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Evaluation of the clinical effects of atropine in combination with remifentanil in children undergoing surgery for acute appendicitis

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2065-2072页

作者： Yu-Juan Li Yong-Yan Chen Xia-Lan Lin wei-zhi zhang Department of Anesthesiology Shanxi Provincial Children’s HospitalTaiyuan 030013Shanxi ProvinceChina

BACKGROUND Acute appendicitis(AA)is the most common cause of acute abdomen in *** significantly influences the surgical treatment of AA in children,making the scientific and effective selection of anesthetics *** To assess the clinical effect of atropine(ATR)in combination with remifentanil(REMI)in children undergoing surgery for *** In total,108 cases of pediatric AA treated between May 2020 and May 2023 were selected,58 of which received ATR+REMI[research group(RG)]and 50 who received REMI[control group(CG)].Comparative analyses were conducted on the time to loss of eyelash reflex,pain resolution time,recovery time from anesthesia,incidence of adverse events(AEs;respiratory depression,hypoxemia,bradycardia,nausea and vomiting,and hypotension),intraoperative responses(head shaking,limb activity,orientation recovery,safe departure time from the operating room),hemodynamic parameters[oxygen saturation(SPO2),mean arterial pressure,heart rate,and respiratory rate],postoperative sedation score(Ramsay score),and pain level[the Face,Legs,Activity,Cry,Consolability(FLACC)Behavioral Scale].RESULTS Compared with the CG,the RG showed significantly shorter time to loss of eyelash reflex,pain resolution,recovery from anesthesia,and safe departure from the operating ***,the incidence rates of overall AEs(head shaking,limb activity,etc.)were lower,and influences on intraoperative hemodynamic parameters and stress response indexes were *** Ramsay score at 30 min after extubation and the FLACC score at 60 min after extubation were significantly lower in the RG than in the *** ATR+REMI is superior to REMI alone in children undergoing AA surgery,with a lower incidence of AEs,fewer influences on hemodynamics and stress responses,and better post-anesthesia recovery.

关键词： Atropine Remifentanil Pediatric acute appendicitis Surgery Clinical efficacy

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Dosimetric risk factors for radiation esophagitis in patients with breast cancer following regional nodal radiation

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World Journal of Clinical Cases 2024年第17期12卷 2995-3003页

作者： Mei-Chen Ji zhi-Jia Li Ke Li Yun-Xiao Wang Bo Yang Lin-Lin Lv Ying Su zhi-wei zhang Zhong-Chao Huo Qing Qi Yong-Chang Lu zhi-Qiang Cui Yan-Bao Liu Oncology Center The Affiliated Hospital of Hebei University of EngineeringHandan 056002Hebei ProvinceChina General Surgery Department Handan First HospitalHandan 056002Hebei ProvinceChina Department of Breast Surgery The Affiliated Hospital of Hebei University of EngineeringHandan 056002Hebei ProvinceChina School of Clinical Medicine Hebei University of EngineeringHandan 056002Hebei ProvinceChina

BACKGROUND Radiation esophagitis(RE)is one of the most common clinical symptoms of regional lymph node radiotherapy for breast ***,there are fewer studies focusing on RE caused by hypofractionated radiotherapy(HFRT).AIM To analyze the clinical and dosimetric factors that contribute to the development of RE in patients with breast cancer treated with HFRT of regional lymph *** Between January and December 2022,we retrospectively analysed 64 patients with breast cancer who met our inclusion criteria underwent regional nodal intensity-modulated radiotherapy at a radiotherapy dose of 43.5 Gy/*** Of the 64 patients in this study,24(37.5%)did not develop RE,29(45.3%)developed grade 1 RE(G1RE),11(17.2%)developed grade 2 RE(G2RE),and none developed grade 3 RE or *** univariable logistic regression analysis found G2RE to be significantly correlated with the maximum dose,mean dose,relative volume 20-40,and absolute volume(AV)*** stepwise linear regression analyses found AV30 and AV35 to be significantly associated with G2RE(P<0.001).The optimal threshold for AV30 was 2.39 mL[area under the curve(AUC):0.996;sensitivity:90.9%;specificity:91.1%].The optimal threshold for AV35 was 0.71 mL(AUC:0.932;sensitivity:90.9%;specificity:83.9%).CONCLUSION AV30 and AV35 were significantly associated with *** thresholds for AV30 and AV35 should be limited to 2.39 mL and 0.71 mL,respectively.

关键词： Breast cancer Dosimetric parameters Radiation esophagitis Esophagitis Hypofractionated radiotherapy

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体外培养弓形虫裂殖子

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中国兽医科学 2024年第4期54卷 566-567页

作者： Jin-Lei Wang Ting-Ting Li Nian-zhang zhang Meng Wang Li-Xiu Sun zhi-wei zhang Bao-Quan Fu Hany M Elsheikha Xing-Quan Zhu

弓形虫病是由弓形虫(Toxoplasma gondii)引起的一种重要的人兽共患寄生虫病,对全球公共卫生体系和畜牧业发展造成巨大威胁。据估计,全球大约有三分之一的人口感染了弓形虫。孕妇在怀孕初期首次感染弓形虫,可能会导致胎儿发育异常、流产... 详细信息

弓形虫病是由弓形虫(Toxoplasma gondii)引起的一种重要的人兽共患寄生虫病,对全球公共卫生体系和畜牧业发展造成巨大威胁。据估计,全球大约有三分之一的人口感染了弓形虫。孕妇在怀孕初期首次感染弓形虫,可能会导致胎儿发育异常、流产、畸形或死胎,每年约有超过五万起流产与此相关。因此,弓形虫是孕期必检病原之一。另外,弓形虫引起的动物流产问题也非常严重,绵羊的流产率介于11%~25%,猪的流产率介于5%~15%,每年由此而造成的经济损失超3亿元。

关键词：人兽共患寄生虫病弓形虫流产率裂殖子畜牧业发展三分之一全球公共卫生体外培养

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Cystamine ameliorates liver fibrosis induced by carbon tetrachloride via inhibition of tissue transglutaminase

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World Journal of Gastroenterology 2007年第32期13卷 4328-4332页

作者： Jiang-Feng Qiu zhi-Qi zhang wei Chen zhi-Yong Wu Department of General Surgery Renji Hospital Shanghai Jiaotong University School of Medicine Shanghai 200127 China

AIM： To investigate the anti-fibrosis effect of the tissue transglutarninase （tTG） specific inhibitor cystarnine on liver fibrosis. METHODS： Sixty-eight male Sprague Dawley rats were divided into three groups： normal control, liver fibrosis control and cystamine-treated group. Liver fibrosis was induced by intraperitoneal injection of carbon tetrachloride （CCl4）, and Cystarnine was administrated by intraperitoneal injection starting 2 d before the first administration of CCl4. Animals in each group were further divided into 2 subgroups according to two time points of 4 wk and 8 wk after treatment. Hepatic function, pathological evaluation （semi-quantitative scoring system, SSS） and liver hydroxyproline （Hyp） content were examined. Real-time PCR was used to detect the expression of tTG, smooth muscle alpha actin （α-SMA）, tissue inhibitor of metalloproteinase 1 （TIMP-1） and collagen-1 mRNA. The expressions of tTG and α-SMA protein were detected by Western Blotting. RESULTS： Eight weeks after treatment, the SSS score of liver was significantly less in the cystamine group than that in the fibrosis control group （P 〈 0.01）. The levels of alanine arninotransferase （ALT） and total bile acid （TBA） at the 4 wk and 8 wk time points were decreased in the cystamine group compared with those in fibrosis controls （P 〈 0.01）. Liver hydroxyproline content at the 4 wk and 8 wk time points showed a substantial reduction in the cystamine group compared to fibrosis controls （P 〈 0.01）. The expression of tTG, α-SMA, collagen-1, TIMP-1 mRNA and tTG, as well as α-SMA protein was downregulated in the cystamine group compared to fibrosis controls. CONCLUSION： Cystamine can ameliorate CCl4 induced liver fibrosis and protect hepatic function. The possible mechanism is related to the reduced synthesis of the extracellular matrix （ECM） caused by the inhibition of hepatic stellate cell activation and decreased expression of TIMP-1.

关键词： Tissue transglutaminase Cystamine Liver fibrosis Cross linking Extracellular matrix

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Advanced sodium-ion capacitor based on antimony-carbon composite anode

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Rare Metals 2022年第10期41卷 3360-3369页

作者： wei-Qing Yu Chun-Yan Zhu Ru-Tao Wang Jian-Chao Chen Qing-Yuan Liu Shu-Xian zhang zhi-Jie Gao Cheng-Xiang Wang zhi-wei zhang Long-wei Yin Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationSchool of Materials Science and EngineeringShandong UniversityJinan250061China Suzhou Institute of Shandong University Suzhou215123China College of Chemical Engineering and Safety Binzhou UniversityBinzhou256603China

Alloy-type materials with the characteristics of high theoretical capacity,low sodiation/desodiation potential,and good conductivity are considered as one of the most promising anodes for sodium-ion batteries or ***,the large volume change during the sodiation leads to poor cyclability and slow kinetics,thus presenting the main issue impeding the practical ***,we propose a facile wet chemistry and pyrolysis method to synthesize Sb-carbon composite that Sb nanoparticles or single atoms are confined and/or dispersed in the wrinkled carbon framework with high nitrogen *** unique architecture of Sb-carbon composite increases atomic interface contact/interaction with Na~+,facilitating ion diffusion and alleviating the volume change of Sb during the charge/discharge ***-cell test shows that Sb-carbon composite exhibits a high-rate capability and stable cycling ***,sodium-ion capacitors fabricated by employing Sb-carbon composite as anode and home-made active carbon as cathode,deliver both high-energy density of 157 Wh·kg^(-1)and high-power density of 25 kW·kg^(-1)as well as excellent cycling performance exceeding 4000 cycles.

关键词： Antimony Nitrogen doping carbon Alloy-type anode Sodium-ion capacitor

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An Inverse Electromagnetic Scattering Method for One-Dimensional Inhomogeneous Media

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Chinese Physics Letters 2011年第1期28卷 82-85页

作者： LIN zhi-wei XU Xin zhang Xiao-Juan FANG Guang-You Key Laboratory for Electromagnetic Radiation and Detection Technology Institute of Electronics Chinese Academy of Sciences Beijing 100190

A frequency-domain inversion scheme for reconstructing the permittivity profile of one-dimensional inhomoge- neous media is proposed. The generalized reflection coefficients and the generalized transmission coefficients of the inhomogeneous media are used as the input data of the inverse model. A Newton-like iterative algorithm known as the generalized pulse-spectrum technique with the Tikhonov regularization is applied to solve the in- verse problem. Novel boundary conditions are proposed for the inverse problem and therefore the permittivity at the boundary of the inhomogeneous media is not required as prior knowledge. The choice of frequency points of the frequency-domain method is also investigated. Numerical examples are carried out to validate the inversion technique. Good agreements between the reconstructed profiles and the true profiles are shown.

关键词： Mathematical physics Accelerators beams and electromagnetism

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Electromagnetic Scattering and Inverse Scattering of Layered Media with a Slightly Rough Surface

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Chinese Physics Letters 2011年第1期28卷 86-89页

作者： LIN zhi-wei XU Xin zhang Xiao-Juan FANG Guang-You Key Laboratory for Electromagnetic Radiation and Sen ~ing Technology Institute o1 Electronics Chinese Academy ot Sciences Beijing 100190

An electromagnetic （EA1） scattering model for layered media covered by a 3D infinite rough surface and the corresponding inversion technique are investigated. The work aims at remote sensing the surface roughness and dielectric constant for different depths of bear soil through radar measurement data. The forward problem is carried out by the wave decomposition method. The small perturbation method （SPM） and EM boundary conditions are employed to solve the integral equations introduced by the wave decomposition method. The second-order SPM solution of the scatteringfield is involved in the computation of the forward problem for the first time. The backseattering coefficients of multiple frequencies, multiple angles and multiple polarizations are employed to create a nonlinear optimization problem. A genetic algorithm is introduced to help the inversion procedure approaeh to the global minimum of the cost function. Examples are carried out to validate the inversion technique. The inverion results show good agreement with the forward problem with given parameters and pose good tolerance to the input data with the additive white Gaussian noise.

关键词： INVERSE scattering transform SURFACE roughness ELECTROMAGNETIC wave scattering LAYER structure (Solids) DIELECTRICS RANDOM noise theory

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Application of self-care based on full-course individualized health education in patients with chronic heart failure and its influencing factors

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World Journal of Clinical Cases 2019年第16期7卷 2165-2175页

作者： Jing Sun zhi-wei zhang Yue-Xian Ma wei Liu Chun-Ying Wang Department of Nursing the Second Affiliated Hospital of Qiqihar Medical UniversityQiqihar 161000Heilongjiang ProvinceChina Department of Cardiovascular the Second Affiliated Hospital of Qiqihar Medical UniversityQiqihar 161000Heilongjiang ProvinceChina

BACKGROUND The treatment of heart failure not only needs to relieve the clinical symptoms and improve the quality of life for patients but also needs to select scientific and reasonable ways to prevent or delay the progression of the disease,thus reducing the mortality and hospitalization *** the previous regimen can effectively relieve symptoms in the early stage of treatment,long-term use may cause adverse events,such as arrhythmia,and even increase ***,conventional treatment cannot meet the actual health needs of patients,and scientific nursing intervention is very *** To investigate the application of self-care based on full-course individualized health education (FCIHE) and its influencing factors in patients with chronic heart failure (CHF).METHODS We enrolled CHF patients who were admitted to our center between September 2015 and June 2016 and divided them into an intervention group (n = 50) and control group (n = 50) using a random number *** nursing care was applied to the control group,and FCIHE was offered to the intervention *** self-care behavior,6-min walking distance (6MWD),and 36-item short form health survey (SF-36) scores were compared between the two *** influencing factors of the self-care were also *** The 6MWD was not significantly different between the two groups at admission (P > 0.05);however,at 3 and 6 mo after discharge,6MWD was significantly increased,and it was significantly longer in the intervention group (P 0.05);however,at 3 and 6 mo after discharge,the total scores for self-care maintenance,management,confidence,and behavior of the intervention group were significantly higher than those of the control group (P 0.05);however,at 3 mo and 6 mo after discharge,the score

关键词： Full-course individualized health education Chronic heart failure Self-care Influencing factors

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QCM Detection of Adhesion, Spreading and Proliferation of Human Breast Cancer Cells (MCF-7) on a Gold Surface

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Chinese Chemical Letters 2006年第4期17卷 509-512页

作者： Xue En JIA zhi wei zhang Liang TAN You Yu zhang Qing Ji XIE zhi Min HE Shou Zhuo YAO Key Laboratory of Chemical Biology ＆ Traditional Chinese Medicine Research （Ministry of Education） College of Chemistry and Chemical Engineering Hunan Normal University Changsha 410081 Cancer Research Institute Xiangya Medical College Central South University Changsha 410078

The quartz crystal microbalance （QCM） was used to monitor the one-day incubation of human breast cancer cells （MCF-7） on the gold electrode. In combination with an optical microscope simulation experiment, the cell-population pictures at various stages, the QCM responses to the cells＇ adhesion, spreading and proliferation on the electrode surface were discussed. The △f0 and △R1 responses were found mainly from mixed effects of viscodensity and surface stress, and in proportion to the cell coverage, rather than to the number of cells at the electrode. The significant fore-and-aft changes in cyclic voltammetry and electrochemical impedance spectroscopy of the ferri-ferrocyanide redox couple also proved that the cells were adhesion to the gold surface.

关键词： Quartz crystal microbalance optical microscopy cyclic voltammetry electrochemical impedance spectroscopy human breast cancer cells (MCF-7).

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Synergistic effect of bromocriptine and tumor necrosis factor-a on reversing hepatoceiiuiar carcinoma multidrug resistance in nude mouse MDRl model of liver neoplasm

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World Journal of Gastroenterology 2005年第36期11卷 5621-5626页

作者： Lei Ding Xiao-Ping Chen zhi-wei zhang Jian Guan Wan-Guang zhang Hai-Ping Wang zhi-Hui Wang Chun-Lei Li Hepatic Surgery Center Affiliated Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China Department of Ultrasonography Affiliated Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China

AIM： To investigate the effect of bromocripUne （BCT） and tumor necrosis factor-α ClNF-α） on hepatocellular carcinoma （HCC） multidrug resistance （MDR） in nude mouse HDR model of liver neoplasm. METHODS： Human hepatocarcinoma cell line HepG2t drug resistant hepatocarcinoma cell line HepG2/adriamycin （ADM） and hepatocarcinoma cell line transfected with TNF-α gene HepG2JADM/TNF were injected into the liver of nude mice via orthotopic implantation and MDR model of liver neoplasm in vivo was established （HepG2t ADM, TNF, BCT groups）. Among these groups, BCT group and TNF group were treated with BCT through gastric canal. Each group was divided into control group and chemotherapy group. Size and weight of the tumor were measured. Furthermore, tumor his^logical character and growth of the nude mice were observed and their chemosensitivity was tested. MDR-associated genes and proteins （MRP, LRP） of implanted tumors were detected by immunohistochemistry, reverse transcriptase polymerase chain reaction, and apoptosis rate of hepatocarcinoma cells was detected by TUNEL assay. RESULTS： The nude mouse model of each cell line was inoculated successfully. The tumor growth rate and weight were significantly different among groups. After chemotherapy, abdominal cavity tumor growth inhibition rate was higher in BCT group （67%） compared to ADM and TNF groups, and similar to HepG2group （54%）. MDRI and LRPmRNA could be detected in all groups, but TNF-α was detected only in TNF and BCT groups. Furthermore, MDR1 and LRP protein expression of tumors in TNF and BCT groups was low similar to HepG2 group. The apoptosis rate of hepatocarcinoma cells was much higher in BCT group than in other groups with TUNEL assay. CONCLUSION： BCT and TNF-a can reverse HCC MDR in nude mouse MDR1 model of liver neoplasm. 2005 The WJG Press and Elsevier Inc. All rights reserved

关键词： Bromocriptine Tumor necrosis factor-α Hepatocellular carcinoma

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