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Two haplotype-resolved genome assemblies for AAB allotriploid bananas provide insights into banana subgenome asymmetric evolution and Fusarium wilt control

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Plant Communications 2024年第2期5卷 243-260页

作者： Wen-Zhao Xie Yu-Yu Zheng weidi He Fangcheng Bi Yaoyao Li Tongxin Dou Run zhou Yi-Xiong Guo Guiming Deng Wenhui Zhang Min-Hui Yuan Pablo Sanz-Jimenez Xi-Tong Zhu Xin-Dong Xu Zu-Wen zhou zhi-wei zhou Jia-Wu Feng Siwen Liu Chunyu Li Qiaosong Yang Chunhua Hu Huijun Gao Tao Dong Jiangbo Dang Qigao Guo Wenguo Cai Jianwei Zhang Ganjun Yi Jia-Ming Song Ou Sheng Ling-Ling Chen Institute of Fruit Tree Research Guangdong Academy of Agricultural SciencesKey Laboratory of South Subtropical Fruit Biology and Genetic Resource UtilizationMinistry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Tropical and Subtropical Fruit Tree ResearchGuangzhou 510640China College of Informatics Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning 530004China College of Horticulture and Landscape Architecture Southwest UniversityChongqing 400715China

Bananas(Musa spp.)are one of the world’s most important fruit crops and play a vital role in food security for many developing *** banana cultivars are triploids derived from inter-and intraspecific hybrid-izations between the wild diploid ancestor species Musa acuminate(AA)and ***(BB).We report two haplotype-resolved genome assemblies of the representative AAB-cultivated types,Plantain and Silk,and precisely characterize ancestral contributions by examining ancestry mosaics across the *** asymmetric evolution is observed in their subgenomes,which can be linked to frequent homol-ogous exchange *** reveal the genetic makeup of triploid banana cultivars and verify that subge-nome B is a rich source of disease resistance *** 58.5%and 59.4%of Plantain and Silk genes,respectively,are present in all three haplotypes,with>50%of genes being differentially expressed alleles in different *** observed that the number of upregulated genes in Plantain is significantly higher than that in Silk at one-week post-inoculation with Fusarium wilt tropical race 4(Foc TR4),which con-firms that Plantain can initiate defense responses faster than ***,we compared genomic and transcriptomic differences among the genes related to carotenoid synthesis and starch metabolism between Plantain and *** study provides resources for better understanding the genomic architecture of culti-vated bananas and has important implications for Musa genetics and breeding.

关键词： bananas Plantain Silk asymmetric evolution homologous exchange Fusarium wilt

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The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2023

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Cancer Communications 2024年第1期44卷 127-172页

作者： Feng-Hua Wang Xiao-Tian Zhang Lei Tang Qi Wu Mu-Yan Cai Yuan-Fang Li Xiu-Juan Qu Hong Qiu Yu-Jing Zhang Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Chang Wang Hao Liu Miao-Zhen Qiu Wen-Long Guan Sheng-Xiang Rao Jia-Fu Ji Yan Xin wei-Qi Sheng Hui-Mian Xu zhi-wei zhou Ai-Ping zhou Jing Jin Xiang-Lin Yuan Feng Bi Tian-Shu Liu Han Liang Yan-Qiao Zhang Guo-Xin Li Jun Liang Bao-Rui Liu Lin Shen Jin Li Rui-Hua Xu Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer HospitalBeijingP.R.China Department of Radiology Peking University Cancer HospitalBeijingP.R.China Department of Endoscopy Center Peking University Cancer HospitalBeijingP.R.China Department of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoningP.R.China Department of Medical Oncology Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Radiotherapy Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Department of Medical Oncology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China Department of Surgical Oncology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Medical Oncology Fujian Cancer HospitalFuzhouFujianP.R.China Tumor Center The First Hospital of Jilin UniversityChangchunJilinP.R.China Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Department of Radiology Zhongshan HospitalFudan UniversityShanghaiP.R.China Department of

The 2023 update of the Chinese Society of Clinical Oncology(CSCO)Clini-cal Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in China,reflecting the latest advancements in evidence-based medicine,healthcare resource availability,and precision *** updates address the differences in epidemiological characteristics,clinicopatho-logical features,tumor biology,treatment patterns,and drug selections between Eastern and Western gastric cancer *** revisions include a structured template for imaging diagnosis reports,updated standards for molecular marker testing in pathological diagnosis,and an elevated recommendation for neoadju-vant chemotherapy in stage III gastric *** advanced metastatic gastric cancer,the guidelines introduce new recommendations for immunotherapy,anti-angiogenic therapy and targeted drugs,along with updated management strategies for human epidermal growth factor receptor 2(HER2)-positive and deficient DNA mismatch repair(dMMR)/microsatellite instability-high(MSI-H)***,the guidelines offer detailed screening recommendations for hereditary gastric cancer and an appendix listing drug treatment regimens for various stages of gastric *** 2023 CSCO Clinical Guidelines for Gastric Cancer updates are based on both Chinese and international clinical research and expert consensus to enhance their applicability and relevance in clinical practice,particularly in the heterogeneous healthcare landscape of China,while maintaining a commitment to scientific rigor,impartiality,and timely revisions.

关键词： Chinese Society of Clinical Oncology(CSCO) gastric cancer diagnosis surgery neoadjuvant adjuvant radiotherapy chemotherapy targeted therapy immunotherapy

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The Application of Ion Mobility-Mass Spectrometry in Untargeted Metabolomics: from Separation to Identification

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Journal of Analysis and Testing 2020年第3期4卷 163-174页

作者： Ming-Du Luo zhi-wei zhou Zheng-Jiang Zhu Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China University of Chinese Academy of Sciences Beijing 100049China

Untargeted metabolomics aims to comprehensively profile metabolites as many as possible in biological ***,ion mobility-mass spectrometry(IM-MS)has emerged as a powerful technology for untargeted *** emerging role of IM-MS in untargeted metabolomics enables the separation of metabolite isomers and generation of multidimension data to support the identification of *** this review,we first introduced the basic principles of IM-MS instruments commonly used for untargeted ***,we demonstrated the application of IM-MS for metabolite separation and identification of both known and unknown ***,we discussed the future developments of IM-MS technology to improve untargeted metabolomics.

关键词： Ion mobility-mass spectrometry Untargeted metabolomics Collison cross section(CCS) Metabolite identification Isomer separation

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A Comparative Research of Two English Translations of the Chapter “Comprehensive Discourse on Phenomena Corresponding to Yin and Yang” in Huangdi's Internal Classic

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Chinese Medicine and Culture 2022年第1期5卷 52-57页

作者： zhi-wei zhou Yan-Qing Li Hai-Ying Li Institute of Science Technology and HumanitiesShanghai University of Traditional Chinese MedicineShanghai 201203China

Culture-loaded words refer to words with specific cultural connotations that can express an abstract or a specific concept,which may be related to religious beliefs or social customs,but do not exist in other languages and ***,culture-loaded words bring some difficulties to translation *** Di Nei Jing(《黄帝内经》Huangdi’s Internal Classic)is the foundation of traditional Chinese medicine(TCM)theory,and is listed as the first of the four classics of *** contains a large number of cultureloaded words,which embody the ancient Chinese traditional *** translation of culture-loaded words is a difficult but crucial point in the translation of Huangdi’s Internal Classic and directly relates to the quality of the translation of Huangdi’s Internal Classic as a *** the two English versions of Maoshing Ni and Li Zhaoguo as examples,this work identifies the culture-loaded words appearing in the chapter“Yin Yang Ying Xiang Da Lun”(阴阳应象大论Comprehensive Discourse on Phenomena Corresponding to the Yin and Yang).This work studies the strategies and translation process of culture-loaded words in Huangdi’s Internal Classic,with a view to contribute to the English translation of TCM classics.

关键词： Culture-loaded words Huang Di Nei Jing(《黄帝内经》Huangdi’s Internal Classic) Translation

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Identification of molecular biomarkers for the diagnosis of gastric cancer and lymph-node metastasis

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Gastroenterology Report 2019年第1期7卷 57-66,I0002页

作者： Sharvesh Raj Seeruttun Wing Yan Cheung wei Wang Cheng Fang zhi-Min Liu Jin-Qing Li Ting Wu Jun Wang Chun Liang zhi-wei zhou Department of Gastric Surgery Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China State Key Laboratory of Oncology in South China GuangzhouGuangdong 510060P.R.China Collaborative Innovation Center for Cancer Medicine GuangzhouGuangdong 510060P.R.China Division of Life Science Center for Cancer Research and State Key Lab for Molecular NeuroscienceHong Kong University of Science and TechnologyHong KongP.R.China Fok Ying Tung Research Institute Hong Kong University of Science and TechnologyHong KongP.R.China Biomedical Research Institute Shenzhen-Peking University-Hong Kong University of Science and Technology Medical CenterShenzhenGuangdong 518036P.R.China

Background and objective:Biomarkers are important tools for prompt diagnosis of *** study aimed to identify reliable biomarkers for clinical applications in the diagnosis of gastric cancer and lymph-node(LN)***:Between 1 December 2014 and 31 December 2015,we prospectively collected samples of gastric-cancer tissues,corresponding matched-pair normal gastric mucosa,and their peri-gastric metastatic and non-metastatic LNs to identify quantitatively reliable genes using quantitative real-time polymerase chain *** quantity(RQ)was used to calculate the mRNA expression levels of our target *** were calculated using one-way analysis of variance(ANOVA)and Tukey’s multiple comparison *** graphs were plotted using GraphPad ***:Of nine assessed genes,the mRNA levels of inhibin beta A(INHBA)and secreted phosphoprotein 1(SPP1)were most consistently highly expressed in tumor tissues by 15.4-and 15.6-fold,respectively,as compared with normal tissues(P<0.001),with 91.3%sensitivity and 95.7%specificity(receiver operating characteristic[ROC]curve area=0.974)for the former and 82.6%sensitivity and 87.0%specificity(ROC curve area=0.924)for the *** analysis revealed no differentiating significance of SPP1 mRNA expression between metastatic and non-metastatic LNs(P=0.470).In contrast,the INHBA mRNA level was up-regulated 4.1-fold in metastatic LNs(P<0.001),with 80.0%sensitivity and 81.5%specificity(ROC curve area=0.857),and was also able to successfully differentiate between more severe disease conditions,T3 and T4(P=0.003),M0 and M1(P=0.043)and different histological variants(intestinal type vs diffuse type,P=0.019).Conclusions:Our results showed that INHBA was the most optimally reliable biomarker for diagnosing gastric cancer and LN metastasis.

关键词： Diagnosis gastric cancer lymph node metastasis molecular biomarker

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Coefficients of earth pressure at rest in thick and deep soils

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Mining Science and Technology 2009年第2期19卷 252-255页

作者： TIAN Qiu-hong XU zhi-wei zhou Guo-qing ZHAO Xiao-dong HU Kun State Key Laboratory for Geomechanics ＆ Deep Underground Engineering School of Architecture and Civil Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

The effect of test methods and stress paths on the experimental value of the coefficient of earth pressure at rest, K0, was investigated under high pressures. The results indicate that the rigid pressure chamber and flexible lateral confining pressure medium method gives a stress ratio at the initial stage that is not the real K0. Moreover, K0 increases during the loading process becoming greater at high pressures. In the unloading process, however, K0 increases only at the initial stage but decreases thereafter. In addition, the incremental magnitude definition, K0=dσ3/dσ1, gives higher values than the total magnitude definition, K0=σ3/σ1, under loading. This is also true during initial stages of unloading. The experiment results also indicate that earth pressure at rest in deep and thick soils can be estimated by a power function of axial and confining pressures. It is necessary to choose the appropriate Kn to avoid some accidents.

关键词： experimental research earth pressure at rest loading and unloading paths thick and deep soils

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Using p53-immunostained large specimens to determine the distal intramural spread margin of rectal cancer

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World Journal of Gastroenterology 2006年第10期12卷 1626-1629页

作者： zhi-Zhong Pan De-Sen Wan Chang-Qing Zhang Jian-Yong Shao Li-Ren Li Gong Chen zhi-wei zhou Fu-Long Wang Department of Abdominal Surgery Cancer Hospital Sun Yat-Sen University Guangzhou 510060 Guangdong Province China

AIM： To determine the distal intramural spread （DIS） margin of rectal cancer.METHODS： Sixty-one p53-positive specimens of rectal cancer were used. After conventional hematoxylin and eosin （H＆E） staining, the DIS margin of rectal cancer in large specimens was examined by immunohistochemistry. The patients were divided into A, B, C, and D groups. After a long-term follow-up, the survival curves of the four groups were estimated using the life table. RESULTS： Fifty-one of the sixty-one cases （83.6%） had DIS. The extent of DIS ranged 0.11-3.5 cm; meanwhile *** of DIS measured by H＆E staining was 0.13 cm. The significant difference was found between the means （t=5.622, P〈0.0001）. Only 1 of 51 patients had DIS greater than 3 cm. The DIS was less than 1.0 cm in most rectal cancer patients. The long-term results indicated that the survival rate of the patients whose DIS was greater than 1.0 cm was lower than that of the patients whose DIS was less than 0.5 cm. CONCLUSION： Rectal cancer patients with DIS greater than 1.0 cm have poor prognosis.

关键词： Rectal cancer Distal intramural spread p53 Immunohistochemistry Large specimen

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Electromagnetic scattering and imaging simulation of extremely large-scale sea-ship scene based on GPU parallel technology

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Journal of Electronic Science and Technology 2024年第2期22卷 16-23页

作者： Cheng-wei Zhang zhi-Qin Zhao wei Yang Li-Lai zhou Hai-Yu Zhu Southwest China Institute of Electronic Technology Chengdu610036China School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China Tencent Company Shenzhen518054China

Aiming to solve the bottleneck problem of electromagnetic scattering simulation in the scenes of extremely large-scale seas and ships,a high-frequency method by using graphics processing unit(GPU)parallel acceleration technique is *** the implementation of different electromagnetic methods of physical optics(PO),shooting and bouncing ray(SBR),and physical theory of diffraction(PTD),a parallel computing scheme based on the CPU-GPU parallel computing scheme is realized to balance computing ***,a multi-GPU framework is further proposed to solve the computational difficulty caused by the massive number of ray tubes in the ray tracing *** using the established simulation platform,signals of ships at different seas are simulated and their images are achieved as *** is shown that the higher sea states degrade the averaged peak signal-to-noise ratio(PSNR)of radar image.

关键词： Multi graphics processing unit Radar imaging Sea-ship Shooting and bouncing rays

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HBV infection decreases risk of liver metastasis in patients with colorectal cancer:A cohort study

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World Journal of Gastroenterology 2011年第6期17卷 804-808页

作者： Hai-Bo Qiu Zhao-Lei Zeng zhi-Qiang Wang Hui-Yan Luo Rajiv Prasad Keshari zhi-wei zhou Rui-Hua Xu Li-Yi Zhang State Key Laboratory of Oncology in South China Guangzhou 510060 Guangdong Province China Department of Medical Oncology Sun Yat-Sen University Cancer Center Guangzhou 510060 Guangdong Province China Department of Gastric and Pancreatic Surgery Sun Yat-Sen University Cancer Center Guangzhou 510060 Guangdong Province China Department of Clinical Oncology University of HongKong Pokfulam HongKong China Department of Research Sun Yat-Sen University Cancer Center Guangzhou 510060 Guangdong Province China

AIM:To evaluate the effect of hepatitis B virus (HBV) infection on liver metastasis of colorectal ***:A total of 1298 colorectal cancer patients were recruited from January 2001 to March 2005 in this ***-linked immunosorbent assay was used to test serum HBV markers for colorectal *** were divided into study (infection) group and control (non-infection) *** features of patients in two groups were ***:Liver metastasis was found in 319 out of the 1298 colorectal cancer *** incidence of liver metastasis was significantly lower in study group than in control group (14.2% vs 28.2%,P < 0.01).HBV infection significantly decreased the risk of liver metastasis [hazard ratio (HR):0.50,95% confidence interval (95% CI):0.38-0.66],but the incidence of extrahepatic metastasis was significantly higher in study group than in control group (31.9% vs 17.0%,P < 0.01).The HR was the lowest in chronic hepatitis B group (HR:0.29,95% CI:0.12-0.72).The number of liver metastatic lesions was significantly less in study group than in control group with a higher surgical resection ***,no significant difference was found in survival rate between the two groups (P=0.95).CONCLUSION:HBV infection decreases the risk of liver metastasis in patients with colorectal cancer and elevates the surgical resection rate of liver metastatic lesions.

关键词： Hepatitis B virus Colorectal cancer Liver metastasis Risk

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Learnware:small models do big

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Science China(Information Sciences) 2024年第1期67卷 39-50页

作者： zhi-Hua zhou zhi-Hao TAN National Key Laboratory for Novel Software Technology Nanjing University

There are complaints about current machine learning techniques such as the requirement of a huge amount of training data and proficient training skills,the difficulty of continual learning,the risk of catastrophic forgetting,and the leaking of data privacy/*** research efforts have been focusing on one of those concerned issues separately,paying less attention to the fact that most issues are entangled in *** prevailing big model paradigm,which has achieved impressive results in natural language processing and computer vision applications,has not yet addressed those issues,whereas becoming a serious source of carbon *** article offers an overview of the learnware paradigm,which attempts to enable users not to need to build machine learning models from scratch,with the hope of reusing small models to do things even beyond their original purposes,where the key ingredient is the specification which enables a trained model to be adequately identified to reuse according to the requirement of future users who know nothing about the model in advance.

关键词： artificial intelligence machine learning learnware

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