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Comprehensive bibliometric analysis of pharmacotherapy for bipolar disorders:Present trends and future directions

World Journal of Psychiatry 2025年第1期15卷 153-167页

作者： Bo-Fan Chen Li Liu Fang-Zhen lin Hai-Min Zeng Hai-Qiang Huang Chun-Fang Zhang Cong-Cong Liu Xiang Chen Jie Peng Yun-Fa wang zhi-lin wang Bin Chen De-Le Liu Yun Liu Zheng-Zheng Li Xin-Xing Zeng The Second Affiliated Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Second Clinical Medical College Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Rehabilitation Medicine The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Provincial People’s Hospital The First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006Jiangxi ProvinceChina Department of Psychiatry Jiangxi Mental HospitalHospital of Nanchang UniversityNanchang UniversityNanchang 330029Jiangxi ProvinceChina

BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood *** drug treatment modalities are crucial for managing *** To analyze the current status and future trends of global research on BD drug treatment over the last *** The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment.A total of 2624 articles were *** visualization and analysis were conducted using CiteSpace,VOSviewer,Pajek,Scimago Graphica,and R-studio bibliometrix to identify RESULTS The United States,China,and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration *** University of Pittsburgh,Massachusetts General Hospital,and the University of Michigan have been identified as the major research institutions in this *** Journal of Affective Disorders is the most influential journal.A keyword analysis revealed research hotspots related to clinical symptoms,drug efficacy,and genetic mechanisms.A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited *** This study provides a detailed overview of the field of BD drug treatment,highlighting key contributors,research hotspots,and future *** study findings can be employed as a reference for future research and policymaking,which may enable further development and optimization of BD pharmacotherapy.

关键词： Bipolar disorder Drug treatment Bibliometric analysis Visualization Mental disorder

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Selective Laser Melting of 30CrMnSiA Steel: Laser Energy Density Dependence of Microstructural and Mechanical Properties

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Acta Metallurgica Sinica(English Letters) 2018年第8期31卷 807-814页

作者： lin-zhi wang Wen-Hou Wei Chongqing Key Laboratory of Additive Manufacturing Technology and Systems Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences

Three-dimensional parts of the 30 CrMnSiA steel were successfully fabricated using selective laser melting（SLM）. The microstructures and mechanical properties of the SLM-processed 30 CrMnSiA samples were investigated by scanning electron microscope and transmission electron microscopy. The results indicate that the microstructures of the 30 CrMnSiA samples consist mainly of lath martensite and acicular martensite. The value of the surface roughness decreases with increasing laser energy density（LED） before it reaches a minimum and then increases with further increasing LED. The relative density, microhardness and ultimate tensile strength of the SLM-processed samples initially increase and then decrease with increasing LED. By taking the relative density, surface roughness, microhardness and ultimate tensile strength into account, the optimized LED should be in the range of 46.15–51.28 J mm^（-3） for the SLM-processed30 CrMnSiA alloys. In addition, the differences in the microstructures and mechanical properties between the conventionally wrought 30 CrMnSiA sample and SLM-processed 30 CrMnSiA samples were also studied.

关键词： 30CrMnSiA Selective laser melting Laser energy density Microstructure Mechanical properties

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Effects of the types of overlap on the mechanical properties of FSSW welded AZ series magnesium alloy joints

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International Journal of Minerals,Metallurgy and Materials 2012年第3期19卷 231-235页

作者： Dan wang Jun Shen lin-zhi wang School of Materials Science and Engineering Chongqing UniversityChongqing 400044China

The effects of the types of overlap on the mechanical properties of the friction stir spot welding （FSSW） welded AZ series magnesium alloy joints were investigated by microstructural observations, microhardness tests, and tensile tests. The results show that the microstructure of the stir zone adjacent to the periphery of the rotating pin is mainly composed of the upper sheet. The average distance D between the longitudinal segment of the curved interface and the keyhole periphery, the tensile shear force, and the microhardness of the stir zone of the FSSW welded AZ61 alloy joint are the highest in all samples. During FSSW of AZ31 and AZ61 dissimilar magnesium alloys, the irregular deformation of the longitudinal segment of the curved interface appears, while the microhardness of the stir zone is higher when AZ61 alloy is the upper sheet. Moreover, the microhardness of the stir zone increases initially and then decreases sharply in the longitudinal test position.

关键词： magnesium alloys friction stir welding microstructure microhardness tensile properties

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Groundwater discharge drives water quality and greenhouse gas emissions in a tidal wetland

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Water Science and Engineering 2022年第2期15卷 141-151页

作者： zhi-lin wang Mahmood Sadat-Noori William Glamore Water Research Laboratory School of Civil&Environmental EngineeringUniversity of New South Wales SydneySydneyNSW 2052Australia

Wetlands play an important role in the global carbon cycle as they can be sources or sinks for greenhouse *** discharge into wetlands can affect the water chemistry and act as a source of dissolved greenhouse gases,including CO_(2)and CH_(4).In this study,surface water quality parameters and CO_(2)and CH_(4)concentrations were evaluated in a tidal wetland(Hunter Wetlands National Park,Australia)using time series ***(^(222)Rn),a natural ground water tracer,was used to investigate the role of groundwater as a pathway for transporting dissolved CO_(2)and CH_(4)into the *** addition,water-to-air CO_(2)and CH_(4)fluxes from the wetland were also *** results showed a high concentration of radon in wetland surface water,indicating the occurrence of ground water *** concentration had a strong negative relationship with water depth with a determination coefficient(R^(2))of 0.7,indicating that tidal pumping was the main driver of groundwater discharge to the *** concentration also showed a positive relationship with CO_(2)and CH_(4)concentrations(R^(2)=0.4 and 0.5,respectively),while the time series data revealed that radon,CO_(2),and CH_(4)concentrations peaked concurrently during low *** implied that groundwater discharge was a source of CO_(2)and CH_(4)to the *** wetland had an average water-to-air CO_(2)flux of 99.1 mmol/(m^(2)·d),twice higher than the global average CO_(2)flux from *** average CH_(4)flux from the wetland was estimated to be 0.3 mmol/(m^(2)d),which is at the higher end of the global CH_(4)flux range for *** results showed that groundwater discharge could be an important,yet unaccounted source of CO_(2)and CH_(4)to tidal *** work has implications for tidal wetland carbon budgets and emphasizes the role of groundwater as a subsurface pathway for carbon transport.

关键词： Groundwater discharge Methane Carbon dioxide Radon Global warming Climate change

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Mechanical properties and friction behaviors of CNT/AlSi_(10)Mg composites produced by spark plasma sintering

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International Journal of Minerals,Metallurgy and Materials 2017年第5期24卷 584-593页

作者： lin-zhi wang Ying Liu Jiao-jiao Wu Xi Zhang Chongqing Key Laboratory of Additive Manufacturing Technology and Systems Chongqing Institute of Green and Intelligent TechnologyChinese Academy of Sciences College of Material Science and Engineering Sichuan University College of Material Science and Engineering Southwest Jiaotong university

The mechanical properties and friction behaviors of CNT/AlSi10Mg composites produced by spark plasma sintering (SPS) were investigated. The results showed that the densities of the sintered composites gradually increased with increasing sintering temperature and that the highest microhardness and compressive strength were achieved in the specimen sintered at 450A degrees C. CNTs dispersed uniformly in the Al-Si10Mg matrix when the addition of CNTs was less than 1.5wt%. However, when the addition of CNTs exceeded 1.5wt%, the aggregation of CNTs was clearly observed. Moreover, the mechanical properties (including the densities, compressive strength, and microhardness) of the composites changed with CNT content and reached a maximum value when the CNT content was 1.5wt%. Meanwhile, the minimum average friction coefficient and wear rate of the CNT/AlSi10Mg composites were obtained with 1.0wt% CNTs.

关键词： metal matrix composites carbon nanotubes (CNTs) aluminum silicon magnesium alloys spark plasma sintering mechanical properties friction

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Grain Refining Efficiency of SHS Al-Ti-B-C Master Alloy for Pure Aluminum and Its Effect on Mechanical Properties

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Acta Metallurgica Sinica(English Letters) 2016年第8期29卷 742-747页

作者： Xu-Guang An Ying Liu Jin-Wen Ye lin-zhi wang Peng-Yue wang School of Materials Science and Engineering Sichuan University Key Laboratory of Advanced Special Material and Technology Ministry of Education

A new Al-5Ti-0.75B-0.2C master alloy was successfully prepared by self-propagating high-temperature（SHS）reaction from an Al-Ti-B_4C system with molten *** and phase characterization of the prepared Al-5Ti-0.75B-0.2C master alloy show that the nearly spherical TiC particles,hexagonal or rectangular TiB_2 particles,and blocklike TiAl_3 particles distribute uniformly in the aluminum *** refining test on commercial pure aluminum indicates that Al-5Ti-0.75B-0.2C master alloy exhibits a better grain refining performance than Al-5Ti-lB master *** addition of 0.2 wt%Al-5Ti-0.75B-0.2C master alloy,the average grain size of a-Al can be effectively refined to160 ± 5 μm from about 3000 μm,and the tensile strength and elongation are increased by about 20%and 14.1%due to the grain refinement.

关键词： Aluminum Al-Ti-B-C master alloy Self-propagating high-temperature(SHS) Grain refinement Mechanical properties

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Preparation of CNT/AlS i10Mg composite powders by high-energy ball milling and their physical properties

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International Journal of Minerals,Metallurgy and Materials 2016年第3期23卷 330-338页

作者： lin-zhi wang Ying Liu Wen-hou Wei Xu-guang An Tao Zhang Ya-yun Pu College of Materials Science and Engineering Sichuan University Chongqing Key Laboratory of Multi-scale Manufacturing Technology Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences College of Materials Science and Engineering Chongqing University

This study investigated the effects of carbon nanotube （CNT） concentration on the micro-morphologies and laser absorption proper- ties of CNT/AlSi10Mg composite powders produced by high-energy ball milling. A scanning electron microscope, X-ray diffractometer, laser particle size analyzer, high-temperature synchronous thermal analyzer, and UV/VIS/NIR spectrophotometer were used for the analysis of micro- graphs, phases, granulometric parameters, thermal properties, and laser absorption properties of the composite powders, respectively. The results showed that the powders gradually changed from flake- to granule-like morphology and the average particle size sharply decreased with in- creases in milling rotational speed and milling time. Moreover, a uniform dispersion of CNTs in AlSi10Mg powders was achieved only for a CNT content of 1.5wt%. Laser absorption values of the composite powders were also observed to gradually increase with the increase of CNT concentration, and different spectra displayed characteristic absorption peaks at a wavelength of approximately 826 nm.

关键词： metal matrix composites aluminum alloys carbon nanotubes powder metallurgy particle size distribution ball milling physi-cal properties

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Tongguan Liqiao acupuncture therapy improves dysphagia after brainstem stroke

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Neural Regeneration Research 2016年第2期11卷 285-291页

作者： Chun-hong Zhang Jin-ling Bian zhi-hong Meng Li-na Meng Xue-song Ren zhi-lin wang Xiao-yan Guo Xue-min Shi Department of Acupuncture and Moxibustion the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Department of Acupuncture and Moxibustion Tianjin University of Traditional Chinese Medicine

Tongguan Liqiao acupuncture therapy has been shown to effectively treat dysphagia after stroke-based pseudobulbar paralysis. We presumed that this therapy would be effective for dysphagia after bulbar paralysis in patients with brainstem infarction. Sixty-four patients with dysphagia following brainstem infarction were recruited and divided into a medulla oblongata infarction group（n = 22）, a midbrain and pons infarction group（n = 16）, and a multiple cerebral infarction group（n = 26） according to their magnetic resonance imaging results. All patients received Tongguan Liqiao acupuncture for 28 days. The main acupoints were Neiguan（PC6）, Renzhong（DU26）, Sanyinjiao（SP6）, Fengchi（GB20）, wangu（GB12）, and Yifeng（SJ17）. Furthermore, the posterior pharyngeal wall was pricked. Before and after treatment, patient swallowing functions were evaluated with the Kubota Water Test, Fujishima Ichiro Rating Scale, and the Standard Swallowing Assessment. The Barthel Index was also used to evaluate their quality of life. Results showed that after 28 days of treatment, scores on the Kubota Water Test and Standard Swallowing Assessment had decreased, but scores on the Fujishima Ichiro Rating Scale and Barthel Index had increased in each group. The total efficacy rate was 92.2% after treatment, and was most obvious in patients with medulla oblongata infarction（95.9%）. These findings suggest that Tongguan Liqiao acupuncture therapy can repair the connection of upper motor neurons to the medulla oblongata motor nucleus, promote the recovery of brainstem infarction, and improve patient＇s swallowing ability and quality of life.

关键词： nerve regeneration traditional Chinese medicine acupuncture stroke bulbar palsy brain infarction swallowing disorder dysphagia acupoints neurological rehabilitation neural regeneration

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A New Fluorescent Sensor for Transition Metal Ions in Aqueous Solution

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Chinese Chemical Letters 2000年第6期11卷 551-554页

作者： Li Jian JIANG zhi lin wang Xiao Qing JIANG Qin Hui LUO(Coordination Chemistry Institute Nanjing University Nanjing 210093) Coordination Chemistry Institute Nanjing University Nanjing 210093 China

A new fluorescent sensor consisted of fluorenyl and dioxotetraaza unit, dimethyl-6-(9-fluorenyl)-1,4,8,11-tetraazaundencane-5,7-dione (L), was synthesize fluorescent sensor for transition metal ions in aqueous solution.

关键词： fluorenyl dioxotetramine fluorescence sensor transition metal

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New Insights into Genotype-phenotype Correlations in Chinese Facioscapulohumeral Muscular Dystrophy： A Retrospective Analysis of 178 Patients

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Chinese Medical Journal 2015年第13期128卷 1707-1713页

作者： Feng lin zhi-Qiang wang Min-Ting lin Shen-Xing Murong Ning wang Department of Neurology and Institute of Neurology First Affiliated Hospital Fujian Medical University Fuzhou Fujian 350005 China

Background： Facioscapulohumeral muscular dystrophy （FSHD）, a common autosomal dominant muscular disorder, is caused by contraction of the D4Z4 repeats on 4q35. The complicated genotype-phenotype correlation among different ethnic population remains a controversial subject. We aimed to refine this correlation in order to provide new information for genetic counseling. Methods： Here, a cohort of[36 Chinese families including 178 affected individuals and 137 unaffected members were investigated. Genetic analyses were pertbrmed using the pl 3E-11, 4qA and 4qB probes after pulsed field gel electrophoresis separation and southern blotting. A I 0-grade FSHD clinical severity scale was adopted for clinical assessment. The genotype-phenotype correlation was established by linear regression analyses. Results： We observed a roughly inversed correlation between the short EcoRl fragment size and age-corrected clinical severity score in 154 symptomatic patients （P 〈 0.05）. Compared to male patients, a significant higher proportion of females in both asymptomatic carriers and severe patients showed larger variation in the size of short EcoRI fragment. A high incidence （ 19/42, 45.2%） ofasymptomatic （or minimally affected） carriers was found in familial members. Conclusions： Although the number of D4Z4 repeats is known as one of the critical influences on genotype-phenotype correlation, a rnajority ofphenotypic spectrum was still incompatible with their heterozygous contraction of the D4Z4 repeat, especial in female cases. Our resuhs suggest that there are multi-factors synergistically modulating the phenotypic expression.

关键词： Asymptomatic Facio-scapulohumeral Muscular Dystrophy Genetic Counseling Phenotype

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