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Targeted inhibition of myeloid-derived suppressor cells in the tumor microenvironment by low-dose doxorubicin to improve immune efficacy in murine neuroblastoma

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Chinese Medical Journal 2021年第3期134卷 334-343页

作者： Wei-Li Xu Bao-Jun Shi Suo-Lin Li Feng-Xue Yu Li-Na Guo Meng Li zhi-gang hu Gui-Xin Li hui Zhou Department of Pediatric Surgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei 050000China Department of Central Laboratory The Second Hospital of Hebei Medical UniversityShijiazhuangHebei 050000China Department of General Surgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei 050000China

Background:High agglomeration of myeloid-derived suppressor cells(MDSCs)in neuroblastoma(NB)impeded therapeutic *** study aimed to investigate the role and mechanism of targeted inhibition of MDSCs by low-dose doxorubicin(DOX)to enhance immune efficacy in ***:Bagg albino(BALB/c)mice were used as tumor-bearing mouse models by injecting Neuro-2a cells,and MDSCs were eliminated by DOX or dopamine(DA)***-bearing mice were randomly divided into 2.5 mg/kg DOX,5.0 mg/kg DOX,50.0 mg/kg DA,and control groups(n=20).The optimal drug and its concentration for MDSC inhibition were selected according to tumor *** antigen-specific cytotoxic T cells(CTLs)were ***-bearing mice were randomly divided into DOX,CTL,anti-ganglioside(GD2),DOX+CTL,DOX+anti-GD2,and control *** low-dose DOX administration,immunotherapy was *** levels of human leukocyte antigen(HLA)-I,CD8,interleukin(IL)-2 and interferon(IFN)-γin peripheral blood,CTLs,T-helper 1(Th1)/Th2 cytokines,perforin,granzyme and tumor growth were compared among the *** Wilcoxon two-sample test and repeated-measures analysis of variance were used to analyze ***:The slowest tumor growth(F=6.095,P=0.018)and strongest MDSC inhibition(F=14.632,P=0.001)were observed in 2.5 mg/kg DOX *** of T cells was increased(F=448.721,P<0.001)and then decreased(F=2.047,P=0.186).After low-dose DOX administration,HLA-I(F=222.489),CD8(F=271.686),Th1/Th2 cytokines,CD4^(+)and CD8^(+)lymphocytes,granzyme(F=2376.475)and perforin(F=488.531)in tumor,IL-2(F=62.951)and IFN-γ(F=240.709)in peripheral blood of each immunotherapy group were all higher compared with the control group(all ofP values<0.05).The most significant increases in the aforementioned indexes and the most notable tumor growth inhibition were observed in DOX+anti-GD2 and DOX+CTL ***:Low-dose DOX can be used as a potent immunomodulatory agent that selectively impairs MDSC-induce

关键词： Neuroblastoma Myeloid-derived suppressor cell Tumor microenvironment Doxorubicin Immunotherapy

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Natural hydrogel dressings in wound care: Design, advances, and perspectives

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Chinese Chemical Letters 2024年第10期35卷 28-38页

作者： Xiaoliu Liang Chunliu huang hui Liu hu Chen Jiabao Shou Hongwei Cheng gang Liu State Key Laboratory of Infectious Disease Vaccine Development Xiang An Biomedicine LaboratoryNational Innovation Platform for Industry-Education Integration in Vaccine ResearchState Key Laboratory of Molecular Vaccinology and Molecular DiagnosticsCenter for Molecular Imaging and Translational MedicineSchoolofPublicHealthXiamenUniversityXiamen361102China Department of Burns and Plastics Surgery Liuzhou Worker's HospitalFourth Afliated Hospital of Guangxi Medical UniversityLiuzhou 545000China Institute of Applied Physics and Materials Engineering Zhuhai UM Science&Technology Research InstituteUniversity of MacaoMacao SAR 999078China

Natural hydrogels have emerged as a pivotal innovation in wound care,offering a unique combination of high absorbency,biocompatibility,and ***,due to the complexity of wound healing,the physiological state of the wound varies dynamically,and the mechanism of natural hydrogels that boost wound healing is still *** this review,we firstly provide a comprehensive introduction to the bio-logical process of wound healing,emphasizing the critical stages and factors affecting *** work concludes the composition and properties of natural hydrogels,including collagen,gelatin,hyaluronic acid,chitosan,alginates,cellulose,and fibroin,highlighting their biocompatibility and *** focus shifts to the various crosslinking strategies employed to enhance the structural integrity and functionality of natural *** review further investigates the biological effects of natural hydro-gels in wound healing,detailing their antibacterial,antioxidant,anti-inflammatory,adhesive,and hemo-static ***,we propose the challenges and future perspectives of natural hydrogels in practical *** review offers a comprehensive overview of the current state and poten-tial future advancements in natural hydrogel dressings for wound care,highlighting their critical role in addressing complex and hard-to-heal wounds.

关键词： Natural hydrogel Wound dressing Crosslinking strategy Antibacterial Anti-inflammation

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Tetraphenylethylene dicycle helicates: circularly polarized luminescence and chiral recognition based on emission wavelength change

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Science China Chemistry 2024年第11期67卷 3817-3824页

作者： zhi-Rong Xu Miao-Li Gao Ming hu Wei Yu Yan-Song Zheng Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Chiral tetraphenylethylene(TPE) dicycle tetraaldehyde and TPE dicycle tetraacids bearing optically pure groups on the cycles were designed and synthesized. Due to the propeller-like conformation immobilization of TPE unit, this new class of TPE dicycle was resolved into M-and P-enantiomers, which could emit strong circular polarized luminescence(CPL). Interestingly,these TPE helicates displayed exceptional ability of molecule recognition. While the TPE dicycle tetraaldehyde could detect the microscale water in anhydrous tetrahydrofuran, the chiral TPE dicycle tetraacid could display different fluorescent color after interacting with two enantiomers of a wide variety of chiral amines including monoamines, diamines, and aminols, which could be applied to chiral recognition of these chiral amines. Furthermore, the emission wavelength of TPE dicycle tetraacid was found to change linearly with the enantiomer purity of chiral amine from enantiomer excess(ee) percent-100% to +100%, for the first time showing the potential for quantitative chiral analysis of chiral amines based on emission wavelength change. The emission wavelength was affected less by environmental factors than fluorescence intensity, which would enable the chiral analysis based on wavelength change with higher accuracy and repeatability.

关键词： TPE dicycle helicate CPL chiral recognition enantiomer excess analysis emission wavelength change

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Composite laminar membranes for electricity generation from water evaporation

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Nano Research 2024年第1期17卷 307-311页

作者： Xiao Wang gang Yuan Han Zhou Yu Jiang Shuo Wang Jiaojiao Ma Chongyang Yang Sheng hu State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials(iChEM)College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China

Harvesting clean energy from water evaporation has been extensively investigated due to its *** achieve high efficiency,energy conversion materials should contain multiple features which are difficult to be simultaneously obtained from single-component *** we use composite laminar membranes assembled by nanosheets of graphene oxide and mica,and find a sustained power density induced by water evaporation that is two orders of magnitude larger than that from membranes made by either of the *** power output is attributed to selective proton transport driven by water evaporation through the interlayer nanochannels in the *** process relies on the synergistic effects from negatively charged and hydrophilic mica surfaces that are important for proton selectivity and water transport,and the tunable electrical conductivity of graphene oxide that provides optimized internal *** demonstrated composite membranes offer a strategy of enhancing power generation by combining the advantages from each of their components.

关键词： graphene oxide mica water evaporation electrical double layer surface charge ion selectivity

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Quasi-in-situ Observation and SKPFM Studies on Phosphate Protective Film and Surface Micro-Galvanic Corrosion in Biological Mg-3Zn-xNd Alloys

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Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 648-664页

作者： Zhaochen Yu Kaixuan Feng Shuyun Deng Yang Chen Hong Yan Honggun Song Chao Luo zhi hu School of Advanced Manufacturing Nanchang UniversityNanchang330031China Institute for Advanced Study Nanchang UniversityNanchang330031China

The phosphate protective film and micro-galvanic corrosion of biological Mg-3Zn-xNd (x = 0, 0.6, 1.2) alloys were investigated by scanning and transmission electron microscopy, quasi-in-situ observation, scanning Kelvin probe force microscopy (SKPFM) and electrochemical tests. The results revealed the Mg-Zn-Nd phases formed in Mg-3Zn alloy contained with Nd. Adding Nd resulted in a significant decline in the cracks of the phosphate protective film and micro-galvanic corrosion of alloys, which were recorded by quasi-in-situ observation. In addition, the Volta potential difference of Mg-Zn-Nd/α-Mg (~ 188 mV) was lower than MgZn/α-Mg (~ 419 mV) and Zn-rich/α-Mg (~ 260 mV), and the corrosion rates of alloys markedly decreased after the addition of 0.6 wt% Nd. The improvement in corrosion resistance of Nd-containing alloys was mainly attributed to the following: (i) the addition of Nd reduced the Volta potential difference (second phases/α-Mg);(ii) the phosphate protective film containing Nd_(2)O_(3) deposited on the surface of the alloys, effectively preventing the penetration of harmful anions.

关键词： Magnesium alloys Quasi-in-situ observation Phosphate protective film Scanning Kelvin probe force microscopy(SKPFM) Micro-galvanic corrosion

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The role of lipid metabolism in osteoporosis:Clinical implication and cellular mechanism

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Genes & Diseases 2024年第4期11卷 220-233页

作者： Jing Zhang Wenhui hu zhi Zou Yuheng Li Fei Kang Jianmei Li Shiwu Dong College of Bioengineering Chongqing UniversityChongqing 400044China Department of Biomedical Materials Science College of Biomedical EngineeringArmy Medical University(Third Military Medical University)Chongqing 400038China State Key Laboratory of Trauma and Chemical Poisoning Army Medical University(Third Military Medical University)Chongqing 400038China

In recent years,researchers have become focused on the relationship between lipids and bone metabolism ***,many diseases related to lipid metabolism dis-orders,such as nonalcoholic fatty liver disease,atherosclerosis,obesity,and menopause,are associated with osteoporotic *** has been clinically observed in humans that these lipid metabolism disorders promote changes in osteoporosis-related indicators bone mineral density and bone ***,similar osteoporotic phenotype changes were observed in high-fat and high-cholesterol-induced animal *** lipid metabolism(such as increased oxidized lipids and elevated plasma cholesterol)affects bone microenvironment ho-meostasis via cross-organ communication,promoting differentiation of mesenchymal stem cells to adipocytes,and inhibiting commitment towards ***,disturbances in lipid metabolism affect the bone metabolism balance by promoting the secretion of cyto-kines such as receptor activator of nuclear factor-kappa B ligand by osteoblasts and stimulating the differentiation of ***,this review addresses the possible link be-tween lipid metabolism disorders and osteoporosis and elucidates the potential modulatory mechanisms and signaling pathways by which lipid metabolism affects bone metabolism *** also summarize the possible approaches and prospects of intervening lipid meta-bolismforosteoporosistreatment.

关键词： Bone homeostasis Cross-organ communication Lipid metabolism Osteoclast Osteoporosis

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Learning Sequential and Structural Dependencies Between Nucleotides for RNA N6-Methyladenosine Site Identification

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IEEE/CAA Journal of Automatica Sinica 2024年第10期11卷 2123-2134页

作者： Guodong Li Bowei Zhao Xiaorui Su Dongxu Li Yue Yang zhi Zeng Lun hu Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of ScienceUrumqi 830011China College of Computer Xi’an Jiaotong UniversityXi’an 710049China IEEE

N6-methyladenosine(m6A)is an important RNA methylation modification involved in regulating diverse biological processes across multiple ***,the identification of m6A modification sites provides valuable insight into the biological mechanisms of complex diseases at the post-transcriptional *** a variety of identification algorithms have been proposed recently,most of them capture the features of m6A modification sites by focusing on the sequential dependencies of nucleotides at different positions in RNA sequences,while ignoring the structural dependencies of nucleotides in their threedimensional *** overcome this issue,we propose a cross-species end-to-end deep learning model,namely CR-NSSD,which conduct a cross-domain representation learning process integrating nucleotide structural and sequential dependencies for RNA m6A site ***,CR-NSSD first obtains the pre-coded representations of RNA sequences by incorporating the position information into single-nucleotide states with chaos game representation *** then constructs a crossdomain reconstruction encoder to learn the sequential and structural dependencies between *** minimizing the reconstruction and binary cross-entropy losses,CR-NSSD is trained to complete the task of m6A site *** experiments have demonstrated the promising performance of CR-NSSD by comparing it with several state-of-the-art m6A identification ***,the results of cross-species prediction indicate that the integration of sequential and structural dependencies allows CR-NSSD to capture general features of m6A modification sites among different species,thus improving the accuracy of cross-species identification.

关键词： Cross-domain reconstruction cross-species prediction N6-methyladenosine(m6A)modification site RNA sequence sequential and structural dependencies

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Effect of lanthanum on inclusions in non-oriented electrical steel slabs

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Journal of Iron and Steel Research International 2024年第7期31卷 1680-1691页

作者： Qiang Ren zhi-yuan hu Yun-xia Liu Wei-cheng Zhang Zi-qi Gao Li-feng Zhang School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004HebeiChina School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Research and Development Department Shougang Zhixin Qian'an Electromagnetic Material Co.Ltd.Qian'an 064400HebeiChina School of Mechanical and Materials Engineering North China University of TechnologyBeijing 100144China

The effect of lanthanum on the characteristics of inclusions in the slab of non-oriented electrical steels was investigated through industrial trials and thermodynamic *** number,size,and chemical composition of inclusions in the surface,one-quarter of thickness and the center of slabs with and without lanthanum addition were statistically analyzed using an automatic inclusion analysis *** the lanthanum-free slab,inclusions were predominately ***_(2)O_(3),MgO,and AlN as well as a small number of Al_(2)O_(3)-MgO-CaO and *** number densities of oxide inclusions and AlN decreased from the surface to the center of the slab,which was ascribed to the difference in cooling intensity during the continuous *** the steel with lanthanum addition,inclusions were modified into LaAlO_(3) and La_(2)O_(2)S and gradually transformed into dual-phase MgO-La_(2)S3 with an increasing distance from the slab surface due to the reaction between the lanthanum-containing inclusion and the steel *** uneven distribution of oxide inclusions along the thickness of the slab was eliminated in the lanthanum-bearing slab because the dissolved oxygen was remarkably decreased by ***-bearing inclusions were more likely to agglomerate AlN by inducing the heterogeneous nucleation of AlN on their surface,while small-size ***_(2)O_(3) inclusions hardly showed a coarsening effect on the size of AlN.

关键词： Lanthanum-Inclusion Non-oriented electrical steel Aluminum nitride Heterogenous nucleation

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Thermally modulated photoelectronic synaptic behavior in HfS_(2)/VO_(2) heterostructure

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Rare Metals 2024年第8期43卷 3798-3809页

作者： Le Wang Lin Wang Xiao-Yun Ye Xiong-hu Xu Li-Yan Shang Ya-Wei Li Jin-Zhong Zhang Liang-Qing Zhu zhi-Gao hu Technical Center for Multifunctional Magneto-Optical Spectroscopy(Shanghai) Engineering Research Center of Nanophotonics&Advanced Instrument(Ministry of Education)Department of PhysicsSchool of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Neuromorphic computing is known for its efficient computational speed,low latency,and reduced power consumption,which is considered a pivotal technology to overcome the von Neumann *** synapses are an indispensable component of neuromorphic computational artificial neural *** guarantee effective and precise processing of optical signals,it must have a high responsivity,detectivity,and the ability to adapt to various ***,a synaptic transistor based on the HfS_(2)/VO_(2) heterojunction with a responsivity of8.6×10^(3) A·W^(-1)and a detectivity of 1.26×10^(14)Jones at405 nm laser was ***,the typical synaptic behavior was successfully simulated,including postsynaptic currents(PSCs),the transition from shortterm plasticity(STP)to long-term plasticity(LTP).When VO_(2) converts from the semiconductor state to the metal state,the HfS_(2)/VO_(2) heterojunction transforms into a Schottky heterojunction from a TypeⅡheterojunction with ***'s important,the heterojunction still exhibits excellent responsivity and detectivity,as well as stability of synaptic *** addition,the classical Pavlovian conditioning experiment is simulated under different laser intensity to study the brain's associative learning *** results demonstrate that the HfS_(2)/VO_(2) heterojunction synapse exhibits significant responsivity and detectivity and is adaptable to high-temperature environments,showing great potential for neuromorphic computational applic ations.

关键词： HfS_(2) VO_(2) Phase transition Photoelectric synapse Heterojunction

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Patterns and drivers of avian taxonomic and phylogenetic beta diversity in China vary across geographical backgrounds and dispersal abilities

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Zoological Research 2024年第1期45卷 125-135页

作者： Jian-Chao Liang zhi-Feng Ding Chun-Lin Li Yi-Ming hu zhi-Xin Zhou Gan-Wen Lie Xiao-Nan Niu Wen-Bin huang hui-Jian hu Xing-Feng Si Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhouGuangdong 510260China School of Resources and Environmental Engineering Anhui UniversityHefeiAnhui 230601China Guangdong Eco-Engineering Polytechnic GuangzhouGuangdong 510520China huizhou Institute of Forestry(huizhou Botanical Garden Management Service Center) HuizhouGuangdong 516001China Administration of National Nature Reserve for Marine Ecology of Guangdong Nanpeng Islands ShantouGuangdong 515900China Zhejiang Zhoushan Archipelago Observation and Research Station Institute of Eco-ChongmingZhejiang Tiantong Forest Ecosystem National Observation and Research StationSchool of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China

Geographical background and dispersal ability may strongly influence assemblage dissimilarity;however,these aspects have generally been overlooked in previous large-scale beta diversity ***,we examined whether the patterns and drivers of taxonomic beta diversity(TBD)and phylogenetic beta diversity(PBD)of breeding birds in China vary across(1)regions on both sides of the hu Line,which demarcates China’s topographical,climatic,economic,and social patterns,and(2)species with different dispersal *** and PBD were calculated and partitioned into turnover and nestedness components using a moving window *** representing climate,habitat heterogeneity,and habitat quality were employed to evaluate the effects of environmental *** distance was considered to assess the impact of dispersal *** partitioning analysis was applied to assess the relative roles of these *** general,the values of TBD and PBD were high in mountainous areas and were largely determined by environmental ***,different dominant environmental filters on either side of the hu Line led to divergent beta diversity ***,climate-driven species turnover and habitat heterogeneity-related species nestedness dominated the regions east and west of the line,***,bird species with stronger dispersal ability were more susceptible to environmental filtering,resulting in more homogeneous *** results indicated that regions with distinctive geographical backgrounds may present different ecological factors that lead to divergent assemblage dissimilarity patterns,and dispersal ability determines the response of assemblages to these ecological *** a single universal explanation for the observed pattern without considering these aspects may lead to simplistic or incomplete ***,a comprehensive understanding of large-scale beta diversity patterns and effective pla

关键词： Beta diversity Environmental filtering Dispersal limitation hu Line Species dispersal ability Breeding birds

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