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Overcome Debye Length Limitations for Biomolecule Sensing Based on Field Effective Transistors

Chinese Journal of Chemistry 2021年第4期39卷 999-1008页

作者： zhi Zheng Hongyuan Zhang Tianyou Zhai Fan xia Engineering Research Center of nano-Geomaterials of Ministry of Education Faculty of Materials Science and ChemistryChina University of GeosciencesWuhanHubei430074 China State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhanHubei 430074Chino

Biosensors based on field effective transistor(FET)have aroused tremendous attention in the past few years owning to their huge application in drug discovery,disease diagnosis and environmental *** FET biosensors possess small volume,high sensitivity at ultra-low concentration,considerable mechanical strength,as well as excellent stability in solution,which plays a vital role in the point of care testing(POCT)*** advances have summarized some progress involved in the improvement of morphology and structure of channel materials,the functionalization of organic molecule,the influence of device operation and sensing environment on the detecting ***,for FET biosensors,the charge screening phenomena were inevitable in the solution,which seriously degrade the device *** this article,we summarize recent advances to overcome debye length limitations for biomolecule sensing based on *** will firstly describe the charge screening mechanism,then focous on the strategy to overcome charge screening,including synthesizing special channel materials with crumpled morphology,designing aptamer binding mode,and modulating device ***,we discuss the major challenges and perspectives about overcoming debye length limitations of FET *** summaries provide further insights to realize real-time,lable-free,high-sensitivity FET sensors for medical healthcare.

关键词： Debye length Interactions Field effective transistors Biosensors Biomolecule

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Global Asymptotics of Orthogonal Polynomials Associated with a Generalized Freud Weight

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Chinese Annals of Mathematics,Series B 2018年第3期39卷 553-596页

作者： zhi-Tao WEN Roderick WONG Shuai-xia XU Department of Mathematics Taiyuan University of TechnologyTaiyuan 030024China Liu Bie Ju Centre for Mathematical Sciences City University of Hong KongHong KongChina Institut Franco-Chinois de l’Energie Nucleaire Sun Yat-sen UniversityGuangzhou 510275China

In this paper, the authors consider the asymptotic behavior of the monic polynomials orthogonal with respect to the weight function w（x） = /x/2αe-（x4＋tx2）, x ∈R, where α is a constant larger than - 1/2 and t is any real number. They consider this problem in three separate cases：（i） c 〉 -2, （ii） c = -2, and （iii） c 〈 -2, where c ：= tN-1/2 is a constant, N = n ＋ a and n is the degree of the polynomial. In the first two cases, the support of the associated equilibrium measure μ is a single interval, whereas in the third case the support of μt consists of two intervals. In each case, globally uniform asymptotic expansions are obtained in several regions. These regions together cover the whole complex plane. The approach is based on a modified version of the steepest descent method for Riemann-Hilbert problems introduced by Deift and Zhou （1993）.

关键词： Orthogonal polynomials Globally uniform asymptotics Riemann-Hilbertproblems The second Painlev6 transcendent Theta function

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Sediment Transport Capacity Under the River–Tide Interaction in the Changjiang Estuary

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China Ocean Engineering 2019年第2期33卷 207-218页

作者： FENG zhi-yong TAN Guang-ming xia Jun-qiang State Key Laboratory of Water Resource and Hydropower Engineering Science Wuhan University

Sediment transport capacity is a fundamental parameter in sediment transport theory and its accurate calculation is important from both theoretical and engineering viewpoints. The capacity of sediment transport has been studied extensively by many researchers in the last decades. Nevertheless, the underlying mechanism behind sediment transport capacity in estuaries remains poorly understood. The current study aims to explore the impact of the river–tide interaction on sediment transport and establish a formula of sediment transport capacity under the river–tide interaction. The impact of the river–tide interaction on the hydrodynamics and sediment dynamics in the Changjiang Estuary was analyzed, a practical method for describing the variation in tide-runoff ratio was established,and a formula of sediment transport capacity considering the impact of river–tide interaction was proposed by introducing the tide-runoff ratio. The new method bridged the gap between two well-known sediment transport capacity methods by considering the variation in the index a for the gravitational term and overcomes the drawback of distinguishing flood/dry season or spring/ebb tide in the calculation of estuarine sediment transport. A large amount of flow and sediment data obtained from the Changjiang Estuary were collected to verify the proposed formula. The effect of salt-fresh water mixture and the morphological evolution on sediment transport capacity of the Changjiang Estuary were discussed.

关键词： sediment transport capacity river tide interaction hydrodynamics and sediment dynamics Changjiang Estuary (Yangtze Estuary)

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Jet Vectoring Control Using a Novel Synthetic Jet Actuator

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Chinese Journal of Aeronautics 2007年第3期20卷 193-201页

作者： LUO Zhen-bing xia zhi-xun XIE Yong-gao College of Aerospace and Materials Engineering National University of Defense Technology Changsha 410073 China

A primary air jet vectoring control system with a novel synthetic jet actuator （SJA） is presented and simulated numerically. The results show that, in comparison with an existing traditional synthetic jet actuator, which is able to perform the duty of either ＂push＂ or ＂pull＂, one novel synthetic jet actuator can fulfill both ＂push＂ and ＂pull＂ functions to vector the primary jet by shifting a slide block inside it. Therefore, because the new actuator possesses greater efficiency, it has potentiality to replace the existing one in various appli- cations, such as thrust vectoring and the reduction of thermal signature. Moreover, as the novel actuator can fulfill those functions that the existing one can not, it may well be expected to popularize it into more flow control systems.

关键词： jet vectoring control synthetic jet actuator slide block flow control

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Purification and Characterization of the Catalytic Domain of Protein Tyrosine Phosphatase SHP-1 and the Preparation of Anti-ΔSHP-1 Antibodies

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Chemical Research in Chinese Universities 2008年第5期24卷 592-596页

作者： LI Wan-nan ZHUANG Yan LI He SUN Ying FU Yao WU xiao-xia ZHAO zhi-zhuang FU Xue-qi Edmond H. Fischer Signal Transduction Laboratory College of Life Sciences Key Laboratory for Molecular Enzymology ＆ Engineering Ministry of Education dilin UniversilT Changchun 130021 P. R. China Department of Pathology The University of Oklahoma Health Science Center OK 73104 USA

This study is focused on the expression of an SH2 domain-truncated form of protein tyrosine phosphatase SHP-1（designated ΔSHP-1） and the preparation of its polyclonal antibodies. A cDNA fragment encoding ΔSHP-1 was amplified by PCR and then cloned into the pT7 expression vector. The recombinant pT7-ΔSHP-1 plasmid was used to transform Rosetta（DE3） E. coli cells. ΔSHP-1 was distributed in the exclusion body of E. coli cell extracts and was purified through a two-column chromatographic procedure. The purified enzyme exhibited an expected molecular weight on SDS-gels and HPLC gel filtration columns. It possesses robust tyrosine phosphatase activity and shows typical enzymatic characteristics of classic tyrosine phosphatases. To generate polyclonal anti-ΔSHP-1 antibodies, purified recombinant ΔSHP-1 was used to immunize a rabbit. The resultant anti-serum was subjected to purification on ΔSHP-1 antigen affinity chromatography. The purified polyclonal antibody displayed a high sensitivity and specificity toward ΔSHP-1. This study thus provides the essential materials for further investigating the biological function and pathological implication of SHP-1 and screening the inhibitors and activators of the enzyme for therapeutic drug development.

关键词： SHP-1 Protein tyrosine phosphatase Polyclonal antibodies

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Metabolic interaction:tumor-derived lactate inhibiting CD8^(+)T cell cytotoxicity in a novel route

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Signal Transduction and Targeted Therapy 2023年第3期8卷 874-876页

作者： Ke Wang Yong Zhang zhi-nan Chen National Translational Science Center for Molecular Medicine&Department of Cell Biology Fourth Military Medical UniversityXi’an710032China Department of Pulmonary and Critical Care Medicine the First Affiliated Hospital of Fourth Military Medical UniversityXi’an710032China

Recently,an interesting study published in Cell Metabolism discovered a novel metabolic interaction between tumors and T cells,identifying that tumor-derived lactate inhibited CD8^(+)T cell cytotoxicity by inducing a switch of pyruvate utilization from pyruvate carboxylase(PC)to pyruvate dehydrogenase(PDH),and PDH inhibition facilitated PC activity and T cell cytotoxicity through increasing succinate secretion.

关键词： cytotoxicity inhibited inhibiting

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High-Order Two-Scale Asymptotic Paradigm for the Elastodynamic Homogenization of Periodic Composites

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Acta Mechanica Solida Sinica 2024年第1期37卷 124-138页

作者： Wei-zhi Luo Mu He Liang xia Qi-Chang He State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China Laboratoire Modélisation et Simulation Multi-Echelle MSME UMR 8208 CNRSUniversite Gustave Eiffel77454 Marne-la-ValléeFrance

The classical two-scale asymptotic paradigm provides macroscopic and microscopic analyses for the elastodynamic homogenization of periodic composites based on the spatial or/and temporal variable,which offers an approximate framework for the asymptotic homogenization analysis of the motion ***,in this framework,the growing complexity of the homogenization formulation gradually becomes an obstacle as the asymptotic order *** such a context,a compact,fast,and accurate asymptotic paradigm is *** work reviews the high-order spatial two-scale asymptotic paradigm with the effective displacement field representation and optimizes the implementation by symmetrizing the tensor to be ***,the modified implementation gets rid of the excessive memory consumption required for computing the high-order tensor,which is demonstrated by representative one-and two-dimensional *** numerical results show that(1)the contrast of the material parameters between media in composites directly affects the convergence rate of the asymptotic results for the homogenization of periodic composites,(2)the convergence error of the asymptotic results mainly comes from the truncation error of the modified asymptotic homogenized motion equation,and(3)the excessive norm of the normalized wavenumber vector in the two-dimensional inclusion case may lead to a non-convergence of the asymptotic results.

关键词： Composites Homogenization Asymptotic analysis Dynamics Dispersion

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Mechanism of interfacial effects in sodium-ion storage devices

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nano Research 2024年第3期17卷 1313-1326页

作者： Yifan Wei Lingxing Zan Huicong xia Wenfu Yan Jia-nan Zhang College of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China Key Laboratory of Advanced Energy Catalytic and Functional Material Preparation of Zhengzhou City Zhengzhou 450001China Key Laboratory of Chemical Reaction Engineering of Shaanxi Province College of Chemistry&Chemical EngineeringYan’an UniversityYan’an 716000China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry and College of Chemistry Jilin UniversityChangchun 130012China

Rechargeable sodium-ion batteries(SIBs)are considered as the next-generation secondary *** performance of SIB is determined by the behavior of its electrode surface and the electrode–electrolyte interface during charging and ***,the characteristics of these surfaces and interfaces should be analyzed to realize large-scale energy storage systems with high energy density and long-cycle *** various studies have investigated the properties of electrode materials,few studies have focused on the construction of stable and efficient SIB interfaces,and even fewer have explored the mechanisms of interfacial effects;however,the strategies of regulating interfacial effects are yet to be completely ***,the results obtained thus far are insufficient to draw systematic *** present study reviews the literature on the mechanism of interfacial effects in Na+storage *** interfaces in a sodium-ion storage device include a heterogeneous interface between electrode materials,a solid electrolyte interphase,and a cathode electrolyte *** interfacial effects during the intercalation,transformation,and alloy reactions and the resulting overall battery performance were theoretically *** this review,we aim to provide a theoretical basis for optimizing the structures of electrode surface and electrode–electrolyte interface to optimize the performance of *** addition,the challenges of investigating interfacial effects and several possible helpful methods and opportunities for studying the mechanisms of interfacial effects in SIBs will be presented.

关键词： sodium-ion storage interfacial effects solid electrolyte interphase cathode electrolyte interphase

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Synonymous codon usage pattern in model legume Medicago truncatula

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Journal of Integrative Agriculture 2018年第9期17卷 2074-2081页

作者： SONG Hui LIU Jing CHEN Tao nan zhi-biao State Key Laboratory of Grassland Agro-ecosystems College of Pastoral Agriculture Science and Technology Lanzhou University Grassland Agri-husbandry Research Center Qingdao Agricultural University

Synonymous codon usage pattern presumably reflects gene expression optimization as a result of molecular evolution. Though much attention has been paid to various model organisms ranging from prokaryotes to eukaryotes, codon usage has yet been extensively investigated for model legume Medicago truncatula. In present study, 39 531 available coding sequences （CDSs） from M. truncatula were examined for codon usage bias （CUB）. Based on analyses including neutrality plots, effective number of codons plots, and correlations between optimal codons frequency and codon adaptation index, we conclude that natural selection is a major driving force in M. truncatula CUB. We have identified 30 optimal codons encoding 18 amino acids based on relative synonymous codon usage. These optimal codons characteristically end with A or T, except for AGG and TTG encoding arginine and leucine respectively. Optimal codon usage is positively correlated with the GC content at three nucleotide positions of codons and the GC content of CDSs. The abundance of expressed sequence tag is a proxy for gene expression intensity in the legume, but has no relatedness with either CDS length or GC content. Collectively, we unravel the synonymous codon usage pattern in M. truncatula, which may serve as the valuable information on genetic engineering of the model legume and forage crop.

关键词： codon usage gene expression Medicago truncatula natural selection optimal codon

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Solventless ketalization of glycerol to solketal with acetone over the ionic liquid[P(C4H9)3C14H29][TsO]

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Chinese Journal of Chemical Engineering 2020年第1期28卷 158-164页

作者： Yu Ji Tengda Zhang xia Gui Haijian Shi zhi Yun College of Chemistry and Chemical Engineering Nanjing Tech UniversityNanjing 210009China

The ketalization of glycerol with acetone was conducted over an ionic liquid[P(C4H9)3C14H29][TsO](TTPT)in a batch reactor.A scheme to obtain the purified product using TTPT as a homogeneous catalyst is proposed and a maximum solketal yield of 86%is achieved at acetone/glycerol molar ratio of 6/1,reaction time of 0.5 h,reaction temperature of 303 K,catalyst amount of 5 wt%of *** was recycled and reused for ten times without obvious losses in terms of quantity and ***,effects of various experimental parameters(stirring speed,catalyst loadings,temperature and reactant composition)on the reaction kinetics are *** terms of kinetics modeling,Kγis fitted by reactant composition at the temperature range 298 K–323 K,which was a concise strategy that showed good precision in the kinetics *** activation energy for this ketalization reaction was evaluated to be 28.2 kJ·mol^-*** addition,the kinetics of the reaction at a temperature exceeding the boiling point of acetone were also *** believe that all the results are important for further development of a technology for the continuous synthesis of solketal.

关键词： Ionic liquid Ketalization Solketal Glycerol Reaction kinetics Reactive distillation

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