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Forty-six cases of nasopharyngeal carcinoma treated with 50 Gy radiotherapy plus hematoporphyrin derivative:20 years of follow-up and outcomes from the Sun Yat-sen University Cancer Center

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Chinese Journal of Cancer 2016年第6期35卷 53-62页

作者： Bing-Qing Xu Zi-Wei Tu Ya-Lan Tao zhi-gang liu Xiao-Hui Li Wei Yi Chang-Bing Jiang Yun-Fei Xia State Key Laboratory of Oncology in South China Department of Radiation OncologyCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center651 Dongfeng East RoadGuangzhou 510060GuangdongPRChina Department of Radiation Oncology The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510060GuangdongPRChina

Background:With the improved overall survival(OS) of nasopharyngeal carcinoma(NPC) patients,the importance of quality of life(Qo L) is increasingly being *** some radiosensitive NPC patients,whether low?dose radio?therapy can improve the Qo L without affecting clinical efficacy is *** study aimed to assess the survival rates and Qo L of NPC patients treated with 50 Gy radiotherapy plus hematoporphyrin derivative(HPD).Methods:Forty?six newly diagnosed NPC patients treated with 50 Gy radiotherapy plus HPD between June 1988 and July 1992 were *** patients were restaged according to the 7th edition of the American Joint Commit?tee on Cancer staging *** radiotherapy plan was designed on the basis of pretreatment computed tomog?*** OS,local recurrence?free survival(LRFS),distant metastasis?free survival(DMFS),and disease?free survival(DFS) rates were estimated using the Kaplan–Meier *** L was assessed using the Late Radiation Morbidity Scoring Criteria of the Radiation Therapy Oncology ***:The 5?year OS,LRFS,DMFS,and DFS rates were 74.3%,72.6%,82.1%,and 61.2%,*** corre?sponding 10?year rates were 38.4%,62.9%,78.5%,and 49.8%,respectively,and the 20?year rates were 27.7%,51.4%,78.5%,and 40.7%,*** of the patients developed severe radiation?related complications,such as radiation?induced temporal lobe necrosis,hearing loss,trismus,and ***:Some NPC patients were sensitive to 50 Gy radiotherapy plus HPD,and this sensitivity was characterized by long?term survival without significant late treatment morbidities.

关键词： Low-dose radiotherapy Nasopharyngeal carcinoma Radiosensitivity Quality of life

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Inhibition of viability of human retinal microvascular endothelial cells by vialinin A under high glucose condition

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1809-1815页

作者： zhi-gang Chen Gao-Qin liu Wei-Ming liu Pei-Rong Lu Department of Ophthalmology the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Jiangsu Clinical Immunology Institute the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

AIM:To investigate the effects of vialinin A on viability of human retinal endothelial cells(HRECs)under high glucose condition and its potential ***:The HRECs were divided into four groups:normal glucose control group(NG,5 mmol/L D-glucose),high glucose group(HG,30 mmol/L D-glucose),HG+1μmol/L vialinin A group,and HG+5μmol/L vialinin A *** cell viabilities were measured with cell counting kit-8(CCK-8)assay for proliferation,with scratch assay for migration,and tube formation,for evaluation of the impact of vialinin A on cellular ***-time PCR and Western blotting were used to determine the expression level of vascular endothelial growth factor(VEGF).RESULTS:The proliferative capacity and migration of HRECs was reduced by 5μmol/L vialinin A in high glucose environment(both P<0.05).Vialinin A also inhibited highglucose-induced tube formation of *** expression level of VEGF and PI3K in HRECs was also significantly decreased by vialinin A(P<0.05).CONCLUSION:Vialinin A inhibits the cell viability of *** may serve as a potential target for anti-angiogenic therapy.

关键词： vialinin A vascular endothelial growth factor human retinal endothelial cells cell viability

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Safety and efficacy of a nerve matrix membrane as a collagen nerve wrapping: a randomized, single-blind, multicenter clinical trial

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Neural Regeneration Research 2021年第8期16卷 1652-1659页

作者： Yong-Bin Gao zhi-gang liu Guo-Dong Lin Yang Guo Lei Chen Bo-Tao Huang Yao-Bin Yin Chen Yang Li-Ying Sun Yan-Bo Rong Shanlin Chen Department of Hand Surgery Beijing Jishuitan HospitalBeijingChina Department of Hand Surgery The First Bethune Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Hand and Foot Surgery Yantai Yuhuangding HospitalYantaiShandong ProvinceChina

A new nerve matrix membrane derived from decellularized porcine nerves has been shown to retain the major extracellular matrix components, and to be effective in preventing adhesion between the nerve anastomosis sites and the surrounding tissues in a rat sciatic nerve transection model, thereby enhancing regeneration of the nerve. The effectiveness of the membrane may be attributed to its various bioactive components. In this prospective, randomized, single-blind, parallel-controlled multicenter clinical trial, we compared the safety and efficacy of the new nerve matrix membrane with a previously approved bovine tendon-derived type I collagen nerve wrapping. A total of 120 patients with peripheral nerve injury were recruited from Beijing Jishuitan Hospital, The First Bethune Hospital of Jilin University, and Yantai Yuhuangding Hospital, China. The patients were randomly assigned to undergo end-to-end and tension-free neurorrhaphy with nerve matrix membrane(n = 60, 52 male, 8 female, mean age 41.34 years, experimental group) or tendon-derived collagen nerve wrapping(n = 60, 42 male, 18 female, mean age 40.17 years, control group). Patients were followed-up at 14 ± 5, 30 ± 7, 90 ± 10 and 180 ± 20 days after the operation. Safety evaluation included analyses of local and systemic reactions, related laboratory tests, and adverse reactions. Efficacy evaluation included a static 2-point discrimination test, a moving 2-point discrimination test, and a Semmes–Weinstein monofilament examination. Sensory nerve function was evaluated with the British Medical Research Council Scale and Semmes–Weinstein monofilament examination. The ratio(percentage) of patients with excellent to good results in sensory nerve recovery 180 ± 20 days after the treatment was used as the primary effectiveness index. The percentages of patients with excellent to good results in the experimental and control groups were 98.00% and 94.44%, respectively, with no significant difference between the two gro

关键词： clinical trial extracellular matrix nerve conduit nerve matrix nerve repair neural regeneration neurorrhaphy peripheral nerve injury sensory nerve recovery

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Number and Distribution of Fiducial Fibers in a Spectroscopic Survey Telescope

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Research in Astronomy and Astrophysics 2022年第2期22卷 108-117页

作者： Shi-Peng Duan Zeng-Xiang Zhou Jia-Le Zuo Meng-Tao Li zhi-gang liu Hong-Zhuan Hu Jian-Ping Wang Xiang-Qun Cui Yong Zhang Hao-Tong Zhang Department of Precision Machinery and Precision Instrumentation University of Science and Technology of ChinaHefei 230026China National Astronomical Observatories/Nanjing Institute of Astronomical Optics&Technology Chinese Academy of ScienceNanjing 210042China CAS Key Laboratory of Astronomical Optics&Technology Nanjing Institute of Astronomical Optics&TechnologyNanjing 210042China National Astronomical Observatories Chinese Academy of SciencesBeijing 100012China

To date,the Large Sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST)has been in operation for 12 *** improve the telescope's astronomical observation accuracy,the original open-loop fiber positioning system of LAMOST is in urgent need of *** upgrade plan is to install several fiber view cameras(FVCs)around primary mirror B to build a closed-loop feedback control *** FVCs are 20 m from the focal *** reduce a series of errors when the cameras detect the positions of the optical fibers,we designed fiducial fibers on the focal surface to be fiducial points for the *** the number of fiducial fibers can improve the detection accuracy of the FVC system,but it will also certainly reduce the number of fiber positioners that can be used for ***,the focus of this paper is how to achieve the quantity and distribution that meet the requirements of system *** this paper,we introduce the necessity of using fiducial fibers,propose a method for selecting their number and present several methods for assessing the uniformity of their ***,we implement particle swarm optimization to find the best distribution of fiducial fibers.

关键词： instrumentation detectors-techniques image processing-methods data analysis-telescopes

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Rational design of ZnCdS/TpPa-1-COF heterostructure photocatalyst by strengthening the interface connection in solar hydrogen production reactions

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Nano Research 2024年第3期17卷 1027-1034页

作者： Di Yang zhi-gang Li Xinghao Zhang Zenghuan Ren Weihan Lu Haining liu Xiaomeng Guo Jijie Zhang Xian-He Bu Tianjin Key Laboratory of Metal and Molecule-Based Material Chemistry School of Materials Science and EngineeringNankai UniversityTianjin 300350China College of Chemistry and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018China State Key Laboratory of Elemento-Organic Chemistry College of ChemistryNankai UniversityTianjin 300071China

ZnCdS quantum dots(QDs)are highly coveted in photocatalysis research for their exceptional visible-light responses and high light-absorption ***,their practical application is hindered by their tendency to aggregate,due to having high surface *** address this issue,herein,a heterostructure is synthesized by growing ZnCdS QDs with a size of approximately 5 nm onto the surface of a two-dimensional(2D)covalent organic framework(COF),*** approach suppresses the aggregation of the QDs and improves their *** ZnCdS/TpPa-1-COF composite exhibited a peak hydrogen evolution rate of 6244.16μmol·g^(-1)·h^(-1),which was 2.89 and 4.18 times greater than that of ZnCdS and TpPa-1-COF,*** zero-dimensional/two-dimensional(0D/2D)heterojunction formed by ZnCdS and TpPa-1-COF generates a strong interfacial force,which is attributed to the intimate contact between the *** connections accelerate charge separation,improve the utilisation of reduced electrons,and reduce the extent of agglomeration of the ZnCdS QDs,thereby resulting in high hydrogen production activity of the ***,the photocatalytic mechanism is studied using Kelvin probe force microscopy and theoretical *** study offers a novel approach for creating sulfide photocatalysts and is crucial for investigating the potential practical applications of the related photocatalysts.

关键词： covalent organic frameworks quantum dots photocatalysis hydrogen generation heterojunction

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Highly efficient 1D p-Te/2D n-Bi_(2)Te_(3) heterojunction self-driven broadband photodetector

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Nano Research 2024年第3期17卷 1864-1874页

作者： Chenchen Zhao Dongbo Wang Jiamu Cao zhi Zeng Bingke Zhang Jingwen Pan Donghao liu Sihang liu Shujie Jiao Tianyuan Chen gang liu Xuan Fang Liancheng Zhao Jinzhong Wang School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China School of Astronautics Harbin Institute of TechnologyHarbin 150001China Center for High Pressure Science and Technology Advanced Research Shanghai 201203China State Key Laboratory of High Power Semiconductor Lasers Changchun University of Science and TechnologyChangchun 130022China

Broadband photodetectors with self-driven functions have attracted intensive scientific interest due to their low energy consumption and high optical ***,high-performance broadband self-driven photodetectors are still a significant challenge due to the complex fabrication processes,environmental toxicity,high production costs of traditional 3D semiconductor materials and sharply raised contact resistance,severe interfacial recombination of 2D materials and 2D/3D mixed dimension ***,1D p-Te/2D n-Bi_(2)Te_(3) heterojunctions are constructed by the simple and low-cost hydrothermal method.1D p-Te/2D n-Bi_(2)Te_(3) devices are applied in photoelectrochemical(PEC)photodetectors,with their high performance attributed to the good interfacial contacts reducing interface *** device demonstrated a broad wavelength range(365–850 nm)with an Iph/Idark as high as *** R_(i),D^(*),and external quantum efficiency(EQE)values of the device were as high as 12.07 mA/W,5.87×10^(10) Jones,and 41.05%,respectively,which were significantly better than the performance of the prepared Bi_(2)Te_(3) and Te devices.A comparison of the freshly fabricated device and the device after 30 days showed that 1D p-Te/2D n-Bi_(2)Te_(3) had excellent stability with only 18.08%decay of *** is anticipated that this work will provide new emerging material for future design and preparation of a high-performance self-driven broadband photodetector.

关键词： topological insulating states interfacial recombination self-driven 1D p-Te/2D n-Bi_(2)Te_(3) photodetector

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Recent advances in halide perovskite memristors:From materials to applications

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Frontiers of physics 2024年第2期19卷 73-104页

作者： Sixian liu Jianmin Zeng Qilai Chen gang liu Department of Micro/Nano Electronics School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Aerospace Science&Industry Shenzhen(Group)Co.Ltd. Shenzhen 518000China

With the emergence of the Internet of Things(IoT)and the rapid growth of big data generated by edge devices,there has been a growing need for electronic devices that are capable of processing and transmitting data at low power and high *** Complementary Metal-Oxide-Semiconductor(CMOS)devices are nonvolatile and often limited by their ability for certain IoT applications due to their unnecessary power consumption for data movement in von Neuman architecture-based *** has led to a surge in research and development efforts aimed at creating innovative electronic components and systems that can overcome these shortcomings and meet the evolving needs of the information era,which share features such as improved energy efficiency,higher processing speeds,and increased *** are a novel type of electronic device that has the potential to break down the barrier between storage and *** storing data and processing information within the same device,memristors can minimize the need for data movement,which allows for faster processing speeds and reduced energy *** further improve the energy efficiency and reliability of memristors,there has been a growing trend toward diversifying the selection of dielectric materials used in *** perovskites(HPs)have unique electrical and optical properties,including ion migration,charge trapping effect caused by intrinsic defects,excellent optical absorption efficiency,and high charge mobility,which makes them highly promising in applications of *** this paper,we provide a comprehensive overview of the recent development in resistive switching behaviors of HPs and the underlying ***,we summarize the diverse range of HPs,their respective performance metrics,as well as their applications in various ***,we critically evaluate the current bottlenecks and possible opportunities in the future research of HP memristors.

关键词： halide perovskite memristor mechanism neuromorphic computing non-volatile memory

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A Correlation-Based Stochastic Model for Massive MIMO Channel

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China Communications 2024年第1期21卷 175-187页

作者： Yang liu gang Li Chengxiang Wang National Mobile Communications Research Laboratory School of Information Science and EngineeringSoutheast UniversityNanjing 211189China School of Internet of Things Engineering Jiangnan UniversityWuxi 214122China Pervasive Communication Research Center Purple Mountain LaboratoriesNanjing 211111China

In this paper,the channel impulse response matrix(CIRM)can be expressed as a sum of couplings between the steering vectors at the base station(BS)and the eigenbases at the mobile station(MS).Nakagami distribution was used to describe the fading of the coupling between the steering vectors and the *** measurements were carried out to evaluate the performance of this proposed ***,the physical implications of this model were illustrated and the capacities are *** addition,the azimuthal power spectrum(APS)of several models was ***,the channel hardening effect was simulated and *** showed that the proposed model provides a better fit to the measured results than the other CBSM,i.e.,Weichselberger ***,the proposed model can provide better tradeoff between accuracy and complexity in channel *** CIRM model can be used for massive MIMO design in the future communication system design.

关键词： CBSM channel capacity channel hardening channel modeling massive MIMO

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Phylotranscriptomic discordance is best explained by incomplete lineage sorting within Allium subgenus Cyathophora and thus hemiplasy accounts for interspecific trait transition

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Plant Diversity 2024年第1期46卷 28-38页

作者： Zengzhu Zhang gang liu Minjie Li State Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems College of EcologyLanzhou UniversityLanzhou 730000GansuPR China

The transition of traits between genetically related lineages is a fascinating topic that provides clues to understanding the drivers of speciation and *** can be learned about this process from phylogeny-based trait ***,such inference is often plagued by genome-wide gene-tree discordance(GTD),mostly due to incomplete lineage sorting(ILS)and/or introgressive hybridization,especially when the genes underlying the traits appear ***,by collecting transcriptomes,whole chloroplast genomes(cpDNA),and population genetic datasets,we used the coalescent model to turn GTD into a source of information for ILS and employed hemiplasy to explain specific cases of apparent“phylogenetic discordance”between different morphological traits and probable species phylogeny in the Allium *** concatenation and coalescence methods consistently showed the same phylogenetic topology for species tree inference based on single-copy genes(SCGs),as supported by the KS ***,GTD was high across the genomes of ***:~27%e38.9%of the SCG trees were in conflict with the species *** and nuclear incongruence was also *** coalescent simulations indicated that such GTD was mainly a product of *** hemiplasy risk factor calculations supported that random fixation of ancient polymorphisms in different populations during successive speciation events along the *** phylogeny may have caused the character transition,as well as the anomalous cpDNA *** study exemplifies how phylogenetic noise can be transformed into evolutionary information for understanding character state transitions along species phylogenies.

关键词： Hemiplasy Multispecies coalescence Lineage sorting Gene tree discordance Phylotranscriptomics Allium subg.Cyathophora

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Comparative analysis of the microbiome of sympatric wintering Bean Geese,Domestic Ducks,humans,and soil at Shengjin Lake of China reveals potential public risk to human health

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Avian Research 2024年第2期15卷 279-286页

作者： gang liu Na Xu Chongyang Yu College of Life Sciences Anhui Medical UniversityHefei 230032China

The gut microbiota of migratory waterbirds is affected by various complex factors,including cross-species transmission,which increases the risk of pathogen spreading among sympatric animals and poses a potential public health risk to *** this study,we investigated the microbial communities of wintering Bean Geese(Anser fabalis),Domestic Ducks(*** domesticus),humans,and soil using high-throughput sequencing of the 16S rRNA gene region in Shengjin Lake,*** total,6,046,677 clean reads were obtained,representing 41,119 operational taxonomic units(OTUs)across the four *** dominant microbial phyla were the Proteobacteria,Firmicutes,Bacteroidota,and *** Sorensen similarity index and alpha and beta diversity results showed that the gut microbial communities of Bean Geese and Domestic Ducks were more similar to those of the other *** analysis revealed that Faecalibacterium prausnitzii,Pseudomonas fragi,and Bradyrhizobium elkanii were hubs of the three major *** common microbiomes were iden-tified in Bean Geese,Domestic Ducks,humans,and soil in Shengjin Lake.A total of 96 potential pathogens were identified among the four groups,with 20 specific potentially pathogenic microbiomes found in the gut of Bean *** of these pathogens are responsible for significant financial losses in the poultry industry and pose risks to human *** pneumoniae,Morganella morganii,Escherichia coli,and Ralstonia insidiosa are potential core pathogens found in the four groups at Shengjin Lake that can cause diseases in humans and an-imals and facilitate cross-species transmission through various ***,humans are at risk of con-tracting these pathogens from migratory birds because of their frequent contact with domestic ***,further studies are required to explore the potential pathogenic species and transmission pathways among sympatric wintering Bean Geese,Domestic Ducks,humans,and soil.

关键词： Microbiome Migratory waterbird Pathogens Poultry Sympatric species

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