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Multifunctional RGD coated a single-atom iron nanozyme:A highly selective approach to inducing ferroptosis and enhancing immunotherapy for pancreatic cancer

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Nano Research 2024年第6期17卷 5469-5478页

作者： Haoqi Pan Xu Chen Mingming Xiao He Xu Jiansheng Guo zhiyi Lu dong cen Xianjun Yu Si Shi Department of Pancreatic Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Shanghai Pancreatic Cancer Institute Shanghai 200032China Pancreatic Cancer Institute Fudan UniversityShanghai 200032China Key Laboratory of Advanced Fuel Cells and Electrolyzers Technology of Zhejiang Province Qianwan Institute of CNITECHNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Department of Pathology of Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou 310016China Key Laboratory of Laparoscopic Technology of Zhejiang Province Department of General SurgerySir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China

Nanozyme is a new promising approach to cancer therapy for its ability to induce ferroptosis by activating H_(2)O_(2)via a traditional radical pathway and enhance cancer ***,short half-life period of hydroxyl radical(·OH)results in unsatisfied ***,we synthesized a single-atom iron nanozyme(Fe-SAzyme),which can activate H_(2)O_(2)via a non-radical pathway to generate Fe-based reactive oxygen species(ROS)(O=FeO_(3)=O)for promoting the ferroptosis of pancreatic cancer *** Fe-SAzyme could be specifically phagocytosed by pancreatic cancer cells,increasing ROS levels and inhibiting glutathione(GSH)synthesis,which activates *** magnetic resonance imaging(MRI)showed decreased T2 signal after intravenous injection of RGD@Fe-AC(AC=activated carbon).Moreover,RGD@Fe-AC promoted dendritic cell(DC)maturation,overcame Treg-mediated immunosuppression,activated T cells to trigger adaptive immune responses,and enhanced the efficacy ofα-PD-L1 *** research demonstrated that RGD@Fe-AC provided a straightforward,easily implemented,and selective approach for pancreatic cancer treatment and immunotherapy.

关键词： single-atom iron nanozyme pancreatic cancer immunotherapy ferroptosis

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Observation of therapeutic effect of lamp irradiation combined with purple gromwell oil gauze on alleviating intestinal colic in patients

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1749-1755页

作者： Bi-zhi cen Yin-Song Chen Li-Ping Li Jing-Wen Wu Yan-Fen Xie Department of Tumor center Foshan Hospital of Traditional Chinese MedicineFoshan 528000Guangdong ProvinceChina

BACKGROUND Intestinal colic is a common complication in patients who have undergone radical surgery for colorectal *** Chinese medicine has advantages,including safety and stability,for the treatment of intestinal *** irra-diation for abdominal ironing has been applied in the treatment of many gas-trointestinal *** gromwell oil has the effects of clearing heat,cooling blood,reducing swelling,and relieving *** The general effective rate in the observation group was 95.00%,which was significantly higher than that in the control group(86.67%,P0.05).After 1,2,3,and 4 d of treatment,the duration of symptoms in both groups were decreased,and the duration in the observation group was significantly lower than that in the control group(96.54±9.57 vs 110.45±11.23,87.26±12.07 vs 104.44±11.68,80.45±16.21 vs 99.44±14.95,73.18±15.58 vs 92.17±14.20;P0.05).CONCLUSION The use of lamp irradiation combined with purple gromwell oil gauze in patients with intestinal colic after radical surgery for colorectal cancer can reduce symptom duration,alleviate intestinal colic,and improve treatment efficacy,and this approach is *** is worth promoting the use of this treatment in clinical practice.

关键词： Lamp irradiation Purple gromwell oil gauze Intestinal colic Radical surgery for colorectal cancer Therapeutic effect

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Impacts of multi-scenario land use change on ecosystem services and ecological security pattern: A case study of the Yellow River Delta

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Research in Cold and Arid Regions 2024年第1期16卷 30-44页

作者： XueHua cen Hua Zhang College of Geography and Environmental Science Northwest Normal UniversityLanzhouGansu 730070China

The Yellow River Delta(YRD), a critical economic zone along China's eastern coast, also functions as a vital ecological reserve in the lower Yellow River. Amidst rapid industrialization and urbanization, the region has witnessed significant land use/cover changes(LUCC), impacting ecosystem services(ES) and ecological security patterns(ESP). Investigating LUCC's effects on ES and ESP in the YRD is crucial for ecological security and sustainable development. This study utilized the PLUS model to simulate 2030 land use scenarios, including natural development(NDS), economic development(EDS), and ecological protection scenarios(EPS). Subsequently, the InVEST model and circuit theory were applied to assess ES and ESP under varying LUCC scenarios from 2010 to 2030. Findings indicate:(1) Notable LUCC from 2010 to 2030, marked by decreasing cropland and increasing construction land and water bodies.(2) From 2010 to 2020, improvements were observed in carbon storage,water yield, soil retention, and habitat quality, whereas 2020–2030 saw increases in water yield and soil retention but declines in habitat quality and carbon storage. Among the scenarios, EPS showed superior performance in all four ES.(3) Between 2010 and 2030, ecological sources, corridors, and pinchpoints expanded, displaying significant spatial heterogeneity. The EPS scenario yielded the most substantial increases in ecological sources,corridors, and pinchpoints, totaling 582.89 km^(2), 645.03 km^(2),and 64.43 km^(2), respectively. This study highlights the importance of EPS, offering insightful scientific guidance for the YRD's sustainable development.

关键词： Land use change Multi-scenario simulation Ecosystem services Ecological security pattern The Yellow River Delta Circuit theory

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Association of Thyroid Nodules with Various Elements in Urine and Blood Serum: A Case-Control Study

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Biomedical and Environmental Sciences 2024年第3期37卷 320-324页

作者： LI Xiang zhi WU Cai Lian cen Li Ting HUANG Ming Le HUANG Min Min QIU Mei Ting LU Xiao Ling Guangxi Key Laboratory on Precise Prevention and Treatment for Thyroid Tumor The Second Affiliated Hospital of Guangxi University of Science and TechnologyGuangxi University of Science and TechnologyLiuzhou 545006GuangxiChina Department of Public Health School of MedicineGuangxi University of Science and TechnologyLiuzhou 545005GuangxiChina Academic and Research Department The Second Affiliated Hospital of Guangxi University of Science and TechnologyGuangxi University of Science and TechnologyLiuzhou 545006GuangxiChina

Thyroid nodules are a common clinical problem caused by various factors,including environmental and nutritional factors and genetic *** environment can modulate and influence not only the risk of thyroid nodules but also the severity of disease in humans[1].The environment is awash with elements,and all mineral elements,including heavy metals and trace elements,are considered potentially toxic.A significantly higher incidence of thyroid cancer has been reported in populations exposed to low doses of metallic elements in volcanic areas over a long period[2].As research on thyroid disorders continues,it is becoming clear that abnormalities in trace elements in the body can affect the development of thyroid-related disorders.

关键词： Blood doses Serum

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Multi-Smart Meter Data Encryption Scheme Basedon Distributed Differential Privacy

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Big Data Mining and Analytics 2024年第1期7卷 131-141页

作者： Renwu Yan Yang Zheng Ning Yu cen Liang School of Electronic Electrical Engineering and PhysicsFujian University of TechnologyFuzhou 350118China Department of Computing Sciences at The College at Brockport State University of New YorkNew YorkNY 14420USA

Under the general trend of the rapid development of smart grids,data security and privacy are facing serious challenges;protecting the privacy data of single users under the premise of obtaining user-aggregated data has attracted widespread *** this study,we propose an encryption scheme on the basis of differential privacy for the problem of user privacy leakage when aggregating data from multiple smart ***,we use an improved homomorphic encryption method to realize the encryption aggregation of users’***,we propose a double-blind noise addition protocol to generate distributed noise through interaction between users and a cloud platform to prevent semi-honest participants from stealing data by colluding with one ***,the simulation results show that the proposed scheme can encrypt the transmission of multi-intelligent meter data under the premise of satisfying the differential privacy *** if an attacker has enough background knowledge,the security of the electricity information of one another can be ensured.

关键词： smart grid homomorphic encryption data aggregation differential privacy cloud computing

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Genetic profile of Chinese patients with Charcot-Marie-Tooth disease

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Chinese Medical Journal 2020年第21期133卷 2633-2634页

作者： zhi-Yuan Ouyang You Chen Da-Qiang Qin zhi-dong cen Xiao-Sheng Zheng Fei Xie Si Chen Hao-Tian Wang De-Hao Yang Xin-Hui Chen Le-Bo Wang Bao-Rong Zhang Wei Luo Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Cancer Institute Key Laboratory of Cancer Prevention and InterventionChina National Ministry of EducationThe Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Department of Neurology Affiliated Hospital of Jiangsu UniversityZhenjiangJiangsu 212001China Department of Intensive Care Unit Zhejiang HospitalHangzhouZhejiang 310030China Department of Neurology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouZhejiang 310016China Chu Kochen Honors College Zhejiang UniversityHangzhouZhejiang 310058China

To the Editor:Charcot-Marie-Tooth disease(CMT)encompasses a genetically heterogeneous group of inherited neuropathies,characterized by progressive distal muscle weakness and atrophy,sensory deficits,impaired tendon reflexes,and foot deformities.[1]To date,more than 80 causative genes have been identified in CMT patients,associated with either autosomal dominant or recessive inheritance,or X-linked *** traditional classification of CMT was based on peripheral neuropathy type,as determined by nerve conduction *** more causative genes were identified and the overlap of neuropathy phenotypes became apparent,the traditional classification system proved unwieldy and ***,CMT needs to be distinguished from several entities including systemic disorders with neuropathy and other types of hereditary *** clinical practice,overlap of phenotypes can present a major challenge in reaching the correct *** study aimed to investigate the genetic profile in a cohort of Chinese CMT patients and evaluate the role of genetic testing in the diagnosis and subtyping of CMT.

关键词： Marie patients impaired

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Accelerating BERT inference with GPU-efficient exit prediction

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Frontiers of Computer Science 2024年第3期18卷 31-42页

作者： Lei LI Chengyu WANG Minghui QIU cen CHEN Ming GAO Aoying ZHOU Shanghai Engineering Research center of Big Data Management School of Data Science and EngineeringEast China Normal UniversityShanghai 200062China Alibaba Group Hangzhou 311121China KLATASDS-MOE School of StatisticsEast China Normal UniversityShanghai 200062China

BERT is a representative pre-trained language model that has drawn extensive attention for significant improvements in downstream Natural Language Processing(NLP)*** complex architecture and massive parameters bring BERT competitive performance but also result in slow speed at model inference *** speed up BERT inference,FastBERT realizes adaptive inference with an acceptable drop in accuracy based on knowledge distillation and the early-exit ***,many factors may limit the performance of FastBERT,such as the teacher classifier that is not knowledgeable enough,the batch size shrinkage and the redundant computation of student *** overcome these limitations,we propose a new BERT inference method with GPU-Efficient Exit Prediction(GEEP).GEEP leverages the shared exit loss to simplify the training process of FastBERT from two steps into only one step and makes the teacher classifier more knowledgeable by feeding diverse Transformer outputs to the teacher *** addition,the exit layer prediction technique is proposed to utilize a GPU hash table to handle the token-level exit layer distribution and to sort test samples by predicted exit *** this way,GEEP can avoid batch size shrinkage and redundant computation of student *** results on twelve public English and Chinese NLP datasets prove the effectiveness of the proposed *** source codes of GEEP will be released to the public upon paper acceptance.

关键词： BERT FastBERT inference acceleration model distillation early exit text classification

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Scale offers the possibility of identifying adherence to lifestyle interventions in patients with non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2024年第25期30卷 3179-3181页

作者： cen-Qin Liu Bing Hu Department of Gastroenterology and Hepatology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastroenterology and Hepatology/Medical Engineering Integration Laboratory of Digestive Endoscopy West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

Nonalcoholic fatty liver disease(NAFLD)is the most common chronic liver disorder,and dietary and lifestyle interventions remain the mainstays of NAFLD *** et al established a prediction system to evaluate adherence to lifestyle interventions in patients with NAFLD and choose optimal ***,we discuss the application scenarios of the scale and the areas warranting further attention,aiming to provide a possible reference for clinical recommend-ations.

关键词： Nonalcoholic fatty liver disease Dietary and lifestyle interventions Scale Adherence Exercise

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Structured Multi-Head Attention Stock Index Prediction Method Based Adaptive Public Opinion Sentiment Vector

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Computers, Materials & Continua 2024年第1期78卷 1503-1523页

作者： Cheng Zhao Zhe Peng Xuefeng Lan Yuefeng cen Zuxin Wang School of Economics Zhejiang University of TechnologyHangzhouChina College of Management Zhejiang University of TechnologyHangzhouChina Informatization Office Zhejiang University of TechnologyHangzhouChina School of Information and Electronic Engineering Zhejiang University of Science&TechnologyHangzhouChina School of Economics and Management Universiti Putra MalaysiaDaerah PetalingNegeri SelangorMalaysia

The present study examines the impact of short-term public opinion sentiment on the secondary market,with a focus on the potential for such sentiment to cause dramatic stock price fluctuations and increase investment *** quantification of investment sentiment indicators and the persistent analysis of their impact has been a complex and significant area of *** this paper,a structured multi-head attention stock index prediction method based adaptive public opinion sentiment vector is *** proposedmethod utilizes an innovative approach to transform numerous investor comments on social platforms over time into public opinion sentiment vectors expressing complex *** then analyzes the continuous impact of these vectors on the market through the use of aggregating techniques and public opinion data via a structured multi-head attention *** experimental results demonstrate that the public opinion sentiment vector can provide more comprehensive feedback on market sentiment than traditional sentiment polarity ***,the multi-head attention mechanism is shown to improve prediction accuracy through attention convergence on each type of input information *** absolute percentage error(MAPE)of the proposedmethod is 0.463%,a reduction of 0.294% compared to the benchmark attention ***,the market backtesting results indicate that the return was 24.560%,an improvement of 8.202% compared to the benchmark *** results suggest that themarket trading strategy based on thismethod has the potential to improve trading profits.

关键词： Public opinion sentiment structured multi-head attention stock index prediction deep learning

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Performance and mechanism of CO_(2) absorption during the simultaneous removal of SO_(2) and NO_(x) by wet scrubbing process

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Journal of Environmental Sciences 2024年第1期135卷 534-545页

作者： Peng Lu Xianhui Yan Lyumeng Ye Dingsheng Chen dongyao Chen Jianhang Huang Chaoping cen Guangdong Province Engineering Laboratory for Air Pollution Control South China Institute of Environmental SciencesMinistry of Ecology and EnvironmentGuangzhou 510655China Guangdong Provincial Key Laboratory of Water and Air Pollution Control Guangzhou 510655China School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhou 510275China

The co-removal of CO_(2)while removing SO_(2)and NOxfrom industrial flue gas has great potential of carbon emission reduction but related research is *** this study,a wet scrubbing process with various urea solutions for desulfurization and denitrification was explored for the possibility of CO_(2)*** results showed that the urea-additive solutions were efficient for NOxand SO_(2)abatement,but delivered<10%CO_(2)absorption *** addition of Ca(OH)_(2)dramatically enhanced the CO_(2)absorption,remained the desulfurization efficiency,unfortunately restricted the denitrification *** various operating parameters,pH of solution played a determining role during the *** contradictory pH demands of CO_(2)absorption and denitrification were observed and discussed in detail.A higher pH of solution than 10 was favorable for CO_(2)absorption,while the oxidizing of NO to NO_(2),NO_(2)^(-)or NO_(3)^(-)by NaClO_(2)was inhibited in this ***7

关键词： CO_(2)absorption Synergistic desulfurization and denitrification Wet scrubbing process Urea-NaClO_(2)-Ca(OH)_(2)absorbent Carbonation reaction

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