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Actomyosin is Involved in the Organization of the Microtubule Preprophase Band in Arabidopsis Suspension Cultured Cells

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Journal of Integrative Plant Biology 2006年第1期48卷 53-61页

作者： Chun-Li Li zhi-ling chen Ming Yuan State Key Laboratory of Plant Physiology and Biochemistry Department of Plant Sciences College of Biological Sciences China Agricultural University Beijing 100094 China College of Life Sciences Capital Normal University Beijing 100037 China

The microtubule preprophase bands （PPBs） participate in the sequence of events to position cell plates in most plants. However, the mechanism of PPB formation remains to be clarified. In the present study, the organization of PPBs in Arabidopsis suspension cultured cells was investigated by confocal laser scanning microscopy combined with pharmacological treatments of reagents specific for the cytoskeleton elements. Double staining of F-actin and microtubules （MTs） showed that actin filaments were arranged randomly and no colocalization with cortical MTs was observed in the interphase cells. However, cortical actin filaments showed colocalization with MTs during the formation of PPBs. A broad actin band formed with the broad MT band in the initiation of PPB and narrowed down together with the MT band to form the PPB. Nevertheless, broad MT bands were formed but failed to narrow down in cells treated with the F-actin disruptor latrunculin A. In contrast, in the presence of the F-actin stabilizer phalloidin, PPB formation did not exhibit any abnormality. Therefore, the integrity, but not the dynamics, of the actin cytoskeleton is necessary for the formation of normal PPBs. Treatment with 2, 3-butanedine monoxime, a myosin inhibitor, also resulted in the formation of broad MT bands, indicating that actomyosin may be involved in the rearrangement of MTs to form the PPBs. Double staining of MTs and myosin revealed that myosin concentrated on the PPB region during PPB formation. It is suggested that the actin cytoskeleton at the PPB site may serve as a rack to transport cortical MTs by using myosin when the broad MT band narrows down to form the PPB.

关键词： Arabidopsis suspension cultured cell 2,3-butanedine monoxime microfilament microtubule preprophase band myosin.

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Cone-beam computed tomography noise reduction method based on U-Net with convolutional block attention module in proton therapy

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Nuclear Science and Techniques 2024年第7期35卷 89-100页

作者： Xing-Yue Ruan Xiu-Fang Li Meng-Ya Guo Mei chen Ming Lv Rui Li zhi-ling chen Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai201800China University of Chinese Academy of Sciences Beijing100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China Department of Radiation Oncology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai Key Laboratory of Proton therapy Shanghai201801China

Cone-beam computed tomography(CBCT) is mostly used for position verification during the treatment process. However,severe image artifacts in CBCT hinder its direct use in dose calculation and adaptive radiation therapy re-planning for proton therapy. In this study, an improved U-Net neural network named CBAM-U-Net was proposed for CBCT noise reduction in proton therapy, which is a CBCT denoised U-Net network with convolutional block attention modules. The datasets contained 20 groups of head and neck images. The CT images were registered to CBCT images as ground truth. The original CBCT denoised U-Net network, sCTU-Net, was trained for model performance comparison. The synthetic CT(SCT) images generated by CBAM-U-Net and the original sCTU-Net are called CBAM-SCT and U-Net-SCT images, respectively. The HU accuracies of the CT, CBCT, and SCT images were compared using four metrics: mean absolute error(MAE), root mean square error(RMSE), peak signal-to-noise ratio(PSNR), and structure similarity index measure(SSIM). The mean values of the MAE, RMSE, PSNR, and SSIM of CBAM-SCT images were 23.80 HU, 64.63 HU, 52.27 dB, and 0.9919, respectively,which were superior to those of the U-Net-SCT images. To evaluate dosimetric accuracy, the range accuracy was compared for a single-energy proton beam. The γ-index pass rates of a 4 cm × 4 cm scanned field and simple plan were calculated to compare the effects of the noise reduction capabilities of the original U-Net and CBAM-U-Net on the dose calculation results. CBAM-U-Net reduced noise more effectively than sCTU-Net, particularly in high-density tissues. We proposed a CBAM-U-Net model for CBCT noise reduction in proton therapy. Owing to the excellent noise reduction capabilities of CBAM-U-Net, the proposed model provided relatively explicit information regarding patient tissues. Moreover, it maybe be used in dose calculation and adaptive treatment planning in the future.

关键词： Proton therapy Cone-beam CT CBAM-U-Net γ-index

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Design of a rapid-cycling synchrotron for flash proton therapy

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Nuclear Science and Techniques 2023年第10期34卷 1-11页

作者： Ying Shi Man-Zhou Zhang Lian-Hua Ou-Yang zhi-ling chen Xiu-Fang Li De-Ming Li Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China

The purpose of this study was to design a rapid-cycling synchrotron, making it capable of proton beam ultrahigh dose rate irradiation, inspired by laser accelerators. The design had to be cheap and simple. We consider our design from six aspects: the lattice, injection, extraction, space charge effects, eddy current effects and energy switching. Efficiency and particle quantity must be addressed when injected. The space charge effects at the injection could affect particles' number. The eddy current effects in the vacuum chambers would affect the magnetic field itself and generate heat, all of which need to be taken into account. Fast extraction can obtain 10^(10) protons/pulse, equal to instantaneous dose rate up to 10~7 Gy/s in a very short time, while changing various extraction energies rapidly and easily to various deposition depths. In the further research, we expect to combine a delivery system with this accelerator to realize the FLASH irradiation.

关键词： FLASH Rapid-cycling synchrotron Proton therapy

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Follicular carcinoma of the thyroid with a single metastatic lesion in the lumbar spine:A case report

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World Journal of Clinical Cases 2022年第26期10卷 9493-9501页

作者： Yao-Kun chen Yu-Chun chen Wei-Xun Lin Jie-Hua Zheng Yi-Yuan Liu Juan Zou Jie-Hui Cai Ze-Qi Ji ling-zhi chen zhi-Yang Li Ye-Xi chen Department of Thyroid Breast and Hernia SurgeryThe Second Affiliated Hospital of Shantou University Medical CollegeShantou 515000Guangdong ProvinceChina Department of Bone Joint and Spine SurgeryThe Second Affiliated Hospital of Shantou University Medical CollegeShantou 515000Guangdong ProvinceChina

BACKGROUND The bone is the second most common site of thyroid cancer metastasis,after the *** options for bone metastasis of thyroid cancer include surgery,radioiodine therapy(RAIT),external radiation therapy,thyroid-stimulating hormone(TSH)inhibition,bisphosphonates,and small-molecule targeted *** most cases,thyroid carcinoma is found in the thyroid tissue;reports of follicular thyroid carcinoma with a single metastasis to the lumbar spine are *** SUMMARY We report a case of bone metastasis as the only clinical manifestation of thyroid *** patient was a 67-year-old woman with lumbar pain for 7 years and aggravation with intermittent claudication who had previously undergone partial thyroidectomy of a benign thyroid *** abnormal nodules were found in the bilateral thyroid ***,imaging studies were consistent with a spinal tumor,and the lesion was diagnosed as a metastatic follicular carcinoma of thyroid *** adopted a multidisciplinary collaboration and comprehensive treatment *** patient underwent lumbar spine surgery,total resection of the thyroid,postoperative TSH suppression therapy,and *** were no complications associated with the operation,and the patient had good postoperative *** has experienced no *** Follicular thyroid carcinoma is associated with early hematogenous metastasis,and the bone is a typical site of *** bone metastasis is not a contraindication to medical procedures,and providing the appropriate therapy can result in better outcomes and quality of life for these patients.

关键词： Case report Thyroid carcinoma Lumbar spine Metastasis Surgery

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Reformatted method for two-dimensional detector arrays measurement data in proton pencil beam scanning

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Nuclear Science and Techniques 2021年第6期32卷 83-93页

作者： Meng-Ya Guo Xiu-Fang Li Jie Wang Qi Liu Xiu-Zhen Deng Man-Zhou Zhang Li-Ren Shen Yue-Hu Pu zhi-ling chen Shanghai Institute of Applied Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Shanghai APACTRON Particle Equipment Co.Ltd Shanghai 201800China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China

The spatial resolution of a commercial two-dimensional(2D)ionization chamber(IC)array is limited by the size of the individual detector and the center-to-center distance between *** dose distributions with areas of steep dose gradients,inter-detector dose values are derived by the interpolation of nearby detector readings in the conventional mathematical interpolation of 2D IC array *** may introduce significant errors,particularly in proton spot scanning *** this study,by combining logfile-based reconstructed dose values and detector measurements with the Laplacian pyramid image blending method,a novel method is proposed to obtain a reformatted dose distribution that provides an improved estimation of the delivered dose distribution with high spatial ***,the similarity between the measured original data and the downsampled logfilebased reconstructed dose is regarded as the confidence of the reformatted dose ***,we quantify the performance benefits of this new approach by directly comparing the reformatted dose distributions with 2D IC array detector mathematically interpolated measurements and original low-resolution *** result shows that this new method is better than the mathematical interpolation and achieves gamma pass rates similar to those of the original low-resolution *** reformatted dose distributions generally yield a confidence exceeding 95%.

关键词： 2D ion chamber array detectors Laplacian pyramid image blending High-resolution reformatted methods Pencil beam scanning Proton therapy

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Suppressed effects of Phyllanthus urinaria *** acetate extract on hepatitis B virus both in vitro and in vivo

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Precision Medicine Research 2023年第3期5卷 20-28页

作者： zhi-ling chen Rui Zhang School of Basic Medicine and Life Sciences Hainan Medical UniversityHaikou 571199China School of Tropical Medicine Hainan Medical UniversityHaikou 571199China

Background:Phyllanthus urinaria L.(***)extract(PUE)has been used to inhibit hepatitis B virus(HBV).However,the underlying mechanism remains *** investigate which PUE fractions and main components lead to against HBV and approach the relevant molecular ***:*** was extracted with water,and then the decoction was extracted by petroleum ether,ethyl acetate,and n-butanol in *** HepG2.2.15 cell was treated with aqueous fraction,petroleum ether fraction,ethyl acetate fraction and n-butanol fraction,gallic acid(GA,C7H6O5)and corilagin(CL,C27H22O18),*** medium was collected for hepatitis B surface antigen(HBsAg)and hepatitis B e antigen *** counting kit-8 method was used to identify cell ***,the levels of cellular oxygen consumption,reactive oxygen species,and reduced glutathione were *** HBV modeling mice were treated with ethyl acetate fraction,entecavir and physiological saline,*** serum was collected for HBsAg and inflammatory cytokines *** tissue metabolites were screened by LC-MS/MS ***:The ethyl acetate fraction(EAF)of *** could significantly inhibit HBV secretion in HepG2.2.15(Pling group,EAF significantly decreased the expression levels of HBsAg,IL-1β,IFN-α(Pchenodeoxycholate(P<0.05).Kyoto Encyclopedia of Genes and Genomes results show that the differential metabolites were mainly enriched in ATP-binding cassette transporters ***:***

关键词： hepatitis B virus Phyllanthus urinaria L. fractions reactive oxygen species formation metabolomics

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On UR-Rings

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Journal of Mathematical Research and Exposition 2009年第2期29卷 355-361页

作者： YING zhi ling chen Jian Long Department of Mathematics Sout-heast University Jiangsu 210096 China

A ring is said to be UR if every element can be written as the sum of a unit and a regular element. These rings are shown to be a unifying generalization of regular rings, clean rings and （S, 2）-ring~. Some relations of these rings are studied and several properties of clean rings and （S, 2）-rings are extended. PAng extensions of UR-rings are also investigated.

关键词： clean rings G-clean rings regular rings (S, 2)-rings UR-rings.

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SAPT:a synchrotron-based proton therapy facility in Shanghai

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Nuclear Science and Techniques 2023年第10期34卷 36-46页

作者： Man-Zhou Zhang De-Ming Li Li-Ren Shen Hai-Rong Zhang zhi-ling chen Han-Wen Du Ming Gu Rui Li De-Kang Liu Yue-Hu Pu Jun-Feng Yu Jian-Feng chen Chu chen Chun-Long Guo Hao Guo Ge-Yang Jiang zhi-Qiang Jiang Lin Jin Wen-Jing Li Xiu-Fang Li Ye Lin Ming Liu Yong-Hao Liu Ya-Juan Liu Ming Lv Qing-Ru Mi Lian-Hua Ouyang Wei-Guo Shi Hang Shu Qi-Sheng Tang Kun Wang zhi-Shan Wang Jun Wu Xiao-Bing Wu Jia-Qiang Xu Wen-Zhen Xu Chong-Xian Yin cheng Yu Ren-Xian Yuan Qi-Bing Yuan Hai-Qun Zhang Miao Zhang Wen-zhi Zhang Li-Ying Zhao Wei-Min Zhou Shou-Xian Fang Xi-Dong Sun Zhen-Tang Zhao Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China APACTRON Particle Equipment Co. Ltd.Shanghai 201815China The Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Because of its excellent dose distribution,proton therapy is becoming increasingly popular in the medical application of cancer treatment.A synchrotron-based proton therapy facility was designed and constructed in *** synchrotron,beam delivery system,and other technical systems were commissioned and reached their expected *** a clinical trial of 47 patients was finished,the proton therapy facility obtained a registration certificate from the National Medical Products *** characteristics of the accelerator and treatment systems are described in this article.

关键词： Proton therapy Synchrotron Slow extraction Gantry Beam delivery system

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The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang zhiying chen Yinyi Xiong Qin Zhou ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

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弯剪共同作用下活性粉末混凝土梁截面分析程序探讨

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科学技术与工程 2016年第36期16卷 61-67页

作者：金凌志陈璇梅臣桂林理工大学广西岩土力学与工程重点实验室土木与建筑工程学院桂林541004

为了研究配箍率对高强箍筋活性粉末混凝土(RPC)梁抗剪性能的影响,开展6根配置HRB400级箍筋RPC梁的抗剪试验。考虑RPC的材料特征参数与钢纤维对斜截面承载力的影响,分析有腹筋与无腹筋梁在剪力传递机理及裂缝控制方面的差异。基于修正压... 详细信息

为了研究配箍率对高强箍筋活性粉末混凝土(RPC)梁抗剪性能的影响,开展6根配置HRB400级箍筋RPC梁的抗剪试验。考虑RPC的材料特征参数与钢纤维对斜截面承载力的影响,分析有腹筋与无腹筋梁在剪力传递机理及裂缝控制方面的差异。基于修正压力场理论,对开裂后的混凝土在拉、压应力下的本构关系及裂缝处的应力平衡条件进行适当修正;将弯矩效应叠加至纯剪作用下的截面分析中建立RPC梁在弯剪复合作用下的分析模型,并采用MATLAB软件编制RPC梁斜截面抗剪强度分析计算程序;对RPC简支梁的试验结果与计算结果进行对比分析。研究结果表明该计算程序能够较好地预测高强钢筋RPC梁的受剪承载力,具有一定的参考和实用价值。

关键词：活性粉末混凝土 HRB400级箍筋弯剪复合作用修正压力场理论抗剪承载力

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