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Genome-wide Identification,Classification and Expression Analysis of Lhc Supergene Family in Castor Bean(Ricinus communis L.)

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Agricultural Biotechnology 2013年第6期2卷 44-48,51页

作者： zhi zou Qixing HUANG Feng AN Rubber Research Institute Chinese Academy of Tropical Agricultural Sciences/Key Laboratory of Biology and Genetic Resources of Rubber TreeMinistry of Agriculture Institute of Tropical Biosciences and Biotechnology CATAS/Key Laboratory of Biology and Genetic Resources of Torpical CropsMinistry of Agriculture

Light-harvesting chlorophyll a/b-binding （LHC） proteins are a group of nuclear-encoded thylakoid proteins that play a key role in plant photosynthesis and are widely involved in light harvesting, energy transfer to the reaction center, maintenance of thylakoid membrane structure, photoprotection and response to en- vironmental conditions, etc. Although/dw supergene family is well characterized in model plants such as Arabidopsis, rice and poplar, little information is available in castor bean （Ricinus communis L. ）. In this study, a genome-wide search was carried out for the first time to identify castor bean L/w genes and analyze the gene structures, biochemical properties, evolutionary relationships and expression characteristics based on the published data of castor bean genome and ESTs. According to the results, a total of 28 Rclhcs genes representing 13 gene families （ l_hca , l_hcb , Elip , Ohpl , Ohp2 , SEP1, SEP2 , SEP3 , SEP4 , SEP5 , PsbS , Rieske and FCII） and 25 subgene families were identified in castor bean genome; to be specific, 25 and 5 genes were found to have corresponding ESTs in NCBI and have al- ternative splicing isoforlns, respectively. These RcLhcs contain 0 to 9 introns and distribute on 26 of the 25 878 released scaffolds. All RcLhcs genes were found to be expressed in all examined tissues, i.e. leaf, flower, II/III stage endosperm, V/VI stage endosperm and seed, with the highest expression level in leaf tissue.

关键词： Ricinus communis L. Lhc supergcne family Genomc-wide Classification Expression analysis

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Understanding the spatial interaction of ultrasounds based on three-dimensional dual-frequency ultrasonic field numerical simulation

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China Foundry 2024年第1期21卷 29-43页

作者： Zhao-yang Yin Qi-chi Le Yan-chao Jiang Da-zhi Zhao Qi-yu Liao Qi zou Key Lab of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang 110819China School of Materials Science and Engineering Northeastern UniversityShenyang 110819China

A transient 3D model was established to investigate the effect of spatial interaction of ultrasounds on the dual-frequency ultrasonic field in magnesium alloy *** effects of insertion depth and tip shape of the ultrasonic rods,input pressures and their ratio on the acoustic field distribution were discussed in ***,the spacing,angle,and insertion depth of two ultrasonic rods significantly affect the interaction between distinct *** a result,various acoustic pressure distributions and cavitation regions are *** spherical rods mitigate the longitudinal and transversal attenuation of acoustic pressure and expand the cavitation volume by 53.7%and 31.7%,respectively,compared to the plate and conical *** the input pressure will enlarge the cavitation region but has no effect on the acoustic pressure distribution *** acoustic pressure ratio significantly affects the pressure distribution and the cavitation region,and the best cavitation effect is obtained at the ratio of 2:1(P15:P20).

关键词： dual-frequency ultrasonic numerical model acoustic pressure spatial interaction magnesium alloy

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Preparation and antibacterial activity of aromatic derivatives of β-aminopropionic and γ-aminobutyric acid

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Chinese Journal of Chemistry 1997年第4期15卷 366-370页

作者： GUAN,Jing-Qu HU,Zun-Ju zou,zhi-Chen WU,zhi-GuangDepartment of Chemistry,Shandong Teachers’ University,Jinan,Shandong 350014,China Institute of Photographic Chemistry,Chinese Academy of Sciences,Beijing 100101,China Department of Chemistry Shandong Teachers' University Jinan Shandong 250014 China Institute of Photographic Chemistry Chinese Academy of Sciences Beijing 100101 China

Ten aromatic derivatives of β-aminopropionic acid and γ-aminobutyric acid were *** compositions and structures were identified by elemental analysis,IR,and 1H *** have been examined for their antibacterial action against Staphylococcua aurens and Escherichia *** compounds showed higher activity than the aromatic derivatives of ct-amino acid which were reported *** general conclusion to be drawn is that the distance between amino and carboxylic group in these molecules could affect their antibacterial ***,those compounds with p-methyl substituent in phenyl ring exhibit higher activity than the others,and all the compounds exhibit higher activity against Escherichia coli and against Staphylococcua aureus.

关键词： Antibacterial agent aromatic derivatives β-aminopropionic acid γ-aminobutyric acid

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Research on the Dynamic Compressibility of Polyurethane Microcellular Elastomer and its Application for Impact Resistance

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Chinese Journal of Polymer Science 2024年第8期42卷 1185-1197页

作者： zhi-Ying Zhao Hao Jiang Xiao-Dong Li Xu-Dong Zhang Xing Su Mei-Shuai zou School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China

The packaging materials with cushioning performance are used to prevent the internal contents from being damaged by the impact and vibration of external *** polyurethane microcellular elastomers(PUMEs)can absorb energy through cell collapse and molecular chain *** this study,PUMEs with different densities were investigated by scanning electron microscopy,dynamic mechanical analysis and dynamic compression *** exhibited significant im pact resistance and the maximum peak stress attenuation ratio reached 73.33%.The protective equipment was made by PUME with the optimal density of 600 kg/m^(3),and then the acceleration sensing device installed with the same protective equipment fell from a height of 3,5 and 10 m to evaluate the energy-absorbing property and reusability of *** results showed that PUMEs equipment reduced the peak acceleration of the device by 93.84%,with a maximum deviation of 9%between actual test and simulation,and shortened the impact time of first landing by 57.39%.In addition,the equipment PUMEs equipment could effectively reduce the stress on the protected items.

关键词： Polyurethane microcellular elastomer Impact velocity Stress attenuation ratio Impact resistance

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Viral-mediated gene therapy in pediatric neurological disorders

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World Journal of Pediatrics 2024年第6期20卷 533-555页

作者： Jing Peng Wei-Wei zou Xiao-Lei Wang zhi-Guo Zhang Ran Huo Li Yang Department of Pediatrics Clinical Research Center for Chidren Neurodevelopmental disablities of Hunan ProvinceXiangya HospitalCentral South UniversityChangsha 410008China Reproductive Medicine Center Department of Obstetrics and Gynecologythe First Affiliated Hospital of Anhui Medical UniversityHefeiChina State Key Laboratory of Reproductive Medicine Nanjing Medical UniversityNanjingChina

Background Due to the broad application of next-generation sequencing,the molecular diagnosis of genetic disorders in pediatric neurology is no longer an unachievable ***,treatments for neurological genetic disorders in children remain primarily *** the other hand,with the continuous evolution of therapeutic viral vectors,gene therapy is becoming a clinical *** this perspective,we wrote this review to illustrate the current state regarding viral-mediated gene therapy in childhood neurological *** sources We searched databases,including PubMed and Google Scholar,using the keywords"adenovirus vector,""lentivirus vector,"and"AAv"for gene therapy,and"immunoreaction induced by gene therapy vectors,""administration routes of gene therapy vectors,"and"gene therapy"with"NCL,""SMA,""DMD,""congenital myopathy,""MPS""leukodystrophy,"or"pediatric metabolic disorders".We also screened the database of *** using the keywords"gene therapy for children"and then filtered the results with the ones aimed at neurological *** time range of the search procedure was from the inception of the databases to the *** We presented the characteristics of commonly used viral vectors for gene therapy for pediatric neurological disorders and summarized their merits and drawbacks,the administration routes of each vector,the research progress,and the clinical application status of viral-mediated gene therapy on pediatric neurological *** Viral-mediated gene therapy is on the brink of broad clinical ***-mediated gene therapy will dramatically change the treatment pattern of childhood neurological disorders,and many children with incurable diseases will meet the dawn of a ***,the vectors must be optimized for better safety and efficacy.

关键词： Gene therapy Neurological disorders Pediatrics Viral vectors

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Glutamate decarboxylase 1 gene polymorphisms are associated with respiratory symptoms in panic disorder

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World Journal of Psychiatry 2023年第7期13卷 435-443页

作者： zhi-Li zou Jian Qiu Xiao-Bo Zhou Yu-Lan Huang Jin-Yu Wang Bo Zhou Yuan Zhang Sichuan Provincial Center for Mental Health Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengdu 610000Sichuan ProvinceChina Personalized Drug Therapy Key Laboratory of Sichuan Province Sichuan Academy of Medical Sciences&Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Genetic factors play an important role in the pathogenesis of panic disorder(PD).However,the effect of genetic variants on PD remains *** To evaluate the associations between glutamate decarboxylase 1(GAD1)gene polymorphisms and PD risk and assess the effect of GAD1 gene polymorphisms on the severity of clinical symptoms in *** We recruited 230 PD patients and 224 healthy controls in this *** participants were assessed for anxiety and panic symptom severity using the Hamilton Anxiety Rating Scale(HAM-A)and Panic Disorder Severity Scale(PDSS).GAD1 gene polymorphisms(rs1978340 and rs3749034)were genotyped and assessed for allele *** There were no significant differences between cases and controls in the genotype distributions or allele frequencies of GAD1(rs1978340 and rs3749034).In addition,the effect of GAD1(rs1978340 and rs3749034)on PD severity was not ***,regarding respiratory symptoms,patients with the GAD1 rs1978340 A/A genotype had significantly higher scores than those with the A/G or G/G *** Here,we showed that the A/A genotype of GAD1 rs1978340 was associated with increased severity of respiratory symptoms in patients with PD.

关键词： Panic disorder Gene polymorphisms Respiratory symptoms Allele frequencies Pathogenesis Chinese population

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基于rtfMRI-NF技术调控失眠障碍患者杏仁核活性对大脑度中心性的影响

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磁共振成像 2024年第7期15卷 64-69页

作者：谷宇昂张淼贾淑蕾孙永兵祁菲武肖玲邹智李中林周菁窦社伟闫峰山李永丽新乡医学院河南省人民医院新乡453003 郑州大学人民医院郑州450003 河南省人民医院医学影像科郑州450003 河南省人民医院/郑州大学人民医院核医学科郑州450003 郑州大学人民医院/河南省人民医院健康管理科郑州450003

目的探讨实时功能磁共振成像神经反馈(real-time functional magnetic resonance imaging neurofeedback, rtfMRI-NF调控失眠障碍(insomnia disorder, ID)患者杏仁核活性对大脑度中心性(degree centrality, DC)的影响。材料与方法本研究采用rtfMRI-NF调控34例ID患者杏仁核活性,结合临床多导睡眠监测(Polysomography, PSG)、匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index, PSQI)等量表对患者进行干预前后评估。使用配对t检验分析干预前后功能成像数据的DC值差异,并探讨调控前后DC值变化及其与临床量表等数据的相关性。结果经rtfMRI-NF调控后,ID患者的PSQI、失眠严重程度指数(Insomnia Severity Index Scale, ISI)等量表评分均显著降低(P均<0.05)。此外,右侧海马旁回的DC值显著增高(GRF校正,体素水平P<0.001,团块水平P<0.05),并与睡眠效率差值呈负相关r=-0.478,P<0.05);而右侧背外侧额上回等区域的DC值降低(GRF校正,体素水平P<0.001,团块水平P<0.05),并与干预后ISI评分呈正相关(r=0.488,P<0.05)。结论 rtfMRI-NF技术可重塑ID患者特定脑区的DC值,并有效提高ID患者的睡眠质量。

关键词：失眠障碍实时功能磁共振成像神经反馈磁共振成像静息态功能磁共振成像杏仁核度中心性

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miR-93 suppresses proliferation and colony formation of human colon cancer stem cells

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World Journal of Gastroenterology 2011年第42期17卷 4711-4717页

作者： Xiao-Feng Yu Jian zou zhi-Jun Bao Jie Dong Department of Gastroenterology Huadong Hospital Fudan University Shanghai 200040 China

AIM： TO identify differentially expressed microRNAs （miRNAs） in human colon cancer stem cells （SW1116csc） and study their function in SW1116csc proliferation. METHODS： SW1116csc were isolated from the human colon cancer cell line, SW1116 and cultured in serum- free medium. A miRNA microarray was used to detect differential expression profiles of rniRNAs in SW1116csc and SW1116 cells. Real-time quantitative polymerase chain reaction （PCR） was performed to verify the dif- ferential expression of candidate miRNAs obtained from the microarray. Target mRNAs of differentially expressed miRNAs were predicted with target predic- tion tools, miRNA expression plasmids were transfected into SW1116csc using Lipofectamine 2000 reagent. Cell proliferation curves were generated with trypan blue staining, and the colony formation rate of transfected cells was measured with the soft agar colony formation assay. Expression of target mRNAs and proteins from differentially expressed miRNAs were detected using reverse transcription （RT）-PCR and western ***： Compared with expression in SW1116 cells, 35 miRNAs （including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa- miR-32） were upregulated more than 1.5-fold, and 11 miRNAs （including hsa-miR-93, hsa-miR-1231, hsa- miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561） were downregulated in SW1116csc. The miRNA microarray results were further validated with quantitative RT-PCR. miR-93 was downregulated, and its predicted mRNA targets included BAMBI, CCND2, CDKNIA, HDACS, KIF23, MAP3K9, MAP3K11, MYCN, PPARD, TLE4 and ZDHHCl. Overexpressed miR-93 sig- nificantly inhibited cell proliferation and colony forma- tion by SW1116csc. Furthermore, miR-93 negatively regulated the mRNA and protein levels of HDAC8 and TLE4. CONCLUSION： Some miRNAs were differentially ex- pressed during differentiation of SW1116csc into SW1116 cells, miR-93 may inhibit SW1116csc proliferation and colony formation.

关键词： miR-93 Stem cell Colon cancer Expres-sion profile

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Mathematical Simulation of Burden Distribution in COREX Melter Gasifier by Discrete Element Method

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Journal of Iron and Steel Research International 2012年第9期19卷 36-42页

作者： LI Hai-feng , LUO zhi-guo , zou Zong-shu , SUN Jun-jie , HAN Li-hao , DI Zhan-xia ( Northeastern University , Shenyang 110004 , Liaoning , China ) Northeastern University Shenyang Liaoning China

COREX process is one of the earliest industrialized smelting reduction ironmaking technology.A numerical simulation model based on discrete element method ( DEM ) has been developed to analyze the burden distribution in the melter gasifier of COREX *** DEM considering the collisions between particles can directly reproduce the charging *** burden trajectory , the location and the burden surface profile are analyzed in melter gasifier with a mixing charging of coal and direct reduction iron ( DRI ) at the same *** the porosity of packed bed has an important effect on the gas flow distribution of melter gasifier , a method to calculate porosity has been *** distribution of DRI and coal and the porosity in the radial direction are given under different charging patterns , which is necessary to judge the gas flow distribution and provide base data for further researching the melter gasifier for the next work in the *** research results can be used to guide the operation of adjusting charging and provide important basis for optimizing the charging patterns in order to obtain the reasonable gas distribution.

关键词： COREX melter gasifier burden distribution gas distribution discrete element method

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Influence of phase components of tungsten oxide on homogeneity of ultrafine tungsten powder

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中国有色金属学会会刊：英文版 2000年第3期10卷 421-423页

作者： LIAO Ji qiao(廖寄乔) zou zhi qiang(邹志强) L Hai bo(吕海波) CHEN Shao yi(陈绍衣) HUANG Bai yun(黄伯云) Cent S Univ Technol Natl Key Lab Powder Met Changsha 410083 Peoples R China

The influence of phase components of tungsten oxide on homogeneity of ultrafine tungsten powder by conventional hydrogen reduction techniques was studied. Results show that phase components of tungsten oxide play a crucial role on homogeneity of metal tungsten powder; ultrafine and homogeneous tungsten powder can be produced from oxides which consist of only one phase. Due to the different reduction rates (or different reduction paths) of oxide which comprises different phases, the multi phase components tungsten oxide leads to a fine but in homogeneous metal tungsten powder.

关键词： tungsten oxide phase components ultrafine tungsten powder homogeneity

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