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Leukocyte cell-derived chemotaxin 2(LECT2)regulates liver ischemia-reperfusion injury

Liver Research 2024年第3期8卷 165-171页

作者： Meng-Qi Dong Yuan Xie zhi-liang tang Xue-Wen Zhao Fu-Zhen Lin Guang-Yu Zhang zhi-Hao Huang zhi-Min Liu Yuan Lin Feng-Yong Liu Wei-Jie Zhou State Key Laboratory of Organ Failure Research Department of General SurgeryGuangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal TumorNanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Hepato-Biliary-Pancreatic and Hernia Surgery The First People's Hospital of ZhaoqingZhaoqingGuangdongChina Department of Interventional Radiology Senior Department of OncologyFifth Medical Center of PLA General HospitalBeijingChina

Background and aim Hepatic ischemia–reperfusion injury(IRI)is a significant challenge in liver transplantation,trauma,hypovolemic shock,and hepatectomy,with limited effective interventions *** study aimed to investigate the role of leukocyte cell-derived chemotaxin 2(LECT2)in hepatic IRI and assess the therapeutic potential of Lect2-short hairpin RNA(shRNA)delivered through adeno-associated virus(AAV)*** and methods This study analyzed human liver and serum samples from five patients undergoing the Pringle ***2-knockout and C57BL/6J mice were *** IRI was induced by clamping the hepatic *** included recombinant human LECT2(rLECT2)and ***2 expression levels and serum biomarkers including alanine aminotransferase(ALT),aspartate aminotransferase(AST),creatinine,and blood urea nitrogen(BUN)were *** analysis of liver necrosis and quantitative reverse-transcription polymerase chain reaction were *** Serum and liver LECT2 levels were elevated during hepatic *** LECT2 protein and mRNA levels increased post ***2-knockout mice had reduced weight loss;hepatic necrosis;and serum ALT,AST,creatinine,and BUN ***2 treatment exacerbated weight loss,hepatic necrosis,and serum biomarkers(ALT,AST,creatinine,and BUN).AAV-Lect2-shRNA treatment significantly reduced weight loss,hepatic necrosis,and serum biomarkers(ALT,AST,creatinine,and BUN),indicating therapeutic *** Elevated LECT2 levels during hepatic IRI increased liver *** knockout or shRNA-mediated knockdown of Lect2 reduced liver damage,indicating its therapeutic ***-mediated Lect2-shRNA delivery mitigated hepatic IRI,offering a potential new treatment strategy to enhance clinical outcomes for patients undergoing liver-related surgeries or trauma.

关键词： Hepatic ischemia-reperfusion injury(IRI) Leukocyte cell-derived chemotaxin 2 (LECT2) Adeno-associated virus(AAV)

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Design optimization of the S-frame to improve crashworthiness

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Acta Mechanica Sinica 2014年第4期30卷 589-599页

作者： Shu-Tian Liu Ze-Qi Tong zhi-liang tang Zong-Hua Zhang State Key Laboratory of Structure Analysis for Industrial Equipment Dalian University of Technology

In this paper, the S-frames, the front side rail structures of automobile, were investigated for crashworthihess. Various cross-sections including regular polygon, nonconvex polygon and multi-cell with inner stiffener sections were investigated in terms of energy absorption of S-frames. It was determined through extensive numerical simulation that a multi-celI S-frame with double vertical internal stiffeners can absorb more energy than the other configurations. Shape optimization was also carried out to improve energy absorption of the S-frame with a rectangular section. The center composite design of experiment and the sequential response surface method （SRSM） were adopted to construct the approximate design sub-problem, which was then solved by the feasible direction method. An innovative double S- frame was obtained from the optimal result. The optimum configuration of the S-frame was crushed numerically and more plastic hinges as well as shear zones were observed during the crush process. The energy absorption efficiency of the structure with the optimal configuration was improved compared to the initial configuration.

关键词： Thin-walled structure S-frame Axial crush Response surface Crashworthiness

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Grain-boundary segregation and grain growth in nanocrystalline substitutional solid solution alloys

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Journal of Materials Science & Technology 2024年第1期168卷 239-249页

作者： Fawei tang Chao Hou Hao Lu zhi Zhao Xiaoyan Song Faculty of Materials and Manufacturing Key Laboratory of Advanced Functional MaterialsMinistry of Education of ChinaBeijing University of TechnologyBeijing 100124China

A model for describing solute segregation at grain boundaries has been developed for substitutional solid solution alloys,which integrates multiple factors from atomic to microstructural scales.A concept of mo-lar Gibbs free energy of segregation was introduced to evaluate the segregating capability of the solute elements in a closed system,through which the influences of grain boundary structure,grain size,ma-terial composition,and external conditions were *** on the evaluation of various energy forms related to solute segregation and grain growth processes,the nature of the thermal stabilization of nanograin structures by solute segregation was disclosed.A criterion for the destabilization of nanostruc-tures,which is determined by the competition of the change rates between the molar Gibbs free energy of segregation and the total energy of grain boundaries with grain size,has been *** study provided guideline to achieve high-temperature stability of nanograin structures of solid solution alloys even for the weakly segregating nanocrystalline systems.

关键词： Substitutional solid solution Grain boundary segregation Thermal stabilization Solute concentration Grain size

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Exoskeleton active assistance strategy for human muscle activation reduction during linear and circular walking

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Advances in Manufacturing 2024年第3期12卷 484-496页

作者： Wen-Tao Sheng Ke-Yao liang Hai-Bin tang School of Intelligent Manufacturing Nanjing University of Science and TechnologyNanjing210094People’s Republic of China School of Mechatronics Engineering Harbin Institute of TechnologyHarbin150001People’s Republic of China

The exoskeleton is employed to assist humans in various domains including military missions,rehabilitation,industrial operation,and activities of daily living(ADLs).Walking is a fundamental ADL,and exoskeletons are capable of reducing the activation and metabolism of lower extremity muscles through active assistance during *** improve the performance of active assistance strategy,this article proposes a framework using an active hip ***,it correlates to an already established Bayesian-based human gait recognition algorithm,with a particular focus on linear and circular walking within industrial and ADL *** theorizing this strategy for exoskeletons,this study further reveals,in part,the activation characteristics of human hip muscles for the instruction and regulation of active assistance duration and onset *** proposed active assistance strategy provides new insights for enhancing the performance of assistive robots and facilitating human robot interaction within the context of ADLs.

关键词： Human-robot interaction Hip exoskeleton Muscle activation Walking assistance

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Circularly polarized light emission and detection by chiral inorganic semiconductors

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Frontiers of Optoelectronics 2024年第2期17卷 43-49页

作者： Zha Li Wancai Li Dehui Li Wei tang Huageng liang Huaibing Song Chao Chen liang Gao Jiang tang Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China International Health Care Center National Center for Global Health and MedicineTokyo 162‑8655Japan Hepato‑Biliary‑Pancreatic Surgery Division Department of SurgeryThe University of Tokyo HospitalTokyo 113‑8655Japan Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Faculty of Materials Science and Chemistry China University of GeosciencesWuhan 430074China

Chiral inorganic semiconductors with high dissymmetric factor are highly desirable,but it is generally difficult to induce chiral structure in inorganic semiconductors because of their structure rigidity and *** this study,we introduced chiral ZnO film as hard template to transfer chirality to CsPbBr_(3) film and PbS quantum dots(QDs)for circularly polarized light(CPL)emission and detection,*** prepared CsPbBr_(3)/ZnO thin film exhibited CPL emission at 520 nm and the PbS QDs/ZnO film realized CPL detection at 780 nm,featuring high dissymmetric factor up to around *** electron transition based mechanism is responsible for chirality transfer.

关键词： High dissymmetric factor Circularly polarized light emission Semiconductor Hard template,Chirality

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Genesis of the Nuri Cu-W-Mo Deposit,Tibet,China:Constraints from in situ Trace Elements and Sr Isotopic Analysis of Scheelite

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 117-131页

作者： WANG Yiyun WU zhishan CHEN Wenqing DU Qing’an tang Liwei SHI Hongzhao MA Guotao ZHANG zhi liang Wei WU Bo MIAO Hengyi Chengdu Center China Geological Survey(Geoscience Innovation Center of Southwest China)Chengdu 610081China The Second Geological Institute of China’s Metallurgical Geology Bureau Fuzhou 351111China

The Nuri deposit is the only Cu-W-Mo polymetallic deposit with large-scale WO3 resources in the eastern section of the Gangdese metallogenic belt,Tibet,***,the genetic type of this deposit has been controversial since its *** on a study of the geological characteristics of the deposit,this study presents mineralization stages,focusing on the oxide stage and the quartz-sulfide stage where scheelite is mainly formed,referred to as Sch-A and Sch-B,*** LA-ICP-MS trace element and Sr isotope analyses,the origin,evolutionary process of the oreforming fluid and genesis of the ore deposit are *** Electron Microscope-Cathodoluminescence(SEMCL)observations reveal that Sch-A consists of three generations,with dark gray homogenous Sch-A1 being replaced by relatively lighter and homogeneous Sch-A2 and Sch-A3,with Sch-A2 displaying a gray CL image color with vague and uneven growth bands and Sch-A3 has a light gray CL image color with hardly any growth *** contrast,Sch-B exhibits a‘core-rim’structure,with the core part(Sch-B1)being dark gray and displaying a uniform growth band,while the rim part(Sch-B2)is light gray and *** normalized distribution pattern of rare earth elements in scheelite and Sr isotope data suggest that the early ore-forming fluid in the Nuri deposit originated from granodiorite porphyry and,later on,some country rock material was mixed in,due to strong water-rock *** the O-H isotope data further indicates that the ore-forming fluid in the Nuri deposit originated from magmatic-hydrothermal sources,with contributions from metamorphic water caused by water-rock interaction during the mineralization process,as well as later meteoric *** intense water-rock interaction likely played a crucial role in the precipitation of scheelite,leading to varying Eu anomalies in different generations of scheelite from the oxide stage to the quartz-sulfide stage,while also causing a

关键词： trace elements in situ Sr isotopes tungsten mineralization Gangdese metallogenic belt Tibet

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Strategy for suppressing abnormal grain growth of ZK60 Mg alloy during solution by pre-compression:A quasi-in-situ study

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Journal of Materials Science & Technology 2024年第4期171卷 115-128页

作者： Zhenxu Wang liang Chen Jianwei tang Cunsheng Zhang Guoqun Zhao Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) Shandong UniversityJinanShandong 250061China Department of Mechanical Engineering Kyushu UniversityFukuoka 819-0395Japan

Abnormal grain growth(AGG)easily takes place in Mg alloys during high-temperature solutions,result-ing in deterioration of mechanical ***,the compression prior to solution(pre-compression)was conducted to suppress AGG,and the microstructure evolution as well as suppressing mechanisms was investigated based on quasi-in-situ *** compression along the transverse direction,//ED grains preferentially nucleated and rapidly grew up,and the initial//ED texture was *** grain growth modes of heat-induced and strain-induced grain boundary migrations were *** former was attributed to the high interfacial energy of grain boundaries with large *** latter consumed the adjacent grains with high storage energy,forming abnormal grains with irregular *** compression with a reduction>6%could obviously suppress *** suppressing effects were mainly attributed to weakening the size advantage of//ED grains,increasing nucleation,reducing grain boundary character distribution,and redistributing storage energy *** 12%compression along the transverse direction,30°misorientation of//ED grains and high energy grain boundaries were ***{10-12}tensile twins and{10-15}high index twins induced by com-pression increased the nucleation of static ***,compression introduces high-density dislocations,which also contributed to suppressing AGG behavior during solution.

关键词： Quasi-in-situ analysis Mg alloy Abnormal grain growth Compression Microstructure

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Mendelian randomization analysis of causal relationship between cheese intake and diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1905-1910页

作者： Cheng-Ye tang Dong-Yong tang Ying-Qin Yang Yu-Bing liang Hao liang Department of Ophthalmology the First Affiliated Hospital of Guangxi Medical UniversityNanning 530000Guangxi Zhuang Autonomous RegionChina Department of Ophthalmology the Affiliated Hospital of Guilin Medical UniversityGuilin 541001Guangxi Zhuang Autonomous RegionChina Department of Anesthesiology Guangxi Medical University Cancer HospitalNanning 530000Guangxi Zhuang Autonomous RegionChina

AIM:To assess whether there is a possible causal link between the intake of cheese and the risk of diabetic retinopathy(DR)utilizing a two-sample Mendelian randomization(MR)***:The research data were obtained from summary statistics of genome-wide association studies(GWAS).Genetic loci closely related to cheese intake were extracted as instrumental variables(IVs),and DR was the outcome *** data were extracted from individuals of European *** data of cheese intake consisted of 451486 samples with 9851867 single nucleotide polymorphisms(SNPs),while the DR data consisted of 206234 samples with 16380446 ***-one genetic loci closely related to cheese intake were selected as *** analysis was performed by inverse-variance weighted(IVW)method and MR-Egger regression *** causal relationship between cheese intake and DR was evaluated using odds ratios(ORs)and 95%confidence intervals(CIs).Egger-intercept test was used to test horizontal pleiotropy and sensitivity analysis was performed by leave-one-out ***:The P value of the IVW method was less than 0.05,indicating a significant negative correlation between cheese intake and ***-Egger regression showed that the intercept was 0.01 with a standard error of 0.022,and a P-value of 0.634,indicating no evidence of horizontal pleiotropy affecting the IVs related to the exposure ***,heterogeneity tests confirmed the absence of heterogeneity,and the“leave-one-out”sensitivity analysis demonstrated that the results were ***:Cheese intake is causally negatively correlated with the occurrence of DR,and cheese intake could reduce the risk of DR.

关键词： cheese intake diabetic retinopathy Mendelian randomization analysis

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IHVFL: a privacy-enhanced intention-hiding vertical federated learning framework for medical data

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Cybersecurity 2024年第2期7卷 96-112页

作者： Fei tang Shikai liang Guowei Ling Jinyong Shan College of Computer Science and Technology Chongqing University of Posts and TelecommunicationsNo.2Chongwen RoadNan'an DistrictChongqing 400065China School of Cyber Security and Information Law Chongqing University of Posts and TelecommunicationsChongqing 400065China sudo Technology Co. LTD.Beijing 100083China

Vertical Federated Learning(VFL)has many applications in the field of smart healthcare with excellent ***,current VFL systems usually primarily focus on the privacy protection during model training,while the preparation of training data receives little *** real-world applications,like smart healthcare,the process of the training data preparation may involve some participant's intention which could be privacy information for this *** protect the privacy of the model training intention,we describe the idea of Intention-Hiding Vertical Feder-ated Learning(IHVFL)and illustrate a framework to achieve this privacy-preserving ***,we construct two secure screening protocols to enhance the privacy protection in feature ***,we implement the work of sample alignment bases on a novel private set intersection ***,we use the logistic regression algorithm to demonstrate the process of *** show that our model can perform better efficiency(less than 5min)and accuracy(97%)on Breast Cancer medical dataset while maintaining the intention-hiding goal.

关键词： Medical data Vertical federated learning Privacy-presserving Intention-hiding Logistic regression

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Study on the influence of food emulsion components on its lubrication characteristics and smooth perception

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Friction 2024年第11期12卷 2491-2504页

作者： Shanhua QIAN liang WANG Ziyan ZHENG Qichen tang Da BIAN School of Mechanical Engineering Jiangnan UniversityWuxi 214122China Jiangsu Key Laboratory of Advanced Food Manufacturing Equipment and Technology Jiangnan UniversityWuxi 214122China

Due to the increasing risk of obesity and cardiovascular diseases caused by high-fat diets,low-fat foods have become a priority demand for consumers’***,the smoothness perception and scientific assessment methods of the existing low-fat foods should be *** this study,three food emulsions were prepared,and their lubrication characteristics,sensory evaluation of smoothness,and electroencephalogram(EEG)signals were assessed to preliminarily investigate the effects of food emulsion components on their above *** results showed that fat substitute(FSU)and fat could significantly reduce coefficient of friction(CoF)of the food emulsions,with average CoF reduced by 28%and 63%compared to the original food *** addition,fat-enriched food emulsions continued to exhibit excellent lubrication characteristics after adding artificial saliva,with an average CoF reduced by 31.1%compared to that of the food emulsions without artificial *** FSU and fat improved the smoothness of food emulsions,and the lubricating properties of fat were more pronounced,with fat-enriched food emulsion which could provide a substantial improvement in smoothness compared to the fat-free food *** of subjects’EEG signals revealed that food emulsion with lower CoF and higher smoothness triggered higher P3 amplitudes and longer *** findings provide better insights into the scientific evaluation of food texture and the development of low-fat foods.

关键词： food emulsion soft friction sensory evaluation electroencephalogram(EEG)signal fat substitute

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