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Solitary Wave and Non-traveling Wave Solutions to Two Nonlinear Evolution Equations

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Communications in Theoretical Physics 2005年第3X期44卷 479-482页

作者： YAN zhi-Lian liu xi-Qiang School of Mathematical Sciences Liaocheng University Liaocheng 252059 China

By applying the extended homogeneous balance method, we find some new explicit solutions to two nonlinear evolution equations, which include n-resonance plane solitary wave and non-traveling wave solutions.

关键词：非线性发展方程扩展性平衡性 Boussinesq变量方程非行波解孤波解

Symmetry Reductions and Explicit Solutions for a Generalized Zakharov-Kuznetsov Equation

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Communications in Theoretical Physics 2006年第1期45卷 29-32页

作者： YAN zhi-Lian liu xi-Qiang School of Mathematical Sciences Liaocheng University Liaocheng 252059 China

一个概括 Zakharov-Kuznetsov 方程的对称的二种类型经由一个直接对称方法被获得。由选择发生在对称的合适的参数，我们也发现某对称减小和 generalizedZakharov-Kuznetsov 方程的新明确的答案。

关键词：对称性直接解法普遍性Zakharov-Kuznetsov方程非线性方程

Effect of cytochrome P4502C19(CYP2C19)gene polymorphism and clopidogrel reactivity on long term prognosis of patients with coronary heart disease after PCI

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Journal of Geriatric Cardiology 2024年第1期21卷 90-103页

作者： Cheng-Yan HU Yan-Ling WANG Zhen-xing FAN xi-Peng SUN Shuai WANG zhi liu Department of Geriatrics Fu Xing HospitalCapital Medical UniversityBeijingChina Department of Cardiology Xuanwu Hospital Capital Medical UniversityBeijingChina Emergency Department of Xuanwu Hospital Capital Medical UniversityBeijingChina

Objective To investigate the impact of CYP2C19 gene polymorphism on clopidogrel reactivity and its association with longterm clinical outcome in patients with coronary heart disease(CHD)undergoing percutaneous coronary intervention(PCI).Methods In total,675 patients were *** on the platelet inhibition rate,patients were categorized into two groups:clopidogrel low responsiveness(CLR)and normal clopidogrel responsiveness(NCR).The CLR group was divided into ticagrelor and clopidogrel group based on the antiplatelet drugs used in the follow-up *** were classified into three groups(normal metabolizer,intermediate metabolizer,and poor metabolizer)based on the CYP2C19 *** aimed to evaluate the impact of CYP2C19 gene polymorphism on clopidogrel *** cumulative rates of 12-month all-cause deaths,major adverse cardiovascular events(MACCEs),and bleeding events were *** CLR was observed in 44.4%of the overall *** differences were observed in the platelet inhibition rate of clopidogrel among the three metabolic genotypes(P0.05).Conclusions Low response to clopidogrel in CHD patients is correlated with CYP2C19 gene ***2C19 genotyping combined with platelet reactivity is an independent predictor of 12-months MACCEs in patients with clopidogrel treatment after PCI,which is better than either test alone.

关键词： CYP2C19 drugs PCI

Development and validation of a prognostic immunoinflammatory index for patients with gastric cancer

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World Journal of Gastroenterology 2024年第24期30卷 3059-3075页

作者： zhi-Chang Ba xi-Qing Zhu zhi-Guo Li Yuan-Zhou Li Department of Radiology Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina Department of Gastrointestinal Surgery Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina

BACKGROUND Studies have demonstrated the influence of immunity and inflammation on the development of *** single biomarkers of immunity and inflam-mation have been shown to be clinically predictive,the use of biomarkers integrating both to predict prognosis in patients with gastric cancer remains to be *** To investigate the prognostic and clinical significance of inflammatory biomarkers and lymphocytes in patients undergoing surgical treatment for gastric *** Univariate COX regression analysis was performed to identify potential prognostic factors for patients with gastric cancer undergoing surgical *** absolute shrinkage and selection operator-COX(LASSO-COX)regression analysis was performed to integrate these factors and formulate a new prognostic immunoinflammatory index(PII).The correlation between PII and clinical charac-teristics was statistically *** incorporating the PII score were devised and validated based on the time-dependent area under the curve and decision curve *** Patients exhibiting elevated neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,and systemic immune inflammatory index displayed inferior progression-free survival(PFS)and overall survival(OS).Conversely,low levels of CD3(+),CD3(+)CD8(+),CD4(+)CD8(+),and CD3(+)CD16(+)CD56(+)T lymphocytes were associated with improved PFS and OS,while high CD19(+)T lymphocyte levels were linked to worse PFS and *** PII score demonstrated associations with tumor characteristics(primary tumor site and tumor size),establishing itself as an independent prognostic factor for both PFS and ***-dependent area under the curve and decision curve analysis affirmed the effectiveness of the PII-based nomogram as a robust prognostic predictive *** PII may be a reliable predictor of prognosis in patients with gastric cancer undergoing surgical treatment,and it offers insights into cancer-related immune-inflammatory re

关键词： Gastric cancer Immunity Inflammation Prognosis Nomogram

Synergic action of linear dispersion, second-order nonlinearity, and third-order nonlinearity in shaping the spectral profile of a femtosecond pulse transporting in a lithium niobate crystal

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Photonics Research 2024年第4期12卷 774-783页

作者： LIHONG HONG YUANYUAN liu zhi-YUAN LI State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China

We present a detailed theoretical and numerical analysis on the temporal-spectral-spatial evolution of a highpeak-power femtosecond laser pulse in two sets of systems:a pure lithium niobate(LN)plate and a periodically poled lithium niobate(PPLN)*** develop a modified unidimensional pulse propagation model that considers all the prominent linear and nonlinear processes and carried out the simulation process based on an improved split-step Fourier transformation *** theoretically analyze the synergic action of the linear dispersion effect,the second-order nonlinearity(2nd-NL)second-harmonic generation(SHG)effect,and the third-order nonlinearity(3rd-NL)self-phase modulation(SPM)effect,and clarify the physical mechanism underlying the peculiar and diverse spectral broadening patterns previously reported in LN and PPLN thin plate *** analysis and discussion provides a deeper insight into the synergetic contribution of these linear and nonlinear effects brought about by the interaction of a femtosecond laser pulse with the LN nonlinear crystal and helps to draw a picture to fully understand these fruitful optical physical processes,phenomena,and laws.

关键词： pulse nonlinearity lithium

Synergistic effect between Er-doped MoS_(2)nanosheets and interfacial Mo-N coupling phases for enhanced electrocatalytic hydrogen evolution

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Rare Metals 2024年第3期43卷 1301-1308页

作者： Nian-Peng Li Lei Zhang Hua Zhang Fan-Fei Min Lei Wang Sam Toan xi-Jun liu Guang-zhi Hu State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines School of Materials Science and EngineeringAnhui University of Science and TechnologyHuainan232001China Donghai Laboratory Zhoushan316021China Department of Chemical Engineering University of Minnesota-DuluthDuluthMN55812USA School of Ecology and Environmental Science Institute for Ecological Research and Pollution Control of Plateau LakesYunnan UniversityKunming650504China MOE Key Laboratory of New Processing Technology for Non-Ferrous Metals and Materials Guangxi Key Laboratory of Processing for Non-Ferrous Metals and Featured MaterialsGuangxi UniversityNanning530004China

Hydrogen production via electrochemical water splitting is a promising and green *** one of the most representative transition metal sulfides layered materials,Molybdenum disulfide(MoS_(2))has immense potential for the hydrogen evolution reaction(HER).We successfully prepared a nitrogen-doped carbon(NC)in situ-grown erbium-doped MoS_(2)polyhedral structure(Er-MoS_(2)/NC)that incorporates an interfacial Mo-N coupling phase.

关键词： hydrogen interfacial coupling

Unleashing the Power of Bio-based Thermotropic Liquid Crystal Modifiers:Toughening and Reinforcing Petroleum-based Epoxy Resin without Compromising Other Properties

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Chinese Journal of Polymer Science 2024年第8期42卷 1093-1102页

作者： Qing-Yun Lu Hong-Wei Gu Jia-Hui Li Qian-Qian Fan Bei-Tao liu Yan Kou xi-Gao Jian zhi-Huan Weng State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart MaterialsLiaoning Technology Innovation Center of High Performance Resin MaterialsDepartment of Polymer Science&EngineeringDalian University of TechnologyDalian 116024China Thermochemistry Laboratory Liaoning Province Key Laboratory of Thermochemistry for Energy and MaterialsDalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China

Toughening the petroleum-based epoxy resin blends with bio-based modifiers without compromising their modulus,mechanical strength,and other properties is still a big challenge in view of the *** this study,a bio-based liquid crystal epoxy resin(THMT-E P)with an s-triazine ring structure was utilized to modify a petroleum-based bisphenol A epoxy resin(E51)with 4,4'-diaminodiphenylsulfone(DDS)as a curing agent,and the blended systems were evaluated for their thermal stability,mechanical properties,and flame *** results showed that the impact strength of the blended system initially increased and then decreased with the increase in THMT-EP content,and it reached the a maximum value of 26.5 kJ/m^(2)when the THMT-EP content was 5%,which was 31.2%higher than that of E51/***,the flexural strength,modulus,and glass transition tem perature of the blended system were all simultaneously improved with the addition of *** the same time,the addition of THMT-EP enhanced the flame retardancy of the system by increasing the char yield at 700℃and decreasing the peak heat release rate and total heat release *** work paves the way for a more sustainable improvement in the comprehensive performance of epoxy resin.

关键词： Epoxy resin Toughening Bio-based Thermotropic liquid crystal

Equivalence between the internal observability and equation

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 89-97页

作者： liu Wen-jun TU zhi-yu School of Mathematics and Statistics Nanjing University of Information Science and TechnologyNanjing 210044China

This paper is concerned with a third order in time linear Moore-Gibson-Thompson equation which describes the acoustic velocity potential in ultrasound wave *** by the work of Kaltenbacher,Lasiecka and Marchand(Control Cybernet.2011,40:971-988),we establish an observability inequality of the conservative problem,and then discuss the equivalence between the exponential stabilization of a dissipative system and the internal observational inequality of the corresponding conservative system.

关键词： Moore-Gibson-Thompson equation internal observability exponential stability

Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1637-1650页

作者： Yuanliang Yan Shangjun Zhou xi Chen Qiaoli Yi Songshan Feng Zijin Zhao Yuanhong liu Qiuju Liang zhijie Xu zhi Li Lunquan Sun Department of Pharmacy Xiangya HospitalCentral South UniversityChangsha 410008China Department of Neurosurgery Xiangya HospitalCentral South UniversityChangsha 410008China Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008China xiangya Cancer Center Xiangya HospitalCentral South UniversityChangsha 410008China Key Laboratory of Molecular Radiation Oncology Hunan Province Changsha 410008China institute of Cancer Research National Clinical Research Center for Geriatric Disorders(Xiangya)Xiangya HospitalCentral South UniversityChangsha 410008China

Temozolomide(TMZ)represents a standard-of-care chemotherapeutic agent in glioblastoma(GBM).However,the development of drug resistance constitutes a significant hurdle in the treatment of malignant *** specific innovative approaches,such as immunotherapy,have shown favorable clinical outcomes,the inherent invasiveness of most gliomas continues to make them challenging to ***,there is an urgent need to identify effective therapeutic targets for gliomas to overcome chemoresistance and facilitate drug *** investigation used mass spectrometry to examine the proteomic profiles of six pairs of GBM patients who underwent standard-of-care treatment and surgery for both primary and recurrent tumors.A total of 648 proteins exhibiting significant differential expression were *** Set Enrichment Analysis(GSEA)unveiled notable alterations in pathways related to METABOLISM_OF_LIPIDS and BIOLOGICAL_OxiDATIONS between the primary and recurrent *** through glioma tissue arrays and the xiangya cohort confirmed substantial upregulation of inositol 1,4,5-triphosphate(IP3)kinase B(ITPKB)in the recurrence group,correlating with poor survival in glioma *** TMZ-resistant cells,the depletion of ITPKB led to an increase in reactive oxygen species(ROS)related to NADPH oxidase(NOX)activity and restored cell sensitivity to ***,the decreased phosphorylation of the E3 ligase Trim25 at the S100 position in recurrent GBM samples accounted for the weakened ITPKB ***,in turn,elevated ITPKB stability and impaired ROS ***,ITPKB depletion or the ITPKB inhibitor GNF362 effectively overcome TMZ chemoresistance in a glioma xenograft mouse *** findings reveal a novel mechanism underlying TMZ resistance and propose ITPKB as a promising therapeutic target forTMZ-resistant GBM.

关键词： TMZ homeostasis impaired