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Journal of Hydrodynamics 2022年第6期34卷 1021-1031页

作者： Guang-hang Wang Yan Du zhi-jian xiao jian Huang zhi-ying Wang Hong-chen Li Jing-zhu Wang Yi-wei Wang Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing100190China School of Future Technology University of the Chinese Academy of SciencesBeijing100049China School of Engineering Science University of the Chinese Academy of SciencesBeijing100049China Department of Biomedical Engineering ThoraxcenterErasmus MC University Medical Center RotterdamRotterdamThe Netherlands

When it is generated in extreme vicinity to a water surface,an oscillating bubble bursts into the atmosphere and high-pressure gas is simultaneously exhausted from it,forming a splash sheet and an open *** dynamics of the splash sheet induced by the bursting of the oscillating bubble has drawn increasing attention,but it is not clearly *** conduct a numerical simulation in the framework of open-source software *** volume of fluid and Reynolds-Averaged Navier-Stokes methods are used to precisely capture the gas-liquid interface and obtain flow structure,*** addition,an experimental setup is carried out based on an object distance compensation method for validation of the numerical *** patterns are summarized:(1)An open splash,(2)A sealed splash depending on whether a splash sheet completely *** numerical results shows that the bubble bursting is induced by the Rayleigh-Taylor ***,the splash closures are discussed for two patterns.

关键词： Cavitation bubble ventilation splash sheet flow patterns Rayleigh-Taylor instability

Effects of cavitation on vortex-induced vibration of a flexible circular cylinder simulated by fluid-structure interaction method

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Journal of Hydrodynamics 2022年第3期34卷 499-509页

作者： zhi-jian xiao Shi-hao Yang Cao Yu Zhen Zhang Lei Sun jiang Lai Yan-ping Huang Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing100190China Nuclear Power Institute of China Chengdu610041China Beijing Electro-mechanical Engineering Institute Beijing100074China State Key Laboratory of Mechanical Behavior and System Safety of Traffic Engineering Structures Shijiazhuang Tiedao UniversityShijiazhuang050043China

To investigate the effects of the cavitation on the vortex-induced vibration,the flow and the vibration characteristics of a flexible circular cylinder in the non-cavitating and cavitating flows at Re=200 are simulated using a fluid-structure interaction(FSI)solver,developed in the OpenFOAM *** accuracy of the fluid-structure interaction solver is verified using the benchmark *** a freely vibrating circular cylinder,the characteristics of the vortex-induced vibration are determined at different frequency *** frequency lock-in is observed in both the cavitating flow and the non-cavitating flow,and the lock-in frequency range is larger in the cavitating flow with a smaller vibration *** the lock-in frequency range,due to the reduction of the fluid forces and the resonance effects at the dominant frequency,the vibration amplitude is decreased in the cavitating flow,as compared to the non-cavitating ***,the low-density vapor and the cavitation collapse weaken the constraints of the flow and the stability of the shedding vortices,respectively,making the flow around the circular cylinder more sensitive to the structural ***,the lock-in frequency range is larger in the cavitating flow.

关键词： Fluid-structure interaction(FSI) cavitation lock-in frequency vortex-induced vibrations OpenFOAM

The Improvement of Bulk-Heterojunction Order in Polymer Photovoltaic Device

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光谱学与光谱分析 2011年第12期31卷 3175-3179页

作者： YUAN Dan CHEN zhi-jian xiao Li-xin MU Li-ping QU Bo GONG Qi-huang State Key Laboratory for Mesoscopic Physics and Department of Physics Peking UniversityBeijing 100871China

The blend morphology and vertical arrangement are critical to the performance of organic bulk-heterojunction photovoltaic *** the present paper,the authors proposed a new annealing method that controls the blend morphology and vertical arrangement of two materials by means of simultaneously applying external electrical field and violet irradiation on the active layer of poly(3-hexylthiophene) (P3HT) and -phenyl C61-butyric acid methyl ester(PCBM) during annealing *** using this annealing method,the power conversion efficiency increased by 36%,which was caused by vertical phased-separated blend of crystalline P3HT and PCBM and better charge extraction of electrodes.X-ray photoelectron spectroscopy(XPS) was measured to prove more fullerene derivatives at the organic/cathode interfaces by using this annealing *** X-ray diffraction(XRD) analysis and UV-Vis absorption spectrum analysis also revealed more ordered polymer crystallization.

关键词： Polymer photovoltaic device Bulk-heterojunction Annealing method

Study on mechanisms of hypertension in rat adult offspring following prenatal exposure to immuno-inflammatory stimulants

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沈阳药科大学学报 2008年第S1期25卷 109-110页

作者： ZHOU jian-zhi,LI xiao-hui(Institute of Materia Medica,College of Pharmacy,Third Military Medical University,Chongqing 400038,China)

Objective Essential hypertension(EH)is one of the most common cardiovascular disease and the main causes of human *** significant progress has been made in our lab,it was found that exterior stimulation during pregnancy may play a key role in chronicle adult ***,what factors affect the growth of fetus after those exterior stimulation and why has not been *** on our previous finding,this study intends to investigate how immuno-inflammatory stimulation affect the development of *** ***-Dawley(SD)rats,dams in each group received *** of 0.79 mg·kg-1 LPS,8 mg·kg-1 zymosan or sterile saline respectively on their gestational days 8,10,and *** serums were collected in tail nick at 2 h after the last injection,and the amniotic fluid was mixed at 2,12,24,48 h after the last ***-α and IL-6 levels of serum and amniotic fluid were measured by RIA ***-α and IL-6 mRNA levels were quantitated in amnion,placenta,amniotic fluid,Embryo and macrophage by real-time fluorescent *** *** serum level of TNF-α and IL-6 in LPS group and zymosan group was higher than that in control group(P<0.01).It showed that there was immuno-imflammatory response after LPS or zymosan injection in *** mRNA levels of TNF-α and IL-6 was very higher in macrophage than in other *** embryo,the mRNA level of IL-6 was more than other organization,but the mRNA level of TNF-α was lower than other ***,the IL-6 mRNA level of LPS group and zymosan group was higher several dozens times than control group on 24 h and 48 *** It suggested that IL-6 was important in the model that prenatalexposure to immuno-inflammatory stimulant results in increases of blood pressure and body weight in rats.

关键词： hypertension inflammation embryo

Multiparameter magnetic resonance imaging-based radiomics model for the prediction of rectal cancer metachronous liver metastasis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 62-72页

作者： zhi-Da Long xiao Yu zhi-Xiang Xing Rui Wang Department of Hepatobiliary and Pancreaticosplenic Surgery Jingzhou Hospital Affiliated to Yangtze UniversityJingzhou 434100Hubei ProvinceChina

BACKGROUND The liver,as the main target organ for hematogenous metastasis of colorectal cancer,early and accurate prediction of liver metastasis is crucial for the diagnosis and treatment of ***,this study aims to investigate the application value of a combined machine learning(ML)based model based on the multiparameter magnetic resonance imaging for prediction of rectal metachronous liver metastasis(MLM).AIM To investigate the efficacy of radiomics based on multiparametric magnetic resonance imaging images of preoperative first diagnosed rectal cancer in predicting MLM from rectal *** We retrospectively analyzed 301 patients with rectal cancer confirmed by surgical pathology at Jingzhou Central Hospital from January 2017 to December *** participants were randomly assigned to the training or validation queue in a 7:3 *** first apply generalized linear regression model(GLRM)and random forest model(RFM)algorithm to construct an MLM prediction model in the training queue,and evaluate the discriminative power of the MLM prediction model using area under curve(AUC)and decision curve analysis(DCA).Then,the robustness and generalizability of the MLM prediction model were evaluated based on the internal validation set between the validation queue *** Among the 301 patients included in the study,16.28%were ultimately diagnosed with MLM through pathological *** analysis showed that carcinoembryonic antigen,and magnetic resonance imaging radiomics were independent predictors of ***,the GLRM prediction model was developed with a comprehensive nomogram to achieve satisfactory *** prediction performance of GLRM in the training and validation queue was 0.765[95%confidence interval(CI):0.710-0.820]and 0.767(95%CI:0.712-0.822),*** with GLRM,RFM achieved superior performance with AUC of 0.919(95%CI:0.868-0.970)and 0.901(95%CI:0.850-0.952)in the training and validation queue,respect

关键词： Rectal cancer Metachronous liver metastases Magnetic resonance imaging Radiomics Machine learning

Damage to Liver Function after TACE of Anticancer Drugs in Hepatocellular Carcinoma:Evaluation of Two Kinds of Anticancer Drugs

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介入放射学杂志 2006年第6期15卷 351-355页

作者： LU Wei LI Yan-hao YU zhi-jian HE xiao-feng CHEN Yong ZHAO jian-bo Department of Interventional Radiology Nan.fang Hospital Southern Medical University 510515

Objective To study the damage of liver function after transcatheter arterial chemoembolization (TACE) with low-dose versus conventional-dose anticancer drugs in patients with hepatocellular carcinoma (HCC). Methods One hundred and twelve patients with unresectable HCC were randomly divided into two groups (A and B) to receive superselective TACE. Low-dose anticancer drugs including mitomycin C (MMC) 2 ～ 8 mg,epirubicin (EPI) 5 ～ 10 mg and carboplatin (CBP) 100 mg were used in group A (n = 52),and conventional-dose of anticancer drugs (MMC 10 mg,EPI 40 mg and CBP 300 mg)for patients in group B(n = 60). Lipiodol-anticancer drugs emulsion was injected into the feeding arteries of tumor and then followed by embolization of gelatin sponge (GS) or polyvinyl alcohol (PVA) particles. Laboratory examination of the liver function including Child-Pugh scores,total bilirubin (TBIL),albumin (ALB) and alanine aminotransferase (ALT) were evaluated respectively before TACE and at third day,one week and four weeks after this procedure. Results In both groups,TBIL,ALT,and Child-Pugh scores increased (P 0.05). On the contrary in group B,a significant difference (P < 0.05) was found in the comparison of these parameters (except ALT). Conclusion Superselective TACE with low-dose anticancer drugs may induce transient impairment of liver function in the patients with HCC,but those patients used conventional-dose of anticancer drugs frequently cause lasting and more serious worsening of liver function. (J Intervent Radiol,2006,15: 351-355)

关键词： Carcinoma Hepatocellular chemoembolization Therapeutic liver function

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国际组织高层领导语言素养研究:中国视角

外语学刊 2024年第5期 10-17页

作者：张治国翦晓晓上海海事大学外国语学院上海201306

国际组织高层领导位高权重,有更多的话语权和影响力,但在国际组织中担任高层领导的中国人偏少。这种现象的出现跟许多因素有关,其中一个重要因素是我国参与国际组织高层领导候选人的语言素养不足。为此,本文探讨了中国在国际组织中担任... 详细信息

国际组织高层领导位高权重,有更多的话语权和影响力,但在国际组织中担任高层领导的中国人偏少。这种现象的出现跟许多因素有关,其中一个重要因素是我国参与国际组织高层领导候选人的语言素养不足。为此,本文探讨了中国在国际组织中担任高层领导职务人员的语言素养情况,旨在发现一些规律,供国人参考。我们首先收集整理了30位在国际组织中担任过或仍在担任高层领导的中国人的履历;然后根据这些履历中的教育背景和工作经历来梳理他们在语言素养方面的发展特点或规律;依此,最后提出6种基于语言素养的国际组织高端人才培育模式。

关键词：国际组织高层领导语言素养中国视角

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混沌码正交频分复用SAR抗干扰能力研究

系统仿真学报 2009年第22期21卷 7359-7362,7367页

作者：冯祥芝许小剑北京航空航天大学电子信息工程学院北京100083

传统线性调频波合成孔径雷达(LFM-SAR)不能对抗复制欺骗干扰,提出采用混沌码正交频分复用合成孔径雷达(COFDM-SAR)信号,利用混沌码初值敏感性可产生大量不同混沌码序列,使COFDM-SAR每一个脉冲的信号正交,从而使其不但能抗噪声压制干扰,... 详细信息

传统线性调频波合成孔径雷达(LFM-SAR)不能对抗复制欺骗干扰,提出采用混沌码正交频分复用合成孔径雷达(COFDM-SAR)信号,利用混沌码初值敏感性可产生大量不同混沌码序列,使COFDM-SAR每一个脉冲的信号正交,从而使其不但能抗噪声压制干扰,而且具有抗复制欺骗干扰的能力。给出了COFDM-SAR信号生成方法和成像处理方法,并对其抗噪声调频干扰、复制欺骗干扰等典型有源干扰的能力与LFM-SAR进行了比较。计算机仿真结果表明,COFDM-SAR的抗复制欺骗和抗噪声压制干扰的能力均优于LFM-SAR。

关键词：混沌码正交频分复用合成孔径雷达抗干扰

Study on mechanisms of hypertension in rat adult offspring following prenatal exposure to immuno-inflammatory stimulants

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Study on mechanisms of hypertension in rat adult offspring f...

Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

两岸三地药理学与临床药理学术会议

作者： ZHOU jian-zhi LI xiao-hui (Institute of Materia Medica, College of Pharmacy, Third Military Medical University, Chongqing 400038, China)

Objective Essential hypertension (EH) is one of the most common cardiovascular disease and the main causes of human *** significant progress has been made in our lab,it was found that exte- rior stimulation during pregnancy may play a key role in chronicle adult ***,what factors af- fect the growth of fetus after those exterior stimulation and why has not been *** on our previ- ous finding,this study intends to investigate how immuno-inflammatory stimulation affect the development of *** ***-Dawley (SD) rats,dams in each group received *** of 0.79 mg·kg LPS,8 mg·kg zymosan or sterile saline respectively on their gestational days 8,10,and *** serums were collected in tail nick at 2 h after the last injection,and the amniotic fluid was mixed at 2,12, 24,48 h after the last ***-αand IL-6 levels of serum and amniotic fluid were measured by RIA ***-αand IL-6 mRNA levels were quantitated in amnion,placenta,amniotic fluid,Embryo and macrophage by real-time fluorescent *** *** serum level of TNF-αand IL-6 in LPS group and zymosan group was higher than that in control group (P<0.01).It showed that there was immuno-imflammatory response after LPS or zymosan injection in *** mRNA levels of TNF-αand IL-6 was very higher in macrophage than in other *** embryo,the mRNA level of IL-6 was more than other organization,but the mRNA level of TNF-αwas lower than other ***, the IL-6 mRNA level of LPS group and zymosan group was higher several dozens times than control group on 24 h and 48 *** It suggested that IL-6 was important in the model that prenatalexposure to immuno-inflammatory stimulant results in increases of blood pressure and body weight in rats.

关键词： hypertension inflammation embryo

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen Gao Jing-Wen Li Hui Ye Xue-zhi Zhang jian-Xiang Liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly