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构建方便、安全、可靠的新电子政务系统

苏州大学学报（工科版） 2003年第5期23卷 25-29页

作者：芮延年董玉民张志红纽秀山苏州大学机电工程学院江苏苏州215021 青岛建筑工程学院山东青岛266021

现代新型电子政务管理系统包括“行政决策系统”、“行政执行系统”和“行政监督系统”。本文通过研究构建了电子政务系统的功能模型,并在此基础上对电子政务系统的权限管理、数字签名,进行了较为深入的研究,为构建方便、安全、可靠的... 详细信息

现代新型电子政务管理系统包括“行政决策系统”、“行政执行系统”和“行政监督系统”。本文通过研究构建了电子政务系统的功能模型,并在此基础上对电子政务系统的权限管理、数字签名,进行了较为深入的研究,为构建方便、安全、可靠的新电子政务系统平台奠定了理论基础。

关键词：电子政务管理系统功能模型权限管理数字签名构建

Enhanced corrosion resistance of epoxy resin coating via addition of CeO_(2) and benzotriazole

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Chinese Journal of Chemical Engineering 2024年第3期67卷 89-96页

作者： Xu Han Ruijie Guo Baolong niu hong Yan College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of EducationTaiyuan University of TechnologyTaiyuan 030024China

The use of fillers to enhance the corrosion protection of epoxy resins has been widely *** this work,cerium dioxide(CeO_(2))and benzotriazole(BTA)were introduced into an epoxy resin to enhance the corrosion resistance of Q235 carbon *** electron microscopy results indicated that the CeO_(2) grains were rod-like and ellipsoidal in shape,and the distribution pattern of BTA was analyzed by energy dispersive *** dynamic potential polarization curve proved the excellent corrosion resistance of the composite epoxy resin with CeO_(2) and BTA co-addition,and electrochemical impedance spectroscopy test analysis indicated the significantly enhanced long-term corrosion protection performance of the composite *** the optimal protective performance was provided by the coating containing 0.3%(mass)CeO_(2) and 20%(mass)BTA,which was attributed to the barrier performance of CeO_(2) particles and the chemical barrier effect of *** formation of corrosion products was analyzed using X-ray *** addition,the corrosion resistance mechanism of the coating was also discussed in detail.

关键词： Benzotriazole Cerium dioxide Corrosion resistance Carbon steel Epoxy resin coating Preparation

A multifunctional separator with Mg(OH)2 nanoflake coatings for safe lithium-metal batteries

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Journal of Energy Chemistry 2021年第1期30卷 75-83,I0003页

作者： Dian-Hui Han Meng Zhang Peng-Xian Lu Yun-Lu Wan Qiu-Ling Chen hong-Yu niu zhi-Wei Yu School of Materials Science and Engineering Henan University of TechnologyZhengzhou 450007HenanChina Zhengzhou Key Laboratory for Clean Energy Henan University of TechnologyZhengzhou 450007HenanChina

Dendrite growth and thermal runaway induce serious safety hazards,impeding the practical applications of lithium metal batteries(LMBs).Although extensive advances have been attained in terms of LMB safety,most work only focus on a single aspect at a *** paper reports a multifunctional separator coated by Mg(OH)2 nanoflakes with various excellent properties including electrolyte wettability,ionic conductivity,Li+ transference number,puncture strength,thermal stability and flame *** used in LMBs,the Mg(OH)2 nanoflake coatings enable uniform Li+ distributing,which makes it homogeneous to deposit lithium,realizing effective dendrite suppression and less volume ***,Mg(OH)2 coatings can ensure LMBs are in normal conditions without thermal runaway until 140 ℃.A part of lithium can be converted into Li+ ions by Mg(OH)2 during repeated charge/discharge cycles,not only reducing the risk of separator damage and consequent short circuit,but also replenishing the capacity loss of *** Mg(OH)2 nanoflakes can coat on all kinds of commercial separators to improve their performances,which offers a facile but effective strategy for fabricating multifunctional separators and a comprehensive insight into enhancing LMB safety.

关键词： Dendrite-free Thermal stability Li metal batteries Multifunctional separators Mg(OH)2 nanoflakes

Damage identification method of girder bridges based on finite element model updating and modal strain energy

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Science China(Technological Sciences) 2015年第4期58卷 701-711页

作者： niu Jie ZONG Zhou hong CHU Fu Peng School of Civil Engineering Southeast University Vibration Engineering Section College of Engineering Mathematics and Physical Sciences University of Exeter Fujian Academy of Building Research

A timely and accurate damage identification for bridge structures is essential to prevent sudden failures/collapses and other catastrophic *** on response surface model(RSM)updating and element modal strain energy(EMSE)damage index,this paper proposes a novel damage identification method for girder bridge *** effectiveness of the proposed damage identification method is investigated using experiments on four simply supported steel *** Xiabaishi Bridge,a prestressed continuous rigid frame bridge with large span,as the engineering background,the proposed damage identification method is validated by using numerical simulation to generate different bearing damage ***,the efficiency of the method is justified by considering its application to identifying cracking damage for a real continuous beam bridge called Xinyihe *** is concluded that the EMSE damage index is sensitive to the cracking damage and the bearing *** locations and levels of multiple cracking damages and bearing damages can be also *** results illuminate a great potential of the proposed method in identifying damages of real bridge structures.

关键词： damage identification response surface model finite element model updating element modal strain energy damage index girder bridge

Cascading V_(2)O_(3)/N-doped carbon hybrid nanosheets as high-performance cathode materials for aqueous zinc-ion batteries

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Chinese Chemical Letters 2022年第3期33卷 1430-1434页

作者： Yue niu Denghui Wang Yingjie Ma Linjie zhi CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100039China

In recent years, especially when there is increasing concern about the safety issue of lithium-ion batteries (LIBs), aqueous Zn-ion batteries (ZIBs) have been getting a lot of attention because of their cost-effectiveness, materials abundance, high safety, and ecological friendliness. Their working voltage and specific capacity are mainly determined by their cathode materials. Vanadium oxides are promising cathode materials for aqueous ZIBs owing to their low cost, abundant resources, and multivalence. However, vanadium oxide cathodes still suffer from unsatisfactory capacity, poor stability, and low electrical conductivity. In this work, cascading V_(2)O_(3)/nitrogen doped carbon (V_(2)O_(3)/NC) hybrid nanosheets are prepared for high-performance aqueous ZIBs by pyrolyzing pentyl viologen dibromide (PV) intercalated V_(2)O5 nanosheets. The unique structure features of V_(2)O_(3)/NC nanosheets, including thin sheet-like morphology, small crystalline V_(2)O_(3) nanoparticles, and conductive NC layers, endow V_(2)O_(3)/NC with superior performance compared to most of the reported vanadium oxide cathode materials for aqueous ZIBs. The V_(2)O_(3)/NC cathode exhibits the discharge capacity of 405 mAh/g at 0.5 A/g, excellent rate capability (159 mAh/g at 20 A/g), and outstanding cycling stability with 90% capacity retention over 4000 cycles at 20 A/g.

关键词： Aqueous zinc ion batteries Cathode materials Vanadium oxides Nitrogen doped carbon 2D nanosheets High performance

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng hongbin Wu Xiaojian Xu Fei niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

Genetic alterations in hepatocellular carcinoma: An update

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World Journal of Gastroenterology 2016年第41期22卷 9069-9095页

作者： Zhao-Shan niu Xiao-Jun niu Wen-hong Wang Laboratory of Micromorphology School of Basic Medicine Medical Department of Qingdao University Oncology Specialty Medical Department of Qingdao University Department of Pathology School of Basic Medicine Medical Department of Qingdao University

Hepatocellular carcinoma(HCC) is one of the leading causes of cancer-related deaths worldwide. Although recent advances in therapeutic approaches for treating HCC have improved the prognoses of patients with HCC, this cancer is still associated with a poor survival rate mainly due to late diagnosis. Therefore, a diagnosis must be made sufficiently early to perform curative and effective treatments. There is a need for a deeper understanding of the molecular mechanisms underlying the initiation and progression of HCC because these mechanisms are critical for making early diagnoses and developing novel therapeutic strategies. Over the past decade, much progress has been made in elucidating the molecular mechanisms underlying hepatocarcinogenesis. In particular, recent advances in next-generation sequencing technologies have revealed numerous genetic alterations, including recurrently mutated genes and dysregulated signaling pathways in HCC. A better understanding of the genetic alterations in HCC could contribute to identifying potential driver mutations and discovering novel therapeutic targets in the future. In this article, we summarize the current advances in research on the genetic alterations, including genomic instability, single-nucleotide polymorphisms, somatic mutations and deregulated signaling pathways, implicated in the initiation and progression of HCC. We also attempt to elucidate some of the genetic mechanisms that contribute to making early diagnoses of and developing molecularly targeted therapies for HCC.

关键词： Genetic alterations Chromosomal instability Somatic mutations Signaling pathways Hepatocellular carcinoma

Long non-coding RNAs in hepatocellular carcinoma: Potential roles and clinical implications

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World Journal of Gastroenterology 2017年第32期23卷 5860-5874页

作者： Zhao-Shan niu Xiao-Jun niu Wen-hong Wang Laboratory of Micromorphology School of Basic MedicineMedical Department of Qingdao University Oncology Specialty Medical Department of Qingdao University Department of Pathology School of Basic MedicineMedical Department of Qingdao University

Long non-coding RNAs(lnc RNAs) are a subgroup of non-coding RNA transcripts greater than 200 nucleotides in length with little or no protein-coding potential. Emerging evidence indicates that lnc RNAs may play important regulatory roles in the pathogenesis and progression of human cancers, including hepatocellular carcinoma(HCC). Certain lnc RNAs may be used as diagnostic or prognostic markers for HCC, a serious malignancy with increasing morbidity and high mortality rates worldwide. Therefore, elucidating the functional roles of lnc RNAs in tumors can contribute to a better understanding of the molecular mechanisms of HCC and may help in developing novel therapeutic targets. In this review, we summarize the recent progress regarding the functional roles of lnc RNAs in HCC and explore their clinical implications as diagnostic or prognostic biomarkers and molecular therapeutic targets for HCC.

关键词： Hepatocellular carcinoma Long non-coding RNAs Function Biomarker Therapeutic target

Recent progress in molecular mechanisms of postoperative recurrence and metastasis of hepatocellular carcinoma

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World Journal of Gastroenterology 2022年第46期28卷 6433-6477页

作者： Zhao-Shan niu Wen-hong Wang Xiao-Jun niu Laboratory of Micromorphology School of Basic MedicineQingdao UniversityQingdao 266071Shandong ProvinceChina Department of Pathology School of Basic MedicineQingdao UniversityQingdao 266071Shandong ProvinceChina Department of Internal Medicine Qingdao Shibei District People's HospitalQingdao 266033Shandong ProvinceChina

Hepatectomy is currently considered the most effective option for treating patients with early and intermediate hepatocellular carcinoma(HCC).Unfortunately,the postoperative prognosis of patients with HCC remains unsatisfactory,predominantly because of high postoperative metastasis and recurrence ***,research on the molecular mechanisms of postoperative HCC metastasis and recurrence will help develop effective intervention measures to prevent or delay HCC metastasis and recurrence and to improve the long-term survival of HCC ***,we review the latest research progress on the molecular mechanisms underlying postoperative HCC metastasis and recurrence to lay a foundation for improving the understanding of HCC metastasis and recurrence and for developing more precise prevention and intervention strategies.

关键词： Hepatocellular carcinoma Recurrence Metastasis Mechanisms Postoperation Intervention