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Cystamine ameliorates liver fibrosis induced by carbon tetrachloride via inhibition of tissue transglutaminase

World Journal of Gastroenterology 2007年第32期13卷 4328-4332页

作者： Jiang-Feng Qiu zhi-Qi zhang wei Chen zhi-Yong Wu Department of General Surgery Renji Hospital Shanghai Jiaotong University School of Medicine Shanghai 200127 China

AIM： To investigate the anti-fibrosis effect of the tissue transglutarninase （tTG） specific inhibitor cystarnine on liver fibrosis. METHODS： Sixty-eight male Sprague Dawley rats were divided into three groups： normal control, liver fibrosis control and cystamine-treated group. Liver fibrosis was induced by intraperitoneal injection of carbon tetrachloride （CCl4）, and Cystarnine was administrated by intraperitoneal injection starting 2 d before the first administration of CCl4. Animals in each group were further divided into 2 subgroups according to two time points of 4 wk and 8 wk after treatment. Hepatic function, pathological evaluation （semi-quantitative scoring system, SSS） and liver hydroxyproline （Hyp） content were examined. Real-time PCR was used to detect the expression of tTG, smooth muscle alpha actin （α-SMA）, tissue inhibitor of metalloproteinase 1 （TIMP-1） and collagen-1 mRNA. The expressions of tTG and α-SMA protein were detected by Western Blotting. RESULTS： Eight weeks after treatment, the SSS score of liver was significantly less in the cystamine group than that in the fibrosis control group （P 〈 0.01）. The levels of alanine arninotransferase （ALT） and total bile acid （TBA） at the 4 wk and 8 wk time points were decreased in the cystamine group compared with those in fibrosis controls （P 〈 0.01）. Liver hydroxyproline content at the 4 wk and 8 wk time points showed a substantial reduction in the cystamine group compared to fibrosis controls （P 〈 0.01）. The expression of tTG, α-SMA, collagen-1, TIMP-1 mRNA and tTG, as well as α-SMA protein was downregulated in the cystamine group compared to fibrosis controls. CONCLUSION： Cystamine can ameliorate CCl4 induced liver fibrosis and protect hepatic function. The possible mechanism is related to the reduced synthesis of the extracellular matrix （ECM） caused by the inhibition of hepatic stellate cell activation and decreased expression of TIMP-1.

关键词： Tissue transglutaminase Cystamine Liver fibrosis Cross linking Extracellular matrix

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Advanced sodium-ion capacitor based on antimony-carbon composite anode

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Rare Metals 2022年第10期41卷 3360-3369页

作者： wei-Qing Yu Chun-Yan Zhu Ru-Tao Wang Jian-Chao Chen Qing-Yuan Liu Shu-Xian zhang zhi-Jie Gao Cheng-Xiang Wang zhi-wei zhang Long-wei Yin Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationSchool of Materials Science and EngineeringShandong UniversityJinan250061China Suzhou Institute of Shandong University Suzhou215123China College of Chemical Engineering and Safety Binzhou UniversityBinzhou256603China

Alloy-type materials with the characteristics of high theoretical capacity,low sodiation/desodiation potential,and good conductivity are considered as one of the most promising anodes for sodium-ion batteries or ***,the large volume change during the sodiation leads to poor cyclability and slow kinetics,thus presenting the main issue impeding the practical ***,we propose a facile wet chemistry and pyrolysis method to synthesize Sb-carbon composite that Sb nanoparticles or single atoms are confined and/or dispersed in the wrinkled carbon framework with high nitrogen *** unique architecture of Sb-carbon composite increases atomic interface contact/interaction with Na~+,facilitating ion diffusion and alleviating the volume change of Sb during the charge/discharge ***-cell test shows that Sb-carbon composite exhibits a high-rate capability and stable cycling ***,sodium-ion capacitors fabricated by employing Sb-carbon composite as anode and home-made active carbon as cathode,deliver both high-energy density of 157 Wh·kg^(-1)and high-power density of 25 kW·kg^(-1)as well as excellent cycling performance exceeding 4000 cycles.

关键词： Antimony Nitrogen doping carbon Alloy-type anode Sodium-ion capacitor

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Hydrogel forming microneedles loaded with VEGF and Ritlecitinib/polyhydroxyalkanoates nanoparticles for mini-invasive androgenetic alopecia treatment

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Bioactive Materials 2024年第8期38卷 95-108页

作者： Yan-Wen Ding Yang Li zhi-wei zhang Jin-wei Dao Dai-Xu wei Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an710069China School of Clinical Medicine Chengdu UniversityChengduChina Dehong Biomedical Engineering Research Center Dehong Teachers’CollegeDehongYunnan ProvinceChina Shaanxi Key Laboratory for Carbon Neutral Technology Xi’an710069China

Androgenetic alopecia(AGA),the most prevalent clinical hair loss,lacks safe and effective treatments due to downregulated angiogenic genes and insufficient vascularization in the perifollicular microenvironment of the bald scalp in AGA *** this study,a hyaluronic acid(HA)based hydrogel-formed microneedle(MN)was designed,referred to as V-R-MNs,which was simultaneously loaded with vascular endothelial growth factor(VEGF)and the novel hair loss drug Ritlecitinib,the latter is encapsulated in slowly biodegradable polyhydroxyalkanoates(PHAs)nanoparticles(R-PHA NPs)for minimally invasive AGA *** integration of HA based hydrogel alongside PHA nanoparticles significantly bolstered the mechanical characteristics of microneedles and enhanced skin penetration *** to the biosafety,mechanical strength,and controlled degradation properties of HA hydrogel formed microneedles,V-R-MNs can effectively penetrate the skin’s stratum corneum,facilitating the direct delivery of VEGF and Ritlecitinib in a minimally invasive,painless and long-term sustained release manner.V-R-MNs not only promoted angiogenesis and improve the immune microenvironment around the hair follicle to promote the proliferation and development of hair follicle cells,but also the application of MNs to the skin to produce certain mechanical stimulation could also promote *** comparison to the clinical drug minoxidil for AGA treatment,the hair regeneration effect of V-R-MN in AGA model mice is characterized by a rapid onset of the anagen phase,improved hair quality,and greater *** introduces a new,clinically safer,and more efficient strategy for AGA treatment,and serving as a reference for the treatment of other related diseases.

关键词： Hydrogel forming microneedles Polyhydroxyalkanoates VEGF Ritlecitinib Androgenetic alopecia treatment

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An Inverse Electromagnetic Scattering Method for One-Dimensional Inhomogeneous Media

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Chinese Physics Letters 2011年第1期28卷 82-85页

作者： LIN zhi-wei XU Xin zhang Xiao-Juan FANG Guang-You Key Laboratory for Electromagnetic Radiation and Detection Technology Institute of Electronics Chinese Academy of Sciences Beijing 100190

A frequency-domain inversion scheme for reconstructing the permittivity profile of one-dimensional inhomoge- neous media is proposed. The generalized reflection coefficients and the generalized transmission coefficients of the inhomogeneous media are used as the input data of the inverse model. A Newton-like iterative algorithm known as the generalized pulse-spectrum technique with the Tikhonov regularization is applied to solve the in- verse problem. Novel boundary conditions are proposed for the inverse problem and therefore the permittivity at the boundary of the inhomogeneous media is not required as prior knowledge. The choice of frequency points of the frequency-domain method is also investigated. Numerical examples are carried out to validate the inversion technique. Good agreements between the reconstructed profiles and the true profiles are shown.

关键词： Mathematical physics Accelerators beams and electromagnetism

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Electromagnetic Scattering and Inverse Scattering of Layered Media with a Slightly Rough Surface

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Chinese Physics Letters 2011年第1期28卷 86-89页

作者： LIN zhi-wei XU Xin zhang Xiao-Juan FANG Guang-You Key Laboratory for Electromagnetic Radiation and Sen ~ing Technology Institute o1 Electronics Chinese Academy ot Sciences Beijing 100190

An electromagnetic （EA1） scattering model for layered media covered by a 3D infinite rough surface and the corresponding inversion technique are investigated. The work aims at remote sensing the surface roughness and dielectric constant for different depths of bear soil through radar measurement data. The forward problem is carried out by the wave decomposition method. The small perturbation method （SPM） and EM boundary conditions are employed to solve the integral equations introduced by the wave decomposition method. The second-order SPM solution of the scatteringfield is involved in the computation of the forward problem for the first time. The backseattering coefficients of multiple frequencies, multiple angles and multiple polarizations are employed to create a nonlinear optimization problem. A genetic algorithm is introduced to help the inversion procedure approaeh to the global minimum of the cost function. Examples are carried out to validate the inversion technique. The inverion results show good agreement with the forward problem with given parameters and pose good tolerance to the input data with the additive white Gaussian noise.

关键词： Broadcasting Technology Data Degradation Measurement Methods

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Application of self-care based on full-course individualized health education in patients with chronic heart failure and its influencing factors

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World Journal of Clinical Cases 2019年第16期7卷 2165-2175页

作者： Jing Sun zhi-wei zhang Yue-Xian Ma wei Liu Chun-Ying Wang Department of Nursing the Second Affiliated Hospital of Qiqihar Medical UniversityQiqihar 161000Heilongjiang ProvinceChina Department of Cardiovascular the Second Affiliated Hospital of Qiqihar Medical UniversityQiqihar 161000Heilongjiang ProvinceChina

BACKGROUND The treatment of heart failure not only needs to relieve the clinical symptoms and improve the quality of life for patients but also needs to select scientific and reasonable ways to prevent or delay the progression of the disease,thus reducing the mortality and hospitalization *** the previous regimen can effectively relieve symptoms in the early stage of treatment,long-term use may cause adverse events,such as arrhythmia,and even increase ***,conventional treatment cannot meet the actual health needs of patients,and scientific nursing intervention is very *** To investigate the application of self-care based on full-course individualized health education (FCIHE) and its influencing factors in patients with chronic heart failure (CHF).METHODS We enrolled CHF patients who were admitted to our center between September 2015 and June 2016 and divided them into an intervention group (n = 50) and control group (n = 50) using a random number *** nursing care was applied to the control group,and FCIHE was offered to the intervention *** self-care behavior,6-min walking distance (6MWD),and 36-item short form health survey (SF-36) scores were compared between the two *** influencing factors of the self-care were also *** The 6MWD was not significantly different between the two groups at admission (P > 0.05);however,at 3 and 6 mo after discharge,6MWD was significantly increased,and it was significantly longer in the intervention group (P 0.05);however,at 3 and 6 mo after discharge,the total scores for self-care maintenance,management,confidence,and behavior of the intervention group were significantly higher than those of the control group (P 0.05);however,at 3 mo and 6 mo after discharge,the score

关键词： Full-course individualized health education Chronic heart failure Self-care Influencing factors

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QCM Detection of Adhesion, Spreading and Proliferation of Human Breast Cancer Cells (MCF-7) on a Gold Surface

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Chinese Chemical Letters 2006年第4期17卷 509-512页

作者： Xue En JIA zhi wei zhang Liang TAN You Yu zhang Qing Ji XIE zhi Min HE Shou Zhuo YAO Key Laboratory of Chemical Biology ＆ Traditional Chinese Medicine Research （Ministry of Education） College of Chemistry and Chemical Engineering Hunan Normal University Changsha 410081 Cancer Research Institute Xiangya Medical College Central South University Changsha 410078

The quartz crystal microbalance （QCM） was used to monitor the one-day incubation of human breast cancer cells （MCF-7） on the gold electrode. In combination with an optical microscope simulation experiment, the cell-population pictures at various stages, the QCM responses to the cells＇ adhesion, spreading and proliferation on the electrode surface were discussed. The △f0 and △R1 responses were found mainly from mixed effects of viscodensity and surface stress, and in proportion to the cell coverage, rather than to the number of cells at the electrode. The significant fore-and-aft changes in cyclic voltammetry and electrochemical impedance spectroscopy of the ferri-ferrocyanide redox couple also proved that the cells were adhesion to the gold surface.

关键词： Quartz crystal microbalance optical microscopy cyclic voltammetry electrochemical impedance spectroscopy human breast cancer cells (MCF-7).

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Synergistic effect of bromocriptine and tumor necrosis factor-a on reversing hepatoceiiuiar carcinoma multidrug resistance in nude mouse MDRl model of liver neoplasm

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World Journal of Gastroenterology 2005年第36期11卷 5621-5626页

作者： Lei Ding Xiao-Ping Chen zhi-wei zhang Jian Guan Wan-Guang zhang Hai-Ping Wang zhi-Hui Wang Chun-Lei Li Hepatic Surgery Center Affiliated Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China Department of Ultrasonography Affiliated Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China

AIM： To investigate the effect of bromocripUne （BCT） and tumor necrosis factor-α ClNF-α） on hepatocellular carcinoma （HCC） multidrug resistance （MDR） in nude mouse HDR model of liver neoplasm. METHODS： Human hepatocarcinoma cell line HepG2t drug resistant hepatocarcinoma cell line HepG2/adriamycin （ADM） and hepatocarcinoma cell line transfected with TNF-α gene HepG2JADM/TNF were injected into the liver of nude mice via orthotopic implantation and MDR model of liver neoplasm in vivo was established （HepG2t ADM, TNF, BCT groups）. Among these groups, BCT group and TNF group were treated with BCT through gastric canal. Each group was divided into control group and chemotherapy group. Size and weight of the tumor were measured. Furthermore, tumor his^logical character and growth of the nude mice were observed and their chemosensitivity was tested. MDR-associated genes and proteins （MRP, LRP） of implanted tumors were detected by immunohistochemistry, reverse transcriptase polymerase chain reaction, and apoptosis rate of hepatocarcinoma cells was detected by TUNEL assay. RESULTS： The nude mouse model of each cell line was inoculated successfully. The tumor growth rate and weight were significantly different among groups. After chemotherapy, abdominal cavity tumor growth inhibition rate was higher in BCT group （67%） compared to ADM and TNF groups, and similar to HepG2group （54%）. MDRI and LRPmRNA could be detected in all groups, but TNF-α was detected only in TNF and BCT groups. Furthermore, MDR1 and LRP protein expression of tumors in TNF and BCT groups was low similar to HepG2 group. The apoptosis rate of hepatocarcinoma cells was much higher in BCT group than in other groups with TUNEL assay. CONCLUSION： BCT and TNF-a can reverse HCC MDR in nude mouse MDR1 model of liver neoplasm. 2005 The WJG Press and Elsevier Inc. All rights reserved

关键词： Bromocriptine Tumor necrosis factor-α Hepatocellular carcinoma

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Postoperative outcomes and recurrence patterns of intermediatestage hepatocellular carcinoma dictated by the sum of tumor size and number

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World Journal of Gastroenterology 2022年第44期28卷 6271-6281页

作者： Xin-Sheng Hu Hui-Yuan Yang Chao Leng zhi-wei zhang Hepatic Surgery Center Tongji HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

BACKGROUND The selection criteria for Barcelona Clinic Liver Cancer(BCLC)intermediate-stage hepatocellular carcinoma(HCC)patients who would truly benefit from liver resection(LR)remain *** To identify BCLC-B HCC patients more suitable for *** We included patients undergoing curative LR for BCLC stage A or B multinodular HCC(MNHCC)and stratified BCLC-B patients by the sum of tumor size and number(N+S).Overall survival(OS),recurrence-free survival(RFS),recurrence-to-death survival(RTDS),recurrence patterns,and treatments after recurrence in BCLC-B patients in each subgroup were compared with those in BCLC-A *** In total,143 patients who underwent curative LR for MNHCC with BCLC-A(n=25)or BCLC-B(n=118)were retrospectively *** to the N+S,patients with BCLC-B HCC were divided into two subgroups:BCLC-B1(N+S≤10,n=83)and BCLC-B2(N+S>10,n=35).Compared with BCLC-B2 patients,those with BCLC-B1 had a better OS(5-year OS rate:67.4%vs 33.6%;P<0.001),which was comparable to that in BCLC-A patients(5-year OS rate:67.4%vs 74.1%;P=0.250),and a better RFS(median RFS:19 mo vs 7 mo;P<0.001),which was worse than that in BCLC-A patients(median RFS:19 mo vs 48 mo;P=0.022).Further analysis of patients who developed recurrence showed that both BCLC-B1 and BCLC-A patients had better RTDS(median RTDS:Not reached vs 49 mo;P=0.599),while the RTDS in BCLC-B2 patients was worse(median RTDS:16 mo vs not reached,P<0.001;16 mo vs 49 mo,P=0.042).The recurrence patterns were similar between BCLC-B1 and BCLC-A patients,but BCLC-B2 patients had a shorter recurrence time and a higher proportion of patients had recurrence with macrovascular invasion and/or extrahepatic metastasis,both of which were independent risk factors for *** BCLC-B HCC patients undergoing hepatectomy with N+S≤10 had mild recurrence patterns and excellent OS similar to those in BCLC-A MNHCC patients,and LR should be considered in these patients.

关键词： Hepatocellular carcinoma Multinodular Intermediate-stage Liver resection Recurrence pattern Prognosis

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Occult pancreaticobiliary reflux is a pathogenic factor of some benign biliary diseases and gallbladder cancer

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Hepatobiliary & Pancreatic Diseases International 2023年第3期22卷 288-293页

作者： Lu Wang zhi-wei zhang Tong Guo Peng Xie Xiao-Rui Huang Ya-Hong Yu Department of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyKey Laboratory of Organ TransplantationMinistry of EducationNHC Key Laboratory of Organ TransplantationKey Laboratory of Organ TransplantationChinese Academy of Medical SciencesWuhan 430000China Department of Biliopancreatic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000China

Background:Pancreaticobiliary maljunction(PBM)is a well-known high-risk factor for biliary malignant tumors because of constant pancreaticobiliary reflux(PBR).However,the impact of occult pancreaticobiliary reflux(OPR),which is characterized by high bile amylase levels in individuals with anatomically normal pancreaticobiliary junction,on biliary diseases remains *** aim of this study was to assess the correlation between OPR and biliary ***:We enrolled 94 consecutive patients with normal pancreaticobiliary junction and primary biliary diseases confirmed by magnetic resonance *** prospectively collected patients’bile samples and measured bile amylase *** investigated the incidence of OPR and the difference in bile amylase levels among these patients and assessed the correlation between high bile amylase levels(HBAL)and benign or malignant biliary diseases,as well as the OPR risk ***:The incidence of OPR was 36.6%in patients with benign biliary diseases,26.7%in those with cholangiocarcinoma and 62.5%in those with gallbladder *** median bile amylase level tended to be higher in patients with gallbladder cancer than in those with benign biliary diseases,but there was no significant difference(165.5 IU/L vs.23.0 IU/L,P=0.212).The prevalence of an HBAL with bile amylase levels of 1000-7500 IU/L was similar in patients with gallbladder cancer and benign biliary ***,the incidence of HBAL with bile amylase levels greater than 7500 IU/L was significantly higher in patients with gallbladder cancer than in those with benign biliary diseases(37.5%vs.4.2%,P=0.012).Multivariate logistic regression analysis revealed that choledocholithiasis was an independent risk factor for ***:OPR can occur in benign and malignant biliary diseases,and it may be a pathogenic factor for some benign biliary diseases and a high-risk factor for gallbladder *** is a correlation between choledocholit

关键词： Occult pancreaticobiliary reflux Biliary diseases Bile amylase Pancreaticobiliary junction Gallbladder cancer

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