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Quinone oxidoreductase 1 is overexpressed in gastric cancer and associated with outcome of adjuvant chemotherapy and survival

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World Journal of Gastroenterology 2021年第22期27卷 3085-3096页

作者： zhi-nong jiang Syed Minhaj Uddin Ahmed Qin-Chuan Wang Hong-Fei Shi Xiu-Wen Tang Department of Pathology Affiliated Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016Zhejiang ProvinceChina Department of Biochemistry Zhejiang University School of MedicineHangzhou 310058Zhejiang ProvinceChina Department of Thoracic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Surgical Oncology Affiliated Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016Zhejiang ProvinceChina Department of Pathology The Forth Affiliated Hospital of Zhejiang University School of MedicineHangzhou 322000Zhejiang ProvinceChina

BACKGROUND Quinine oxidoreductase 1(NQO1)plays a vital role in protecting normal cells against oxidative damage and electrophilic *** is highly expressed in many solid tumors,suggesting a role in cancer development and ***,the role of NQO1 in gastric cancer and its effect on cancer development and prognosis have not been fully *** To investigate the clinical relevance of NQO1 protein expression in gastric cancer and to explore the potential of NQO1 to serve as a prognostic biomarker and therapeutic *** In this retrospective study,gastric cancer specimens of 175 patients who were treated between 1995 and 2011 were subjected to immunohistochemistry analyses for *** correlation of NQO1 expression with gastric cancer prognosis and clinical and pathological parameters was *** NQO1 protein was overexpressed in 59.43%(104/175)of the analyzed *** of NQO1 was associated with a significantly inferior *** addition,multivariate analysis suggested that NQO1 overexpression,along with tumor stage and patient age,are prominent prognostic biomarkers for gastric ***,NQO1 overexpression was correlated to a better response to 5-fluorouracil(5-FU)-based adjuvant *** NQO1 overexpression is associated with a significantly poor prognosis and better response to 5-FU in patients with gastric *** findings are relevant for improving therapeutic approaches for gastric cancer patients.

关键词： Gastric cancer Quinone oxidoreductase 1 Prognosis Immunohistochemistry Kaplan-Meier curves Biomarker

Changes of histology and expression of MMP-2 and nm23-H1 in primary and metastatic gastric cancer

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World Journal of Gastroenterology 2008年第10期14卷 1612-1616页

作者： Lin-Bo Wang zhi-nong jiang Miao-Ying Fan Chao-Yang Xu Wen-Jun Chen Jian-Guo Shen Department of Surgical Oncology Sir Run Run Shaw Hospital Zhejiang University College of Medicine Hangzhou 310016 Zhejiang Province China Department of Pathology Sir Run Run Shaw Hospital Zhejiang University College of Medicine Hangzhou 310016 Zhejiang Province China Department of Ultrasonic Diagnostics Sir Run Run Shaw Hospital Zhejiang University College of Medicine Hangzhou 310016 Zhejiang Province China

AIM: To investigate the changes of histology and expression of MMP-2 and nm23-H1 in primary and metastatic gastric cancer. METHODS: One hundred and seventy-seven gastric cancer patients with lymph node and/or distal metastasis between 1997 and 2001 were reviewed. Differences in histology of the primary and metastatic gastric cancer were assessed. MMP-2 and nm23-H1 immunoreactivity was compared in 44 patients with tumor infiltration to the serosa layer. RESULTS: Poorly and moderately differentiated metastatic gastric cancer was found in 88.7% (157/177) and primary gastric cancer in 75.7% (134/177) of the patients. The histological type of metastatic gastric cancer that was not completely in accordance with the preponderant histology of primary gastric cancer was observed in 25 patients (14.1%). MMP-2 immunoreactivity in metastatic gastric cancer was significantly stronger than that in primary gastric cancer, while nm23-H1 immunoreactivity showed no difference in primary and metastatic gastric cancer. CONCLUSION: Metastatic gastric cancer presents more aggressive histological morphology and higher MMP-2 immunoreactivity than primary gastric cancer. This heterogeneity may elicit a possible mechanism of gastric cancer metastasis.

关键词： Heterogeneity Gastric cancer Nm23-H1 MMP-2 Histological change

Isolated splenic metastases from gastric carcinoma:A case report and literature review

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World Journal of Gastroenterology 2013年第31期19卷 5199-5203页

作者： Yi-Ping Zhu Yi-Ping Mou Jun-Jun Ni Yu-Cheng Zhou Jin-Wei jiang zhi-nong jiang Guan-Yu Wang Department of General Surgery Sir Run Run Shaw Hospital Zhejiang University School of Medicine Department of Pathology Sir Run Run Shaw Hospital Zhejiang University School of Medicine

Isolated metastases to the spleen from gastric carcinoma is very *** a few cases have been reported in the *** herein present a case of isolated splenic metastases in a 62-year-old man,occurring 12 mo after total gastrectomy for gastric *** patient underwent a laparoscopic exploration,during which two lesions were found at the upper pole of the spleen,without involvement of other organs.A laparoscopic splenectomy was *** examination confirmed that the splenic tumor was a poorly differentiated adenocarcinoma similar to the primary gastric *** postoperative course was uneventful and the patient has been well for 9 mo,with no tumor *** clinical data of 18 cases of isolated splenic metastases from gastric carcinoma treated by splenectomy were summarized after a literature *** our knowledge,this is the first reported case of isolated splenic metastases undergoing laparoscopic splenectomy.

关键词： Metastasis Splenic neoplasms Stomach neoplasms Laparoscopy Splenectomy

Is adult-onset ulcerative colitis just confined to colon?

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Chinese Medical Journal 2021年第9期134卷 1132-1134页

作者： Ling-Na Ye Jie Mao zhi-nong jiang Qian Cao Department of Gastroenterology Xiasha Branch of Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310016China lnflammatory Bowel Disease Center of Sir Run Run Shaw Hospital College of MedicineZhejiang UniversityHangzhouZhejiang 310016China Department of Pathology Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310016China Department of Gastroenterology Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310016China

To the Editor:Ulcerative colitis(UC)is traditionally known to be confined to the large *** presence of upper gastrointestinal(GI)involvement has long been considered as a sign of Crohn disease(CD)rather than ***,involvement of the upper GI and small intestine has previously been reported in UC.[1,2]Importantly,both the symptoms and endoscopic features easily lead to a misdiagnosis of acute erosive or infectious *** present case highlights the need to consider upper GI involvement of UC as a differential *** case may prompt physician to recognize the possibility of an adult-onset UC subtype involving the upper GI;to consider whether upper GI involvement should be classified as a special and rare type of UC like CD,suggesting that it may be a high-risk factor for active disease or poor prognosis;and to determine whether more aggressive treatment are needed for patients with this kind of condition.

关键词： involvement colon intestine

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SWRCH22A线材拉拔断裂原因分析

南方金属 2018年第5期 5-8页

作者：农之江吴德兴宝武集团广东韶关钢铁有限公司广东韶关512123

针对SWRCH22A线材拉拔过程出现断裂的质量问题,对拉拔钢丝断口样进行宏观分析、金相检测、电镜能谱检测分析.断口为典型笔尖断口,笔尖状断口及漏斗状断口心部端头存在大尺寸夹杂,其成分中含耐火材料成分,拉拔钢丝心部存在大尺寸夹杂缺... 详细信息

针对SWRCH22A线材拉拔过程出现断裂的质量问题,对拉拔钢丝断口样进行宏观分析、金相检测、电镜能谱检测分析.断口为典型笔尖断口,笔尖状断口及漏斗状断口心部端头存在大尺寸夹杂,其成分中含耐火材料成分,拉拔钢丝心部存在大尺寸夹杂缺陷导致拉拔断裂.

关键词： SWRCH22A线材断裂非金属夹杂大尺寸夹杂心部缺陷

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10B21螺栓头部开裂原因分析及改善措施

南方金属 2017年第2期 50-52页

作者：农之江吴德兴宝钢集团广东韶关钢铁有限公司广东韶关512123

针对10B21线材拉拔后在加工M7螺栓过程中发生螺栓头部开裂质量问题,对螺栓进行金相组织检测、电镜能谱检测分析.金相组织检测分析表明,该质量问题是由于盘条表面存在裂纹,经拉拔后存留钢丝,加工螺栓时开裂;利用电镜能谱对裂纹处检测分析... 详细信息

针对10B21线材拉拔后在加工M7螺栓过程中发生螺栓头部开裂质量问题,对螺栓进行金相组织检测、电镜能谱检测分析.金相组织检测分析表明,该质量问题是由于盘条表面存在裂纹,经拉拔后存留钢丝,加工螺栓时开裂;利用电镜能谱对裂纹处检测分析,发现P、Cr、Na、O元素较高,可判定盘条表面裂纹为钢坯内裂造成.通过分析10B21螺栓头部开裂原因,提出了改善10B21方坯质量的措施和方法.

关键词： 10B21线材开裂钢坯内裂缺陷

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冷镦钢线材冷顶锻开裂问题分析及改善措施

南方金属 2015年第6期 30-33页

作者：刘春林农之江张志明北京科技大学冶金与生态工程学院北京100083 宝钢集团广东韶关钢铁有限公司广东韶关512100

冷镦钢是用来加工紧固件的钢铁材料.紧固件加工过程最容易出现的质量问题是镦头开裂,墩头开裂主要原因是线材的缺陷.文章结合实践经验,对冷镦钢线材冷顶锻开裂和产生此类质量缺陷的原因进行分析,并采取相应的改进,使顶锻开裂得以改善.

关键词：冷镦钢顶锻开裂表面质量夹杂组织

Constructing 2D bismuth-based heterostructure for highly efficient photocatalytic CO2 reduction

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Tungsten 2025年第1期7卷 71-79页

作者： Ruo-Hang Xu Hao-Yu jiang Dan-Dan Cui Kun-Rong Du Hong-Run Zhang Sheng-Jie Xu Ya-Qi Li zhi-Zhen Ren Liang Wang Wei-Chang Hao Yi Du School of Physics and BUAA-UOW Joint Research Centre Beihang University Shenzhen Institute of Beihang University Centre for Catalysis and Clean Energy School of Environment and Science Griffith University

Reforming carbon dioxide（CO2） into fuels and valuable chemicals using solar energy holds significant potential for emission reduction and addressing energy supply *** recombination of photocarriers remains a major obstacle,however,to enhancing solar energy conversion efficiency in the photocatalytic reaction *** two-dimensional materials,constructing heterogeneous structures has emerged as an effective strategy to enhance the separation of photoexcited carriers by leveraging the internal electric field at the heterogeneous ***,we present a facile strategy for preparing Bi4NbO8Br/Bi2WO6plate-on-plate Z-scheme junctions with a strong internal electric field by in situ *** unique heterostructure facilitates efficient separation and transport of photoexcited charges by harnessing the internal electric field induced by chemical bonding at the lateral ***,the Bi4NbO8Br/Bi2WO6heterostructure exhibits enhanced CO2photoreduction properties,along with a CO yield rate of approximately 35 μmol·g-1·h-1under full light *** work offers novel insights into the synthesis of unique hetero structures intended to enhance the efficiency of photocatalytic CO2reduction.

关键词： Bi4NbO8Br/Bi2WO6 CO2 reduction Heterostructures Photocatalysts

Toward understanding the role of genomic repeat elements in neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 646-659页

作者： Zhengyu An Aidi jiang Jingqi Chen Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan UniversityShanghaiChina Zhangjiang Fudan International Innovation Center ShanghaiChina

Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements.

关键词： Alzheimer's disease ataxia deep learning long-read sequencing neurodegeneration neurodegenerative diseases Parkinson's disease repeat element structural variant