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Development of CaP nanocomposites as photothermal actuators for doxorubicin delivery to enhance breast cancer treatment

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Journal of Materials Science & Technology 2021年第4期63卷 73-80页

作者： Jie Liu Li Li Run Zhang zhi ping xu Australian Institute for Bioengineering and Nanotechnology The University of QueenslandSt LuciaQLD4072Australia

Breast cancer is the most common one in women worldwide and doxorubicin(Dox)is one of the most commonly used and effective drugs for breast cancer ***,Dox-based chemotherapy faces irreversible cardiotoxicity and unsatisfactory therapy *** is desirable to devise Dox nanoformulations with less adverse effects and greater therapeutic efficacy for this cancer *** this work,a multifunctional calcium phosphate nanoformulation(ICG-Dox/DNA@CaP)was developed by co-loading Dox/DNA complexes and indocyanine green(ICG)molecules for photothermal therapy(PTT)-enhanced *** this nanocomposite,using DNA as Dox carrier facilitated Dox loading into the CaP matrix,and significantly reduced Dox leakage as well as cytotoxicity in comparison with that of free Dox in physiological medium(pH 7.4).In specific,ICG-Dox/DNA@CaP only released Dox in a weakly acidic nuclease-containing environment,such as tumor microenvironment and endosome/***,Dox/DNA complexes exhibited synergistic interactions with ICG-based photothermal effect on tumor cell apoptosis in this ICG-Dox/DNA@CaP *** work has demonstrated a new strategy to combine FDA-approved therapeutics(Dox and ICG)in CaP-based nanomaterials for reduced cytotoxicity and enhanced therapeutic effect,and provided a new way to engineer CaP carriers as multifunctional delivery systems for clinical anti-cancer therapy.

关键词： chemotherapy doxorubicin breast

Amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposites for enhanced gene delivery

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Nano Research 2015年第2期8卷 682-694页

作者： Li Li Wenyi Gu Jian Liu Shiyu Yan zhi ping xu Australian Institute for Bioengineering and Nanotechnology The University of Queensland Brisbane QLD 4072 Australia Department of Chemical Engineering Curtin University Perth WA 6845 Australia

In this work a novel strategy has been developed to prepare well-dispersed amine-functionalized SiO2 nanodot-coated layered double hydroxide nano- composite （NH2-SiO2@LDH） via electrostatic interactions and condensation of （3-aminopropyl）triethoxysilane （APTES）. This nanocomposite system is well dispersed in culture media and phosphate buffered saline, and exhibits low cytotoxicity and good biocompatibility. The fluorescence microscopy images and flow cytometry data indicate that such an NH2-SiO2@LDH nanocomposite is able to efficiently deliver small interfering RNA （siRNA） into the U2OS cell line to inhibit cell proliferation. Thus, NH2-SiOR@LDH nanocomposite has a great potential as a nanocarrier for efficient gene delivery.

关键词： layered double hydroxide(LDH) functionalization self-assembl3~gene delivery

Design,synthesis and insecticidal activity of spiro heterocycle containing neonicotinoid analogs

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Chinese Chemical Letters 2014年第2期25卷 197-200页

作者： Nan-Yang Chen Li-ping Ren Min-Ming Zou zhi-ping xu xu-Sheng Shao Xiao-Yong xu Zhong Li Shanghai Key Laboratory of Chemical Biology School of PharmacyEast China University of Science and Technology

Spiro heterocycles frequently occur in bioactive molecules. In the pursuit of neonicotinoids with spiro hererocycles, three types of novel neonicotinoids with spirobenzofuranone, spirooxindole or spiroacenaphythylenone framework were designed and synthesized. Insecticidal evaluation showed that some of spirobenzofuranone containing neonicotinoids exhibited moderate activity against cowpea aphid, armyworm or brown planthopper.

关键词： Neonicotinoid Spiro heterocycle Activity Insecticide

Facile three-component synthesis and insecticidal evaluation of hexahydroimidazo[1,2-a]pyridine derivatives

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Chinese Chemical Letters 2015年第1期26卷 1-5页

作者： Ye-Feng Fan Wen-Wen Zhang xu-Sheng Shao zhi-ping xu Xiao-Yong xu Zhong Li Shanghai Key Lab of Chemistry Biology School of PharmacyEast China University of Science and Technology Shanghai Collaborative Innovation Center for Biomanufacturing Technology

A series of new hexahydroimidazo[1,2-a]pyridine derivatives were synthesized via convenient and practical three-component reactions. Preliminary bioassays showed that majority of the target compounds exhibited moderate to excellent insecticidal activity against cowpea aphids （Aphis craccivora）. Among them, compound 91 demonstrated significant activity with LCso value of 0.00918 mmol/L which was about 3.8-fold higher than that of imidacloprid （IMI）. Furthermore, the study of stereostructure-activity relationship of four isomers of 9k indicated that configuration played a key role in insecticidal activity of these compounds.

关键词： Neonicotinoids Hexahydroimidazo[ 1,2-a]pyridine Three-component reaction Configuration Insecticidal activity

Synthesis and insecticidal evaluation of tetrahydroimidazo[1,2-a]pyridin-5(1H)-one derivatives

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Chinese Chemical Letters 2016年第1期27卷 7-10页

作者： xuan-Qi Liu Ya-Qin Liu xu-Sheng Shao zhi-ping xu Xiao-Yong xu Zhong Li Shanghai Key Lab of Chemistry Biology School of Pharmacy East China University of Science and Technology Shanghai 200237 China Shanghai Collaborative Innovation Center for Biomanufacturing Technology Shanghai 200237 China

A series of novel tetrahydroimidazo[1,2-a]pyridine-5（1H）-one derivatives containing a electronegative pharmacophore（=CNO_2） were synthesized via practical aza-ene reaction and characterized by ~1H NMR,^（13）C NMR,^（19）F NMR and HRMS. Preliminary bioassays showed that some of the target compounds exhibited good insecticidal activity against brown planthopper（Nilaparvata lugens） and cowpea aphids（Aphis craccivora） at 500 mg L^（-1）. Among them, compound 11 h was active against brown planthopper at100 mg L^（-1）. The insecticidal activities varied significantly depending on the types and patterns of the substituents, which provided guidance for further investigation on structure modifications.

关键词： Neonicotinoids Tetrahydroimidazo[1,2-a]pyridin-5(1H) one Configuration Insecticidal activity

Antibacterial properties of cerium oxide nanoparticles:Recent progresses and future challenges

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Particuology 2024年第10期93卷 264-283页

作者： Heishu Zheng Jiajing Tang Yanhua Wei Xi Deng Yingjuan Zhang Xiangyu Ma xudong Jiang zhi ping xu Hongbing Liao College&Hospital of Stomatology Guangxi Medical UniversityNanning530021China Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction Guangxi Medical UniversityNanning530021China The First Affiliated Hospital of Guangxi Medical University Nanning530021China School of Medicine Guangxi University of Science and TechnologyLiuzhou545005China Institute of Biomedical Health Technology and Engineering and Institute of Systems and Physical Biology Shenzhen Bay LaboratoryShenzhen518107China Australian Institute for Bioengineering and Nanotechnology(Bld 75) The University of QueenslandSt LuciaQueensland 4074Australia

Use of cerium oxide nanoparticles(CeO_(2) NPs)to optimize management of resistant microorganisms has received increasing attention due to non-specific activity of inorganic antibacterial *** the mechanism of action is essential to elucidating the antibacterial activity of CeO_(2) NPs against ***,this review aims to summarize the antibacterial mechanisms of CeO_(2) NPs and correlate the structural and physicochemical properties of CeO_(2) NPs to their antibacterial *** further summarize the strategies for the improvement of the antibacterial performance of CeO_(2) NPs and provide our opinions for future challenges as a conclusion.

关键词： Nanoparticles Cerium oxide Antibacterial activity Nanozyme Fenton reaction

Characterization of Polymer Aging:A Review

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Chinese Journal of Polymer Science 2024年第11期42卷 1642-1660,I0006页

作者： xuan Liu Rui Yang zhi-ping xu Yan Ye Guo-Shuo Tang Min Zhao Qian Zhang Xiang-Ze Meng School of Chemical and Pharmaceutical Engineering Hefei Normal UniversityHefei230601China Department of Chemical Engineering Tsinghua UniversityBeijing100084China

Polymer aging under environmental conditions causes deterioration of service *** the aging behavior and mechanism is important not only for lifetime prediction,but also for material improvement and ***,comprehensive characterization of polymer materials during aging is *** this review,various analytical methods for characterization of chemical changes,physical changes and service properties are *** on that,methods for stabilization evaluation and lifetime prediction,especially sensitive evaluation methods are *** changes include molecular weight changes by chain scission and crosslinking,functional group changes on the surface and in the bulk,formation of free radicals,formation of small molecular species as the degradation products,and chemical distribution by heterogeneous aging and additives *** changes include crystallization changes (post-or chemi-crystallization)and morphology changes (cracking,debonding,etc.).Service property changes include deterioration of processability,mechanical properties,electrical properties and *** the end,existing problems and future research perspective are proposed,including relationship between chemical/physical changes and service properties,introduction of modern mathematical and computer tools.

关键词： Chemical change Physical change Service property Stability evaluation Lifetime prediction

Synthesis and insecticidal activities of novel bridged-neonicotinoids

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Chinese Chemical Letters 2017年第8期28卷 1743-1745页

作者： Dong-Dong Zhang Shu-Xia Cui zhi-ping xu Dong-Mei Li Zhong-Zhen Tian Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials School of Chemistry and Chemical Engineering University of Jinan Shanghai Key Laboratory of Chemical Biology School of Pharmacy East China University of Science and Technology

A series of novel bridged-neonicotinoid analogues were designed and synthesized, which were constructed by starting material 8 with cyclopentenone or cyclohexenone in the presence of catalyst aluminium chloride. All of the compounds were characterized and confirmed by^1H NMR,^（13）C NMR, HRMS and IR. The bioassay tests showed that compounds 5 and 6a showed higher bioactivities than imidacloprid against Aphis craccivora.

关键词： Neonicotinoid Bridged compound Insecticidal activity Michael addition Resistance

Efficient delivery of clay-based nanovaccines to the mouse spleen promotes potent anti-tumor immunity for both prevention and treatment of lymphoma

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Nano Research 2021年第5期14卷 1326-1334页

作者： Ling-Xiao Zhang Ying-Bo Jia Ya-Ru Huang Hui-Na Liu Xia-Mei Sun Ting Cai Rui-Tian Liu zhi ping xu Hwa Mei Hospital University of Chinese Academy of Sciences(Ningbo No.2 Hospital)Ningbo315010China Ningbo Institute of Life and Health Industry University of Chinese Academy of SciencesNingbo315010China Australian Institute for Bioengineering and Nanotechnology The University of QueenslandSt LuciaQLD4072Australia State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Cancer therapeutic nanovaccines are ideal tools to inhibit tumor growth and provide the body with continuous protecting immune ***,the conventional subcutaneous(SC)vaccination normally induces limited anti-tumor immune responses with low therapeutic ***,we devised clay-based nanovaccines and directly delivered them to the spleen via intravenous(IV)injection to induce the stronger anti-tumor immunity with higher efficacy for tumor prevention and *** clay,i.e.,layered double hydroxide(LDH)was prepared as nanoadjuvant with the average size from 77 to 285 nm and co-loaded with the model antigen ovalbumin(OVA)and bioadjuvant CpG to form CpG/OVA-LDH(CO-LDH)*** found that CO-LDH-215(the size of LDH was 215 nm)promoted dendritic cells to present the most antigen,and moreover showed the highest spleen enrichment(~1.67%of CO-LDH-215 enriched in the spleen at 24 h post IV injection).The in vivo immunologic data showed that CO-LDH-215 induced the most potent anti-tumor immune responses and completely prevented the growth of E.G7-OVA tumor in the mouse ***,IV injected CO-LDH-215 nanovaccine more effectively delayed tumor growth than that SC injected,largely due to the direct and quick delivery of more nanovaccines to the *** study demonstrates that the therapeutic efficacy of nanovaccines can be greatly enhanced by targeted delivery of nanovaccines to the spleen via the proper vaccination route.

关键词： cancer immunotherapy nanovaccine layered double hydroxide targeted delivery to the spleen lymphoma