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Open Partial Nephrectomy in Solitary Kidney with Multiple Renal Cell Carcinoma: a Case Report

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Chinese Medical Sciences Journal 2011年第4期26卷 249-250页

作者： ji-rui Niu Quan-zong Mao zhi-gang ji Departments of Urology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

ENAL cell carcinoma （RCC） in a solitary kidney presents a unique clinical challenge to urological surgeons. Partial nephrectomy （PN） or nephron-sparing surgery in this condition provides good oncological and renal fuctional outcomes with an acceptable complication rate.1＇ 2 Long-term renal function remains stable in most patients with solitary kidneys after a reduction of more than 50% in renal mass.

关键词： solitary kidney partial nephrectomy renal function

Combined thoracoscopic and laparoscopic approach to remove a large retroperitoneal compound paraganglioma:A case report

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World Journal of Clinical Cases 2021年第23期9卷 6935-6942页

作者： Chang Liu jin Wen Han-Zhong Li zhi-gang ji Department of Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Urology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

BACKGROUND Paragangliomas(PGLs)are rare catecholamine-secreting neuroendocrine tumors,which often present with secondary *** most common location is the retroperitoneal *** the first time,we report a rare case of large retroperitoneal compound PGL,and we have innovatively applied a new surgical plan to completely remove the *** SUMMARY A 55-year-old middle-aged man was admitted to the hospital for fluctuating blood pressure for more than 1 year with intermittent *** suffered dozens of attacks every *** and urine catecholamines were elevated,somatostatin receptor imaging was positive,and the diagnosis of PGL was *** imaging examination revealed a large tumor on the right front of the mediastinal spine at the level of T10-L1(the posterior space of the right phrenic foot).For the first time in our department,a combined thoracoscopic and laparoscopic operation was used to detect and remove large *** This is the first reported case of using a thoracoscopic and laparoscopic approach simultaneously to remove a large retroperitoneal compound PGL,which may provide a new surgical approach for similar cases.

关键词： Paraganglioma Compound paraganglioma Combined thoracoscopy and laparoscopy Case report

Medical Foreign Bodies in Urinary Bladder: a Case Report

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Chinese Medical Sciences Journal 2013年第3期28卷 192-193页

作者： Hai Wang zhi-gang ji He Xiao ji-rui Niu Department of Urology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Department of Urology Heilongjiang Province Hospital

RETAINED foreign bodies in the urinary tract after surgical or diagnostic procedure, named iatrogenic foreign bodies, are rarely reported, though the estimated incidence was as high as 1/1500 cases.1 Prompt and proper retrieval is required due to potential complications. We report a case of iatrogenic foreign body into the bladder.

关键词： urinary tract foreign body iatrogenicity

1.9 μm Thulium Laser Treats Ureteral Carcinoma via Rigid-ureteroscopy

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Chinese Medical Sciences Journal 2016年第2期31卷 127-128页

作者： jin Wen zhi-gang ji Han-zhong Li Department of Urology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College

RADICAL nephroureterectomy is the gold standardtreatment for patients with upper urinary tracturothelial cell carcinomas.1 However, ureteroscopehas enabled urologists to easily approach theupper urinary tract and resect tumor.2 Patients for whomendoscopic tumor resection is recommended includedthose with a solitary kidney, renal insufficiency, bilateraltransitional cell carcinoma （TCC） of the upper urinary tract。

关键词： laser therapy carcinoma upper urinary tract ureteroscopic treatment

Effects of Sunitinib Malate on Growth of Human Bladder Transitional Cell Line T24 In Vitro

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Chinese Medical Sciences Journal 2015年第1期30卷 51-55页

作者： jin Wen Han-zhong Li zhi-gang ji jing jin Department of Urology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Department of Pharmacy Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College

Objective To investigate the growth-inhibitory effect of sunitinib malate on human bladder transitional cell carcinoma （TCC） in vitro. Methods Human bladder TCC cell line T24 was cultured and exposed to graded concentrations of sunitinib malate for 72 hours in vitro to determine the sensitivities to drug. Cell viability was measured by MTT assay. Cell apoptotic morphology was observed by fluorescence microscope following DAPl staining. Band expressions of Fas, Fas ligand, poly （ADP-ribose） polyrnerase （PARP） and D-actin were analyzed by Western blot. Wound healing process of T24 cells exposed to sunitinib malate was assayed. Results Sunitinib malate exerted a concentration-dependent and time-dependent inhibitory effect on the T24 cell lines. Fluorescence microscopy showed that small vacuoles appeared in the nuclei of T24 cells and the vacuoles were bigger with higher drug concentrations. The expressions of Fas ligand and PARP in T24 cells treated with sunitinib malate exhibited a concentration-dependent increase. Moreover sunitinib malate suppressed the wound healing process in a concentration-dependent manner. Conclusion Sunitinib malate exerted marked inhibitory activity against bladder cancer cell line T24.

关键词： sunitinib bladder cancer proliferation

Status and Change Pattern of Kidney Transplantation:One Center Research

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Chinese Medical Sciences Journal 2012年第2期27卷 112-114页

作者： ji-rui Niu zhi-gang ji Hai Wang jing-min Zhou Zhen-yu Zhang Departments of Urology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Objective To retrospectively investigate the distribution in kidney transplantation for fifteen years in Peking Union Medical College *** We conducted a descriptive research counting up the number of patients who received kidney transplantation each year in our hospital during 1995 and *** The first kidney transplantation in our hospital occurred in the *** number of kidney transplantation increased until reaching a maximum of 47 grafts in 2001;since then the number *** With the decreased number of kidney transplantation,we have realized the shortage of transplantable organs is very *** continuing transplant shortage requires major efforts to expand the donor *** after cardiac death offers the potential to enlarge the donor pool,but we need to strictly control the criteria for potential donors.

关键词： organ transplantation kidney transplantation donor crisis

Clinical Characteristics and Outcome of Gleason Score 10 Prostate Cancer on Core Biopsy Treated by External Radiotherapy and Hormone Therapy

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Chinese Medical Sciences Journal 2015年第2期30卷 90-94页

作者： zhi-peng Mai Wei-gang Yan Han-zhong Li zhi-gang ji Fu-quan Zhang Ke Hu Yu Xiao Department of Urology Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College Department of Radiation Oncology Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College

Objective To evaluate the clinical characteristics and outcomes of patients with Gleason score 10 prostate cancer treated by external radiotherapy and hormone therapy. Methods From January 2003 to March 2014, 1832 patients with prostate cancer were treated, among which 9 patients(represented 0.49%) were identified as Gleason score 10 disease on prostate core biopsy without distant metastases when first diagnosed. All 9 patients were treated by whole pelvic external radiotherapy(The whole pelvic dose was 50.0 Gy and the boost dose ranged from 76.2 to 78.0 Gy) and long-term hormone therapy. We assessed the clinical characteristics, treatment outcomes and treatment toxicities. Survival curves were calculated using the Kaplan-Meier method. Results The median follow-up was 4.8 years. Six patients' pre-treatment prostate-specific antigen(PSA) levels were lower than 20.0 μg/L and three patients' pre-treatment PSA levels were higher than 70.0 μg/L. The median percentage of positive biopsy cores was 91%. Three, four and two cases were classified as T2 c, T3 a and T3 b stage, respectively. Three cases were assessed as N1 stage. The 5-year biochemical failure-free survival, distant metastasis-free survival, cancer specific survival and overall survival rates were 28.6%, 57.1%, 66.7% and 57.1%, respectively. Five patients experienced grade 1-2 acute gastrointestinal toxicities and six patients complained of grade 1-2 acute genitourinary toxicities. No bone fracture or cardiovascular disease was detected. Conclusions Gleason score 10 prostate cancer on core biopsy is usually combined with other high risk factors. The pre-treatment PSA levels lie in two extremes. Timely and active treatments are urgent needed because unfavourable oncological outcomes are often presented.

关键词： prostatic neoplasms biopsy neoplasm grading outcomes

Ureteral Stent Fragmentation:a Case Report and Review of Literature

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Chinese Medical Sciences Journal 2013年第2期28卷 124-126页

作者： ji-rui Niu zhi-gang ji Shi Rong Quan-zong Mao Hua Fan Xiao He Department of Urology Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College

SINCE the introduction of double J stents in 1978, ureteral stents have become an integral tool in treating ureteral obstruction from calculi and other causes.1 Owing to the widespread usageof indwelling ureteral catheters, a number of possible complications such as migration, infection, pyelonephritis, breakage, encrustation, stone formation, and ureteral stents fragmentation have been noted.2 Of all the complications, ureteral stent fragmentation was sporadically reported and believed to be rare. Here we present a case of fragmentation of a new type of double J stent, which was used to provide free drainage to the bladder after balloon dilation.

关键词： ureteral stent fragmentation ureteral foreign body complication

Current Progress and Controversies in Prostate Cancer Management

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Chinese Medical Journal 2017年第24期130卷 2991-2995页

作者： De-Xin Dong zhi-gang ji Department of Urology Chinese Academy of Medical Sciences Peking Union Medical College Hospital Beijing 100730 China

Objective：The optimal management strategy for prostate cancer （PCa） remains *** performed a systemic review of current progress and controversies regarding the diagnosis and treatment of *** Sources：We searched PubMed for recently published articles up to July 2017 using the following key words：＂prostate cancer,＂＂progress,＂＂controversy,＂＂immunotherapy,＂ and ＂prevention.＂ Study Selection：Articles were obtained and reviewed to provide a systematic review of the current progress and controversies regarding PCa ***：The value of serum prostate-specific antigen （PSA） screening remains controversial,but PSA screening is recommended to facilitate the early diagnosis of PCa in high-risk *** biopsy via the transrectal or perineal approach has both advantages and *** was a significant correlation between testosterone levels and PCa *** current research is focused on the mechanisms responsible for *** surveillance has been proposed as a management strategy for low-risk,localized PCa,but there is an urgent need for further clinical studies to establish the criteria for recommending this *** main complications of radical resection for PCa are urinary incontinence and erectile dysfunction,though three-dimensional laparoscopic and robot-assisted laparoscopic techniques have obvious advantages over radical *** is also a therapeutic option for PCa,while immunotherapies may alter the prostate tumor *** studies aim to provide guidance on effective sequential and combination *** remains an important strategy for reducing PCa morbidity and ***：The diagnosis,treatment,and prevention of PCa are complex issues,worthy of intensive *** studies are needed to improve the management of PCa.

关键词： Active Surveillance Advance lmmunotherapy Prevention Prostate Cancer