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Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： zhi-Jian tang Yuan-Ming Pan Wei Li Rui-Qiong Ma Jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

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Existence and Instability of Some Nontrivial Positive Steady States for the SKT Model with Double Cross Diffusion

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Acta Mathematicae Applicatae Sinica 2023年第3期39卷 623-637页

作者： zhi-bao tang School of Mathematical Sciences Capital Normal UniversityBeijing 100048China

This paper is concerned with the nonconstant positive steady states of the Shigesada-Kawasaki-Teramoto model for two competing species with double cross-diffusion *** applying the Lyapunov-Schmidt decomposition method,the higher order expansion and some detailed spectral analysis,we prove the existence,asymptotic behavior and spectral instability of non-trivial steady states in high-dimensional case when one of the two cross-diffusion coefficients is large enough.

关键词： double cross-diffusion existence asymptotic behavior spectral instability

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Review:Advances in research of stress-assisted corrosion fatigue problem

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第2期8卷 221-227页

作者： tang zhi-bo LI Qiang Division of Engineering Zhejiang Ocean University Zhoushan 316004 China

Ceramic materials are notable for their rigidity, insulation and resistance to hostile environment, Nevertheless, if a stressed ceramic component is exposed to chemical attack, it may suffer from a form of delayed fracture known as static fatigue. From the point of view of a designer, it is clearly desirable to determine the behavior of sub-critical crack growth; the crack path and crack growth rate, as a function of material properties and loading conditions are of particular interest. This paper presents a review of advances in stress assisted corrosion problem in history and its corresponding numerical approaches in the last decades, and finally, comes uo with consideration and crucial suggestions for future work.

关键词： Stress corrosion Finite element method (FEM) Fracture Static fatigue Meshless local Petrov-Galerkin (MLPG)

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Series Design of Large-Scale NC Machine Tool

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Journal of China University of Mining and Technology 2007年第2期17卷 272-276页

作者： tang zhi Engineering and Mechanical Institute Donghua University Shanghai 201620 China

Product system design is a mature concept in western developed countries. It has been applied in war industry during the last century. However,up until now,functional combination is still the main method for product system de-sign in China. Therefore,in terms of a concept of product generation and product interaction we are in a weak position compared with the requirements of global markets. Today,the idea of serial product design has attracted much attention in the design field and the definition of product generation as well as its parameters has already become the standard in serial product designs. Although the design of a large-scale NC machine tool is complicated,it can be further optimized by the precise exercise of object design by placing the concept of platform establishment firmly into serial product de-sign. The essence of a serial product design has been demonstrated by the design process of a large-scale NC machine tool.

关键词： large-scale NC machine tool series product design optimized design

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Einstein-Maxwell Field of the Central Mass

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Chinese Physics Letters 2002年第2期19卷 166-168页

作者： Wang Yong-Jiu and tang zhi-Ming Institute of Physics Hu"nan Normal University

We have obtained the exact solution of the Einstein-Maxwell equations outside the central mass with magnetic moment and, at the same time, we have investigated their asymptotic properties

关键词： Magnetic moments

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Analysis on Dissociation of Pyramidal I Dislocation in Magnesium by Generalized-Stacking-Fault Energy

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Acta Metallurgica Sinica(English Letters) 2015年第7期28卷 876-882页

作者： Qun Zu Ya-Fang Guo Xiao-zhi tang Institute of Engineering Mechanics Beijing Jiaotong University

The generalized-stacking-fault energies are calculated to illustrate the dissociation of〈c＋a〉dislocation on pyramidal I plane in *** c surfaces of {1011} plane and its adjacent planes {3034} and {3032} are presented using Liu embedded-atom-method potential method,and one possible dissociation path of 1/3{1123} dislocation on {1011} plane with minimum energy is ***,another two reasonable dissociation paths of 1/3{1123} dislocation successively on {3034} and {3032} planes are also ***,based on molecular dynamics simulations of magnesium single crystals under c-axis compression,the possible slip path is further examined and discussed.

关键词： Generalized-stacking-fault energies (GSFEs) Molecular dynamics (MD) 〈c + a〉 slip Dissociation Magnesium

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Elevational patterns of temperature and humidity in the middle Tianshan Mountain area in Central Asia

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Journal of Mountain Science 2020年第2期17卷 397-409页

作者： Gheyur GHEYRET Anwar MOHAMMAT tang zhi-yao Institute of Ecology College of Urban and Environmental Sciences and Key Laboratory for Earth Surface ProcessesPeking UniversityBeijing 100871China Key Laboratory of Biogeography and Bioresources in Arid Land Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China

The vertical distribution of vegetation types along an elevational gradient in mountain areas largely depends on the elevational changes in air temperature and humidity. In this study, we presented the seasonal and diurnal variations in the elevational gradients of air temperature and humidity on the southern and northern slopes in the middle Tianshan Mountain Range using data collected throughout the year via HOBO data loggers. The measurements were conducted at 12 different elevations from 1548 to 3277 m from September 2004 to August 2005. The results showed that the annual mean air temperature decreased along the elevational gradients with temperature lapse rates of(0.71±0.20)°C/100 m and(0.59±0.05)°C/100 m on the northern and southern slopes, respectively. The annual mean absolute humidity significantly decreased with increasing elevation on the northern slope but showed no significant trend on the southern slope. The annual mean relative humidity did not show a significant trend on the northern slope but increased with increasing elevation on the southern slope. The mean air temperature lapse rate exhibited significant seasonal variation, which is steeper insummer and shallower in winter, and this value varied between 0.37°C/100 m and 0.75°C/100 m on the southern slope and between 0.30°C/100 m and 1.02°C/100 m on the northern slope. The mean absolute and relative humidity also exhibited significant seasonal variations on both slopes, with the maximum occurring in summer and the minimum occurring in winter or spring. The monthly diurnal range of air temperature on both slopes was higher in spring than in winter. The annual range of air temperature on the southern slope was higher than that on the northern slope. Our results suggest that significant spatiotemporal variations in humidity and temperature lapse rate are useful when analyzing the relationships between species range sizes and climate in mountain areas.

关键词： Temperature lapse rate Absolute humidity Relative humidity Annual range of temperature Diurnal range of temperature HOBO data loggers

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Potential for Constraining Propagation Parameters of Galactic Cosmic Rays with the High Energy Cosmic-radiation Detection Facility on Board China's Space Station

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Research in Astronomy and Astrophysics 2023年第8期23卷 290-296页

作者： zhi-Hui Xu Qiang Yuan zhi-Cheng tang Xiao-Jun Bi Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

Precise measurements of the spectra of secondary and primary cosmic rays are crucial for understanding the origin and propagation of those energetic *** High Energy Cosmic-radiation Detection(HERD)facility on board China's Space Station,which is expected to operate in 2027,will push the direct and precise measurements of cosmic-ray fluxes up to PeV *** this work,we investigate the potential of HERD for studying the propagation of cosmic rays using measurements of boron,carbon,and oxygen *** find that,compared with the current results,the new HERD measurements can improve the accuracy of the propagation parameters by 8%–40%.The constraints on the injection spectra at high energies will also be improved.

关键词： (ISM:)cosmic rays-instrumentation detectors-The Galaxy

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Historical record of effects of human activities on absolute and relative concentrations of Polycyclic aromatic hydrocarbons(PAHs) in Lake Chao,China

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Journal of Environmental Sciences 2016年第8期28卷 1-4页

作者： John P.Giesy zhi tang Xiaoli Zhao Department of Veterinary Biomedical Sciences and Toxicology Centre University of Saskatchewan State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences

Polycyclic aromatic hydrocarbons（PAHs）are attracting concern because of their potential toxicity,posing serious threats to health of humans and ecosystems（Kim et al.,2013;Zhao et al.,2016）.Generally,similar to other contaminants＇behaviors（Wu et al.,2001;Zhang et al.,2007,2008;Lu et al.,2009）,PAHs result from natural organic matter and activities of humans,the latter＇s contribution usually outweighing the inputs from other sources（Fernández et al.,2000;Srogi,2007）.

关键词： Polycyclic aromatic hydrocarbons Organic contaminants Aquatic environment Lake sediment PAHs

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Hysteresis model of magnetostrictive actuators and its numerical realization

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第7期8卷 1059-1064页

作者： tang zhi-feng LV Fu-zai XIANG Zhan-qin Modern Manufacture Engineering Institute Zhejiang University Hangzhou 310027 China

This paper presents two numerical realization of Preisach model by Density Function Method (DFM) and F Function Method (FFM) for a giant magnetostrictive actuator (GMA). Experiment and simulation showed that FFM is better than DFM for predicting precision of hysteresis loops. Lagrange bilinear interpolation algorithm is used in Preisach numerical realization to enhance prediction performance. A set of hysteresis loops and higher order reversal curves are predicted and experimentally verified. The good agreement between the measured and predicted curves shows that the classical Preisach model is effective for modelling the quasi-static hysteresis of the GMA.

关键词： Magnetostrictive Actuator Hysteresis Density Function Method (DFM) F Function Method (FFM)

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