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一种基于广义协调条件的八结点平板壳单元

山东大学学报（工学版） 2003年第6期33卷 708-711页

作者：李革寇应昌方治华赵学友包头钢铁学院工程力学系内蒙古包头014010

在适用于中厚板的八结点等参数平板单元的基础上 ,通过引入剪应变与位移的广义协调条件 ,建立了一种平板单元 .以此单元作为弯曲单元 ,以平面Q8元作为平面膜单元 ,构造了一个新型平板壳单元 .新单元可用于厚壳 ,也可用于薄壳 .算例表明 ... 详细信息

在适用于中厚板的八结点等参数平板单元的基础上 ,通过引入剪应变与位移的广义协调条件 ,建立了一种平板单元 .以此单元作为弯曲单元 ,以平面Q8元作为平面膜单元 ,构造了一个新型平板壳单元 .新单元可用于厚壳 ,也可用于薄壳 .算例表明 ,新单元收敛性好。

关键词：广义协调条件等参数平板单元平板壳单元

Effect of Compound Laser Acupuncture-Moxibustion on Blood Glucose, Fasting Insulin and Blood Lipids Levels in Type 2 Diabetic Rats

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Chinese Journal of Integrative Medicine 2020年第1期26卷 33-38页

作者： LI Yuan QIAN zhi-yi CHENG Ke zhao Ling SHEN xue-yong DENG Hai-ping School of Acupuncture-Moxibustion and Tuina Shanghai University of Traditional Chinese Medicine

Objective:To investigate the effect of compound laser acupuncture-moxibustion on blood glucose,fasting insulin and blood lipids levels in type 2 diabetes mellitus(T2DM)***:Forty male Wistar rats were ran domly divided into 4 groups,in eluding the no rmal group,model control group,laser group and sham laser group(n=10 per group).The rats in the normal group were fed with a standard *** in other groups were fed with a high-sugar and high-fat diet for 4 weeks,then intraperitoneally injected with 1%streptozotocin to induce T2DM *** laser group was irradiated by 10.6 μm and 650 nm compound laser on bilateral Pishu(BL 20),Shenshu(BL 23)and Sanyinjiao(SP 6)for 5 min,6 times a week for 5 *** sham laser group received the same treatment as the laser group,but without laser *** model control group and normal group were not *** glucose levels were measured before and after 1,2,3,4 and 5 weeks of *** serum levels of fasting insulin,total cholesterol(TC),triglyceride(TG),low-density lipoprotein(LDL),and high-density lipoprotein(HDL)were analyzed after the last ***:The blood glucose levels in the model control group in creased duri ng the 5 weeks of treatment compared with the no rmal group(P0.05).Conclusion:The compound laser acupuncture-moxibustion of 10.6μm

关键词： type 2 diabetes mellitus compound laser acupuncture-moxibustion hyperglycemia insulin resistance blood lipids

Expression and Characterization of the Intracellular Part of Receptor Protein Tyrosine Phosphatase PTPRU

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Chemical Research in Chinese Universities 2011年第3期27卷 474-477页

作者： WANG Shao-feng HAN Jia-yu FU xue-qi zhao zhi zhuang Joe Edmond H. Fischer Signal Transduction Laboratory College of Life Sciences Jilin University Changehun 130012 P. R. China Department of Pathology University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 USA

PTPRU is an MAM domain-containing receptor-like protein tyrosine phosphatase. Previous studies have demonstrated an important role of the enzyme in the maintenance of epithelial integrity and in the regulation of the Wnt/β-catenin signaling pathway. To better understand the function of PTPRU, we cloned and expressed the intracellular portion of PTPRU as a GST fusion protein in E. coli cells. We purified the protein to homogeneity and used it to immunize mice for antibody production. The resultant antibody specifically recognized PTPRU over-expressed in the cell line. Western blot analyses demonstrated the partition of truncated forms of PTPRU containing the cadherin-like domain in the Triton X-100-insoluble fraction, and immunofluorescent cell staining revealed the localization of these proteins in punctate intracellular structures. Our data suggest that the cadherin-like domain of PTPRU has a major role in determining its intracellular localization.

关键词： Tyrosine phosphatase Cadherin Catenin Microdomain

Combining SVM and CHMM classifiers for porno video recognition

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The Journal of China Universities of Posts and Telecommunications 2012年第3期19卷 100-106页

作者： zhao zhi-cheng School of Information and Communication Engineering Beijing University of Posts and Telecommunications Beijing 100876 China Beijing Key Laboratory of Network System and Network Culture Beijing University of Posts and Telecommunications Beijing 100876 China

Pomo video recognition is important for Intemet content monitoring. In this paper, a novel pomo video recognition method by fusing the audio and video cues is proposed. Firstly, global color and texture features and local scale-invariant feature transform （SIFT） are extracted to train multiple support vector machine （SVM） classifiers for different erotic categories of image frames. And then, two continuous density hidden Markov models （CHMM） are built to recognize porno sounds. Finally, a fusion method based on Bayes rule is employed to combine the classification results by video and audio cues. The experimental results show that our model is better than six state-of-the-art methods.

关键词： pomo video recognition SVM keyframe CHMM audio

P-symmetric Subharmonic Solutions for Nonlinear Hamiltonian Systems

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1388-1408页

作者： Duan zhi ZHANG zhi Hao zhao School of Mathematical Sciences Nankai UniversityTianjin 300071P.R.China

In this paper,we prove that for each positive k≡1 mod m there exists a P-symmetric kmτ-periodic solution xk for asymptotically linear mτ-periodic Hamiltonian systems,which are nonautonomous and endowed with a *** the P-symmetric Hamiltonian function is semi-positive,one can prove,under a new iteration inequality of the Maslov-type P-index,that xk_(1) and xk_(2) are geometrically distinct for k_(1)/k_(2)≥(2n+1)m+1;and xk_(1),xk_(2) are geometrically distinct for k_(1)/k_(2)≥m+1 provided xk_(1) is non-degenerate.

关键词： P-symmetric subharmonic Hamiltonian systems Maslov-type index theory iteration inequality asymptotically linear

Buster Die Shape Design of a Track Link Forging Using FEM Based Back-Tracing Method

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Journal of Materials Science & Technology 2001年第1期17卷 139-140页

作者： Guoqun zhao xue DENG Mold&Die Engineer Technology Research Center Shandong University of TechnologyJinan 250061China

For the preform design of a complex track link forging, fifteen critical sections were selected for two dimensional back-tracing using FEM. The preform shapes of the critical sections are designed and integrated into an ideal 3D busting shape. The buster dies are finally designed according to the ideal busting shape with a little of modification. The 3D simulation of the busting stage is carried out.

关键词： two dimensional preform design

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Modeling pedestrian-vehicle interactions at unsignalized mid-block crosswalk under automated vehicle mixed traffic flow conditions: an agent-based approach

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Journal of Traffic and Transportation Engineering(English Edition) 2025年

作者： Haojie Li Binyue zhao Ziqian Zhang Yingheng Zhang Gang Ren School of Transportation， Southeast University Jiangsu Key Laboratory of Urban ITS Jiangsu Province Collaborative Innovation Center of Modern Urban Traffic Technologies

The introduction of automated vehicles (AVs) is expected to improve the safety and traffic efficiency of the transportation system. However， the impacts of AVs on pedestrian-vehicle interactions (PVIs) remain unclear， especially under the mixed traffic flow condition with AVs and conventional vehicles (CVs). The objective of this paper is to investigate PVIs under AV mixed traffic flow at unsignalized mid-block crosswalk (UMC) where the right of way competition exists and the traffic conditions are more complex. An agent-based simulation model is proposed to evaluate the safety and traffic efficiency under a diverse range of different scenarios. Some agents’ behavioral parameters are calibrated from trajectory and video data collected at two sites in Nanjing. The proposed model is also validated by comparing Post-Encroachment Time (PET) and pedestrian waiting time outputted from simulation with those extracted from empirical data. The simulation results suggest that the introduction of AVs has limited effect on both safety and efficiency levels at UMC under the low AV penetration rate. Compared to the negotiated yielding strategy of AVs， the conservative yielding strategy performs better in terms of pedestrian safety， but worse in improving traffic efficiency. Moreover， the results reveal that pedestrian and vehicle volumes， the proportion of pedestrians familiar with AVs， and the proportion of risk-prone pedestrians could significantly affect the safety and efficiency levels at UMC. Lastly， we provide some practical recommendations for determining treatments for mid-block crosswalks with AV mixed traffic flow to improve pedestrian safety and traffic efficiency.

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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng zhao Bin Dai Lei Ye Tao Song Shuai Huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2