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NLRP3-mediated autophagy dysfunction links gut microbiota dysbiosis to tau pathology in chronic sleep deprivation

Zoological Research 2024年第4期45卷 857-874页

作者： Na Zhao Xiu Chen Qiu-Gu Chen Xue-Ting Liu Fan Geng Meng-Meng Zhu Fu-Ling Yan zhi-jun zhang Qing-Guo Ren Department of Neurology School of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Neurology Affiliated Zhongda HospitalSoutheast UniversityNanjingJiangsu 210009China

Emerging evidence indicates that sleep deprivation(SD)can lead to Alzheimer’s disease(AD)-related pathological changes and cognitive ***,the underlying mechanisms remain *** the present study,we identified the existence of a microbiota-gut-brain axis in cognitive deficits resulting from chronic SD and revealed a potential pathway by which gut microbiota affects cognitive functioning in chronic *** findings demonstrated that chronic SD in mice not only led to cognitive decline but also induced gut microbiota dysbiosis,elevated NLRP3 inflammasome expression,GSK-3βactivation,autophagy dysfunction,and tau hyperphosphorylation in the *** with the“SD microbiota”replicated the pathological and behavioral abnormalities observed in chronic sleep-deprived ***,both the deletion of NLRP3 in NLRP3-/-mice and specific knockdown of NLRP3 in the hippocampus restored autophagic flux,suppressed tau hyperphosphorylation,and ameliorated cognitive deficits induced by chronic SD,while GSK-3βactivity was not regulated by the NLRP3 inflammasome in chronic ***,deletion of NLRP3 reversed NLRP3 inflammasome activation,autophagy deficits,and tau hyperphosphorylation induced by GSK-3βactivation in primary hippocampal neurons,suggesting that GSK-3β,as a regulator of NLRP3-mediated autophagy dysfunction,plays a significant role in promoting tau ***,gut microbiota dysbiosis was identified as a contributor to chronic SD-induced tau pathology via NLRP3-mediated autophagy dysfunction,ultimately leading to cognitive ***,these findings highlight GSK-3βas a regulator of NLRP3-mediated autophagy dysfunction,playing a critical role in promoting tau hyperphosphorylation.

关键词： Chronic sleep deprivation Tau pathology NLRP3 inflammasome Autophagy GSK-3β Microbiota-gut-brain axis

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Boundary Behavior of Large Solutions to the Monge–Ampère Equation in a Borderline Case

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Acta Mathematica Sinica,English Series 2019年第7期35卷 1190-1204页

作者： zhi jun zhang School of Mathematics and Information Science Yantai University

This paper is concerned with the boundary behavior of strictly convex large solutions to the Monge–Ampère equation det D^2u(x) = b(x)f(u(x)), u >0, x∈Ω, where Ω is a strictly convex and bounded smooth domain in R^N with N ≥ 2, f is normalized regularly varying at infinity with the critical index N and has a lower term, and b∈C~∞(Ω) is positive in Ω, but may be appropriate singular on the boundary.

关键词： The Monge–Ampère equations strictly convex large solutions a borderline case boundary behavior

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Synthesis and study of MPNS/SMA nano-composite tanning agent

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Chinese Chemical Letters 2008年第4期19卷 435-437页

作者： Hui Pan Mei Qi zhi jun zhang Laboratory of Special Functional Material Henan UniversityKaifeng 475004PR China

The radical polymerization of maleic anhydride（MA）,styrene（ST）with the vinyl groups introduced onto the surface of the nano-sized silica via solution polymerization method was *** methacryloxypropyl nano-sized silica（MPNS）was used as macromonomer and polymerized with maleic anhydride and styrene by initiating with BPO in *** structure and properties of MPNS/SMA nano-composite were characterized by FT-IR spectra and ***,it was applied as tanning agent compared with the traditional styrene-maleic anhydride copolymer in *** was found that the applied leather had better quality characteristics with the addition of the nano-sized silica.

关键词： Nano-composite Tanning agent Polymerization Leather

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Interference Pattern of Density-Density Correlation for Incoherent Atoms with Vortices Released from an Optical Lattice

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Chinese Physics Letters 2011年第1期28卷 26-29页

作者： XU zhi-jun zhang Dong-Mei LIU Xia-Yin College of Science Zhejiang University of Technology Hangzhou 310023

For a series of incoherent condensate atomic clouds with vortices （an orbital angular momentum） released from an optical lattice, the density-density correlation function of this freely expanding ultracold gases is theoretically investigated. It is shown that the nonzero angular momentum of the atoms has an important effect on the fringe pattern of density-density correlation. Particularly, for a short expansion time, even the rotation direction of the atoms could have an observable effect on the fringe pattern. Observation of this specific fringe pattern would constitute experimental evidence for the presence of a vortex in an atomic condensate.

关键词： Quantum gases, liquids and solids Optics, quantum optics and lasers Statistical physics and nonlinear systems

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Preparation and Application of a Nanocomposite (MPNS/SMA) in Leather Making

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Chinese Chemical Letters 2005年第10期16卷 1409-1412页

作者： Hui PAN zhi jun zhang Hong Xin DANG State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 Lab. of Special Functional Material Henan University Kalfeng 475001

A nanocomposite of MPNS/（Styrene-maleic anhydride） was prepared by the polymerization of methacryloxypropyl nano SiO2 （MPNS）, styrene （ST） and maleic anhydride （MA） with benzoyl peroxide （BPO） as initiator in toluene. The prepared samples were characterized by Fourier transform infrared spectroscopy （PT-IR） and transmission electron microscope （TEM）. Meanwhile, the nanocomposite was applied as a tanning agent in leather making and the results showed that leather treated with MPNS/SMA nanocomposite has excellent quality.

关键词： Nano-sized SiO2 composite polymerization tanning agent.

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Synthesis of a bistable[3]rotaxane and its pH-controlled intramolecular charge-transfer behavior

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Chinese Chemical Letters 2013年第7期24卷 563-567页

作者： Hui Wang zhi-jun zhang Heng-Yi zhang Yu Liu Department of Chemistry State Key Laboratory of Elemento-Organic ChemistryNankai University

A [3]rotaxane I involving two naphtho-21-crown-7 （N21 C7） rings and a dumbbell-shaped component 4 was synthesized. The dumbbell-shape molecule 4 contains one viologen nucleus, two secondary alkyl ammonium sites and two phenyl stoppers. After threading the N21C7 ring with the thread-like ammonium guest 3, the copper（l）-catalyzed Huisgen alkyne-azide 1,3-dipolar cycloaddition （CuAAC ＂click＂ reaction）, was performed to connect the pseudorotaxanes with viologen unit 2 and generate 1. Through treating the [3]rotaxane by the base and acid circularly, the two N21 C7 rings can make shuttling motion along the axle. Meanwhile the distance between the electron-deficient viologen unit and the electron-rich naphthol group can be adjusted precisely along with a remarkable intramolecular charge- transfer （CT） behavior.

关键词： Rotaxane Crown ether Charger transfer (CT) Click chemistry

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Synthesis of dandelion-like three-dimensional nickel nanostructures via solvothermal route

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Chinese Chemical Letters 2008年第9期19卷 1123-1126页

作者： jun Tao Tian Chun Hong Gong Lai Gui Yu zhi Shen Wu zhi jun zhang Key Laboratory of Special Functional Materials of Ministry of Education Henan University Kaifeng 475004 China

The objectives of the present research are synthesizing three-dimensional （3D） nickel nanostructures and investigating their magnetic properties. Thus a template-free method was used to prepare 3D dandelion-like nickel nanostructures via reducing of nickel chloride with hydrazine hydrate in ethylene glycol solution at 100 ℃. The resulting Ni nanostructures were characterized by means of powder X-ray diffraction （XRD）, scanning electron microscopy （SEM）, transmission electron microscopy （TEM）, and selected-area electron diffraction （SAED）. And the magnetic properties of the 3D Ni nanostructures were measured as well. Results indicated that solvothermal process could be successfully used to prepare 3D dandelion-like nanostructures of Ni at a relatively mild temperature of 100℃. And the conclusions were made as follows： as-prepared Ni samples had obvious shape anisotropy and were composed of fine nanocrystallites, while they had significantly enhanced ferromagnetic properties than bulk Ni and Ni nanoparticles.

关键词： Nickel 3D nanostructures Preparation Magnetic properties

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Standard friction prediction model of long-distance hot oil pipelines

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Petroleum Science 2020年第2期17卷 487-498页

作者： Tao Yu Chuan-xian Li Bo Yao zhi-jun zhang Yi Guo Li-jun Liu College of Pipeline and Civil Engineering Shandong Provincial Key Laboratory of Oil&Gas Storage and Transportation SafetyChina University of Petroleum(East China)Qingdao 266580ShandongChina Petrochina Oil and Gas Pipeline Control Center Beijing 100007China Richfit Information Technology Co.Ltd Beijing 100007China

We developed a predictive model for the pipeline friction in the 520-730 m^3/h transmission range using the multi-layerperceptron-back-propagation(MLP-BP)method and analyzing the unit friction data after the pigging of a hot oil *** view of the shortcomings of the MLP-BP model,two optimization methods,the genetic algorithm(GA)and mind evolutionary algorithm(MEA),were used to optimize the MLP-BP *** research results were applied to the standard friction prediction of three sections of a hot oil *** the GA and MEA optimizations,the average errors of the three sections were 0.0041 MPa for the GA and 0.0012 MPa for the MEA,and the mean-square errors were 0.083 and 0.067,*** MEA-BP model prediction results were characterized by high precision and small *** MEABP prediction model was applied to the analysis of the wax formation 60 and 90 days after *** analysis results showed that the model can effectively guide pipe pigging and *** was little sample data for the individual transmission and oil temperature steps because the model was based on actual production data modeling and analysis,which may have affected the accuracy and adaptability of the model.

关键词： Hot oil pipeline Friction MLP-BP GA MEA

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OIL-WATER TWO-PHASE FLOW INSIDE T-junCTION

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Journal of Hydrodynamics 2008年第2期20卷 147-153页

作者： WANG Li-yang WU Ying-xiang ZHENG zhi-chu GUO jun zhang jun TANG Chi Laboratory of Applied Fluid Dynamics Department of Engineering Science Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China

The oil / water two-phase flow inside T-junctions was numerically simulated with a 3-D two-fluid model, and the turbulence was described using the mixture k- ε model. Some experiments of oil / water flow inside a single T-junction were conducted in the laboratory. The results show that the separating performance of T-junction largely depends on the inlet volumetric fraction and flow patterns. A reasonable agreement is reached between the numerical simulation and the experiments for both the oil fraction distribution and the separation efficiency.

关键词： T-junction two-phase flow liquid / liquid separation numerical simulation

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A twin-axial[5]pseudorotaxane based on cucurbit[8]uril and a-cyclodextrin

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Chinese Chemical Letters 2013年第11期24卷 949-952页

作者： Li-Hua Wang zhi-jun zhang Heng-Yi zhang Hai-Lang Wu Yu Liu Department of Chemistry State Key Laboratory of Elemento-Organic Chemistry Nankai University

A twin-axial hetero[5]pseudorotaxane was constructed based on 1-hexyl-4,40-bipyridinium guest 1 and cucurbit[8]uril（CB[8]）and a-cyclodextrin（a-CD）.In its structure,CB[8]included two bipyridinium units to realize the twin-axial mode,and the hexyl chain was threaded into the cavity of ***[5]pseudorotaxane contains two types of macrocyclic hosts while the single axial and twin axial modes co-exist in its *** transformation of[5]pseudorotaxane could be realized by the addition of acid and 2,6-dihydroxynaphthalene（HN）.

关键词： Pseudorotaxane Cucurbituril Cyclodextrin Self-assembly

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