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Advantages of Rho-associated kinases and their inhibitor fasudil for the treatment of neurodegenerative diseases

Neural Regeneration Research 2022年第12期17卷 2623-2631页

作者： Qing Wang Li-Juan Song zhi-bin ding zhi Chai Jie-Zhong Yu Bao-Guo Xiao Cun-Gen Ma Research Center of Neurobiology The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese MedicineShanxi University of Chinese MedicineJinzhongShanxi ProvinceChina Department of Physiology Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Institute of Brain Science Shanxi Key Laboratory of Inflammatory Neurodegenerative DiseasesShanxi Datong UniversityDatongShanxi ProvinceChina Department of Neurology Datong Fifth People’s HospitalDatongShanxi ProvinceChina Institute of Neurology Huashan HospitalInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan UniversityShanghaiChina

Ras homolog(Rho)-associated kinases(ROCKs)belong to the serine-threonine kinase family,which plays a pivotal role in regulating the damage,survival,axon guidance,and regeneration of *** are also involved in the biological effects of immune cells and glial cells,as well as the development of neurodegenerative disorders such as Alzheimer’s disease,Parkinson’s disease,and multiple *** studies by us and others confirmed that ROCKs inhibitors attenuated the symptoms and progression of experimental models of the abovementioned neurodegenerative diseases by inhibiting neuroinflammation,regulating immune imbalance,repairing the blood-brain barrier,and promoting nerve repair and myelin ***,the first ROCKs inhibitor to be used clinically,has a good therapeutic effect on neurodegenerative *** increases the activity of neural stem cells and mesenchymal stem cells,thus optimizing cell *** review will systematically describe,for the first time,the effects of abnormal activation of ROCKs on T cells,B cells,microglia,astrocytes,oligodendrocytes,and pericytes in neurodegenerative diseases of the central nervous system,summarize the therapeutic potential of fasudil in several experimental models of neurodegenerative diseases,and clarify the possible cellular and molecular mechanisms of ROCKs *** review also proposes that fasudil is a novel potential treatment,especially in combination with cell-based *** from this review add support for further investigation of ROCKs and its inhibitor fasudil for the treatment of neurodegenerative diseases.

关键词： Alzheimer’s disease cell-based therapy central nervous system cells fasudil immunocytes multiple sclerosis Parkinson’s disease pericytes Rho kinase inhibitor Rho-associated kinases

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Astrocytes: a double-edged sword in neurodegenerative diseases

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Neural Regeneration Research 2021年第9期16卷 1702-1710页

作者： zhi-bin ding Li-Juan Song Qing Wang Gajendra Kumar Yu-Qing Yan Cun-Gen Ma The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine Research Center of NeurobiologyShanxi University of Chinese MedicineTaiyuanShanxi ProvinceChina Institute of Brain Science Shanxi Key Laboratory of Inflammatory Neurodegenerative DiseasesMedical School of Shanxi Datong UniversityDatongShanxi ProvinceChina Department of Neurology Affiliated Shanxi Bethune HospitalShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neuroscience City University of Hong KongTat Chee AvenueHong Kong Special Administrative RegionChina

Astrocytes play multifaceted and vital roles in maintaining neurophysiological function of the central nervous system by regulating homeostasis, increasing synaptic plasticity, and sustaining neuroprotective effects. Astrocytes become activated as a result of inflammatory responses during the progression of pathological changes associated with neurodegenerative disorders. Reactive astrocytes(neurotoxic A1 and neuroprotective A2) are triggered during disease progression and pathogenesis due to neuroinflammation and ischemia. However, only a limited body of literature describes morphological and functional changes of astrocytes during the progression of neurodegenerative diseases. The present review investigated the detrimental and beneficial roles of astrocytes in neurodegenerative diseases reported in recent studies, as these cells have promising therapeutic potential and offer new approaches for treatment of neurodegenerative diseases.

关键词： A1 A2 astrocytes neurodegenerative diseases neuroinflammation neuron neuroprotection neurotoxicity polarization reactivity

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Hybrid Network Model Based on Data Enhancement for Short-term Power Prediction of New PV Plants

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 77-88页

作者： Shangpeng Zhong Xiaoming Wang bin Xu Hongbin Wu Ming ding the Anhui Province Key Laboratory of Renewable Energy Utilization and Energy Saving Hefei University of TechnologyHefei 230009China the State Grid Anhui Electric Power Research Institute Hefei 230061China

This study proposes a hybrid network model based on data enhancement to address the problem of low accuracy in photovoltaic(PV)power prediction that arises due to insuffi cient data samples for new PV ***,a time-series gener ative adversarial network(TimeGAN)is used to learn the distri bution law of the original PV data samples and the temporal correlations between their features,and these are then used to generate new samples to enhance the training ***,a hybrid network model that fuses bi-directional long-short term memory(BiLSTM)network with attention mechanism(AM)in the framework of deep&cross network(DCN)is con structed to effectively extract deep information from the origi nal features while enhancing the impact of important informa tion on the prediction ***,the hyperparameters in the hybrid network model are optimized using the whale optimi zation algorithm(WOA),which prevents the network model from falling into a local optimum and gives the best prediction *** simulation results show that after data enhance ment by TimeGAN,the hybrid prediction model proposed in this paper can effectively improve the accuracy of short-term PV power prediction and has wide applicability.

关键词： New photovoltaic(PV)plant short-term predic tion time-series generative adversarial network(TimeGAN) hy brid network hyperparameter

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Numerical Investigation on Heat Transfer Characteristics of Microencapsulated Phase Change Material Slurry in a Rectangular Minichannel

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Journal of Thermal Science 2024年第2期33卷 564-577页

作者： WANG zhibin LI Zilong JIA Lisi ding bin CHEN Ying School of Materials and Energy Guangdong University of TechnologyGuangzhou510006China Guangdong Provincial Key Laboratory of Functional Soft Condensed Matter Guangzhou510006China College of New Energy China University of Petroleum(East China)Qingdao266580China

Microencapsulation phase change material slurry(MEPCMS) becomes a potential working fluid for cooling high energy density miniaturized components,thanks to the latent heat absorption of particles in the heat transfer *** this work,the Discrete Phase Model(DPM) based on the Euler-Lagrangian method is used to numerically investigate the convective heat transfer characteristics of MEPCMS flowing through a rectangular minichannel with constant heat *** results show that particles of MEPCMS are mainly subjected to drag force during the *** so,they can migrate from the high-temperature region to the low-temperature region driven by the thermophoretic force,affecting the particle distribution and phase change ***,the Nux of the MEPCMS fluctuates due to particle phase change with varying specific heat ***,the value increases first,then decreases,and eventually increases again until it approaches the fully developed value of the pure base fluid as the particles gradually ***,the heat transfer performance of the MEPCMS is influenced by the combination of fluid inlet temperature fluid inlet velocity(v),and mass concentration(c_(m)) of MEPCM *** result shows that the maximum reduction of the maximum bottom wall temperature difference(ΔT_(w)) is 23.98% at T_(in)=293.15 K,v=0.15 m·s^(-1),c_(m)=10%.

关键词： Microencapsulated Phase Change Material Slurry(MPCMS) Discrete Phase Model(DPM) particle-fluid interaction force minichannel heat sink thermophoresis

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A Hybrid Signal Processing Method Combining Mathematical Morphology and Walsh Theory for Power Quality Disturbance Detection and Classification

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 584-592页

作者： zhi ding Tianyao Ji Mengshi Li Q.H.Wu School of Electric Power Engineering South China University of Technology(SCUT)Guangzhou 510641China

In this paper, a novel signal processing method combining mathematical morphology (MM) and Walsh theory is proposed, which uses Walsh functions to control the structuring element (SE) and MM operators. Based on the Walsh-MM method, a scheme for power quality disturbances detection and classification is developed, which involves three steps: denoising, feature extraction and morphological clustering. First, various evolution rules of Walsh function are used to generate groups of SEs for the multiscale Walsh-ordered morphological operation, so the original signal can be denoised. Next, the fundamental wave of the denoised signal is suppressed by Hadamard matrix;thus, disturbances can be extracted. Finally, the Walsh power spectrum of the waveform extracted in the previous step is calculated, and the parameters of which are taken by morphological clustering to classify the disturbances. Simulation results reveal the proposed scheme can effectively detect and classify disturbances, and the Walsh-MM method is less affected by noise and only involves simple calculation, which has a potential to be implemented in hardware and more suitable for real-time application.

关键词： Hadamard matrix mathematical morphology morphological clustering power quality disturbance Walsh theory

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Prescribed time control based on the periodic delayed sliding mode surface without singularities

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Science China(Information Sciences) 2024年第7期67卷 256-270页

作者： bin ZHOU Yi ding Kang-Kang ZHANG Guang-Ren DUAN Center for Control Theory and Guidance Technology Harbin Institute of Technology

In this paper, nonsingular prescribed-time control is studied based on periodic delayed sliding mode surfaces. Different from the existing sliding mode control, where either singularity problems may appear or the convergence time depends on the initial state, the proposed sliding mode control approaches can achieve prescribed-time convergence without singularity. The proposed nonsingular sliding mode control approaches can be applied to both second-order and high-order nonlinear systems with prescribed-time convergence. As applications of the proposed sliding mode control approaches, the control of hypersonic vehicle systems is revisited. Numerical simulations on the nonlinear model of the hypersonic vehicle system show the effectiveness of the proposed methods.

关键词： prescribed-time control smooth periodic delayed feedback sliding mode control high-order nonlinear systems hypersonic vehicle systems

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Large-Scale Preparation of Mechanically High-Performance and Biodegradable PLA/PHBV Melt-Blown Nonwovens with Nanofibers

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Engineering 2024年第8期39卷 244-252页

作者： Gaohui Liu Jie Guan Xianfeng Wang Jianyong Yu bin ding Shanghai Frontier Science Research Center of Advanced Textiles College of TextilesDonghua UniversityShanghai 201620China College of Materials Science and Engineering Qingdao UniversityQingdao 266071China

Biodegradable polylactic acid(PLA)melt-blown nonwovens are attractive candidates to replace nondegradable polypropylene melt-blown ***,it is still an extremely challenging task to prepare PLA melt-blown nonwovens with sufficient mechanical properties for practical ***,we report a simple strategy for the large-scale preparation of biodegradable PLA/poly(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV)melt-blown nonwovens with high strength and excellent *** this process,a small amount of PHBV is added to PLA to improve the latter’s crystallization rate and *** addition,when the PHBV content increases from 0 to 7.5 wt%,the diameters of the PLA/PHBV melt-blown fibers decrease significantly(with the proportion of nanofibers increasing from 7.7%to 42.9%).The resultant PLA/PHBV(5 wt%PHBV)melt-blown nonwovens exhibit the highest mechanical *** tensile stress,elongation,and toughness of PLA/PHBV(5 wt%PHBV)melt-blown nonwovens reach 2.5 MPa,45%,and 1.0 MJm3,*** importantly,PLA/PHBV melt-blown nonwovens can be completely degraded into carbon dioxide and water after four months in the soil,making them environmentally friendly.A general tensile-failure model of melt-blown nonwovens is proposed in this study,which may shed light on mechanical performance enhancement for nonwovens.

关键词： PLA PHBV Melt-blown Biodegradable Strength Toughness

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Patterns and drivers of avian taxonomic and phylogenetic beta diversity in China vary across geographical backgrounds and dispersal abilities

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Zoological Research 2024年第1期45卷 125-135页

作者： Jian-Chao Liang zhi-Feng ding Chun-Lin Li Yi-Ming Hu zhi-Xin Zhou Gan-Wen Lie Xiao-Nan Niu Wen-bin Huang Hui-Jian Hu Xing-Feng Si Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhouGuangdong 510260China School of Resources and Environmental Engineering Anhui UniversityHefeiAnhui 230601China Guangdong Eco-Engineering Polytechnic GuangzhouGuangdong 510520China Huizhou Institute of Forestry(Huizhou Botanical Garden Management Service Center) HuizhouGuangdong 516001China Administration of National Nature Reserve for Marine Ecology of Guangdong Nanpeng Islands ShantouGuangdong 515900China Zhejiang Zhoushan Archipelago Observation and Research Station Institute of Eco-ChongmingZhejiang Tiantong Forest Ecosystem National Observation and Research StationSchool of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China

Geographical background and dispersal ability may strongly influence assemblage dissimilarity;however,these aspects have generally been overlooked in previous large-scale beta diversity ***,we examined whether the patterns and drivers of taxonomic beta diversity(TBD)and phylogenetic beta diversity(PBD)of breeding birds in China vary across(1)regions on both sides of the Hu Line,which demarcates China’s topographical,climatic,economic,and social patterns,and(2)species with different dispersal *** and PBD were calculated and partitioned into turnover and nestedness components using a moving window *** representing climate,habitat heterogeneity,and habitat quality were employed to evaluate the effects of environmental *** distance was considered to assess the impact of dispersal *** partitioning analysis was applied to assess the relative roles of these *** general,the values of TBD and PBD were high in mountainous areas and were largely determined by environmental ***,different dominant environmental filters on either side of the Hu Line led to divergent beta diversity ***,climate-driven species turnover and habitat heterogeneity-related species nestedness dominated the regions east and west of the line,***,bird species with stronger dispersal ability were more susceptible to environmental filtering,resulting in more homogeneous *** results indicated that regions with distinctive geographical backgrounds may present different ecological factors that lead to divergent assemblage dissimilarity patterns,and dispersal ability determines the response of assemblages to these ecological *** a single universal explanation for the observed pattern without considering these aspects may lead to simplistic or incomplete ***,a comprehensive understanding of large-scale beta diversity patterns and effective pla

关键词： Beta diversity Environmental filtering Dispersal limitation Hu Line Species dispersal ability Breeding birds

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Design of a Multifrequency Signal Parameter Estimation Method for the Distribution Network Based on HIpST

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Energy Engineering 2024年第3期121卷 729-746页

作者： bin Liu Shuai Liang Renjie ding Shuguang Li Tongliao Power Supply Company State Grid East Inner Mongolia Electric Power Co.Ltd.Tongliao028000China School of Electrical Engineering Northeast Electric Power UniversityJilin132012China

The application of traditional synchronous measurement methods is limited by frequent fluctuations of electrical signals and complex frequency components in distribution ***,it is critical to find solutions to the issues of multifrequency parameter estimation and synchronous measurement estimation accuracy in the complex environment of distribution *** utilizing the multifrequency sensing capabilities of discrete Fourier transform signals and Taylor series for dynamic signal processing,a multifrequency signal estimation approach based on HT-IpDFT-STWLS(HIpST)for distribution networks is ***,by introducing the Hilbert transform(HT),the influence of noise on the estimation algorithm is ***,signal frequency components are obtained on the basis of the calculated signal envelope spectrum,and the interpolated discrete Fourier transform(IpDFT)frequency coarse estimation results are used as the initial values of symmetric Taylor weighted least squares(STWLS)to achieve high-precision parameter estimation under the dynamic changes of the signal,and the method increases the number of discrete ***,the accuracy of this proposed method is verified by simulation *** show that this proposed method can accurately achieve the parameter estimation of multifrequency signals in distribution *** approach provides a solution for the application of phasor measurement units in distribution networks.

关键词： Discrete fourier transform taylor series hilbert transform multifrequency signal parameter estimation

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Numerical evaluations on the fluid production in the in-situ conversion of continental shale oil reservoirs

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Petroleum Science 2024年第4期21卷 2485-2501页

作者： Zhao-bin Zhang Maryelin Josefina Brice?o Montilla Shou-ding Li Xiao Li Jian-Peng Xing Yan-zhi Hu Key Laboratory of Shale Gas and Geoengineering Institute of Geology and Geophysics Chinese Academy of Sciences Institute of Earth Sciences Chinese Academy of Sciences College of Earth and Planetary Sciences University of Chinese Academy of Sciences Institute of Energy Peking University

In-situ conversion presents a promising technique for exploiting continental oil shale formations,characterized by highly fractured organic-rich rock. A 3D in-situ conversion model, which incorporates a discrete fracture network, is developed using a self-developed thermal-flow-chemical(TFC) *** of the model elucidates the in-situ conversion process in three stages and defines the transformation of fluids into three distinct outcomes according to their end stages. The findings indicate that kerogen decomposition increases fluid pressure, activating fractures and subsequently enhancing permeability. A comprehensive analysis of activated fracture permeability and heating power reveals four distinct production modes, highlighting that increasing heating power correlates with higher cumulative fluid production. Activated fractures, with heightened permeability, facilitate the mobility of heavy oil toward production wells but hinder its cracking, thereby limiting light hydrocarbon ***, energy efficiency research demonstrates the feasibility of the in-situ conversion in terms of energy utilization, especially when considering the surplus energy from high-fluctuation energy sources such as wind and solar power to provide heating.

关键词： In-situ conversion Continental shale oil Natural fracture network TFC model

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