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局部晚期食管癌新辅助治疗的研究进展

生命科学 2024年第2期36卷 275-282页

作者：陈志富徐利本王燕吴朝阳江苏大学附属人民医院肿瘤放疗科镇江212000

食管癌是世界范围内恶性程度高、预后不良的肿瘤之一。手术治疗是局部晚期食管癌治疗的首选方式,但单纯手术治疗效果不佳,总体5年生存率较低。因此,局部晚期食管癌的治疗更倾向于手术联合多种模式的治疗。在局部晚期食管癌中,新辅助治... 详细信息

食管癌是世界范围内恶性程度高、预后不良的肿瘤之一。手术治疗是局部晚期食管癌治疗的首选方式,但单纯手术治疗效果不佳,总体5年生存率较低。因此,局部晚期食管癌的治疗更倾向于手术联合多种模式的治疗。在局部晚期食管癌中,新辅助治疗展示出了明显的生存获益、良好的临床疗效以及可接受的毒性反应,成为局部晚期食管癌的标准治疗模式之一。新辅助治疗主要包括新辅助化疗、新辅助放化疗、新辅助免疫治疗。本文就局部晚期食管癌新辅助治疗的研究进展进行综述。

关键词：局部晚期食管癌新辅助化疗新辅助放化疗新辅助免疫治疗

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玉米籽粒后熟品质性状主成分分析与综合评价

食品科学 2024年第11期45卷 1-7页

作者：曹勇许秀颖蔡丹刘回民张浩赵城彬郑明珠刘景圣吉林农业大学食品科学与工程学院小麦和玉米深加工国家工程研究中心吉林长春130118

为科学评价玉米在后熟阶段籽粒的生理特征和营养品质,对郑单958(Zd958)和先玉335(Xy335)两个品种玉米籽粒在后熟过程中的14个生理生化和品质性状指标,包括水分含量与状态、呼吸速率、可溶性糖含量、α-淀粉酶活性、过氧化氢酶活性、过... 详细信息

为科学评价玉米在后熟阶段籽粒的生理特征和营养品质,对郑单958(Zd958)和先玉335(Xy335)两个品种玉米籽粒在后熟过程中的14个生理生化和品质性状指标,包括水分含量与状态、呼吸速率、可溶性糖含量、α-淀粉酶活性、过氧化氢酶活性、过氧化物酶活性、己糖激酶活性、异柠檬酸脱氢酶活性、脂肪酸值、淀粉含量、千粒质量和快消化淀粉含量变化进行分析与综合评价。结果表明,玉米籽粒在后熟过程中的品质性状变化存在显著差异(P<0.05)。运用主成分分析法对玉米籽粒后熟品质性状进行综合评价,提取出不耐储因子、产量因子和消化特征因子3个主成分。3个主成分的贡献率分别为53.436%、18.466%和12.857%,累计贡献率为84.759%。根据综合分析F值变化规律,可以对玉米的后熟品质与后熟时间进行判定。新收获玉米Zd958和Xy335的后熟时间分别为50、30d。本研究结果可以为新玉米后熟品质的判定及玉米的加工利用提供参考。

关键词：玉米后熟品质性状主成分分析综合评价

Phase-locked single-mode terahertz quantum cascade lasers array

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Journal of Semiconductors 2024年第6期45卷 87-91页

作者： Yunfei xu Weijiang Li Yu Ma Quanyong Lu Jinchuan Zhang Shenqiang Zhai Ning Zhuo Junqi Liu Shuman Liu Fengmin Cheng Lijun Wang Fengqi Liu Key Laboratory of Semiconductor Materials Science Institute of SemiconductorsChinese Academy of SciencesBeijing Key Laboratory of Low Dimensional Semiconductor Materials and DevicesBeijing100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Division of Quantum Materials and Devices Beijing Academy of Quantum Information SciencesBeijing 100193China

We demonstrated a scheme of phase-locked terahertz quantum cascade lasers(THz QCLs)array,with a single-mode pulse power of 108 mW at 13 *** device utilizes a Talbot cavity to achieve phase locking among five ridge lasers with first-order buried distributed feedback(DFB)grating,resulting in nearly five times amplification of the single-mode *** to the optimum length of Talbot cavity depends on wavelength,the combination of Talbot cavity with the DFB grating leads to better power amplification than the combination with multimode Fabry-Perot(F-P)*** Talbot cavity facet reflects light back to the ridge array direction and achieves self-imaging in the array,enabling phase-locked operation of *** set the spacing between adjacent elements to be 220μm,much larger than the free-space wavelength,ensuring the operation of the fundamental supermode throughout the laser's dynamic range and obtaining a high-brightness far-field *** scheme provides a new approach for enhancing the single-mode power of THz QCLs.

关键词： quantum cascade lasers phase locking terahertz single mode

高管声誉驱动绿色创新的双路径机制：时间导向与信号传递的视角

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科学学与科学技术管理 2024年第8期45卷 162-181页

作者：徐宁白英杰李昱潼山东大学管理学院中国人民大学商学院

由利益不一致与信息不对称所导致的委托代理问题是制约企业绿色创新的关键桎梏，从优化高管激励的视角出发探索构建绿色创新导向的内生驱动机制是实现绿色转型升级的治本之策。以委托代理理论为基础，运用2007—2021年A股制造业上市公... 详细信息

由利益不一致与信息不对称所导致的委托代理问题是制约企业绿色创新的关键桎梏，从优化高管激励的视角出发探索构建绿色创新导向的内生驱动机制是实现绿色转型升级的治本之策。以委托代理理论为基础，运用2007—2021年A股制造业上市公司数据探究了高管声誉契约对企业绿色创新的影响及驱动机制。结果表明：高管声誉对制造业企业绿色创新具有显著的促进效应；从解决时间导向代理问题与信息不对称问题的视角出发，高管声誉可以约束高管的短视主义与机会主义行为，通过塑造长期导向和提高信息透明度的中介机制来驱动绿色创新。进一步研究发现，高管声誉也能够显著提升企业绿色创新质量。低碳城市试点政策与政府补贴等政府行为因素强化了高管声誉对绿色创新的正向影响，在国有企业中高管声誉的治理效应更加显著。

关键词：高管声誉绿色创新长期导向信息透明度政府行为

LA-D-B1,a novel Abemaciclib derivative,exerts anti-breast cancer effects through CDK4/6

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BIOCELL 2024年第5期48卷 847-860页

作者： LING MA ZIRUI JIANG XIAO HOU YUTING xu ZIYUN CHEN SIYI ZHANG HANxuE LI SHAOJIE MA GENG ZHANG XIUJUN WANG JING JI Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening College of PharmacyJiangsu Ocean UniversityLianyungang222000China School of Medicine Xiamen UniversityXiamen361102China

Background:Regulatory proteins involved in human cellular division and proliferation,cyclin-dependent kinases 4 and 6(CDK4/6)are overexpressed in numerous cancers,including triple-negative breast cancer(TNBC).TNBC is a common pathological subtype of breast cancer that is prone to recurrence and metastasis,and has a single treatment *** one of the CDK4/6 inhibitors,abemaciclib can effectively inhibit the growth of breast *** this study,we synthesized LA-D-B1,a derivative of Abemaciclib,and investigated its anti-tumor effects in breast ***:Cellular viability was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** cloning and migration abilities were determined by colony formation assay and wound healing *** invasion abilities and adhesion were determined by cell invasion assay and cell adhesion *** impact of compound LA-D-B1 on cell proliferation and the cell cycle was analyzed through Western blotting,which quantified the levels of proteins associated with the cyclin-dependent kinase(CDK)4/6-cyclin D-Rb-E2F *** in vivo anti-tumor activity of compound LA-D-B1 was investigated using a chick chorioallantoic membrane(CAM)***:The study demonstrated that LA-D-B1 effectively suppressed breast cancer cell proliferation,induced apoptosis,and caused cell cycle ***,LA-D-B1 reduced the expression of key proteins in the CDK4/6-cyclin D-Rb-E2F pathway,including CDK4,CDK6 and *** results also indicated significant antitumor activity of LA-D-B1 in a transplanted tumor ***:In this study,LA-D-B1 demonstrated a potent anti-tumor effect by effectively suppressing cell proliferation and inhibiting cell cycle progression in breast *** findings highlight the potential of LA-D-B1 as a valuable compound for enhancing therapeutic outcomes and controlling the progression of breast cancer.

关键词： CDK4/6 inhibitor Breast cancer Antitumor activity Cell cycle

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TY复合墩施工期受力特性及抗裂方案研究

公路 2024年第8期69卷 204-210页

作者：陈清河李刚徐德志郑和晖黄茅海跨海通道管理中心珠海市519000 中交第二航务工程局有限公司武汉市430040 长大桥梁建设施工技术交通行业重点实验室武汉市430040 交通运输行业交通基础设施智能制造技术研发中心武汉市430040 广东省交通规划设计研究院股份有限公司广州市510507

黄茅海通道中引桥采用TY复合墩+分体式钢箱梁结构,复合墩采用翻模法+托架法施工,钢箱梁通过浮吊分幅架设。采用有限元法对结构复杂且偏心受压的TY复合墩进行施工全过程受力分析,结果表明,复合墩施工过程面临较大开裂风险,盖梁浇筑时V腿... 详细信息

黄茅海通道中引桥采用TY复合墩+分体式钢箱梁结构,复合墩采用翻模法+托架法施工,钢箱梁通过浮吊分幅架设。采用有限元法对结构复杂且偏心受压的TY复合墩进行施工全过程受力分析,结果表明,复合墩施工过程面临较大开裂风险,盖梁浇筑时V腿根部、预应力张拉时盖梁外侧底缘局部及钢箱梁分幅架设时墩身的开裂风险大。基于复合墩施工期抗裂方案研究,采用增设预应力解决V腿根部开裂问题,并通过优化预应力方案解决盖梁开裂问题;提出横向移梁、增设配重、增加竖向预应力这3种墩身抗裂方案,并开展可行性及相对最优解分析,通过技术性及经济比选推荐采用增设竖向预应力方案。现场应用结果表明,上述各项措施能有效降低复合墩施工期的开裂风险。

关键词：桥梁工程 TY复合墩 V腿抗裂预应力优化横向移梁增设配重竖向预应力

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基于低频射电偏振特征的极高能宇宙线背景剔除

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天文学报 2024年第4期65卷 148-160页

作者：孙志豪马鹏雄张克文张超许鑫中国科学院紫金山天文台南京210023 中国科学技术大学天文与空间科学学院合肥230026 北京大学物理学院北京100871 西安电子科技大学电子工程学院西安710071

自触发射电阵列的设计是宇宙线大气簇射的射电探测所面临的机遇和难题之一,例如由背景源产生高振幅的瞬时噪声会导致射电阵列的误触发,而阵列设计需要避免由噪声导致的误触发.大气簇射射电信号独有的偏振特征为解决阵列的误触发问题提... 详细信息

自触发射电阵列的设计是宇宙线大气簇射的射电探测所面临的机遇和难题之一,例如由背景源产生高振幅的瞬时噪声会导致射电阵列的误触发,而阵列设计需要避免由噪声导致的误触发.大气簇射射电信号独有的偏振特征为解决阵列的误触发问题提供了解决方案,而利用信号偏振特征解决阵列误触发的方法的前提是射电信号的电场重建.由于背景噪声也会通过天线响应耦合到最终的观测数据中,这对正确重建射电信号的电场构成不可忽视的挑战.基于GRAND(Giant Radio Array for Neutrino Detection)验证阵列GP300(GRAND-Proto 300)的样机,结合模拟软件ZHAireS(ZHS AIR-shower Extended Simulations)模拟大气簇射产生的射电信号,耦合三极化天线的真实响应并使用最小二乘法重建电场,研究了射电信号的偏振特性,最终统计了以偏振为基础的天线的触发效率.

关键词：星际介质:宇宙线星际介质:射电探测辐射:偏振星际介质:大气簇射

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基于改进储备池计算的高精度扭秤动力学状态预测方法

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中国惯性技术学报 2024年第6期32卷 604-612页

作者：徐鹏姚镇东强丽娥王智李华东国科大杭州高等研究院基础物理与数学科学学院杭州310024 中国科学院国家空间科学中心北京100190 中国科学院大学北京100049 中国科学院力学研究所引力波实验中心北京100190 兰州大学兰州理论物理中心兰州730000 中国科学院长春光学精密机械与物理研究所长春130033

在空间引力波探测任务中,超高精度惯性传感器在入轨之前必须经过地面测试与评价,悬丝扭秤是地面测试的首选装置。为了获得悬丝扭秤的精确动力学模型,以减小其固有系统误差,提出了一种基于改进储备池计算(RC)的扭秤动力学预测模型。所提... 详细信息

在空间引力波探测任务中,超高精度惯性传感器在入轨之前必须经过地面测试与评价,悬丝扭秤是地面测试的首选装置。为了获得悬丝扭秤的精确动力学模型,以减小其固有系统误差,提出了一种基于改进储备池计算(RC)的扭秤动力学预测模型。所提模型利用注意力机制强化时间序列数据的长期依赖特征,并通过贝叶斯优化算法定位模型最优超参数空间,提高了动力学模型的预测精度。在实验室收集的扭秤转角时序数据上验证了所提方法的有效性,相较于传统RC的模型预测误差平均降低40%以上,可以为惯性传感器的地面测试提供可靠的动力学参考。

关键词：惯性传感器扭秤数据处理储备池计算时间序列预测

Real-world effectiveness of early insulin therapy on the incidence of cardiovascular events in newly diagnosed type 2 diabetes

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2953-2959页

作者： Sihui Luo xueying Zheng Wei Bao Sheng Nie Yu Ding Tong Yue Yilun Zhou Ying Hu Hua Li Qiongqiong Yang Qijun Wan Bicheng Liu Hong xu Guisen Li Gang xu Chunbo Chen Huafeng Liu Yongjun Shi Yan Zha Yaozhong Kong Guobin Su Ying Tang Mengchun Gong Linong Ji Fan Fan Hou Jianping Weng Department of Endocrinology First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHeifeiChina Institute of Public Health Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Division of Nephrology National Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchNanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Nephrology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina The Second Affiliated Hospital of Zhejiang University School of Medicine HangzhouChina Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhouChina Department of Nephrology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouChina The Second People’s Hospital of Shenzhen Shenzhen UniversityShenzhenChina Institute of Nephrology Zhongda HospitalSoutheast University School of MedicineNanjingChina Children’s Hospital of Fudan University ShanghaiChina Renal Department and Institute of Nephrology Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaSichuan Clinical Research Center for Kidney DiseasesChengduChina Division of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Critical Care Medicine Maoming People’s HospitalMaomingChina Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City Institute of NephrologyAffiliated Hospital of Guangdong Medical UniversityZhanjiangChina Huizhou Central People’s Hospital Sun Yat-Sen UniversityHuizhouChina Guizhou Provincial People’s Hospital Guizhou UniversityGuiyangChina Department of Nephrology the First People’s Hospital of FoshanFoshanChina Department of Nephrology Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospitalthe Second Clinical CollegeGuangzhou University of Chinese Medicin

Early insulin therapy is capable to achieve glycemic control and restoreβ-cell function in newly diagnosed type 2 diabetes(T2D),but its effect on cardiovascular outcomes in these patients remains *** this nationwide real-world study,we analyzed electronic health record data from 19 medical centers across China between 1 January 2000,and 26 May *** included 5424 eligible patients(mean age 56 years,2176 women/3248 men)who were diagnosed T2D within six months and did not have prior cardiovascular *** Cox regression models were used to estimate the associations of early insulin therapy(defined as the first-line therapy for at least two weeks in newly diagnosed T2D patients)with the incidence of major cardiovascular events including coronary heart disease(CHD),stroke,and hospitalization for heart failure(HF).During 17,158 persons years of observation,we documented 834 incident CHD cases,719 stroke cases,and 230 hospitalized cases for *** diagnosed T2D patients who received early insulin therapy,compared with those who did not receive such treatment,had 31%lower risk of incident stroke,and 28%lower risk of hospitalization for *** significant difference in the risk of CHD was *** found similar results when repeating the aforesaid analysis in a propensity-score matched population of 4578 patients and with inverse probability of treatment weighting *** findings suggest that early insulin therapy in newly diagnosed T2D may have cardiovascular benefits by reducing the risk of incident stroke and hospitalization for HF.

关键词： cardiovascular treatment nationwide