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Olfactory ensheathing cells promote the migration of Schwann cells by nerve growth factor

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Olfactory ensheathing cells promote the migration of Schwann...

Predicting Lactobacillus delbrueckii ***-Streptococcus thermophilus interactions based on a highly accurate semi-supervised learning method

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： li CAO,Yan-ling ZHU,zhi-Da SU,Bao-Lai LU,zhi-hui HUANG,li-Fang MU,Cheng HE Department of Neurobiology,The Second Military Medical University,Shanghai 200433,China

＜正＞Transplantation of Schwann cells（SCs） and olfactory ensheathing cells（OECs） have emerged as very promising therapies for spinal cord *** important features of interaction between SCs and OECs are beginning to be appreciated,although the underlying mechanism remains *** the present study,we tested the effects of OECs on SCs migration using a range of in vitro migration *** found that SCs migrated abundantly upon OECs monolayer, and the migration-promoting effects were identified to be due to the secreted diffusible factors in OEC-derived conditioned medium（OEC-CM）.Furthermore,neutralizing nerve growth factor（NGF） in OEC-CM with NGF antibody could block this ***,we found that NGF promotes SCs migration even on astrocyte *** together,these findings provide the first evidence that OECs can promote SCs migration in astrocytic environment by secreted NGF.

关键词： olfactory ensheathing cells Schwann cells cell migration nerve growth factor spinal cord injury

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Science China(life Sciences) 2025年第2期68卷 558-574页

作者： Shujuan Yang Mei Bai Weichi liu Weicheng li zhi Zhong Lai-Yu Kwok Gaifang Dong zhihong Sun Key Laboratory of Dairy Biotechnology and Engineering Ministry of EducationInner Mongolia Agricultural UniversityHohhot 010018China Key Laboratory of Dairy Products Processing Ministry of Agriculture and Rural AffairsInner Mongolia Agricultural UniversityHohhot 010018China Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering Inner Mongolia Agricultural UniversityHohhot 010018China Collaborative Innovative Center for Lactic Acid Bacteria and Fermented Dairy Products Ministry of EducationInner Mongolia Agricultural UniversityHohhot 010018China College of Computer and Information Engineering Inner Mongolia Agricultural UniversityHohhot 010018China Inner Mongolia Autonomous Region Key Laboratory of Big Data Research and Application of Agriculture and Animal Husbandry Hohhot 010018China

Lactobacillus delbrueckii ***(***)and Streptococcus thermophilus(***)are commonly used starters in milk *** experiments revealed that *** interactions(Lb St I)substantially impact dairy product quality and *** biological humidity experiments are time-consuming and labor-intensive in screening interaction combinations,an artificial intelligence-based method for screening interactive starter combinations is ***,in the current research on artificial intelligence based interaction prediction in the field of bioinformatics,most successful models adopt supervised learning methods,and there is a lack of research on interaction prediction with only a small number of labeled ***,this study aimed to develop a semi-supervised learning framework for predicting Lb St I using genomic data from 362 isolates(181per species).The framework consisted of a two-part model:a co-clustering prediction model(based on the Kyoto Encyclopedia of Genes and Genomes(KEGG)dataset)and a Laplacian regularized least squares prediction model(based on K-mer analysis and gene composition of all isolates datasets).To enhance accuracy,we integrated the separate outcomes produced by each component of the two-part model to generate the ultimate Lb St I prediction results,which were verified through milk fermentation *** through milk fermentation experiments confirmed a high precision rate of 85%(17/20;validated with 20 randomly selected combinations of expected interacting isolates).Our data suggest that the biosynthetic pathways of cysteine,riboflavin,teichoic acid,and exopolysaccharides,as well as the ATP-binding cassette transport systems,contribute to the mutualistic relationship between these starter bacteria during milk ***,this finding requires further experimental *** presented model and data are valuable resources for academics an

关键词： Lactobacillus delbrueckii subsp.bulgaricus and Streptococcus thermophilus interaction prediction semi-supervised learning dairy starter artificial intelligence milk fermentation

I_(2)-DMSO mediated tetra-functionalization of enaminones for the construction of novel furo[2,3:4,5]pyrimido[1,2-b]indazole skeletons via in situ capture of ketenimine cations

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Chinese Chemical Letters 2025年第1期36卷 277-282页

作者： You Zhou li-Sheng Wang Shuang-Gui Lei Bo-Cheng Tang zhi-Cheng Yu Xing li Yan-Dong Wu Kai-Lu Zheng An-Xin Wu National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs The First Dongguan Affiliated HospitalSchool of PharmacyGuangdong Medical UniversityDongguan 523808China State Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityHong Kong SAR 999077China

The first-ever synthesis of the unknown furo[2,3:4,5]pyrimido[1,2-b]indazole skeleton was demonstrated based on the undiscovered tetra-functionalization of enaminones,with simple substrates and reaction *** key to realizing this process lies in the multiple trapping of the in situ generated ketenimine cation by the 3-aminoindazole,which results in the formation of four new chemical bonds and two new rings in one ***,the products of this new reaction were found to exhibit aggregationinduced emission(AIE)without modification.

关键词： Unknown skeleton Tetra-functionalization Ketenimine cations Aggregation-induced emission

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大型土木工程结构的模型试验仿真

系统仿真学报 2008年第18期20卷 4987-4990页

作者：杜永峰邱志涛李慧兰州理工大学防震减灾研究所兰州730050

近年来仿真技术得到了迅速发展,在国民经济各个领域中都发挥出了重要的作用。大型土木工程结构试验不但试验周期长而且还要消耗大量的人力、物力和财力,试验中的某些现象较难捕捉,这些都给利用硬模型试验结果揭示结构损伤机理带来了困... 详细信息

近年来仿真技术得到了迅速发展,在国民经济各个领域中都发挥出了重要的作用。大型土木工程结构试验不但试验周期长而且还要消耗大量的人力、物力和财力,试验中的某些现象较难捕捉,这些都给利用硬模型试验结果揭示结构损伤机理带来了困难。利用仿真技术的无破坏性和可多次重复性就可以克服这些困难。通过一组厚板筏式基础试件的冲切损伤实例,说明了仿真技术在土木工程结构试验中的应用。利用有限元软件ADINA,较为理想地模拟了搁置于弹塑性地基上的筏板和仅有周边支承的普通平板在竖向荷载作用下发生冲切破坏时的裂缝分布和发展状况,为硬模型试验设计提供了有效的帮助,同时对解释硬模型试验的破坏机理发挥了重要的作用。

关键词：仿真冲切试验装置有限元损伤

DNA walker induced “signal on” fluorescence aptasensor strategy for rapid and sensitive detection of extracellular vesicles in gastric cancer

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Chinese Chemical Letters 2025年第2期36卷 328-331页

作者： Gaojian Yang zhiyang li Rabia Usman Zhu Chen Yuan liu Song li hui Chen Yan Deng Yile Fang Nongyue He State Key Laboratory of Digital Medical Engineering School of Biological Science and Medical Engineering Southeast University Department of Clinical Laboratory the Affiliated Drum Tower Hospital of Nanjing University Medical School Hunan Key Laboratory of Biomedical Nanomaterials and Devices Hunan University of Technology Institute of Cytology and Genetics School of Basic Medical Sciences Hengyang Medical School University of South China Institute for Future Sciences University of South China

The extracellular vesicles show great potential as a noninvasive biomarker for the early detection of cancer. Hence, there is an urgent requirement to create biosensors that are time-saving, simple, and easily scalable in order to accomplish rapid, sensitive, and quantitative detection of extracellular vesicles. In this study, we present a self-propelled DNA walker powered by endonuclease *** CI, which enables the development of a “signal on” sensing platform for the rapid and highly sensitive detection of extracellular vesicles. The DNA motor employed tracks made of streptavidin magnetic beads, which consisted of substrate strands labeled with fluorescein and motor strands locked by aptamers. The aptamer recognition of the target protein on extracellular vesicles unlocked the motor strand, initiating the DNA motor process. After replacing the optimal buffer solution containing the endonuclease *** I, the motor strands autonomously moved along the streptavidin magnetic beads track, continuously releasing fluorescent molecules and producing detectable fluorescence signals. Under optimal conditions, the detection range was from 2×10～4particles/mL to 2×10～9particles/mL, with a detection limit of 2.9×10～3particles/mL,demonstrating excellent selectivity. This method has demonstrated good selectivity in different tumorderived extracellular vesicles and performs well in complex biological samples. The ability to effectively analyze surface proteins of extracellular vesicles in a short period of time gives our DNA walker a tremendous potential for developing simple and cost-effective clinical diagnostic devices.

关键词： Aptamer Detection Extracellular vesicles Nt.BbvCI Streptavidin magnetic beads

Heat shock transcription factors regulate thermotolerance gene networks in tomato(Solanum lycopersicum)flower buds

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Horticultural Plant Journal 2025年第1期11卷 199-210页

作者： Hongwei li Yun liu Yongyao li Qinqin Yang Tailai Yang zhi Zhou Yafei li Na Zhang Yaqing Lyu Yingfang Zhu Tao lin College of Horticulture China Agricultural UniversityBeijing 100193China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518124China State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifengHenan 450046China

Tomato(Solanum lycopersicum)is an important fruit and vegetable crop in *** fertility of tomato reproductive organs can be dramatically decreased when ambient temperatures rise above 35°C,reducing tomato fruit *** is necessary to identify transcription factors(TFs)and target genes involved in heat stress response(HSR)signaling cascades in tomato flower buds to improve tomato plant *** this study,we profiled genes expressed in three developmental stages of tomato flower *** and turquoise modules for heat stress(HS)were identified through gene co-expression network analysis,and the genes within these modules were enriched in HS-related *** focusing on the TFs in the two modules,we identified several novel HSR-related TFs,including SlWRKY75,SlMYB117,and ***,homology analysis illustrated a conserved signaling cascade in ***,we identified and experimentally validated four HSF-regulated genes,namely SlGrpE,SlERDJ3A,SlTIL,and SlPOM1,that likely modulate thermotolerance in *** results provide a high-resolution atlas of gene expression during tomato flower bud development under HS conditions,which is a valuable resource for uncovering potential regulatory networks associated with the HSR in tomato.

关键词： Tomato Heat stress Transcriptome Transcription factor Thermotolerance

Planar Hall plateau in magnetic Weyl semimetals

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Science Bulletin 2025年第2期70卷 187-192页

作者： Lei li Chaoxi Cui Run-Wu Zhang zhi-Ming Yu Yugui Yao Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(MOE)School of PhysicsBeijing Institute of TechnologyBeijing 100081China Beijing Key Lab of Nanophotonics&Ultrafine Optoelectronic Systems School of PhysicsBeijing Institute of TechnologyBeijing 100081China International Center for Quantum Materials Beijing Institute of TechnologyZhuhai 519000China

Despite the rapid progress in the study of planar Hall effect(PHE)in recent years,all the previous works only showed that the PHE is connected to local geometric quantities,such as Berry ***,for the first time,we point out that the PHE in magnetic Weyl semimetals is directly related to a global quantity,namely,the Chern number of the Weyl *** leads to a remarkable consequence that the PHE observation predicted here is robust against many system details,including the Fermi *** main difference between non-magnetic and magnetic Weyl points is that the latter breaks time-reversal symmetry T,thus generally possessing an energy *** semiclassical Boltzmann theory,we investigate the PHE in generic magnetic Weyl models with energy tilt and arbitrary Chern *** find that by aligning the magnetic and electric fields in the same direction,the trace of the PHE conductivity contributed by Berry curvature and orbital moment is proportional to the Chern number and the energy tilt of the Weyl points,resulting in a previously undiscovered quantized PHE plateau by varying the Fermi *** further confirm the existence of PHE plateaus in a more realistic lattice model without T *** proposing a new quantized physical quantity,our work not only provides a new tool for extracting the topological character of the Weyl points but also suggests that the interplay between topology and magnetism can give rise to intriguing physics.

关键词： Magnetic Weyl semimetals Planar Hall effect Quantized plateau Chern number

High-temperature oxidation behavior and degradation mechanism of chromium-coated zirconium alloy cladding: a review

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Tungsten 2025年第1期7卷 50-70页

作者： Yi li Bei-Qi Wang Xin-Yin Zhang Shi-Jie Wang Cong-Yi li hui-Long Yang Ran-Ran Su Tong liu School of Mechanical Engineering Shanghai Jiao Tong University College and Graduate School of Arts and Sciences University of Virginia Global Institute of Future Technology Shanghai Jiao Tong University

Accident-tolerant fuels(ATF) have been extensively studied to reduce the production rate and total amount of heat and hydrogen generated from high-temperature steam oxidation during severe ***-coated zirconium alloy cladding has become one of the most promising candidates for ATF because of its excellent corrosion and oxidation *** paper provides a comprehensive overview of the research progress on oxidation behaviors and degradation mechanisms in chromium-coated zirconium alloy cladding under high-temperature *** techniques to strengthen the oxidation resistance are highlighted and ***,challenges and opportunities for various future directions are addressed.

关键词： Accident-tolerant fuel Chromium coating Degradation mechanism High-temperature oxidation behavior Zirconium alloy cladding

Modular assembly of Co4-thiacalix[4]arene units and Keggin-type SiW12O40 for visible-light photothermal conversion

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Tungsten 2025年第1期7卷 112-119页

作者： Jia-hui li Qing Zhao Dong-Ao Mao Kun Zhou Bao-Kuan Chen Yan-Feng Bi School of Petrochemical Engineering Liaoning Petrochemical University

The construction of metal-organic coordination clusters（MCCs） using modular secondary building units is an important method for preparing functional *** this study,two new MCCs modularly assembled from Keggin-type {SiW12O40}H4TC4A=p-tert-Butylthiacalix[4]arene(SiW12) units and thiacalixarene-supported Co4-thiacalix[4]arene(Co4-TC4A polynuclear second-building units（PSBUs,H4TC4A=p-tert-Butylthiacalix[4]arene） are *** two MCCs,abbreviated as Co4-SiW12and Co8-SiW12,were structurally characterized by single-crystal X-ray *** Co4-SiW12is a supramolecular structure involving cation-anion interactions between Co4-TC4A PSBUs and ***8-SiW12features "barbell-like" shapes with two Co4-TC4A coordinatively linked to a Keggin-type SiW12unit on opposite via W-O_t-Co *** coordination of Co4-TC4A to SiW12in Co8-SiW12resulted in significantly improved photothermal conversion performances compared with Co4-SiW12and pure SiW12or ***-gap determination and photophysical analysis combined with density functional theory calculations indicated the binding mode between Co4-TC4A PSBUs and SiW12,which considerably influences the way of electron transport and the conversion ability of visible light to heat.

关键词： Modular construction Photothermal conversion Polyoxometalate Thiacalixarene