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Hyperbaric oxygen preconditioning improves postoperative cognitive dysfunction by reducing oxidant stress and inflammation

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Neural Regeneration Research 2017年第2期12卷 329-336页

作者： zhi-xin gao Jin Rao Yuan-hai Li Department of Anesthesiology First Affiliated Hospital of Anhui Medical University

Postoperative cognitive dysfunction is a crucial public health issue that has been increasingly studied in efforts to reduce symptoms or prevent its occurrence. However, effective advances remain lacking. Hyperbaric oxygen preconditioning has proved to protect vital organs, such as the heart, liver, and brain. Recently, it has been introduced and widely studied in the prevention of postoperative cognitive dysfunction, with promising results. However, the neuroprotective mechanisms underlying this phenomenon remain controversial. This review summarizes and highlights the definition and application of hyperbaric oxygen preconditioning, the perniciousness and pathogenetic mechanism underlying postoperative cognitive dysfunction, and the effects that hyperbaric oxygen preconditioning has on postoperative cognitive dysfunction. Finally, we conclude that hyperbaric oxygen preconditioning is an effective and feasible method to prevent, alleviate, and improve postoperative cognitive dysfunction, and that its mechanism of action is very complex, involving the stimulation of endogenous antioxidant and anti-inflammation defense systems.

关键词： nerve regeneration brain injury hyperbaric oxygenation preconditioning antioxidants antiinflammation reactive oxygen species oxidant stress inflammation protection post-operation cognitive dysfunction neural regeneration

Numerical simulation of operation performance on production and injection of a double well geothermal system in Kailu Basin, Inner Mongolia

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Journal of Groundwater Science and Engineering 2022年第2期10卷 196-208页

作者： Yu-kun Sun Feng Liu Huajun Wang xin-zhi gao School of Energy and Environment Engineering Hebei University of TechnologyTianjin 300401China Institute of Hydrogeology and Environment Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Technology Innovation Center of Geothermal&Hot Dry Rock Exploration and Development Ministry of Natural ResourcesShijiazhuang 050061China Tianjin Geothermal Exploration and Design Institute Tianjin 300250China

Inner Mongolia is abundant in geothermal resources,but the development and utilization of medium-depth geothermal resources for clean heating in winter is still in the preliminary stage compared with the neighboring *** this paper,a recently developed geothermal heating system using the Mesozoic sandstone reservoirs in Baokang of Kailu Basin,Eastern Inner Mongolia was investigated,a threedimensional geological model of a pair of production and injection well was established,and numerical simulations on the long term operation performance were conducted and verified by pumping test and water level recovery test *** effects of flow rates,the direction of wells,injection temperature and ratios on the flow field and water level in the thermal reservoir were *** results show that considering a 30-year operation period and a production rate from 90 m^(3)/h to 110 m^(3)/h,the optimum well spacing can be increased from 225 m to 245 m,with an average value of 235 *** the decrease of the injection temperature,the cold front of the injection water has an increasing influence on the temperature in the production well.A complete injection or the principle of production according to injection is recommended in order to maintain the long-term operation *** addition,the location of the injection well should be arranged in the downstream of the natural flow *** present results can provide a useful guide for the optimum design and performance prediction of geothermal wells,thus maintaining the production and injection balance and promoting the sustainable development and utilization of medium-depth and deep geothermal resources.

关键词： Geothermal well Optimum well spacing Production and injection Numerical simulation Heat breakthrough

Design and synthesis of phosphomolybdate coordination compounds based on {P_(4)Mo_(6)} structural units and their proton conductivity

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Tungsten 2023年第1期5卷 67-74页

作者： zhi-xin gao Sai Sun Bo Li Dong-Ming Cheng Yong-Hui Wang Hong-Ying Zang Yang-Guang Li Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education at Universities of Jilin Province Faculty of ChemistryNortheast Normal UniversityChangchun 130024China

Developing new low-cost and efficient proton-conducting materials remains an attractive and challenging ***,sodium molybdate dihydrate is used as the source of molybdenum,mixed with transition metal chloride and 2-methylimidazole(2-MI),using the "one-pot method" to synthesize two crystalline proton conducting materials based on {P4Mo6} units:H14[C4H6N2]2[M(H_(2)O)5][M(H_(2)O)_(2)]_(2){M[(PO_(3))_(3)(PO_(4))Mo_(6)O_(15)]_(2)}·4H_(2)O(M=Co and Fe)(1-2).Different from the common{P4Mo_(6)},we use H3PO3to adjust the pH value,resulting in two different coordination modes of P atoms in the crystal *** structure is expanded into three-dimensional network by metal *** 75℃ and 98% relative humidity,the proton conductivity of compounds 1 and 2 are 1.33 ×10^(-2)S·cm^(-1)and 1.03×10^(-2)S·cm^(-1),*** high proton conductivity is mainly attributed to the free state of 2-methylimidazole as the proton carrier,which has a fast migration *** the same time,2-methylimidazole,coordination water,and {P4Mo6} anion form a hydrogen bond network to provide multiple pathways for the transmission of protons.

关键词： Proton conduction Polyoxometalate Coordination compound Crystalline material Template Molybdenum

高糖增加大鼠肺微血管内皮细胞基质金属蛋白酶10基因表达

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复旦学报（医学版） 2003年第6期30卷 588-590页

作者：陆志强李欣高鑫复旦大学附属中山医院内分泌科上海200032

目的研究葡萄糖对培养血管内皮细胞表达的影响。方法大鼠肺微内皮细胞在高浓度糖(高糖)和正常浓度糖培养基中培养24 h,作基因芯片分析。结果在超过4000个基因芯片显示的基因中,高糖引起509个基因表达增加,961基因表达减少。其中细胞... 详细信息

目的研究葡萄糖对培养血管内皮细胞表达的影响。方法大鼠肺微内皮细胞在高浓度糖(高糖)和正常浓度糖培养基中培养24 h,作基因芯片分析。结果在超过4000个基因芯片显示的基因中,高糖引起509个基因表达增加,961基因表达减少。其中细胞基质金属蛋白酶(matrix metalloproteinase,MMP)10基因表达增加6.06倍,Wilcoxon配对符号秩检验P=0.0001。结论 MMP10在高糖环境下培养的大鼠肺内皮细胞表达增加,可能对糖尿病慢性并发症的形成过程起一定作用。

关键词：高糖大鼠肺微血管内皮细胞基质金属蛋白酶10 基因表达糖尿病大血管并发症

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药物代谢组学研究现状

中国中药杂志 2018年第6期43卷 1093-1098页

作者：张志新高晓燕北京中医药大学中药学院

药物代谢组学是代谢组学与药学交叉结合产生的一门新的科学分支，近年来在药物治疗个体化研究领域的应用越来越广泛。其研究过程可大致概括为给药前代谢组学分析、给药后药学分析和统计建模分析3部分。首先基于代谢组学技术对个体给药... 详细信息

药物代谢组学是代谢组学与药学交叉结合产生的一门新的科学分支，近年来在药物治疗个体化研究领域的应用越来越广泛。其研究过程可大致概括为给药前代谢组学分析、给药后药学分析和统计建模分析3部分。首先基于代谢组学技术对个体给药前生物样本的代谢表型进行分析，全面综合的评估个体差异。随后采用相应药学研究手段对个体给药后的药物反应表型进行分析。最后基于统计建模分析对给药前个体的代谢表型和药物反应表型进行比较来进行药物疗效或毒性评价、预测，为实现个体化医疗提供理论基础。该文通过对近年来国内外文献进行分析总结，详细综述了药物代谢组学在药物体内行为差异预测研究中的应用及其具体的研究流程和方法，为该方法的进一步扩展应用提供思路参考。

关键词：药物代谢组学代谢组学代谢表型

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中国当代“环境文学”的缺失与建构

天津师范大学学报（社会科学版） 2009年第5期29卷 67-71页

作者：徐志新高红樱天津财经大学人文学院

把东方文学作为一个整体与欧美文学进行比较,可以发现一个明显的现象,就是东方文学中环境文学的缺席。中国文学作为东方文学的组成部分,至今尚未在真正意义上打通自然与文学的内在联系,没有形成体系与系统,但是存在其未来发展的土壤与基... 详细信息

把东方文学作为一个整体与欧美文学进行比较,可以发现一个明显的现象,就是东方文学中环境文学的缺席。中国文学作为东方文学的组成部分,至今尚未在真正意义上打通自然与文学的内在联系,没有形成体系与系统,但是存在其未来发展的土壤与基础,亟待寻求建构的途径。

关键词：中国文学欧美文学环境文学文学功能建构途径

Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen gao Jing-Wen Li Hui Ye Xue-zhi Zhang Jian-Xiang Liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

右胸前外侧小切口心脏不停跳房间隔缺损修补术

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复旦学报（医学版） 2003年第3期30卷 277-278,284页

作者：乔晨晖蔡萍卫洪超郅兴义赵高峰张新郑州大学第一附属医院胸心外科郑州450052

目的总结右胸前外侧小切口心脏不停跳下房间隔缺损修补术的治疗经验。方法手术在常温深度血液稀释体外循环下施行,沿右侧第5肋间切开皮肤,经第3或第4肋间入胸,距右膈神经前2.0cm纵向切开心包,主动脉及上、下腔静脉插管常规建立体外循... 详细信息

目的总结右胸前外侧小切口心脏不停跳下房间隔缺损修补术的治疗经验。方法手术在常温深度血液稀释体外循环下施行,沿右侧第5肋间切开皮肤,经第3或第4肋间入胸,距右膈神经前2.0cm纵向切开心包,主动脉及上、下腔静脉插管常规建立体外循环时间为(36.0±14.4)min。心脏跳动下切开右心房,直接缝合和自体心包片或涤纶片修补缺损。结果 57例患者均痊愈出院。术后气管插管呼吸机辅助时间(6.3±2.8)h,监护时间(35.3±16.4)h,术后住院(7.5±1.2)d。术后胸腔引流量(250.8±175.3)mL。54例(94.7％)未输库血。术后随访3个月～4年,心功能较术前改善。结论采用右胸前外侧小切口心脏不停跳技术修补房间隔缺损,微创美观,安全可靠,手术操作简单,库血用量小,疗效满意。房间隔缺损及合并部分型肺静脉畸形引流患者的手术治疗均可采用此技术。

关键词：右胸前外侧小切口心脏不停跳房间隔缺损修补术切开术后库血体外循环施行立体直接

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企业风险预警管理模型研究

北京邮电大学学报（社会科学版） 2010年第1期12卷 93-97页

作者：赵旭辛制高上海理工大学管理学院上海200093

从企业风险与预警的定义出发,分析了风险预警管理的演化过程,介绍了国内外企业风险预警模型的研究。从多元统计分析方法、人工神经网络(ANN)模型、系统动力学方法、支持向量机(SVM)模型4个主要研究方法对风险预警模型研究进行了综述,指... 详细信息

从企业风险与预警的定义出发,分析了风险预警管理的演化过程,介绍了国内外企业风险预警模型的研究。从多元统计分析方法、人工神经网络(ANN)模型、系统动力学方法、支持向量机(SVM)模型4个主要研究方法对风险预警模型研究进行了综述,指出了目前研究的不足,并对未来风险预警管理模型研究的方向进行了展望。

关键词：企业风险预警管理预警模型