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Response of porcine hepatocytes in primary culture to plasma from severe viral hepatitis patients

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World Journal of Gastroenterology 2005年第48期11卷 7585-7590页

作者： Yong-Bo Cheng Ying-Jie Wang Shi-Chang Zhang Jun liu zhi Chen jia-jia li Institute of Infectious Diseases Southwest Hospital Third Military Medical University Chongqing 400038 China

AIM： To observe the effects of plasma from patients with severe viral hepatitis （SVHP） on the growth and metabolism of porcine hepatocytes and the clinical efficiency of bioartificial liver device.METHODS： Hepatocytes were isolated from male porcines by collagenase perfusion. The synthesis of DNA and total protein, leakages of AST and LDH, changes in glutathione （GSH）, catalase and morphology of porcine hepatocytes exposed to SVHP were investigated to indicate the effect of plasma from patients with severe hepatitis on the growth, injury, detoxification, and morphology of porcine hepatocytes.RESULTS： The synthesis of DNA and protein was inhibited in the medium containing 100% SVHP compared to the controls. The leakages of LDH and AST increased in porcine hepatocytes following exposure to 100% SVHP for 5 h. The difference between 100% SVHP and 10% newborn calf serum （NCS） was significant in t-test （LDH： t = 24.552, P = 0.001; AST： t = 4.169, P = 0.014）. After exposure to SVHP for 24 h, alterations in GSH status were significant （F = 2.746, P〈0.05） between porcine hepatocytes in 100% SVHP and 10% NCS, but no alteration occurred in the culture medium after 48 h （F = 4.378, ,P〈0.05）. A similar profile was observed in catalase activity. Many round vacuoles were observed in porcine hepatocytes cultured in SVHR The membranes of these cells became indistinct and almost all the cells died on d 5.CONCLUSION： Plasma from patients with severe hepatitis inhibits the growth, injures membrane, disturbs GSH homeostasis and induces morphological changes of porcine hepatocytes, It is suggested that SVHP should be pretreated to reduce the toxin load and improve the performance of porcine hepatocytes in extracorporeal liver-support devices.

关键词： Bioartificial liver Porcine hepatocytes Cellculture Plasma toxicity

Evaluating performance dependency of a geomorphologic instantaneous unit hydrograph-based hydrological model on DEM resolution

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Water Science and Engineering 2022年第3期15卷 179-188页

作者： Cheng Yao zhi-jia li Ke Zhang Ying-chun Huang Jing-feng Wang Satish Bastola College of Hydrology and Water Resources Hohai UniversityNanjing 210098China Yangtze Institute for Conservation and Development Hohai UniversityNanjing 210098China State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210098China China Meteorological Administration-Hohai University Joint Laboratory for Hydrometeorological Studies Hohai UniversityNanjing 210098China School of Civil and Environmental Engineering Georgia Institute of TechnologyAtlanta 30332USA Department of Civil and Environmental Engineering University of New OrleansNew Orleans 70148USA

The digital elevation model(DEM)is a type of model that has been widely used in terrain analysis and hydrological *** resolution influences the hydrological and geomorphologic features of delineated catchments and consequently affects hydrological *** study investigated the impacts of DEM resolution on the performance of the XAJ-GIUH hydrological model,a model coupling the widely used Xinanjiang(XAJ)hydrological model with the geomorphologic instantaneous unit hydrograph(GIUH),in flood simulations in small and medium-sized *** test the model performance,the model parameters were calibrated at a fine DEM resolution(30 m)and then directly transferred to the simulation runs using coarser ***,model recalibration was conducted at coarser DEM *** the simulation runs with the model parameters calibrated at the 30-m resolution,the DEM resolution slightly affected the overall shape of the simulated flood hydrographs but presented a greater impact on the simulated peak discharges in the two study *** XAJ-GIUH model consistently underestimated the peak discharges when the DEM resolution became *** qualified ratio of peak simulations decreased by 35%when the DEM resolution changed from 30 m to 600 ***,model recalibration produced comparable model per-formances when DEMs with different resolutions were *** study showed that the impact of DEM resolution on model performance can be mitigated by model recalibration to some extent,if the DEM resolution is not too coarse.

关键词： DEM resolution XAJ-GIUH model Flood simulation Model recalibration Small and medium-sized catchments

Enhanced photocatalytic performance by regulating the Ce^(3+)/Ce^(4+)ratio in cerium dioxide

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Frontiers of Chemical Science and Engineering 2024年第3期18卷 75-87页

作者： zhi li Dongsheng jia Wei Zhang Ying li Mitang Wang Dongliang Zhang School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai200093China

Cerium dioxide(CeO_(2))photocatalysts are used in treating environmental pollution and addressing the energy crisis due to their excellent oxygen storage capacities and abundant oxygen *** this paper,CeO_(2)precursors were synthesized with different water-alcohol ratios via a solvothermal method,and CeO_(2)photocatalysts with different Ce^(3+)/Ce^(4+)ratios were obtained by changing the precursor calcination atmospheres(air,Ar)as well as the calcination *** effects of CeO_(2)with different Ce^(3+)/Ce^(4+)ratios in photocatalytic degradations of methylene blue under visible light were investigated.X-ray photoelectron spectroscopy results showed that the surfaces of the samples calcined under Ar had higher Ce^(3+)/Ce^(4+)ratios and oxygen vacancy concentrations,which reduced the band gaps of the catalysts and improved their utilization of visible *** addition,the many Ce^(3+)/Ce^(4+)redox centers and oxygen vacancies on the sample surfaces improved the separation and transfer efficiencies of the photogenerated *** sample C2-Ar calcined under Ar showed a high adsorption capacity and excellent photocatalytic activity by removing 96%of the methylene blue within 120 min,which was more than twice the degradation rate of the sample(C2-air)prepared via calcination under *** experiments showed that photogenerated holes played a key role in the photocatalytic *** addition,a synergistic photocatalytic mechanism for the Ce^(3+)/Ce^(4+)redox centers and oxygen vacancies was elucidated in detail,and the sensitization of cerium dioxide by dyes aided the degradation of methylene blue.

关键词： CeO_(2) oxygen vacancies Ce^(3+)/Ce^(4+)ratios photocatalytic dye-sensitization

Rapid chemical recycling of waste polyester plastics catalyzed by recyclable catalyst

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Green Chemical Engineering 2024年第2期5卷 257-265页

作者： Yu-Ji Luo jia-Yin Sun zhi li School of Physical Science and Technology ShanghaiTech UniversityShanghai201210China

Waste plastics are serious environmental threats due to their low degradability and low recycling *** and efficient waste plastics recycling technologies are urgently demanded for a sustainable ***,we report a rapid,closed-loop,and streamlined process to convert polyesters such as poly(ethylene terephthalate)(PET)back to its purified *** trifluoromethanesulfonic acid or metal triflates as the recyclable catalyst,polyesters such as PET can be completely depolymerized by simple carboxylic acids within 1 *** coupling this acidolysis with a subsequent hydrogenolysis process,the consumed carboxylic acid was recovered and the closed-loop of PET depolymerization could be *** catalysts and depolymerization agents are fully recycled while only PET and hydrogen are consumed.

关键词： Chemical recycling Waste polyester plastics Acidolysis Recyclable catalyst

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Deep learning for code generation: a survey

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Science China(Information Sciences) 2024年第9期67卷 5-40页

作者： Huangzhao ZHANG Kechi ZHANG Zhuo li jia li jia li Yongmin li Yunfei ZHAO Yuqi ZHU Fang liU Ge li zhi JIN Key Lab of High Confidence Software Technologies (Peking University) Ministry of Education School of Computer Science Peking University School of Computer Science and Engineering Beihang University

In the past decade, thanks to the powerfulness of deep-learning techniques, we have witnessed a whole new era of automated code generation. To sort out developments, we have conducted a comprehensive review of solutions to deep learning-based code generation. In this survey, we generally formalize the pipeline and procedure of code generation and categorize existing solutions according to taxonomy from perspectives of architecture, model-agnostic enhancing strategy, metrics, and tasks. In addition, we outline the challenges faced by current dominant large models and list several plausible directions for future research. We hope that this survey may provide handy guidance to understanding, utilizing, and developing deep learning-based code-generation techniques for researchers and practitioners.

关键词： code generation automated software engineering deep learning large model artificial intelligence

Metabolomic-based analysis reveals bile acid-mediated ovarian failure induced by low temperature in zebrafish

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Zoological Research 2024年第4期45卷 791-804页

作者： Wen-Hao li zhi-Qiang li Meng-Di Bu jia-Zhen li liang-Biao Chen Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Ministry of EducationCollege of Fisheries and Life SciencesShanghai Ocean UniversityShanghai 201306China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdaoShandong 266237China International Research Center for Marine Biosciences Ministry of Science and TechnologyCollege of Fisheries and Life SciencesShanghai Ocean UniversityShanghai 201306China

As ectotherms, fish are highly sensitive to temperature fluctuations, which can profoundly impact their reproductive cycles. In this study, we investigated the fertility and histological characteristics of zebrafish(Danio rerio) ovaries exposed to a temperature gradient ranging from the thermopreferendum temperature of the species,27℃, to lower temperatures of 22℃, 20℃, and 13℃ over a period of two weeks. Comparative metabolomic(six biological replicates for each temperature) and transcriptomic(four biological replicates for each temperature) analyses were conducted under the four temperature conditions. Results indicated that lower temperatures inhibited oocyte development and differential metabolites were involved in steroid hormone production,antioxidant function, and lipid and protein *** reproductive hormones, increased proteolysis,and lipid degradation significantly impeded oocyte development and egg maturation. Notably, a significant increase in bile acid content was noted in the ovaries of the cold-treated fish, indicating that bile acids play a critical role in ovarian failure. Overall, these findings provide valuable insights into the mechanisms governing the reproductive response of fish to cold stress.

关键词： old stress Ovarian failure Metabolome Zebrafish

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Consideration on immunotherapy of liver metastases of malignant tumors

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2374-2381页

作者： Chuang jiang zhi-Hong Zhang jia-Xin li Division of liver Surgery Department of General Surgery and Laboratory of Liver Surgeryand State Key Laboratory of Biotherapy and Collaborative Innovation Center of BiotherapyWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of General Surgery Dafang County People's HospitalBijie 551600Guizhou ProvinceChina

In this editorial,we comment on the article“Analysis of the impact of immuno-therapy efficacy and safety in patients with gastric cancer and liver metastasis”by liu et al that was published in the recent issue of the World Journal of Gastroin-testinal *** has prompted us to think and summarize some thoughts on immunotherapy for malignant tumor liver *** plays a crucial role in the treatment of malignant tumors;however,the presence of liver metastases in advanced tumors may impact its *** patients with liver metastases can still benefit from immunotherapy,multiple clinical studies have indicated that,compared to other sites of metastasis,liver metastases may diminish the effectiveness of *** efficacy of immune checkpoint inhibitors in patients with liver metastases often fails to reach the ideal level,primarily due to the liver metastases exploiting the host's peripheral immune to-lerance mechanisms to promote systemic CD8(+)T cell exhaustion,resulting in a systemic immune-tolerant *** article aims to summarize the reasons for the decreased efficacy of immunotherapy following liver metastasis in various malignant tumors and propose potential clinical strategies for manage-ment.

关键词： liver metastasis Immunotherapy Immune tolerance Cancer Treatment

LAMDA-SSL:a comprehensive semi-supervised learning toolkit

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Science China(Information Sciences) 2024年第1期67卷 306-307页

作者： lin-Han jia Lan-Zhe GUO zhi ZHOU Yu-Feng li National Key Laboratory for Novel Software Technology Nanjing University

Machine learning, particularly deep learning, has achieved remarkable success across a wide range of tasks. However,most of these tasks demand a substantial amount of labeled training data, which can be challenging to obtain in many real-world applications due to difficulties, costs, or time constraints associated with labeling. In this context,semi-supervised learning (SSL) has emerged as a promising paradigm to alleviate the dependency on large labeled datasets by harnessing the power of unlabeled data [1–3].

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Simultaneous Bulk-and Surface-initiated living Polymerization Studied with a Heterogeneous Stochastic Reaction Model

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Chinese Journal of Polymer Science 2024年第3期42卷 364-372,I0008页

作者： jia-Shu Ma zhi-Ning Huang jia-Hao li Bang-Ping jiang Yan-Da liao Shi-Chen Ji Xing-Can Shen State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China)School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China School of Computer Science and Engineering&School of Software Guangxi Normal UniversityGuilin 541004China

To better characterize the properties of surface-initiated polymers, simultaneous bulk-and surface-initiated polymerizations are usually carried out by assuming that the properties of the surface-initiated polymers resemble those of the bulk-initiated polymers. Through a Monte Carlo simulation using a heterogeneous stochastic reaction model, it was discovered that the bulk-initiated polymers exhibit a higher molecular weight and a lower dispersity than the corresponding surface-initiated polymers, which indicates that the equivalent assumption is invalid. Furthermore, the molecular weight distributions of the two types of polymers are also different, suggesting different polymerization mechanisms. The results can be simply explained by the heterogeneous distributions of reactants in the system. This study is helpful to better understand surface-initiated polymerization.

关键词： Surface-initiated polymerization Polymer brush Stochastic reaction model Heterogeneous polymerization Simultaneous polymerization

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