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The protective effects and underlying mechanisms of dapagliflozin on diabetes-induced testicular dysfunction

Asian Journal of Andrology 2023年第3期25卷 331-338页

作者： zhi-chao luo Zi-Run Jin Ya-Fei Jiang Tian-Jiao Wei Ya-Lei Cao Zhe Zhang Rui Wei Hui Jiang Department of Urology Peking University Third HospitalBeijing 100191China Department of Endocrinology and Metabolism Peking University Third HospitalBeijing 100191China Department of Reproductive Medicine Center Peking University Third HospitalBeijing 100191China

Male diabetic individuals present a marked impairment in fertility;however,knowledge regarding the pathogenic mechanisms and therapeutic strategies is unsatisfactory.The new hypoglycemic drug dapagliflozin has shown certain benefits,such as decreasing the risk of cardiovascular and renal events in patients with diabetes.Even so,until now,the effects and underlying mechanisms of dapagliflozin on diabetic male infertility have awaited clarification.Here,we found that dapagliflozin lowered blood glucose levels,alleviated seminiferous tubule destruction,and increased sperm concentrations and motility in leptin receptor-deficient diabetic db/db mice.Moreover,the glucagon-like peptide-1 receptor(GLP-1R)antagonist exendin(9-39)had no effect on glucose levels but reversed the protective effects of dapagliflozin on testicular structure and sperm quality in db/db mice.We also found that dapagliflozin inhibited the testicular apoptotic process by upregulating the expression of the antiapoptotic protein B-cell lymphoma 2(BCL2)and X-linked inhibitor of apoptosis protein(XIAP)and inhibiting oxidative stress by enhancing the antioxidant status,including total antioxidant capacity,total superoxide dismutase(SOD)activity,and glutathione peroxidase(GPx)activity,as well as decreasing the level of 4-hydroxynonenal(4-HNE).Exendin(9-39)administration partially reversed these effects.Furthermore,dapagliflozin upregulated the glucagon-like peptide-1(GLP-1)level in plasma and GLP-1R expression by promoting AKT8 virus oncogene cellular homolog(Akt)phosphorylation in testicular tissue.Exendin(9-39)partially inhibited Akt phosphorylation.These results suggest that dapagliflozin protects against diabetes-induced spermatogenic dysfunction via activation of the GLP-1R/phosphatidylinositol 3-kinase(PI3K)/Akt signaling pathway.Our results indicate the potential effects of dapagliflozin against diabetes-induced spermatogenic dysfunction.

关键词： dapagliflozin diabetes glucagon-like peptide-1 receptor male infertility oxidative stress

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“Periodic”soliton explosions in a dual-wavelength mode-locked Yb-doped fiber laser

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Photonics Research 2020年第3期8卷 246-251页

作者： MENG LIU TI-JIAN LI AI-PING luo WEN-CHENG XU zhi-chao luo Guangzhou Key Laboratory for Special Fiber Photonic Devices and Applications&Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices South ChinaNormal UniversityGuangzhou 510006China

We report the"periodic"soliton explosions induced by intracavity soliton collisions in a dual-wavelength modelocked Yb-doped fiber laser.Owing to the different group velocities of the two wavelengths,the mode-locked solitons centered at different wavelengths would periodically collide with each other.By using the dispersive Fourier transformation technique,it was found that each collision would induce soliton explosions,but none of them would be identical.Therefore,this phenomenon was termed as"periodic"soliton explosions.In addition,the dissipative rogue waves were detected in the dual-wavelength mode-locked state.The experimental results would be fruitful to the communities interested in soliton dynamics and dual-comb lasers.

关键词： fiber soliton mode

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Graphene-decorated microfiber knot as a broadband resonator for ultrahigh-repetition-rate pulse fiber lasers

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Photonics Research 2018年第10期6卷 I0003-I0009页

作者： MENG Liu RUI TANG AI-PING luo WEN-CHENG Xu zhi-chao luo Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices & Guangzhou Key Laboratory for Special Fiber Photonic Devices and Applications South China Normal University Guangzhou 510006 China Guangdong Provincial Engineenng Technology Research Center for Microstructured Functional Fibers and Devices South China Normal University Guangzhou 510006 China

Searching for an ultrahigh-repetition-rate pulse on the order of hundreds of gigahertz(GHz) is still a challenging task in the ultrafast laser community. Recently, high-quality silicon/silica-based resonators were exploited to generate a high-repetition-rate pulse based on the filter-driven four-wave mixing effect in fiber lasers. However,despite their great performance, the silicon/silica-based resonators still have some drawbacks, such as single waveband operation and low coupling efficiency between the fiber and resonators. To overcome these drawbacks,herein we proposed an all-fiber broadband resonator fabricated by depositing the graphene onto a microfiber knot. As a proof-of-concept experiment, the graphene-deposited broadband microfiber knot resonator(MKR)was applied to Er-and Yb-doped fiber lasers operating at two different wavebands, respectively, to efficiently generate hundreds-of-GHz-repetition-rate pulses. Such a graphene-deposited broadband MKR could open some new applications in ultrafast laser technology, broadband optical frequency comb generation, and other related fields of photonics.

关键词：重复频率脉冲激光技术发展现状通讯技术

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Few-layer MoS2-deposited microfiber as highly nonlinear photonic device for pulse shaping in a fiber laser [Invited]

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Photonics Research 2015年第2期3卷 69-78页

作者： Ai-Ping luo Meng Liu Xu-De Wang Qiu-Yi Ning Wen-Cheng Xu zhi-chao luo Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices School of Information and Optoelectronic Science and Engineering South China Normal University

Two-dimensional（2D） materials have emerged as attractive mediums for fabricating versatile optoelectronic devices. Recently, few-layer molybdenum disulfide（MoS2）, as a shining 2D material, has been discovered to possess both the saturable absorption effect and large nonlinear refractive index. Herein, taking advantage of the unique nonlinear optical properties of MoS2, we fabricated a highly nonlinear saturable absorption photonic device by depositing the few-layer MoS2 onto the microfiber. With the proposed MoS2 photonic device, apart from the conventional soliton patterns, the mode-locked pulses could be shaped into some new soliton patterns, namely,multiple soliton molecules, localized chaotic multipulses, and double-scale soliton clusters. Our findings indicate that the few-layer MoS2-deposited microfiber could operate as a promising highlynonlinear photonic device for the related nonlinear optics applications.

关键词： high Mo mode Few-layer MoS2-deposited microfiber as highly nonlinear photonic device for pulse shaping in a fiber laser

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1.7-μm dissipative soliton Tm-doped fiber laser

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Photonics Research 2021年第5期9卷 873-878页

作者： JI-XIANG CHEN XIANG-YUE LI TI-JIAN LI ZE-YU ZHAN MENG LIU CAN LI AI-PING luo PU ZHOU KENNETH K-YWONG WEN-CHENG XU zhi-chao luo Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices&Guangzhou Key Laboratory for Special Fiber Photonic Devices and Applications South China Normal UniversityGuangzhou 510006China College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073China Department of Electrical and Electronic Engineering The University of Hong KongHong KongChina

We report on the dissipative soliton generation in a 1.7-μm net-normal dispersion Tm-doped fiber laser by nonlinear polarization rotation technique. An intra-cavity bandpass filter was employed to suppress the longwavelength emission, while the cavity dispersion was compensated by a segment of ultrahigh numerical aperture(UHNA4) fiber. The dissipative soliton with a central wavelength of 1746 nm was obtained, covering a spectral range from 1737 nm to 1754 nm. The de-chirped duration and energy of the dissipative soliton were 370 fs and 0.2 nJ, respectively. In addition, the dynamics of multiple dissipative solitons were also investigated. Through optimization of the cavity dispersion, the 50 nm broadband dissipative soliton with de-chirped pulse duration of 230 fs could be achieved. The development of dissipative soliton seed laser represents the first step in achieving the chirped pulse amplification system at the 1.7-μm wave band, which would find potential applications in fields such as biomedical imaging and material processing.

关键词： technique. soliton dissipative

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Polysaccharide of Alocasia cucullata Exerts Antitumor Effect by Regulating Bcl-2, Caspase-3 and ERK1/2 Expressions during Long-Time Administration

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Chinese Journal of Integrative Medicine 2024年第1期30卷 52-61页

作者： ZHOU Qi-chun XIAO Shi-lin LIN Ru-kun LI Chan CHEN zhi-jie CHEN Yi-fei luo chao-hua MO zhi-xian LIN Ying-bo School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou(510515)China Clinical and Basic Research Team of TCM Prevention and Treatment of Non-Small Cell Lung Cancer the Second Clinical College of Guangzhou University of Chinese MedicineGuangzhou(510120)China Department of Chinese Medicine Zhujiang Hospital Affiliated to Southern Medical UniversityGuangzhou(510282)China Department of Pharmacy Jiangmen Central HospitalJiangmen(529000)China

Objective: To study the in vitro and in vivo antitumor effects of the polysaccharide of Alocasia cucullata(PAC) and the underlying mechanism. Methods: B16F10 and 4T1 cells were cultured with PAC of 40 μg/m L, and PAC was withdrawn after 40 days of administration. The cell viability was detected by cell counting kit-8. The expression of Bcl-2 and Caspase-3 proteins were detected by Western blot and the expressions of ERK1/2 mRNA were detected by quantitative real-time polymerase chain reaction(qRT-PCR). A mouse melanoma model was established to study the effect of PAC during long-time administration. Mice were divided into 3 treatment groups: control group treated with normal saline, positive control group(LNT group) treated with lentinan at 100 mg/(kg·d), and PAC group treated with PAC at 120 mg/(kg·d). The pathological changes of tumor tissues were observed by hematoxylin-eosin staining. The cell apoptosis of tumor tissues was detected by TUNEL staining. Bcl-2 and Caspase-3 protein expressions were detected by immunohistochemistry, and the expressions of ERK1/2, JNK1 and p38 mRNA were detected by qRT-PCR. Results: In vitro, no strong inhibitory effects of PAC were found in various tumor cells after 48 or 72 h of administration. Interestingly however, after 40 days of cultivation under PAC, an inhibitory effect on B16F10 cells was found. Correspondingly, the long-time administration of PAC led to downregulation of Bcl-2 protein(P <0.05), up-regulation of Caspase-3 protein(P<0.05) and ERK1 mRNA(P<0.05) in B16F10 cells. The above results were verified by in vivo experiments. In addition, viability of B16F10 cells under long-time administration culture in vitro decreased after drug withdrawal, and similar results were also observed in 4T1 cells. Conclusions: Long-time administration of PAC can significantly inhibit viability and promote apoptosis of tumor cells, and had obvious antitumor effect in tumor-bearing mice.

关键词： polysaccharide of Alocasia cucullata tumor cells Bcl-2 Caspase-3 ERK1/2 Chinese medicine

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Combination of diketone and PAO to achieve macroscale oil-based superlubricity at relative high contact pressures

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Friction 2024年第5期12卷 869-883页

作者： Shaonan DU Chenhui ZHANG zhi luo State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing100084China Beijing National Laboratory of Molecular Sciences CAS Key Laboratory of Engineering PlasticsInstitute of ChemistryChinese Academy of SciencesBeijing100190China

1-(4-ethylphenyl)-nonane-1,3-dione(0206)is an oil-soluble liquid molecule with rod-like structure.In this study,the chelate(0206-Fe)with octahedral structure was prepared by the reaction of ferric chloride and 1,3-diketone.The experimental results show that when using 0206 and a mixed solution containing 60%0206-Fe and 40%0206(0206-Fe(60%))as lubricants of the steel friction pairs,superlubricity can be achieved(0.007,0.006).But their wear scar diameters(WSD)were very large(532µm,370µm),which resulted in the pressure of only 44.3 and 61.8 MPa in the contact areas of the friction pairs.When 0206-Fe(60%)was mixed with PAO6,it was found that the friction coefficient(COF)decreased with increase of 0206-Fe(60%)in the solution.When the ratio of 0206-Fe(60%)to PAO6 was 8:2(PAO6(20%)),it exhibited better comprehensive tribological properties(232.3 MPa).Subsequent studies have shown that reducing the viscosity of the base oil in the mixed solution helped to reduce COF and increased WSD.Considering the COF,contact pressure,and running-in time,it was found that the mixed lubricant(Oil3(20%))prepared by the base oil with a viscosity of 19.7 mPa·s(Oil3)and 0206-Fe(60%)exhibited the best tribological properties(0.007,161.4 MPa,3,100 s).

关键词： diketone oil-based lubricants chelate superlubricity

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Quasi-in-situ Observation and SKPFM Studies on Phosphate Protective Film and Surface Micro-Galvanic Corrosion in Biological Mg-3Zn-xNd Alloys

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Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 648-664页

作者： Zhaochen Yu Kaixuan Feng Shuyun Deng Yang Chen Hong Yan Honggun Song chao luo zhi Hu School of Advanced Manufacturing Nanchang UniversityNanchang330031China Institute for Advanced Study Nanchang UniversityNanchang330031China

The phosphate protective film and micro-galvanic corrosion of biological Mg-3Zn-xNd (x = 0, 0.6, 1.2) alloys were investigated by scanning and transmission electron microscopy, quasi-in-situ observation, scanning Kelvin probe force microscopy (SKPFM) and electrochemical tests. The results revealed the Mg-Zn-Nd phases formed in Mg-3Zn alloy contained with Nd. Adding Nd resulted in a significant decline in the cracks of the phosphate protective film and micro-galvanic corrosion of alloys, which were recorded by quasi-in-situ observation. In addition, the Volta potential difference of Mg-Zn-Nd/α-Mg (~ 188 mV) was lower than MgZn/α-Mg (~ 419 mV) and Zn-rich/α-Mg (~ 260 mV), and the corrosion rates of alloys markedly decreased after the addition of 0.6 wt% Nd. The improvement in corrosion resistance of Nd-containing alloys was mainly attributed to the following: (i) the addition of Nd reduced the Volta potential difference (second phases/α-Mg);(ii) the phosphate protective film containing Nd_(2)O_(3) deposited on the surface of the alloys, effectively preventing the penetration of harmful anions.

关键词： Magnesium alloys Quasi-in-situ observation Phosphate protective film Scanning Kelvin probe force microscopy(SKPFM) Micro-galvanic corrosion

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Diagnostic value associated with the combination of saliva pepsin and microorganisms in functional heartburn and gastroesophageal reflux disease

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World Journal of Gastroenterology 2024年第19期30卷 2612-2614页

作者： Yu-Qi Huang chao Yang Wen luo Department of Stomatology The First Affiliated Hospital of Hainan Medical UniversityHaikou 570102Hainan ProvinceChina School of Stomatology Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Research and Development Department Shenzhen Uni-medica Technology Co.LtdShenzhen 518051Guangdong ProvinceChina Department of Stomatology The People’s Hospital of LonghuaShenzhen 518109Guangdong ProvinceChina

Heartburn is a common symptom shared by both gastroesophageal reflux disease(GERD)and functional heartburn(FHB),which can make it challenging to differentiate between the two conditions.However,examining oral manifestations of GERD can be a cost-effective and readily available method to aid in this differentiation process.It may serve as a valuable tool in distinguishing GERD from FHB.

关键词： Gastroesophageal reflux disease Gastric acid Heartburn Differential diagnosis Epidemiology Oral manifestations Prevalence Risk factors Dental erosion Periodontal diseases

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Study on the tribological properties of metal rolling bearing under lubrication with diketone lubricants

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Science China Technological Sciences 2024年第7期67卷 2003-2017页

作者： DU ShaoNan ZHANG ChenHui luo zhi State Key Laboratory of Tribology in Advanced Equipment Tsinghua University Beijing National Laboratory of Molecular Sciences CAS Key Laboratory of Engineering Plastics Institute of Chemistry Chinese Academy of Sciences

In this article, 1-(4-ethylphenyl)-nonane-1,3-dione(0206) was prepared by Claisen condensation. By mixing 0206, chelate, and base oil in a ratio of 3.2:4.8:2, a diketone lubricant(PAO=14(20%)) that can achieve superlubricity was prepared and applied to bearing lubrication experiments. The experimental results show that when the bearing was lubricated by base oil, the friction coefficient(COF) and temperature rise decreased with the decrease of the viscosity of PAO. When PAO=14(20%) was used as the lubricant, the COF of the bearing was the lowest(0.001), and the wear morphology was comparable to that of the bearing lubricated with commercial lubricant. Compared with the base oil with the same viscosity, it is found that the COF and temperature rise of the bearing lubricated by PAO=14(20%) were lower under any experimental conditions. And when the amount of lubricant added was 10 μL, the COF of the bearing lubricated by PAO=14(20%) reached a very low value(0.0004).Bearing ball surface analysis identified the formation of diketone adsorption films. Combined with the previous PAO=14(20%)superlubricity mechanism, it was considered that the occurrence of tribochemical reaction and the bearing effect of chelates were the main reasons for the existence of ultra-low friction coefficient and low wear. In addition, when there were polar molecules in the lubricant, they were adsorbed on the metal surface through tribochemical reactions, resulting in many irregular pits on the surface.

关键词： superlubricity diketone chelate tribochemical recations, bearing lubrication

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