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Long-term outcomes and prognostic factors for patients with esophageal cancer following radiotherapy

World Journal of Gastroenterology 2013年第10期19卷 1639-1644页

作者： Chuang-Zhen chen jian-Zhou chen De-Rui Li zhi-Xiong Lin Ming-Zhen Zhou Dong-Sheng Li zhi-jian chen Department of Radiation Oncology Cancer Hospital of Shantou University Medical College

AIM:To evaluate long-term outcomes and prognostic factors for esophageal squamous cell carcinoma(SCC) treated with three dimensional conformal radiotherapy(3D-CRT).METHODS:Between January 2005 and December 2006,153 patients(120 males,33 females) with pathologically confirmed esophageal SCC and treated with 3D-CRT in Cancer Hospital of Shantou University were included in this retrospective *** age was 60 years(range:37-84 years).The proportion of tumor location was as follows:upper thorax(including the cervical region),73(48%);middle thorax,73(48%);lower thorax,7(5%),*** median radiation dose was 64 Gy(range:50-74 Gy).Fifty four cases(35%) received cisplatin-based concurrent *** and multivariate analysis were performed to determine the association between the correlative factors and ***:The five-year overall survival rate was 26.3%,with a median follow-up of 49 mo(range:3-66 mo) for patients who were still *** univariate analysis,lesion location,lesion length by barium esophagogram,computed tomography imaging characteristics including Y diameter(anterior-posterior,AP,extent of tumor),gross tumor volume of primary lesion(GTV-E),volume of positive lymph nodes(GTV-LN),and the total target volume(GTV-T = GTV-E + GTVLN) were prognostic for overall *** multivariate analysis,only the Y diameter [hazard ratio(HR) 2.219,95%CI 1.141-4.316,P = 0.019] and the GTV-T(HR 1.372,95%CI 1.044-1.803,P = 0.023) were independent prognostic factors for ***:The overall survival of esophageal carcinoma patients undergoing 3D-CRT was *** best predictors for survival were GTV-T and Y diameter.

关键词： Esophageal neoplasm Three dimensional conformal radiotherapy Multivariate analysis Prognostic factor

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Characterization of Two Putative Protein Phosphatase Genes and Their Involvement in Phosphorus Efficiency in Phaseolus vulgaris

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Journal of Integrative Plant Biology 2012年第6期54卷 400-411页

作者： Cui-Yue Liang zhi-jian chen Zhu-Fang Yao jiang Tian Hong Liao State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources Root Biology CenterSouth China Agricultura UniversityGuangzhou 510642China Robert Holley Center for Agriculture and Health United States Department of AgricultureAgricultural Research ServiceCornell UniversityIthacaNew York 14853USA

Protein dephosphorylation mediated by protein phosphatases plays a major role in signal transduction of plant responses to environmental stresses. In this study, two putative protein phosphatases, PvPS2：1 and PvPS2：2 were identified and characterized in bean （Phaseolus vulgaris）. The two PvPS2 members were found to be localized to the plasma membrane and the nucleus by transient expression of PvPS2：GFP in onion epidermal cells. Transcripts of the two PvPS2 genes were significantly increased by phosphate （P1） starvation in the two bean genotypes, G19833 （a P-efficient genotype） and DOR364 （a P-inefficient genotype）. However, G19833 exhibited higher PvPS2：1 expression levels than DOR364 in both leaves and roots during P1 starvation. Increased transcription of PvPS2：1 in response to P1 starvation was further verified through histochemical analysis of PvPS2：I promoter fusion b-glucuronidase （GUS） in transgenic Arabidopsis plants. Analysis of PvPS2：1 overexpression lines in bean hairy roots and Arabidopsis showed that PvS2：1 was involved in root growth and P accumulation. Furthermore, expression levels of two P1 starvation responsive genes were upregulated and the APase activities were enhanced in the overexpressing PvPS2：1 Arabidopsis lines. Taken together, our results strongly suggested that PvPS2：1 positively regulated plant responses to P1 starvation, and could be further targeted as a candidate gene to improve crop P efficiency.

关键词： Phosphorus efficiency HAD protein acid phosphatase bean.

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Response of Lymphocytes to Radiation in Untreated Breast Cancer Patients as Detected with Three Different Genetic Assays

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Biomedical and Environmental Sciences 2008年第6期21卷 499-508页

作者： jian-LIN LOU zhi-jian chen jianG WEI JI-LIANG HE LI-FEN JIN SHI-JIE chen WEI ZHENG SHI-JIE XU Institute of Environmental Medicine Medical College Zhejiang University Jiaxing 310058 Hangzhou Zhejiang China The First Affiliated Hospital of Medical College of Jiaxing University Jiaxing 314001 Zhejiang China

Objective To detect the response of lymphocytes to radiation in untreated breast cancer patients with three different genetic assays. Methods Blood samples were collected from 25 untreated patients and 25 controls. Each blood sample was divided into two parts： one was irradiated by 3-Gy X-ray （irradiated sample）, the other was not irradiated （non-irradiated sample）. The radiosensitivity of lymphocytes was assessed by comet assay, cytokinesis-block micronucleus （CBMN） assay and 6-TG-resistant cells scored （TG） assay. Results The baseline values of micronucleated cell frequency （MCF） and micronucleus frequency （MNF） in the patients were significantly higher than those in the controls （P〈0.01）, and 3-Gy X-ray induced genetic damage to lymphocytes in the patients increased significantly as compared with that in the controls as detected with the three genetic assays （P〈0.01）. The proportion of radiosensitive cases in the patient group was 48% for the mean tail length （MTL）, 40% for the mean tall moment （MTM）, 40% for MCF, 44% for MNF, and 48% for mutation frequencies of the hprt gene （Mfs-hprt）, respectively, whereas the proportion of radiosensitive cases in the control group was only 8% for all the parameters. Conclusion The difference in the lymphocyte radiosensitivity between the breast cancer patients and the controls is significant. Moreover, there are wide individual variations in lymphocyte radiosensitivity of patients with breast cancer. In some cases, the radiosensitivity of the same patient may be different as detected with the different assays. It is suggested that multiple assays should be used to assess the radiosensitivity of patients with breast cancer before therapy.

关键词： Micronucleus assay Comet assay hprt gene mutation Radiosensitivity Breast cancer

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Simultaneous modulated accelerated radiation therapy for esophageal cancer:A feasibility study

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World Journal of Gastroenterology 2014年第38期20卷 13973-13980页

作者： Wu-Zhe Zhang jian-Zhou chen De-Rui Li zhi-jian chen Hong Guo Ting-Ting Zhuang Dong-Sheng Li Ming-Zhen Zhou Chuang-Zhen chen Department of Radiation Oncology Cancer Hospital of Shantou University Medical College

AIM: To establish the feasibility of simultaneous modulated accelerated radiation therapy (SMART) in esophageal cancer (EC).

关键词： Simultaneous modulated accelerated radiation therapy Three-dimensional conformal radiotherapy Intensity-modulated radiation therapy Esophageal cancer Feasibility

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Refrigerant Control Strategies for Residential Air-Conditioning and Heat-Pump System

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湖南大学学报（自然科学版） 2009年第S1期36卷 91-95页

作者： SU Shun-yu,ZHANG Chun-zhi,chen jian(College of Urban Construction,Wuhan University of Science and Technology,Wuhan,Hubei 430070,China) College of Urban Construction Wuhan University of Science and Technology Wuhan 430070 China

This paper simulated the optimal refrigerant charge inventory of a refrigeration system in air-conditioning operation and heat-pump operation respectively,and studied the refrigerant control strategies in this *** void fraction in two-phase fluid region was calculated by Harms *** based on distributed parameter model and Harms model,the refrigerant charge inventory in condenser and evaporator were calculated and analyzed in air-conditioning conditions and heat-pump conditions,*** calculating results of different refrigerant mass between refrigeration and heating conditions indicate that the optimal refrigerant charge inventory in heat-pump conditions is lower than that in air-conditioning *** avoid the decrease of COP due to the surplus refrigerant in heating conditions,we introduced the liquid reservoir control method and associate capillary control *** of them could increase the heating capacity of the air-source heat *** difference of optimal refrigerant charge inventory in air-conditioning and heat-pump system can be controlled by the liquid reservoir or the associate capillary.

关键词： air-source heat pump control strategy distributed parameter model charge inventory

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Photorefractive Effect in Poly(N-vinylcarbazole)-Based Composite Sensitised by C_(60)

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Chinese Chemical Letters 1997年第9期8卷 807-810页

作者： zhi Jie ZHANG Yi Wang chen Yuan Kang HE and Hui Ying chen(Institute of Polymer Science, College of Chemistry, Peking University, Beijing, 100871)zhi jian chen Shu Feng WANG and Qi Huang GONG(Department of Physics, Mesoscopic Physics Laboratory, Peking U Institute of Polymer Science College of Chemistry Peking University Beijing 100871 China Department of Physics Mesoscopic Physics Laboratory Peking University Beijing 100871 China

A new PVK-based photorefractive polymer composite sensitized by C60 and doped with a higher content of EO chromophore was prepared. The high optical quality thin-film was formed between two ITOcovered glass electrodes. Two-beam-coupling (2BC) experiment was performed by using a He-Ne laser (at wavelength 632.8nm), and an obvious photorefractive performance was observed. The dependence of two-beamcoupling gain coefficient on the applied poling dc electric field was measured.

关键词： Photorefractive Effect in Poly Based Composite Sensitised by C N-vinylcarbazole Rev

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Socioeconomics and attributable etiology of primary liver cancer,1990-2019

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World Journal of Gastroenterology 2022年第21期28卷 2361-2382页

作者： Qing-Qing Xing Jing-Mao Li Xuan Dong Dan-Yi Zeng zhi-jian chen Xiao-Yun Lin Jin-Shui Pan Department of Hepatology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005Fujian ProvinceChina Hepatology Research Institute Fujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Statistics Xiamen UniversityXiamen 361000Fujian ProvinceChina School of Medicine Xiamen UniversityXiamen 361000Fujian ProvinceChina

BACKGROUND Primary liver cancer(PLC)is a major contributor to cancer-related *** on global and country-specific levels and trends of PLC are essential for understanding the effects of this disease and helping policymakers to allocate *** To investigate the association between the burden of PLC and socioeconomic development *** Cancer mortality and incidence rates were obtained from the Global Burden of Disease(GBD)2019,and the data were stratified by country and territory,sex,and the Socio-demographic Index(SDI)*** association between the attributable etiology of PLC and socioeconomic development status,represented using the SDI,was *** attributable etiology of PLC included hepatitis B,hepatitis C,alcohol use,and nonalcoholic *** association between the attributable etiology of PLC and SDI was further stratified by sex and geographical location.A confidence analysis was also performed based on bootstrap *** The age-standardized incidence rate of PLC was 6.5[95%confidence intervals(CI):5.9-7.2]per 100000 person-years,which decreased by-27.5%(-37.0 to-16.6)from 1990 to *** countries located in East Asia,South Asia,West Africa,and North Africa shouldered the heaviest burden of PLC in *** terms of incidence rates,the first leading underlying cause of PLC identified was hepatitis B,followed by hepatitis C,alcohol use,and nonalcoholic *** stratification using the SDI,the incidence rate of PLC was the highest for high and middle SDI ***,the leading attributable etiologies of PLC were hepatitis B for the middle and high middle SDI locations while hepatitis C and nonalcoholic steatohepatitis for the high SDI *** The pronounced association between socioeconomic development status and PLC burden indicates socioeconomic development status affects attributable etiologies for *** 2019 data are valuable for policymakers implementing PLC cost-e

关键词： Epidemiology Public health Socioeconomics Primary liver cancer Hepatitis Alcohol

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Machine learning(ML)-assisted optimization doping of KI in MAPbI_(3) solar cells

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Rare Metals 2021年第7期40卷 1698-1707页

作者： Sheng jiang Cun-Cun Wu Fan Li Yu-Qing Zhang Ze-Hao Zhang Qiao-Hui Zhang zhi-jian chen Bo Qu Li-Xin Xiao Min-Lin jiang Institute for Advanced Study Nanchang UniversityJiangxi 330031China School of Materials Science and Engineering Nanchang UniversityJiangxi 330031China State Key Laboratory for Artificial Microstructures and Mesoscopic Physics Department of PhysicsPeking UniversityBeijing 100871China

Perovskite solar cells have drawn extensive attention in the photovoltaic(PV)field due to their rapidly increasing ***,additives have become necessary for the fabrication of highly efficient perovskite solar cells(PSCs).Additionally,alkali metal doping has been an effective method to decrease the defect density in the perovskite ***,the traditional trial-and-error method to find the optimal doping concentration is timeconsuming and needs a significant amount of raw *** this work,in order to explore new ways of facilitating the process of finding the optimal doping concentration in perovskite solar cells,we applied a machine learning(ML)approach to assist the optimization of KI doping in MAPbI_(3) solar *** the aid of ML technique,we quickly found that 3%KI doping could further improve the efficiency of MAPbI_(3) solar *** a result,a highest efficiency of 20.91%has been obtained for MAPbI_(3) solar cells.

关键词： Perovskite solar cell Machine learning KI Doping

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Effects of ＂Phone Consultation＂ to Mental Status and Quality of Life of Patients with Cancer-related Pain and Physicians＇ Work and Life

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麻醉与监护论坛 2011年第2期18卷 119-121页

作者： zhi-yang chen jian-ming Xu Yue-ling chen Pain Clinic Anesthesia Department of Cancer Hospital Department of Oncology Fudan University Shanghai P.R.China 200032

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On UR-Rings

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Journal of Mathematical Research and Exposition 2009年第2期29卷 355-361页

作者： YING zhi Ling chen jian Long Department of Mathematics Sout-heast University Jiangsu 210096 China

A ring is said to be UR if every element can be written as the sum of a unit and a regular element. These rings are shown to be a unifying generalization of regular rings, clean rings and （S, 2）-ring~. Some relations of these rings are studied and several properties of clean rings and （S, 2）-rings are extended. PAng extensions of UR-rings are also investigated.

关键词： clean rings G-clean rings regular rings (S, 2)-rings UR-rings.

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