检索结果-南通市图书馆

Tamarix chinensis Lour inhibits chronic ethanol-induced liver injury in mice

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第12期26卷 1286-1297页

作者： zhi-dan wang Yu Zhang Yi-dan Dai Ke Ren Chen Han Heng-Xiao wang Shuang-Qin Yi Laboratory of Functional Morphology Graduate School of Human Health SciencesTokyo Metropolitan UniversityTokyo 116-8551Japan Institute of Basic Medicine Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250062Shandong ProvinceChina

BACKGROUND Tamarix chinensis Lour(TCL)is a shrub that usually grows in arid or semiarid desert areas and saline-alkali *** is a traditional Chinese herbal medicine with hepatoprotective,antioxidant,antibacterial,and antitumor *** To investigate the possible protective effects of TCL against liver injury induced by chronic ethanol *** C57BL/6J male mice were fed a Lieber-DeCarli lipid diet containing alcohol and received(by gavage)a water-alcohol extract(80%)of TCL(100 and 200 mg/kg BW)or distilled water for 4 *** euthanasia,liver tissues were observed histologically with hematoxylin and eosin staining and Oil red O staining,and the levels of alanine aminotransferase,aspartate transaminase,hepatic lipids,reactive oxygen species,malondialdehyde,and superoxide dismutase were *** addition,expression of the NOD-like receptor family,pyrin domain-containing 3(NLRP3)inflammasome and downstream proinflammatory cytokines were *** Compared with the ethanol group,mice in the TCL-treated group(200 mg/kg)had significantly lower serum levels of alanine aminotransferase(mean,34.1 IU/L vs 45.3 IU/L,P<0.01)and aspartate transaminase(mean,89.6 IU/L vs 115.7 IU/L,P<0.01),as well as marked reduction of hepatic tissue reactive oxygen species(decreased by 27.5%,P<0.01)and malondialdehyde(decreased by 76.6%,P<0.01)levels,with a significant increase of superoxide dismutase(Increased by 73.2%,P<0.01).Expression of the NLRP3 inflammasome and its downstream cytokines[interleukin(IL)-1β,tumor necrosis factor-α,and IL-6],and recruitment of natural killer T cells to the liver,were reduced in the TCLtreated incubation with a Lieber-DeCaril ethanol lipid diet *** These findings suggest that a TCL extract(200 mg/kg)protects against chronic ethanol-induced liver injury,probably by inhibiting the NLRP3-caspase-1-IL-1βsignaling pathway and suppressing oxidative stress.

关键词： Tamarix chinensis Lour Alcoholic liver disease Ethanol-induced liver injury NLRP3 inflammasome Oxidative stress Natural killer T cells

β_1肾上腺素受体与CYP2D6基因多态性对美托洛尔抗高血压治疗的药代动力学和药效学影响(英文)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国临床药理学与治疗学 2007年第10期12卷 1130-1137页

作者： HU Jie HU Zhao-qian HU Ying-zi TAN zhi-rong HU Dong-li LI zhi wang dan ZHANG Wei ZHOU Hong-hao Pharmacogenetics Research Institute Institute of Clinical Pharmacology Central South University Changsha 410078 Hunan China

背景:美托洛尔是临床常用的抗高血压药物,它经由CYP2D6代谢。CYP2D6*10降低CYP2D6活性,是中国人群中最为常见的多态性。β1肾上腺素受体为美托洛尔的作用靶标,Ser49Gly与Gly389Arg多态性显著改变受体功能。CYP2D6与β1肾上腺素受体遗传... 详细信息

背景:美托洛尔是临床常用的抗高血压药物,它经由CYP2D6代谢。CYP2D6*10降低CYP2D6活性,是中国人群中最为常见的多态性。β1肾上腺素受体为美托洛尔的作用靶标,Ser49Gly与Gly389Arg多态性显著改变受体功能。CYP2D6与β1肾上腺素受体遗传多态性对美托洛尔降压疗效的联合影响仍属未知。目的:发现与美托洛尔药代动力学与药效动力学相关的基因多态性位点。为提高高血压病的疗效和减少不良反应提供实验依据。方法:符合WHO/ISH高血压诊断标准的轻、中度高血压患者125例,服用美托洛尔单药治疗12周,每四周检测血压。在临床观察疗效的同时,应用PCR-RFLP方法对患者进行CYP2D6*10与β1肾上腺素受体Ser49Gly和Gly389Arg基因型分析。同时抽取静脉血5mL,高效液相色谱-荧光检测法测定患者美托洛尔谷浓度。结果:美托洛尔谷浓度与CYP2D610基因型显著相关,并呈基因剂量效应。但高血压患者血压降低程度在CYP2D6*1*1、1*10与CYP2D6*10*10组间无差异。Gly49携带者服用美托洛尔后收缩压与舒张压的降低显著大于Ser49Ser纯合子;与Gly389携带者相比,Arg389Arg服用美托洛尔后收缩压与舒张压的降低更为显著,表明Gly49与Arg389型受体对美托洛尔治疗有较好的敏感性。结论:CYP2D6*10突变显著改变美托洛尔的药代动力学,但对美托洛尔的降压效果无显著性影响。β1肾上腺素受体遗传多态性与β受体阻滞药的降压敏感性有一定相关性。

关键词： CYP2D6 β1肾上腺素受体遗传多态性原发性高血压美托洛尔

合理用药治疗急性盆腔炎(附98例临床用药分析)

在线全文

学校读者我要写书评

暂无评论

实用妇产科杂志 2000年第5期16卷 260-261页

作者：李丹志王新湖南医科大学第二附属医院湖南长沙410011

目的 :探讨采用不同抗生素联合治疗方案治疗急性盆腔炎的临床效果。方法 :对伴有高热、中热、低热和无热等四组急性盆腔炎患者分别采用不同抗生素组合治疗 ,观察对比每组患者体温恢复正常、腹痛消失、血象恢复正常所需要的时间。结果 :... 详细信息

目的 :探讨采用不同抗生素联合治疗方案治疗急性盆腔炎的临床效果。方法 :对伴有高热、中热、低热和无热等四组急性盆腔炎患者分别采用不同抗生素组合治疗 ,观察对比每组患者体温恢复正常、腹痛消失、血象恢复正常所需要的时间。结果 :高热组中采用不同二组抗生素治疗的患者在体温恢复正常、腹痛消失所需时间方面均有高度显著性差异 (P<0 .0 1)。中热组中采用不同二组抗生素治疗的患者在体温恢复正常、腹痛消失、血象恢复正常方面亦有显著性差异 (P<0 .0 5 )。低热组中采用不同二组抗生素治疗的患者在体温恢复正常方面有显著性差异 (P<0 .0 5 )。结论 :对于伴有高热的急性盆腔炎患者应首选第三代头孢菌素加灭滴灵进行治疗 ,在中、低及无热组中 ,联合使用青霉素加氨苄青霉素加灭滴灵等常规普通抗生素能够满足临床需要。

关键词：急性盆腔炎抗生素药物疗法合理用药临床分析

波长优选对土壤有机质含量可见光/近红外光谱模型的优化（英文）

在线全文

学校读者我要写书评

暂无评论

发光学报 2016年第11期37卷 1428-1435页

作者：林志丹汪玉冰王儒敬汪六三鲁翠萍张正勇宋良图刘洋中国科学院合肥智能机械研究所安徽合肥230031 中国科技大学自动化系安徽合肥230026 合肥电子工程学院安徽合肥230037

可见光/近红外光谱模型是土壤属性预测的有效工具。波长优选在光谱建模过程中起着重要作用。文中首先利用从安徽省涡阳县采集的130个砂姜黑土土壤样本获得可见光/近红外光谱,然后利用平滑与多重散射校正联合的光谱预处理方式消除光谱中... 详细信息

可见光/近红外光谱模型是土壤属性预测的有效工具。波长优选在光谱建模过程中起着重要作用。文中首先利用从安徽省涡阳县采集的130个砂姜黑土土壤样本获得可见光/近红外光谱,然后利用平滑与多重散射校正联合的光谱预处理方式消除光谱中的无关变量和冗余信息以提高模型预测结果的相关性,再利用SPXY方法挑选建模集样本,分别利用连续投影算法和遗传算法进行波长优选,最后利用留一法进行交互验证建立有机质含量的主成分回归模型。研究结果显示:连续投影算法和遗传算法都可以有效地减少参与建模的波长数并提高模型的准确度,尤其是遗传算法能够更好地提高土壤有机质含量预测精度,其相关系数、预测均方根误差和相对分析误差分别达到0.931 6,0.214 2和2.319 5。通过合适的特征波长选取,不仅计算量可以大大减少,预测精度也会有效提高。

关键词：可见光/近红外光谱有机质含量光谱预处理样本选择波长优化

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu dan-dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Impact of Small-scale Production Mode on Citrus Industry of Hunan Province,China——Based on the Investigation on Citrus Industry in Shimen County

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Agricultural Research 2010年第3期2卷 38-40页

作者： HU zhi-dan1,wang Kui-wu2,BO Xin1,TAN Jie2 1.College of Humanities,Hunan Agricultural University,Changsha 410128,China 2.Department of Scientific Research,Hunan Agricultural University,Changsha 410128,China

Small-scale farmer is defined by the domestic and foreign experts and *** point out that since the fragmentation of production and the diseconomy of scale in small-scale farmer is inconsistent with the characteristics of scale and technology of modern agricultural production,it is necessary to eliminate the adverse effects of existing mode in order to provide theoretical references for the relevant *** industry in Shimen County,Hunan Province,China is introduced from the aspects of natural geographical condition and socio-economic *** of small-scale production mode on citrus production in Shimen County is ***,blindness of small-scale production is the main reason leading to overproduction of ***,small-scale production mode has limitation on the acceptance of new technologies,restricts the operation of geographical trademark,and constraints the enthusiasm of enterprises in entering the agricultural ***,suggestions are put forward,such as encouraging the circulation of rural land,improving the organization degree of farmers,changing the work function of grass-roots government and perfecting the agricultural financial credit system.

关键词： Small-scale production mode Citrus industry Geogra

Effects of the types of overlap on the mechanical properties of FSSW welded AZ series magnesium alloy joints

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2012年第3期19卷 231-235页

作者： dan wang Jun Shen Lin-zhi wang School of Materials Science and Engineering Chongqing UniversityChongqing 400044China

The effects of the types of overlap on the mechanical properties of the friction stir spot welding （FSSW） welded AZ series magnesium alloy joints were investigated by microstructural observations, microhardness tests, and tensile tests. The results show that the microstructure of the stir zone adjacent to the periphery of the rotating pin is mainly composed of the upper sheet. The average distance D between the longitudinal segment of the curved interface and the keyhole periphery, the tensile shear force, and the microhardness of the stir zone of the FSSW welded AZ61 alloy joint are the highest in all samples. During FSSW of AZ31 and AZ61 dissimilar magnesium alloys, the irregular deformation of the longitudinal segment of the curved interface appears, while the microhardness of the stir zone is higher when AZ61 alloy is the upper sheet. Moreover, the microhardness of the stir zone increases initially and then decreases sharply in the longitudinal test position.

关键词： magnesium alloys friction stir welding microstructure microhardness tensile properties

不同剂量异丙酚麻醉对人工流产术中血压和呼吸的影响及比较

在线全文

学校读者我要写书评

暂无评论

实用妇产科杂志 2001年第3期17卷 169-170页

作者：周之丹王苑周惠文曹苹中国福利会国际和平妇幼保健院上海200030

目的 :探讨异丙酚静脉麻醉在人工流产术中最适单次剂量。方法 :人工流产手术 90例。按异丙酚用量不同随机分为 3组 ,每组 30例 ,Ⅰ组 3 5mg/kg、Ⅱ组 3 0mg/kg、Ⅲ组 2 5mg/kg。观察各组的麻醉效果、循环、呼吸及并发症。结果 :Ⅱ组麻... 详细信息

目的 :探讨异丙酚静脉麻醉在人工流产术中最适单次剂量。方法 :人工流产手术 90例。按异丙酚用量不同随机分为 3组 ,每组 30例 ,Ⅰ组 3 5mg/kg、Ⅱ组 3 0mg/kg、Ⅲ组 2 5mg/kg。观察各组的麻醉效果、循环、呼吸及并发症。结果 :Ⅱ组麻醉效果满意 ,并发症发生率低于或等于Ⅰ、Ⅲ组 ;超过此剂量麻醉效果满意 ,但呼吸系统并发症比例明显上升 ,且苏醒延迟 ;少于此剂量麻醉效果欠佳 ,追加药物比例上升。结论 :Ⅱ组异丙酚 3.

关键词：异丙酚人工流产静脉麻醉血压呼吸

Application of internal standard method in recombinant luminescent bacteria test

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2015年第9期27卷 128-134页

作者： Yong-zhi wang dan Li Miao He Environmental Simulation and Pollution Control (ESPC) State Key Joint Laboratory School of Environment Tsinghua University Fudan University Department of Environmental Science & Engineering

Mercury and its organic compounds have been of severe concern worldwide due to their damage to the ecosystem and human health. The development of effective and affordable technology to monitor and signal the presence of bioavailable mercury is an urgent *** Mer gene is a mercury-responsive resistant gene, and a mercury-sensing recombinant luminescent bacterium using the Mer gene was constructed in this study. The mer operon from marine Pseudomonas putida strain SP1 was amplified and fused with prompterless lux CDABE in the p UCD615 plasmid within Escherichia coli cells, resulting in p THE30–E. *** recombinant strain showed high sensitivity and specificity. The detection limit of Hg^2＋was 5 nmol/L, and distinct luminescence could be detected in 30 min. Cd^2＋, Cu^2＋, Zn^2＋, Ca^2＋,Pb^2＋, Mg^2＋, Mn^2＋, and Al^3＋did not interfere with the detection over a range of 10-5–1 m *** of recombinant luminescent bacteria testing in environmental samples has been a controversial issue： especially for metal-sensing recombinant strains, false negatives caused by high cytotoxicity are one of the most important issues when applying recombinant luminescent bacteria in biomonitoring of heavy metals. In this study, by establishing an internal standard approach, the false negative problem was overcome;furthermore, the method can also help to estimate the suspected mercury concentration,which ensures high detection sensitivity of bioavailable Hg2＋.

关键词： Mercury Biomonitoring Recombinant luminescent bacteria p THE30–E.coli Internal standard method False negative