was constructed with M uller *** found that Homerla ove rexpression amelio rated the decreases in retinal thickness and Muller cell viability after ischemia/reperfusion ***,Homerla knockdown promoted NF-κB P65^(Ser536)activation via caspase-8,NF-κB P65 nuclear translocation,NLRP3 inflammasome formation,and the production and processing of interleukin-1βand inte *** opposite results we re observed with Homerla ove ***,the combined administration of Homerla protein and JSH-23 significantly inhibited the reduction in retinal thickness in Homer1^(flox/-)Homer1a^(+/-)/Nestin-Cre^(+/-)mice and apoptosis in M uller cells after ischemia/reperfusion *** together,these studies demonstrate that Homer1a exerts protective effects on retinal tissue and M uller cells via the caspase-8/NF-KB P65/NLRP3 pathway after I/R injury.

关键词： caspase-8 Homer1a interleukin-18 interleukin-1β intraocular pressure ischemia/reperfusion injury JSH-23 Müller cells NLRP3 nuclear factor-kB p65 retina

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Depositional model of the Member Deng-2 marginal microbial mound-bank complex of the Dengying Formation in the southwestern Sichuan Basin, SW China: Implications for the Ediacaran microbial mound construction and hydrocarbon exploration

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Petroleum Science 2024年第2期21卷 806-822页

作者： Jin-Min Song xin Jin Zhong Luo Shu-Gen Liu Shao-Bo Liu xing-zhi Ma zhi-Wu Li Xue-Song Lu Ling-Li Zhao Ke-Ran Li Jia-xin Ren Li-Zhou Tian Hao-Shuang Deng State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengdu610059SichuanChina PetroChina Research Institute of Petroleum Exploration and Development Beijing100083China Xihua University Chengdu610039SichuanChina

Recent advances in hydrocarbon exploration have been made in the Member Deng-2 marginal microbial mound-bank complex reservoirs of the Dengying Formation in the western Sichuan Basin, SW China,where the depositional process is regarded confusing. The microfacies, construction types, and depositional model of the Member Deng-2 marginal microbial mound-bank complex have been investigated using unmanned aerial vehicle photography, outcrop section investigation, thin section identification,and seismic reflections in the southwestern Sichuan Basin. The microbialite lithologic textures in this region include thrombolite, dendrolite, stromatolite, fenestral stromatolite, spongiostromata stone,oncolite, aggregated grainstone, and botryoidal grapestone. Based on the comprehensive analysis of“depositional fabrics-lithology-microfacies”, an association between a fore mound, mound framework,and back mound subfacies has been proposed based on water depth, current direction, energy level and lithologic assemblages. The microfacies of the mound base, mound core, mound flank, mound cap, and mound flat could be recognized among the mound framework subfacies. Two construction types of marginal microbial mound-bank complex have been determined based on deposition location, mound scale, migration direction, and sedimentary facies association. Type Jinkouhe microbial mound constructions(TJMMCs) develop along the windward margin owing to their proximity to the seaward subfacies fore mound, with a northeastwardly migrated microbial mound on top of the mud mound,exhibiting the characteristics of large-sized mounds and small-sized banks in the surrounding area. Type E'bian microbial mound constructions(TEMMCs) primarily occur on the leeward margin, resulting from the presence of onshore back mound subfacies, with the smaller southwestward migrated microbial mounds existing on a thicker microbial flat. The platform margin microbial mound depositional model can be correlated with certain late

关键词： Sichuan Basin The Member Deng-2 Marginal microbial mound-bank complex Depositional model Exploration implications

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Microstructures and mechanical properties of a commercial Mg-Al-Zn-Mn alloy with various hot-extrusion processes

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Rare Metals 2024年第3期43卷 1329-1336页

作者： He Ma Fan-zhi Meng Qiang Yang Ze-Feng Xie Yuan-Ding Huang xin Qiu State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun130022China MagIC-Magnesium Innovation Center Helmholtz-Zentrum Geesthacht21502GeesthachtGermany Engineering Research Center of Optoelectronic Functional Materials Ministry of EducationChangchun University of Science and TechnologyChangchun130022China

Mg-Al-Zn-Mn(AZ)system alloys have become widely used due to their good castability,excellent formability and outstanding corrosion resistance[1-6].However,their strength is still much lower than that of traditional Mg... 详细信息

关键词： alloys alloy corrosion

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Pathogenesis of chronic enteropathy associated with the SLCO2A1 gene:Hypotheses and conundrums

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World Journal of Gastroenterology 2024年第19期30卷 2505-2511页

作者： zhi-xin Xie Yue Li Ai-Ming Yang Dong Wu Qiang Wang State Key Laboratory of Complex Severe and Rare Diseases Department of GastroenterologyPeking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Clinical Medicine Peking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China

Chronic enteropathy associated with the SLCO2A1 gene(CEAS)is a complex gastroenterological condition characterized by multiple ulcers in the small intestine with chronic bleeding and protein *** review explores the potential mechanisms underlying the pathogenesis of CEAS,focusing on the role of SLCO2A1-encoded prostaglandin transporter OATP2A1 and its impact on prostaglandin E2(PGE2)*** have suggested that elevated PGE2 levels contribute to mucosal damage,inflammation,and disruption of the intestinal *** effects of PGE2 on macrophage activation and Maxi-Cl channel functionality,as well as its interaction with nonsteroidal anti-inflammatory drugs play crucial roles in the progression of *** the balance between its protective and pro-inflammatory effects and the complex interactions within the gastrointestinal tract can shed light on potential therapeutic targets for CEAS and guide the development of novel,targeted therapies.

关键词： SLCO2A1 Prostaglandin E2 Chronic enteropathy associated with the SLCO2A1 gene Small intestine Macrophage

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Mesenchymal stem cells for repairing glaucomatous optic nerve

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 748-760页

作者： Bai-Yu Hu Mei xin Ming Chen Ping Yu Liu-zhi Zeng Eye School of Chengdu University of TCM Chengdu 610000Sichuan ProvinceChina Department of Ophthalmology Chengdu First People’s HospitalChengdu 610095Sichuan ProvinceChina

Glaucoma is a common and complex neurodegenerative disease characterized by progressive loss of retinal ganglion cells(RGCs)and ***,there is no effective method to address the cause of RGCs ***,studies on neuroprotective strategies for optic neuropathy have increased in recent *** replacement and neuroprotection are major strategies for treating glaucoma and optic *** medicine research into the repair of optic nerve damage using stem cells has Received considerable *** cells possess the potential for multidirectional differentiation abilities and are capable of producing RGCfriendly microenvironments through paracrine *** article reviews a thorough researches of recent advances and approaches in stem cell repair of optic nerve injury,raising the controversies and unresolved issues surrounding the future of stem cells.

关键词： stem cell glaucoma retinal ganglion cell optic nerve axon regeneration

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