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Outcomes of T3a Prostate Cancer with Unfavorable Prognostic Factors Treated with Brachytherapy Combined with External Radiotherapy and Hormone Therapy

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Chinese Medical Sciences Journal 2015年第3期30卷 143-149页

作者： zhi-peng mai Wei-gang Yan Han-zhong Li Yi Zhou zhi-en Zhou Department of Urology Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College

Objective To evaluate the outcomes of T3 a prostate cancer with unfavorable prognostic factors treated with permanent interstitial brachytherapy combined with external radiotherapy and hormone *** From January 2003 to December 2008,38 patients classified as T3 a prostate cancer with unfavorable prognostic factors were treated with trimodality therapy(brachytherapy + external radiotherapy + hormone therapy).The prescription dose of brachytherapy and external radiotherapy were 110 Gy and 45 Gy,*** duration of hormone therapy was 2-3 *** endpoints of this study included biochemical failure-free survival(BFFS),distant metastasis-free survival(DMFS),cancer-specific survival(CSS),and overall survival(OS).Survival curves were calculated using the Kaplan-Meier *** Log-rank test was used to identify the prognostic predictors for univariate *** The median follow-up was 71 *** serum pre-treatment prostate-specific antigen(PSA) level ranged from 10.0 to 99.8 ng/ml(mean 56.3 ng/ml),the Gleason score ranged from 5 to 9(median 8),and the percentage of positive biopsy cores ranged from 10% to 100%(mean 65%).The 5-year BFFS,DMFS,CSS,and OS rates were 44%,69%,82%,and 76%,*** biochemical failures occurred within 40 *** percentage of positive biopsy cores was significantly correlated with BFFS,DMFS,and OS(all P=0.000),and the Gleason score with DMFS(P=0.000) and OS(P=0.001).Conclusions T3 a prostate cancer with unfavorable prognostic factors presents not so optimistic *** therapy should be applied to prolong the biochemical progression-free or metastasis-free *** percentage of positive biopsy cores and the Gleason score are significant prognostic factors.

关键词： T3a prostatic neoplasms unfavorable trimodality therapy

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Clinical Characteristics and Outcome of Gleason Score 10 Prostate Cancer on Core Biopsy Treated by External Radiotherapy and Hormone Therapy

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Chinese Medical Sciences Journal 2015年第2期30卷 90-94页

作者： zhi-peng mai Wei-gang Yan Han-zhong Li zhi-gang Ji Fu-quan Zhang Ke Hu Yu Xiao Department of Urology Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College Department of Radiation Oncology Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College

Objective To evaluate the clinical characteristics and outcomes of patients with Gleason score 10 prostate cancer treated by external radiotherapy and hormone therapy. Methods From January 2003 to March 2014, 1832 patients with prostate cancer were treated, among which 9 patients(represented 0.49%) were identified as Gleason score 10 disease on prostate core biopsy without distant metastases when first diagnosed. All 9 patients were treated by whole pelvic external radiotherapy(The whole pelvic dose was 50.0 Gy and the boost dose ranged from 76.2 to 78.0 Gy) and long-term hormone therapy. We assessed the clinical characteristics, treatment outcomes and treatment toxicities. Survival curves were calculated using the Kaplan-Meier method. Results The median follow-up was 4.8 years. Six patients' pre-treatment prostate-specific antigen(PSA) levels were lower than 20.0 μg/L and three patients' pre-treatment PSA levels were higher than 70.0 μg/L. The median percentage of positive biopsy cores was 91%. Three, four and two cases were classified as T2 c, T3 a and T3 b stage, respectively. Three cases were assessed as N1 stage. The 5-year biochemical failure-free survival, distant metastasis-free survival, cancer specific survival and overall survival rates were 28.6%, 57.1%, 66.7% and 57.1%, respectively. Five patients experienced grade 1-2 acute gastrointestinal toxicities and six patients complained of grade 1-2 acute genitourinary toxicities. No bone fracture or cardiovascular disease was detected. Conclusions Gleason score 10 prostate cancer on core biopsy is usually combined with other high risk factors. The pre-treatment PSA levels lie in two extremes. Timely and active treatments are urgent needed because unfavourable oncological outcomes are often presented.

关键词： prostatic neoplasms biopsy neoplasm grading outcomes

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Efficient and Stable Perovskite Solar Cells and Modules Enabled by Tailoring Additive Distribution According to the Film Growth Dynamics

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Nano-Micro Letters 2025年第2期17卷 387-400页

作者： Mengen Ma Cuiling Zhang Yujiao Ma Weile Li Yao Wang Shaohang Wu Chong Liu Yaohua mai Institute of New Energy Technology College of Physics&Optoelectronic EngineeringJinan UniversityGuangzhou 510632People’s Republic of China Key Laboratory of New Semiconductors and Devices of Guangdong Higher Education Institutes Jinan UniversityGuangzhou 510632People’s Republic of China Guangdong Mellow Energy Co. LimitedYuanming RoadZhuhai 519075GuangdongPeople’s Republic of China

Gas quenching and vacuum quenching process are widely applied to accelerate solvent volatilization to induce nucleation of perovskites in blade-coating *** this work,we found these two pre-crystallization processes lead to different order of crystallization dynamics within the perovskite thin film,resulting in the differences of additive *** then tailor-designed an additive molecule named 1,3-bis(4-methoxyphenyl)thiourea to obtain films with fewer defects and holes at the buried interface,and prepared perovskite solar cells with a certified efficiency of 23.75%.Furthermore,this work also demonstrates an efficiency of 20.18%for the large-area perovskite solar module(PSM)with an aperture area of 60.84 cm^(2).The PSM possesses remarkable continuous operation stability for maximum power point tracking of T_(90)>1000 h in ambient air.

关键词： Gas quenching Additive distribution Buried passivation Blade coating Crystallization dynamics

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MicroRNA-224靶向CNNM1抑制前列腺癌血管生成的实验研究

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中国现代医学杂志 2017年第17期27卷 19-24页

作者：黄亚强黄红星麦智鹏黎卫郑轶群袁润强中山大学附属中山医院泌尿外科广东中山528403

目的研究microR NA-224(miR-224)对前列腺癌生化复发及血管生成的影响。方法生物信息学分析及荧光素酶报告实验预测细胞周期调节蛋白1(CNNM1)受miR-224负性调控。Taylor前列腺癌数据库分析、验证CNNM1、miR-224的表达关系及其与前列腺... 详细信息

目的研究microR NA-224(miR-224)对前列腺癌生化复发及血管生成的影响。方法生物信息学分析及荧光素酶报告实验预测细胞周期调节蛋白1(CNNM1)受miR-224负性调控。Taylor前列腺癌数据库分析、验证CNNM1、miR-224的表达关系及其与前列腺癌生化复发的相关性。前列腺癌PC3细胞体外培养及动物体内成瘤实验研究CNNM1、miR-224表达对前列腺癌微血管生成标志物CD31的影响。结果 CNNM1表达受miR-224靶向调节,前列腺癌组织中CNNM1与miR-224的表达呈负相关(P<0.05)。miR-224与前列腺癌的生化复发呈负相关(P<0.05),CNNM1与前列腺的生化复发呈正相关(P<0.05);在过表达miR-224的PC3细胞株内,CNNM1和CD31的表达量下降;CNNM1过表达能促进CD31的生成。前列腺癌细胞裸鼠体内成瘤组织免疫组织化学法染色提示,miR-224过表达能抑制前列腺癌组织内微血管形成。结论 miR-224通过靶向调控CNNM1表达,抑制前列腺癌微血管形成,控制前列腺癌生化复发。

关键词：前列腺癌 microRNA-224 细胞周期调节蛋白1 生化复发血管生成

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A copper- and amine-free Sonogashira reaction employing chlorophosphine as new and efficient ligand

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Chinese Chemical Letters 2012年第2期23卷 185-188页

作者： Wen peng mai Jin Wei Yuan zhi Cheng Li Gang Chun Sun Chemistry and Chemical Engineering School Henan University of TechnologyZhengzhou 450001China

An efficient palladium-catalyzed copper- and amine-free Sonogashira coupling reaction of aryl bromides and chlorides was studied using a sterically hindered monooxychlorophosphine as new *** use of 2 mol%Pd（OAc）_2 i... 详细信息

关键词： Palladium Copper-free Coupling Sonogashira reaction Chlorophosphine

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Palladium-catalyzed Suzuki couplings using a novel diaminophosphine oxide as ligand

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Chinese Chemical Letters 2012年第5期23卷 521-524页

作者： Wen peng mai Hui Hui Wang Jin Wei Yuan Liang Ru Yang zhi Cheng Li Chemistry and Chemical Engineering School Henan University of TechnologyZhengzhou 450001China

A novel diaminophosphine oxide was synthesized and applied as ligand in palladium-catalyzed Suzuki couplings reaction of aryl bromides and *** coupling reaction proceeded smoothly at mild conditions using 2 mol%Pd_2（... 详细信息

关键词： Palladium Suzuki reaction Coupling Diaminophosphine oxide

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ALTERNATING PROJECTION BASED PREDICTION-CORRECTION METHODS FOR STRUCTURED VARIATIONAL INEQUALITIES

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Journal of Computational Mathematics 2006年第6期24卷 693-710页

作者： Bing-sheng He Li-zhi Liao mai-jian Qian Department of Mathematics Nanjing University Nanjing 210093 China Department of Mathematics Hong Kong Baptist University Hong Kong China Department of Mathematics California State University FuUerton CA 92834 USA

The monotone variational inequalities VI（Ω, F） have vast applications, including optimal controls and convex programming. In this paper we focus on the VI problems that have a particular splitting structure and in which the mapping F does not have an explicit form, therefore only its function values can be employed in the numerical methods for solving such problems. We study a set of numerical methods that are easily implementable. Each iteration of the proposed methods consists of two procedures. The first （prediction） procedure utilizes alternating projections to produce a predictor. The second （correction） procedure generates the new iterate via some minor computations. Convergence of the proposed methods is proved under mild conditions. Preliminary numerical experiments for some traffic equilibrium problems illustrate the effectiveness of the proposed methods.

关键词： Structured variational inequality Monotonicity Prediction-correction method.

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Efficacy and safety of low-dose thalidomide combined with mesalazine in the treatment of refractory ulcerative colitis in adults

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Gastroenterology Report 2022年第1期10卷 653-655页

作者： Jun-Rong Chen Lei mai Jia-Chen Sun Xiang peng Min Zhang Min zhi Department of General Practice The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Gastroenterology The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhaiGuangdongP.R.China Department of Gastrointestinal Endoscopy The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China

Introduction Inducing and maintaining clinical remission and mucosal healing is essential in the treatment of ulcerative colitis(UC),a nonspecific chronic recurrent inflammatory disorder[1].Mesalazine(5-ASA)is commonly prescribed as a first-line drug for *** the short-term efficacy of ciclosporin and infliximab,some patients may develop methylprednisolone resistance or dependence[2].

关键词： healing clinical treatment

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Characterization of structural and electrical properties of ZnO tetrapods

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International Journal of Minerals,Metallurgy and Materials 2011年第6期18卷 686-690页

作者： Yu-dong Gu Wen-jie mai peng Jiang Department of Advanced Materials and Nanotechnology College of Engineering Peking University Beijing 100084 China School of Materials Science and Engineering Georgia Institute of Technology Atlanta Georgia 30332-0245 USA Department of Physics Jinan University Guangzhou 510632 China National Center for Nanoscience and Technology Beijing 100190 China

ZnO tetrapods were synthesized by a typical thermal vapor-solid deposition method in a horizontal tube *** characterization was carried out by transmission electron microscopy （TEM） and select-area electron diffraction （SAED）,which shows the presence of zinc blende nucleus in the center of tetrapods while the four branches taking hexagonal wurtzite *** electrical transport property of ZnO tetrapods was investigated through an in-situ nanoprobe *** three branches of a tetrapod serve as source,drain,and ＂gate＂,respectively;while the fourth branch pointing upward works as the force trigger by vertically applying external force *** conductivity of each branch of ZnO-tetrapods increases 3-4 times under *** such situation,the electrical current through the branches of ZnO tetrapods can be tuned by external force,and therefore a simple force sensor based on ZnO tetrapods has been demonstrated for the first time.

关键词： zine oxide tetrapods electrical property piezoelectric materials semiconductors nanostructures

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Effects of simulated on-fire processing conditions on the microstructure and mechanical performance of Q345R steel

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International Journal of Minerals,Metallurgy and Materials 2016年第1期23卷 49-56页

作者： Yi-chao peng Hao-hao Xu mai-cang Zhang Department of Materials Technology Zhejiang Energy Technology & Research Co.Ltd. Department of Materials Science and Engineering University of Science and Technology Beijing

A series of simulated on-fire processing experiments on Q345R steel plates was conducted, and the plates＇ Brinell hardness, ten- sile strength, and impact energy were tested. Microstructure morphologies were systematically analyzed using a scanning electron micro- scope with the aim of investigating the effect of the steel＇s microstructure on its performance. All examined performance parameters exhib- ited a substantial decrease in the cases of samples heat-treated at temperatures near 700℃. However, although the banded structure decreased with increasing treatment temperature and holding time, it had little effect on the performance decline in fact. Further analysis revealed that pearlite degeneration near 700℃, which was induced by the interaction of both subcritical annealing and conventional spherical annealing, was the primary reason for the degradation behavior. Consequently, some nonlinear mathematical models of different mechanical perform- ances were established to facilitate processing adjustments.

关键词： low alloy steels heat treatment mechanical properties microstructure nonlinear mathematical models

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