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International Journal of Ophthalmology(English edition) 2023年第4期16卷 514-522页

作者： Li-Li Liu zhi-yi zhao Department of Ophthalmology Liuzhou Workers’Hospitalthe Fourth Affiliated Hospital of Guangxi Medical UniversityLiuzhou 545005Guangxi Zhuang Autonomous RegionChina

AIM:To investigate the retinoprotective role of Apigenin(Api)against high glucose(HG)-induced human retinal microvascular endothelial cells(HRMECs),and to explore its regulatory ***:HRMECs were stimulated by HG for 48h to establish the in vitro cell *** concentrations of Api(2.5,5,and 10μmol/L)were applied for *** counting kit-8(CCK-8),Transwell,and tube formation assays were performed to examine the effects of Api on the viability,migration,and angiogenesis in HG-induced *** permeability was evaluated by Evans blue *** inflammatory cytokines and oxidative stress-related factors were measured using their commercial *** expression of nicotinamide adenine dinucleotide phosphate(NADPH)oxidase 4(NOX4)and p38 mitogen-activated protein kinase(MAPK)was measured by Western ***:Api prevented HG-induced HRMECs viability,migration,angiogenesis,and vascular permeability in a concentration-dependent ***,Api also concentration-dependently inhibited inflammation and oxidative stress in HRMECs exposed to *** addition,HG caused an elevated expression of NOX4,which was retarded by Api *** stimulation facilitated the activation of p38 MAPK signaling in HRMECs,and Api could weaken this activation partly via downregulating NOX4 ***,overexpression of NOX4 or activation of p38 MAPK signaling greatly weakened the protective role of Api against HG-stimulated ***:Api might exert a beneficial role in HGstimulated HRMECs through regulating NOX4/p38 MAPK pathway.

关键词： apigenin retinal microvascular endothelial cell glucose NOX4 p38 MAPK

Combination regimen of leflunomide plus methylprednisolone in a female patient with reactive arthritis and concomitant IgA nephropathy

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Chinese Medical Journal 2010年第3期123卷 375-378页

作者： CHEN yi-zhi zhao Xue-zhi WU Jun MEI Chang-lin Kidney Institute of Chinese People's Liberation Army Shanghai Kidney Disease Quality Control Center Division of Nephrology Shanghai Changzheng Hospital Second Military Medical University Shanghai 200003 China

Spondyloarthropathies （SpAs） include five categories： ankyloslng spondyllns （AS）, reactive arthritis （ReA）,psoriatic arthritis （PsA）, enteropathic arthritis （EA） and undifferentiated spondyloarthropathy （USpA）.2 ReA is an aseptic arthritis occurring after extra-articular infections, particularly genitourinary （GU） or gastrointestinal （GI） tracts. When arthritis is accompanied by conjunctivitis and urethritis, the diagnosis of Reiter syndrome will be suitable for this clinical triad; however, the term ＂ReA＂ has been proposed to substitute for Reiter syndrome.

关键词： arthritis, reactive glomerulonephritis, IgA female leflunomide methylprednisolone

Friction plug−riveting spot welding of AA 7075-T6 aluminum alloy and low carbon steel using 1045 steel rivet

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Transactions of Nonferrous Metals Society of China 2024年第12期34卷 3893-3904页

作者： Ya-jia LIU Jian-yu LI Ze-hao XIE Shu-hai CHEN Jian YANG Ji-hua HUANG zhi-yi zhao School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China

7075-T6 aluminum alloy/low carbon steel joint was carried out via a novel friction plug−riveting spot welding *** process utilized uniquely designed steel rivets with a tip and groove *** macro-morphology formation,microstructure,microhardness and lap shear performance of joints were *** the spindle down distance increased,the rivet tip was friction welded with the lower steel sheet,resulting in the formation of a solid phase welding zone exhibiting metallurgical ***,a hook was formed in the joint,providing the mechanical *** results showed that under optimal parameters of spindle down distance of 3.4 mm,rotation speed of 4000 r/min,and spindle down speed of 2.4 mm/s,the lap shear load of the joints reached a maximum of 14.36 *** occurred at the aluminum alloy base metal.

关键词： friction plug-riveting spot welding aluminum alloy low carbon steel dissimilar metal joining

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中国锦鸡儿属的分子系统发育

植物分类学报 2008年第4期46卷 600-607页

作者：侯鑫刘俊娥赵一之内蒙古大学生命科学学院呼和浩特010021

测定了中国锦鸡儿属Caragana各属下分类群20个代表种的ITS、trnL-F和trnS-G序列。基于3种DNA片段的单独分析所获得的系统发育树具有相似的拓扑结构;3种片段的合并分析提高了各分支的支持度,并获得了相似的系统发育树。落轴亚属***的种... 详细信息

测定了中国锦鸡儿属Caragana各属下分类群20个代表种的ITS、trnL-F和trnS-G序列。基于3种DNA片段的单独分析所获得的系统发育树具有相似的拓扑结构;3种片段的合并分析提高了各分支的支持度,并获得了相似的系统发育树。落轴亚属***的种类构成了一个在系统树上首先分化出来的单系分支,与形态特征和地理分布的研究一致。短齿系***和长齿系***的代表种构成了1个单独的分支,因此短齿系应被放入长齿系所属刺叶组***而不是针刺组***或***。分子系统学证据支持依据叶片宽窄在掌叶组***中再划分2个系的形态学研究结论;但***和针刺系***的亲缘关系较近,系统发育分析的结果似乎不支持在针刺组中单独划分2个系。宿轴类的物种聚成一个单系的分支,因此应被处理为一个组——鬼箭组***;荚果里面被毛和无毛的种类各自构成2个小支,支持依据该特征在组下分系。系统树显示Sanczir定义的***显然为多系类群,应将该组中所包含的刺叶组、针刺组、和鬼箭组的种类划分出来。基于ITS的遗传距离表明卷叶锦鸡儿***与藏锦鸡儿***应该是2个不同的种。

关键词：锦鸡儿属 ITS 系统发育 trnL-F trnS-G

玻璃体腔注射万古霉素和蛇毒降纤酶治疗兔眼球穿通伤并发症的效果

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国际眼科杂志 2010年第10期10卷 1882-1884页

作者：林育华招志毅广西壮族自治区南溪山医院眼科中国广西壮族自治区桂林市541002 暨南大学医学院中国广东省广州市510632

目的：观察玻璃体腔注射蛇毒降纤酶和万古霉素对外伤性增生性玻璃体视网膜病变（proliferative vitreoretinopathy,PVR）的抑制效果.方法：新西兰白兔40只右眼建立外伤性出血性眼球穿通伤动物模型.左眼为空白对照眼.随机分为4组,生理盐... 详细信息

目的：观察玻璃体腔注射蛇毒降纤酶和万古霉素对外伤性增生性玻璃体视网膜病变（proliferative vitreoretinopathy,PVR）的抑制效果.方法：新西兰白兔40只右眼建立外伤性出血性眼球穿通伤动物模型.左眼为空白对照眼.随机分为4组,生理盐水组10眼,玻璃体腔注射生理盐水0.1mL;蛇毒降纤酶组10眼,玻璃体腔注射蛇毒降纤酶0.1U（0.1mL）;万古霉素组10眼,玻璃体腔注射万古霉素1mg（0.1mL）;联合用药10眼,玻璃体腔分别注射蛇毒降纤酶0.1 U及万古霉素1mg.通过裂隙灯显微镜观察眼前节炎症情况,眼前节炎症持续超过2wk以上者行玻璃体腔微生物学培养;直接眼底镜观察玻璃体出血指数、外伤性PVR情况.结果：联合用药组玻璃体出血指数低于生理盐水组（P〈0.01）、外伤性PVR程度低于生理盐水组（P〈0.01）;联合用药组玻璃体出血指数低于万古霉素组（P〈0.05）、外伤性PVR程度低于万古霉素组（P〈0.01）;生理盐水组、蛇毒降纤酶组各发生细菌性眼内炎3例（30%）;万古霉素组、联合用药组未见细菌性眼内炎的发生.结论：在外伤性出血性眼球穿通伤动物模型中,玻璃体腔注射蛇毒降纤酶和万古霉素可能可以促进玻璃体腔出血的吸收、降低外伤性PVR程度和减低感染性眼内炎症发生率.

关键词：眼球穿通伤并发症/药物疗法蛇毒降纤酶/治疗应用万古霉素/治疗应用动物实验

Effect of Si content on interfacial reaction and properties between solid steel and liquid aluminum

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Transactions of Nonferrous Metals Society of China 2021年第9期31卷 2570-2584页

作者： Tian-peng ZOU Gao-yang YU Shu-hai CHEN Ji-hua HUANG Jian YANG zhi-yi zhao Ji-ping RONG Jin YANG School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China School of Materials Engineering Shanghai University of Engineering ScienceShanghai 201620China

The effect of Si content on the microstructures and growth kinetics of intermetallic compounds(IMCs)formed during the initial interfacial reaction(<10 s)between solid steel and liquid aluminum was investigated by a thermophysical simulation *** influence of Si addition on interfacial mechanical properties was revealed by a high-frequency induction *** results showed that IMCs layers mainly consisted ofη-Fe_(2)Al_(5)andθ-Fe_(4)Al_(13).The addition of Si reduced the thickness of the IMCs *** growth of theηphase was governed by the diffusion process when adding 2 wt.%Si to the aluminum *** 5 wt.%or 8 wt.%Si was added to aluminum,the growth was governed by both the diffusion process and interfacial reaction,and ternary phaseτ1/τ9-(Al,Si)_(5)Fe_(3)was formed in theη*** apparent activation energies of theηphase decreased gradually with increasing Si *** joint with pure aluminum metal had the highest tensile strength and impact energy.

关键词： intermetallic compounds Si content solid steel liquid aluminum interfacial reaction mechanical properties

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua Huang Di zhao Lemei Zhu Zheyu Zhang Min yi Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

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不同比例激活剂对富血小板凝胶的生物学影响

中国现代医学杂志 2017年第20期27卷 16-20页

作者：戴静陈建苏招志毅广西省柳州市工人医院眼科广西柳州545005 暨南大学医学院眼科研究室(再生医学教育部重点实验室) 广东广州510632

目的比较不同比例激活剂对富血小板凝胶的生物学影响,研究其用于角膜基质再生的可行性。方法抽取兔全血,经二次离心法制备富血小板血浆(PRP),将PRP与激活剂按不同比例激活,制备PRP凝胶。实验分为3个实验组,分别为9∶1组(PRP∶激活剂=9... 详细信息

目的比较不同比例激活剂对富血小板凝胶的生物学影响,研究其用于角膜基质再生的可行性。方法抽取兔全血,经二次离心法制备富血小板血浆(PRP),将PRP与激活剂按不同比例激活,制备PRP凝胶。实验分为3个实验组,分别为9∶1组(PRP∶激活剂=9∶1)、11∶1组(PRP∶激活剂=11∶1)及5∶1组(PRP∶激活剂=5∶1)。将兔角膜基质细胞与PRP凝胶共同培养,进行组织形态学观察,用细胞增殖-毒性检测试剂盒法,分别检测3个实验组PRP凝胶释放的复合生长因子促角膜基质细胞的增殖作用。对不同实验组制备的PRP凝胶与双层猪角膜基质进行黏附性观察。结果 9∶1组制备的PRP凝胶促进兔角膜基质细胞的增殖和活化作用强于其他实验组。3个实验组中,只有9∶1组制备的PRP凝胶苏木精-伊红染色法染色结果显示,呈有序的网状支架结构,能紧密黏附并固定双层猪角膜基质。结论 PRP与激活剂以9∶1比例制备的PRP凝胶促角膜基质细胞增殖作用最强,同时具有有序网状结构和良好的组织黏附性及相容性,是一种可以用于角膜基质再生的良好支架。

关键词：激活剂富血小板凝胶角膜基质

Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： Shuai Zhang Pei-zhi Liu Yan-Bo Li Qi Zhang Jun-zhao Xiao yi-Fan Wang Tian-Yu Wei Jia-Wei Jiang Ye Wang Qian Peng Liang yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. Furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

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Low‑Temperature Fabrication of Stable Black‑Phase CsPbI_(3)Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

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Nano-Micro Letters 2025年第3期17卷 232-245页

作者： yingjie zhao yicheng Sun Chaoxin Pei Xing yin Xinyi Li yi Hao Mengru Zhang Meng Yuan Jinglin Zhou Yu Chen Yanlin Song College of Chemistry and Pingyuan Laboratory Zhengzhou UniversityZhengzhou 450001People’s Republic of China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Key Laboratory of Bio‑Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049People’s Republic of China

Flexible wearable optoelectronic devices fabricated fromorganic–inorganic hybrid perovskites significantly accelerate the developmentof portable energy,biomedicine,and sensing fields,but their poor thermal stabilityhinders further ***,all-inorganic perovskites possessexcellent thermal stability,but black-phase all-inorganic perovskite filmusually requires high-temperature annealing steps,which increases energy consumptionand is not conducive to the fabrication of flexible wearable *** this work,an unprecedented low-temperature fabrication of stable blackphaseCsPbI3perovskite films is demonstrated by the in situ hydrolysis reactionof diphenylphosphinic chloride *** released diphenyl phosphateand chloride ions during the hydrolysis reaction significantly lower the phasetransition temperature and effectively passivate the defects in the perovskitefilms,yielding high-performance photodetectors with a responsivity of 42.1 AW−1 and a detectivity of 1.3×10^(14)***,high-fidelity imageand photoplethysmography sensors are demonstrated based on the fabricated flexible wearable *** work provides a newperspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hydrolyzation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring