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Responses of HFR-LWC beams under close-range blast loadings accompanying membrane action

Defence Technology（防务技术） 2020年第6期16卷 1167-1187页

作者： Wan-xiang Chen Li-sheng Luo zhi-kun guo Peng Yuan School of Civil Engineering Sun Yat-Sen UniversityZhuhai519082China State Key Laboratory of Disaster Prevention&Mitigation of Explosion&Impact Army Engineering University of PLANanjing210007China Southern Marine Science and Engineering Guangdong Laboratory Zhuhai519082China

The load-carrying capacities and failure patterns of reinforced concrete components can be significantly changed by membrane ***,limited work has been carried out to investigate the blast resistance of Hybrid Fiber Reinforced Lightweight Aggregate Concrete(HFR-LWC)members accompanying membrane *** paper presents a theoretical approach to quantitatively depicting the membrane behavior and its contribution on the behavior of HFR-LWC beams under close-range blast loadings,and the suitability of the proposed model is validated by a series of field *** improved Single-Degree-of-Freedom(SDOF)model was employed to describe the dynamic responses of beam-like members under blast loadings accompanying membrane action,where the mass-load coefficient is determined according to the nonuniformly distributed load induced by close-range explosion,and the membrane action is characterized by an in-plane(longitudinal)force and a resisting *** elastoplastic and recovery responses of HFR-LWC beams under the combined action of blast load and membrane force were analyzed by the promoted model.A specially built end-constrain clamp was developed to provide membrane action for the beam member when they are subjected to blast load *** is demonstrated that the analytical displacement-time histories are in good agreement with experimental results before peak deflections and that the improved SDOF model is an acceptable tool for predicting the behavior of HFR-LWC beams under blast loadings accompanying membrane action.

关键词： Blast load Membrane action HFR-LWC beam Dynamic response Experimental study

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Easily-handled method to isolate mesenchymal stem cells from coagulated human bone marrow samples

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World Journal of Stem Cells 2015年第8期7卷 1137-1144页

作者： Heng-Xiang Wang zhi-Yong Li zhi-kun guo Zi-Kuan guo Department of Hematology General Hospital of Air Force Key and Open Lab for Tissue Regeneration Xinxiang Medical University Department of Experimental Hematology Beijing Radiation Medicine

AIM:To establish an easily-handled method to isolate mesenchymal stem cells(MSCs) from coagulated human bone marrow samples. METHODS: Thrombin was added to aliquots of seven heparinized human bone marrow samples to mimic marrow coagulation. The clots were untreated,treated with urokinase or mechanically cut into pieces before culture for MSCs. The un-coagulated samples and the clots were also stored at 4 ℃ for 8 or 16 h before the treatment. The numbers of colony-forming unit-fibroblast(CFU-F) in the different samples were determined. The adherent cells from different groups were passaged and their surface profile was analyzed with flow cytometry. Their capacities of in vitro osteogenesis and adipogenesis were observed after the cells were exposed to specific inductive ***: The average CFU-F number of urokinasetreated samples(16.85 ± 11.77/106) was comparable to that of un-coagulated control samples(20.22 ± 10.65/106,P = 0.293),which was significantly higher than those of mechanically-cut clots(6.5 ± 5.32/106,P < 0.01) and untreated clots(1.95 ± 1.86/106,P < 0.01). The CFU-F numbers decreased after samples were stored,but those of control and urokinase-treated clots remained higher than the other two groups. Consistently,the numbers of the attached cells at passage 0 were higher in control and urokinase-treated clots than those of mechanically-cut clots and untreated *** attached cells were fibroblast-like in morphology and homogenously positive for CD44,CD73 and CD90,and negative for CD31 and CD45. Also,they could be induced to differentiate into osteoblasts and adipocytes in vitro. CONCLUSION: Urokinase pretreatment is an optimal strategy to isolate MSCs from human bone marrow samples that are poorly aspirated and clotted.

关键词： Coagulated marrow sample Mesenchymal stem cells Is

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人胎儿房室结的细胞分类——图像分析定量研究

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解剖学报 2002年第4期33卷 438-441页

作者：郭志坤郭萍蔡新华新乡医学院解剖学教研室新乡453003 新乡医学院第三附属医院内科新乡453003

目的　探讨胎儿房室结内的细胞类型和大小。　方法　石蜡切片 ,H E染色 ,光镜观察胎儿心脏房室结的细胞形态、类型 ;采用HIPAS 10 0 0图像分析仪对其进行定量分析。　结果　胎儿房室结的细胞主要为亮细胞、暗细胞和移行细胞。亮细胞和... 详细信息

目的　探讨胎儿房室结内的细胞类型和大小。　方法　石蜡切片 ,H E染色 ,光镜观察胎儿心脏房室结的细胞形态、类型 ;采用HIPAS 10 0 0图像分析仪对其进行定量分析。　结果　胎儿房室结的细胞主要为亮细胞、暗细胞和移行细胞。亮细胞和暗细胞为纺锤形或椭圆形 ,少数多边形 ;移行细胞细短柱形。亮细胞和移行细胞的细胞核明显大于暗细胞。　结论　胎儿房室结的起搏细胞包括亮细胞和暗细胞。

关键词：胎儿细胞分类暗细胞亮细胞移行细胞房室结图像分析

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Semi-inclusive lepto-production of hidden-charm exotic hadrons

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Chinese Physics C 2021年第12期45卷 1-7页

作者： zhi Yang Feng-kun guo School of Physics University of Electronic Science and Technology of ChinaChengdu 610054China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China CAS Key Laboratory of Theoretical PhysicsInstitute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

We investigate the semi-inclusive production of hidden-charm exotic states,including the X(3872),Z_(c),Zcs and pentaquark P_(c) states,in lepton-proton scattering *** hadrons are close to the thresholds of a pair of charm and anticharm hadrons and are assumed to possess a hadronic molecular structure as their main *** provide order-of-magnitude estimates of the cross sections,we use Pythia to simulate the short-distance productions of the constituent hadrons,which then rescatter to form exotic *** estimates for the X(3872)and Z_(c)(3900)^(±)states are not in conflict with the upper limits measured in the COMPASS experiment for the exclusive photoproduction *** results indicate that the considered hidden-charm states can be copiously produced at the proposed electron-ion colliders EicC and US-EIC.

关键词： hidden-charm exotic hadrons lepto-production

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Reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： guo-Fu Xu Department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors

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Zonal disintegration phenomenon in rock mass surrounding deep tunnels

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Journal of China University of Mining and Technology 2008年第2期18卷 187-193页

作者： WU Hao FANG Qin guo zhi-kun Engineering Institute of Engineering Corps PLA University of Science and Technology Nanjing Jiangsu 210007 China

Zonal disintegration is a typical static phenomenon of deep rock masses. It has been defined as alternating regions of fractured and relatively intact rock mass that appear around or in front of the working stope during excavation of a deep tunnel. Zonal disintegration phenomenon was successfully demonstrated in the laboratory with 3D tests on analogous gypsum models, two circular cracked zones were observed in the test. The linear Mohr-Coulomb yield criterion was used with a constitutive model that showed linear softening and ideal residual plastic to analyze the elasto-plastic field of the enclosing rock mass around a deep tunnel. The results show that tunneling causes a maximum stress zone to appear between an elastic and plastic zone in the surrounding rock. The zonal disintegration phenomenon is analyzed by considering the stress-strain state of the rock mass in the vicinity of the maximum stress zone. Creep instability failure of the rock due to the development of the plastic zone, and transfer of the maximum stress zone into the rock mass, are the cause of zonal disintegration. An analytical criterion for the critical depth at which zonal disintegration can occur is derived. This depth depends mainly on the character and stress concentration coefficient of the rock mass.

关键词： block-hierarchical structure zonal disintegration phenomenon enclosing rock mass around deep tunnel equivalent material stress concentration coefficient

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Self-healing Behavior of Ethylene Propylene Diene Rubbers Based on Ionic Association

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Chinese Journal of Polymer Science 2019年第7期37卷 700-707页

作者： zhi-Fei Zhang kun Yang Shu-Gao Zhao Lai-Na guo Key Laboratory of Rubber-plastics Ministry of Education/Shandong Provincial Key Laboratory of Rubber-PlasticsQingdao University of Science & TechnologyQingdao 266042China College of Chemical Engineering and Materials Science Tianjin University of Science & TechnologyTianjin 300457China Hutchinson research centerRue Gustave NourryChalette sur Loing45120France

To meet the increasing demand for safe, environmentally friendly and high-performance smart materials, self-healing rubbers are highly desired. Here, the self-healing performance of ethylene propylene diene monomer rubber (EPDM) is reported, which was designed by graft-polymerization of zinc dimethacrylate (ZDMA) onto rubber chains to form a reversible ionic cross-linked network. Single ionic cross-linked network and dual network, combining covalent and ionic cross-links, could be tuned by controlling vulcanization process to achieve tailorable mechanical and self-healing properties. It was found that ionic cross-linked EPDM showed a recovery of more than 95% of the original mechanical strength through a healing process of 1 h at 100 °C. The covalent cross-links could improve mechanical properties but block self-healing. Adding 50 wt% liquid rubber to “dry” EPDM could effectively enhance self-healing capability of the dual cross-linked network and the healed tensile strength could reach 0.9 MPa. A compromise between mechanical performance and healing capability could be potentially tailored by controlling vulcanization process and liquid rubber content.

关键词： Ionic bond Self-healing Ethylene propylene diene rubber Dual-network

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Bandgap characteristics analysis and graded design of a novel metamaterial for flexural wave suppression

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 1-24页

作者： Fan YANG Zhaoyang MA Xingming guo Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering ScienceShanghai University Shanghai Institute of Aircraft Mechanics and Control

A novel elastic metamaterial is proposed with the aim of achieving lowfrequency broad bandgaps and bandgap regulation. The band structure of the proposed metamaterial is calculated based on the Floquet-Bloch theorem, and the boundary modes of each bandgap are analyzed to understand the effects of each component of the unit cell on the bandgap formation. It is found that the metamaterials with a low elastic modulus of ligaments can generate flexural wave bandgaps below 300 Hz. Multi-frequency vibrations can be suppressed through the selective manipulation of bandgaps. The dual-graded design of metamaterials that can significantly improve the bandgap width is proposed based on parametric studies. A new way that can regulate the bandgap is revealed by studying the graded elastic modulus in the substrate. The results demonstrate that the nonlinear gradient of the elastic modulus in the substrate offers better bandgap performance. Based on these analyses, the proposed elastic metamaterials can pave the way for multi-frequency vibration control, low-frequency bandgap broadening, and bandgap tuning.

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Asking one mechanism in glial cells during neuroinflammation

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Neural Regeneration Research 2025年第4期20卷 1077-1078页

作者： Xiaoli guo Chikako Harada Takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

Multiple sclerosis(MS),which is characterized by inflammatory demyelination in the central nervous system(CNS),is the most common neurological disease in the young adult *** autoimmune encephalomyelitis(EAE),an animal model of MS,is often used in preclinical *** data indicate that in addition to immune cells such as T cells and dendritic cells,CNS resident microglia and astrocytes play important roles in demyelinating neuroinflammation(Healy et al.,2022).In particular,microglia are key immune-competent cells that can respond to environmental *** depletion of transforming growth factor-β-activated kinase 1,a mitogen-associated protein kinase kinase kinase,in microglia is reported to reduce CNS inflammation and diminish axonal and myelin damage *** suggests that elucidating the mechanisms of microglia-specific responses during pathologies may help in the development of treatments that reduce EAE/MS disease severity(Goldmann et al.,2013).

关键词： inflammation clinical

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Monogenic gene therapy for glaucoma and optic nerve injury

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Neural Regeneration Research 2025年第3期20卷 815-816页

作者： Chikako Harada Xiaoli guo Takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

The prevalence of glaucoma, the second leading cause of global blindness, is increasing due to aging populations. In glaucoma, degeneration of the optic nerve and retinal ganglion cells(RGCs) causes visual field defec... 详细信息

关键词： visual glaucoma degeneration

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