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Chinese Journal of Polymer Science 2021年第9期39卷 1093-1109页

作者： Jie Zhou Xiao-Yuan Zhang zhi-qiang su State Key Laboratory of Chemical Resource Engineering Beijing Key Laboratory of Advanced Functional Polymer CompositesBeijing University of Chemical TechnologyBeijing 100029China

Hybrids,produced by hybridization of proteins,peptides,DNA,and other new biomolecules with polymers,often have unique functional *** properties,such as biocompatibility,stability and specificity,lead to various smart *** review mainly introduces biomolecule polymer hybrid materials by reversible deactivation radical polymerization(RDRP),emphasizing reverse addition-fragmentation chain transfer(RAFT)polymerization,and nitroxide mediated polymerization(NMP).It includes the methods of RDRP to improve the biocompatibility of biomedical materials and organisms by surface *** key to the current synthesis of biomolecule polymer hybrids is to control ***,this review describes several different kinds of biomolecule polymer hybrid materials and their applications in the biomedical *** progresses provide ideas for the investigation of biodegradable and highly bioactive biomedical soft tissue *** research hotspots of nanotechnology in biomedical fields are controlled drug release materials and gene therapy carrier *** showed that RDRP method could improve the therapeutic effect and reduce the dosage and side effects of the ***,by means of RDRP,the original materials can be modified to develop intelligent polymer materials as membrane materials with selective permeability and surface modification.

关键词： Biomolecule-polymer hybrids RDRP Biomedical applications Drug release Nanotechnology

DIABETOGENIC T CELLS INDUCE AUTOIMMUNE DIABETES IN BALB/c MICE

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Chinese Medical Sciences Journal 2008年第2期23卷 88-94页

作者： Xiao-lei Zou Zeng-yu Zhao Yun-yang Wang zhi-qiang su Ming Xiang Department of Pharmacology College of Pharmacy Tongji Medical College Huazhong University of Science and Technology Wuhan 430030

Objective To investigate the role of T cell and its subsets in the induction of insulifis and type 1 diabetes mellitus （T1DM） in BALB/c mice. Methods Autoimmune diabetes mellitus was developed by intraperitoneal injection of 40 mg/kg streptozotocin （STZ） daily for 5 consecutive days in BALB/c mice as sources of donor cells. Spleen cells from diabetic mice were then cultured for 7 days in the stimulation of interleukin-2 （IL-2） to harvest diabetogenic T cells, which were subse-quently transferred into normal BALB/c mice recipients. MTT, ELISA, and HE staining were used to analyze the lym- phocyte proliferation, cytokine （ IL-2, interferon-γ, IL-4, and IL-10） levels, and pathological changes in pancreatic is- lets. Results As few as 3×10^6 diabetogenic T cells successfully induced diabetes mellitus in recipients pretreated with STZ twice, whereas transfer of equal amount of normal splenocytes, T cell-depleted diabetogenic splenocytes, or diabe-togenic CD4^＋ T cells alone in recipients receiving STZ twice pretreatment was proved not to induce diabetes mellitus either. A markedly increased lymphocyte proliferation, high levels of interferon-γ/and IL-2 in the supernatants of diabeto-genic T cells were observed. In addition, a markedly enhanced lymphocyte proliferation, a high level of interferon-γ/secretion in serum, and numerous lymphocytes infiltration in pancreatic islets were detected in the diabetic mice induced by diabetogenic T cells transfer. Conclusions A novel T1DM murine model is established in STZ-pretreated BALB/c mice by adoptive transfer of diabetogenic T cells. CD4^＋ T cells with interferon-γ/may promote the onset of diabetes mellitus.

关键词： diabetogenic T cells adoptive transfer streptozotocin-induced diabetes mellitus

Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli Zhang Tian Li Jie Miao zhina Zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei Zhang Haiting Li qiang su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

Physical Layer Security Scheme With AoI-Awareness for Industrial IoT Based on Covert Communications

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 276-278页

作者： Yaping Li zhi-Xin Liu Jia-Wei su Ya-Zhou Yuan the Key Laboratory of Industrial Computer Control Engineering of Hebei Province Yanshan University

Dear Editor,Industrial Internet of things(IIoT) is a typical application of cyberphysical system(CPS). In the IIoT, wireless communication is an inevitable trend to replace the deployment-limited wired transmission for cases with large-scale and mobile devices. However, wireless communication gives rise to critical issues related to physical security, such as malicious detections and attacks [1].

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基于学习投入理论的网络学习行为模型研究——以“网络教学平台设计与开发”课程为例

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现代教育技术 2017年第1期27卷 74-80页

作者：马志强苏珊张彤彤江南大学教育信息化研究中心江苏无锡214122

学习投入理论建立了学习投入、学习行为、学习效果之间的关联,为预测学习效果提供了良好的理论架构。文章根据认知与情感投入因素、网络学习行为、学习效果的具体分类,建立了基于学习投入理论的网络学习行为模型,并以"网络教学平台设计... 详细信息

学习投入理论建立了学习投入、学习行为、学习效果之间的关联,为预测学习效果提供了良好的理论架构。文章根据认知与情感投入因素、网络学习行为、学习效果的具体分类,建立了基于学习投入理论的网络学习行为模型,并以"网络教学平台设计与开发"课程为例进行了实证研究,梳理了模型中各要素之间的关系,并通过优化模型的影响因素及其关联,最终构建了基于学习投入理论的网络学习行为修正模型。文章认为,认知投入因素中的认知能力与策略、元认知和情感投入因素中的唤醒、兴趣均显著影响社会性学习行为,在线讨论行为则显著影响满意度和课程持续使用意向。

关键词：网络学习网络学习行为学习投入学习行为模型

考虑双向交通的城市路网交通流元胞自动机模型

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交通运输系统工程与信息 2017年第2期17卷 90-96页

作者：施俊庆李志强李素兰毛程远张欣环浙江师范大学工学院浙江金华321004 武汉市交通科学研究所武汉430015 武汉理工大学交通学院武汉430063

允许车辆借反向车道超车的双向交通道路是城市路网的重要组成部分.本文考虑了双向交通道路的车辆行驶规则,研究了无信号控制交叉口的车辆优先通行权分配规则,构建了一个双向交通的城市路网交通流元胞自动机模型,研究了城市路网交通流的... 详细信息

允许车辆借反向车道超车的双向交通道路是城市路网的重要组成部分.本文考虑了双向交通道路的车辆行驶规则,研究了无信号控制交叉口的车辆优先通行权分配规则,构建了一个双向交通的城市路网交通流元胞自动机模型,研究了城市路网交通流的动态特性.研究结果表明,临界密度随着路网规模的增加而下降,路网交通密度的增加会加速拥堵闭环的形成,换道概率的增加会降低路网车速和缩短局部死锁现象形成的时间,单位时间换道车辆数与换道概率及交通密度之间存在着密切的关系.

关键词：交通工程仿真模型元胞自动机双向交通路网交通流

水力脉动对水电站机组及厂房结构的影响研究与振动控制综述

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长江科学院院报 2016年第10期33卷 135-139页

作者：耿聃宋志强苏晨辉西安理工大学水电学院西安710048

水力振源在某些工况下可能对机组的正常运行造成影响,同时引起厂房结构不同程度的振动,且水力振源频域分布广,作用范围大,是水力、机械、电磁3种振源中最主要的振源,因此研究水力脉动及其造成的影响有着十分重要的意义。现有的研究成果... 详细信息

水力振源在某些工况下可能对机组的正常运行造成影响,同时引起厂房结构不同程度的振动,且水力振源频域分布广,作用范围大,是水力、机械、电磁3种振源中最主要的振源,因此研究水力脉动及其造成的影响有着十分重要的意义。现有的研究成果对于水力振源特性的研究主要依赖于模型试验,存在模型尺寸比例误差和测点过少等问题,对于机组及厂房结构的振动稳定性计算也过于简化。根据计算流体动力学(CFD)数值模拟方法,提出一种新的厂房水力振源研究方法,将水力振源转化为激励作用于转轮、蜗壳、尾水管部位,研究机组及厂房结构的稳定性,是未来可能的水力振源施加新方法,有着重要工程实际意义及应用前景。

关键词：水力脉动 CFD数值模拟机组厂房振动

石墨炉原子吸收光谱法测定绞股蓝中的重金属含量

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化工管理 2018年第15期 72-73页

作者：王志强苏静亳州市产品质量监督检验所安徽亳州236800

对石墨炉原子吸收光谱法测定绞股蓝中的铅、镉的含量进行了研究,以磷酸二氢铵作为基体改进剂,用优级纯的HN03微波消化样品,然后直接进样的分析技术。该法操作简便,取样量少且回收率高,样品基体干扰消除较完全,极大地改善了铅、镉的检出... 详细信息

对石墨炉原子吸收光谱法测定绞股蓝中的铅、镉的含量进行了研究,以磷酸二氢铵作为基体改进剂,用优级纯的HN03微波消化样品,然后直接进样的分析技术。该法操作简便,取样量少且回收率高,样品基体干扰消除较完全,极大地改善了铅、镉的检出限,测定灵敏度大大提高。应用该法,可监控绞股蓝的重金属含量,铅、镉的回收率分别为101.5%,95.6%

关键词：石墨炉原子吸收基体改进剂铅镉

健脾利水活血方联合深部热疗治疗癌性腹水的临床研究

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光明中医 2017年第6期32卷 840-842页

作者：彭植强苏林福建省宁德市中医院肿瘤科宁德352100

目的探讨健脾利水活血方联合深部热疗治疗癌性腹水的临床疗效。方法将64例癌性腹水患者随机分为健脾利水活血方联合深部热疗组和西医常规组,每组32例。检测患者腹水控制有效率、外周血T细胞亚群(CD3^+、CD4^+、CD8^+)和NK细胞值、KPS评... 详细信息

目的探讨健脾利水活血方联合深部热疗治疗癌性腹水的临床疗效。方法将64例癌性腹水患者随机分为健脾利水活血方联合深部热疗组和西医常规组,每组32例。检测患者腹水控制有效率、外周血T细胞亚群(CD3^+、CD4^+、CD8^+)和NK细胞值、KPS评分。结果对照组有效率为53.33%,治疗组有效率为77.42%,两组差异有统计学意义(P0.05)。治疗组患者的卡氏(KPS)评分较治疗前升高,而对照组无明显变化。结论健脾利水活血方联合深部热疗治疗癌性腹水具有良好的临床疗效,增强免疫功能,提高患者的生活质量。

关键词：积聚健脾利水活血方深部热疗癌性腹水免疫功能

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids