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Development and validation of a prognostic immunoinflammatory index for patients with gastric cancer

World Journal of Gastroenterology 2024年第24期30卷 3059-3075页

作者： zhi-chang Ba Xi-Qing Zhu zhi-Guo Li Yuan-Zhou Li Department of Radiology Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina Department of Gastrointestinal Surgery Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina

BACKGROUND Studies have demonstrated the influence of immunity and inflammation on the development of *** single biomarkers of immunity and inflam-mation have been shown to be clinically predictive,the use of biomarkers integrating both to predict prognosis in patients with gastric cancer remains to be *** To investigate the prognostic and clinical significance of inflammatory biomarkers and lymphocytes in patients undergoing surgical treatment for gastric *** Univariate COX regression analysis was performed to identify potential prognostic factors for patients with gastric cancer undergoing surgical *** absolute shrinkage and selection operator-COX(LASSO-COX)regression analysis was performed to integrate these factors and formulate a new prognostic immunoinflammatory index(PII).The correlation between PII and clinical charac-teristics was statistically *** incorporating the PII score were devised and validated based on the time-dependent area under the curve and decision curve *** Patients exhibiting elevated neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,and systemic immune inflammatory index displayed inferior progression-free survival(PFS)and overall survival(OS).Conversely,low levels of CD3(+),CD3(+)CD8(+),CD4(+)CD8(+),and CD3(+)CD16(+)CD56(+)T lymphocytes were associated with improved PFS and OS,while high CD19(+)T lymphocyte levels were linked to worse PFS and *** PII score demonstrated associations with tumor characteristics(primary tumor site and tumor size),establishing itself as an independent prognostic factor for both PFS and ***-dependent area under the curve and decision curve analysis affirmed the effectiveness of the PII-based nomogram as a robust prognostic predictive *** PII may be a reliable predictor of prognosis in patients with gastric cancer undergoing surgical treatment,and it offers insights into cancer-related immune-inflammatory re

关键词： Gastric cancer Immunity Inflammation Prognosis Nomogram

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Toward a Direct Measurement of the Cosmic Acceleration: The Pilot Observation of HI 21 cm Absorption Line at FAST

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Research in Astronomy and Astrophysics 2024年第7期24卷 50-58页

作者： Jiangang Kang chang-zhi Lu Tong-Jie Zhang Ming Zhu Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University School of Physics and Astronomy Beijing Normal University National Astronomical Observatories Chinese Academy of Sciences

This study presents results on detecting neutral atomic hydrogen（H I） 21 cm absorption in the spectrum of PKS PKS1413+13 at redshift z = 0.24670041. The observation was conducted by FAST, with a spectral resolution of10 Hz, using 10 minutes of observing time. The global spectral profile is examined by modeling the absorption line using a single Gaussian function with a resolution of 10 kHz within a 2 MHz bandwidth. The goal is to determine the rate of the latest cosmic acceleration by directly measuring the redshift evolution of the H I 21 cm absorption line with Hubble flow toward a common background quasar over a decade or longer time span. This will serve as a detectable signal generated by the accelerated expansion of the Universe at redshift z < 1, referred to as redshift drift z（5） or the SL effect. The measured H I gas column density in this DLA system is approximately equivalent to the initial observation value, considering uncertainties of the spin temperature of a spiral host galaxy. The high signal-to-noise ratio of 57,obtained at a 10 kHz resolution, strongly supports the feasibility of using the H I 21 cm absorption line in DLA systems to accurately measure the redshift drift rate at a precision level of around 10-10per decade.

关键词： (cosmology:) cosmological parameters (cosmology:) dark energy cosmology: observations cosmology: theory ISM: clouds radio lines: galaxies radio lines: ISM

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Near-infrared non-fused electron acceptors for efficient organic photovoltaics

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Chinese Chemical Letters 2024年第4期35卷 436-441页

作者： Wenxiang Ma Xinyu He Tianyi Chen De-Li Ma Hongzheng Chen chang-zhi Li State Key Laboratory of Silicon and Advanced Semiconductor Materials Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Developing narrow-bandgap organic semiconductors is important to facilitate the advancement of organic photovoltaics(OPVs). Herein, two near-infrared non-fused ring acceptors(NIR NFRAs), PTBFTT-F and PTBFTT-Cl have been developed with A-π_A-π_D-D-π_D-π_A-A non-fused structures. It is revealed that the introduction of electron deficient π-bridge(π_A) and multiple intramolecular noncovalent interactions effectively retained the structural planarity and intramolecular charge transfer of NFRAs, extending strong NIR photon absorption up to 950 nm. Further, the chlorinated acceptor, with the enlarged π-surface compared to the fluorinated counterpart, promoted not only molecular stacking in solid, but also the desirable photochemical stability in ambient, which are helpful to thereby improve the exciton and charge dynamics for the corresponding OPVs. Overall, this work provides valuable insights into the design of NIR organic semiconductors.

关键词： Organic photovoltaic Near-infrared Non-fused electron acceptor Noncovalent interaction Stability

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Curing the vulnerable heterointerface via organic-inorganic hybrid hole transporting bilayers for efficient inverted perovskite solar cells

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Chinese Chemical Letters 2024年第6期35卷 254-257页

作者： Kangrong Yan Ziqiu Shen Yanchun Huang Benfang Niu Hongzheng Chen chang-zhi Li State Key Laboratory of Silicon and Advanced Semiconductor Materials Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

To promote the practices of perovskite photovoltaics,it requires to develop efficient perovskite solar cells(PVSCs)standing long-time operation under the adverse ***,we demonstrate that the tailor-made conjugated polymers as conductive adhesives stabilized the originally redox-reactive heterointerface between perovskite and metal oxide,facilitating the access of efficient and stable inverted *** was revealed that bithiophene and phenyl alternating conjugated polymers with partial glycol chains atop of the metal oxide layer has resulted in effective organic-inorganic hybrid hole transporting bilayers,which allow maintaining efficient hole extraction and transport,meanwhile preventing halide migration to directly contact with the nickel oxide(NiO_(x))*** a result,the corresponding inverted PVSCs with the organic-inorganic hole transporting bilayers have achieved an excellent power conversion efficiency of 23.22%,outperforming 20.65% of bare NiO_(x)-based ***,the encapsulated PVSCs with organic-inorganic bilayers exhibited the excellent photostability with 91% of the initial efficiency after 1000-h one-sun equivalent illumination in ambient ***,this work provides new insights into stabilizing the vulnerable heterointerface for perovskite solar cells.

关键词： Perovskite solar cells Conjugated polymer Hole transporting bilayer Charge extraction Heterointerface degradation

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A homopolymolybdate-supported plate-like 2D cobalt network constructed from a new pyrazole-amide-pyridyl ligand: highly electrochemical activity in both capacitive performance and the detection of Cr(Ⅵ)

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Tungsten 2024年第2期6卷 422-427页

作者： Xiu-Li Wang Yong-Zhen Chen zhi-Han chang Yu-Chun Lin Jing-Yi Ma College of Chemistry and Materials Engineering Bohai UniversityJinzhou 121013China Professional Technology Innovation Center of Liaoning Province for Conversion Materials of Solar Cell Jinzhou 121013China

By employing a new semi-rigid pyrazole-amide-derived bis(pyridyl)ligand[N,N'-bis(4-picolylamine)-1-hydropyrazole(4-dpap)],a new homopolymolybdate-based two-dimensional(2D)plate-like complex[Co(4-dpap)(H_(2)O)(β-Mo_(8)O_(2)6)1/2](1)has been prepared under solvothermal condition and structurally ***β-Mo_(8)anions are fi xed between the 2D metal–organic networks[Co(4-dpap)(H_(2)O)]n 2n+via hydrogen-bonding *** 1 possesses satisfactory specifi c capacitance of 1512.4 F·g^(−1)(current density:1 A·g^(−1))and good cycling stability(90.8%after 1000 cycles).Moreover,1 represents a promising amperometric sensor for measurement of Cr(Ⅵ)with low detection limit(0.042μmol·L^(−1))and high *** insertion ofβ-Mo_(8)anions between the unique 2D metal−organic networks improves the active area of polyoxometalates,which further promotes electrochemical performance.

关键词： Homopolymolybdate Metal–organic network Pyrazole-amide-derived bis(pyridyl)ligand Supercapacitor Electrochemical sensor

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RPRD1B/CREPT facilitates the progression of diffuse large B-cell lymphoma by inhibiting apoptosis through the NF-κB signaling pathway

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Asian Pacific Journal of Tropical Biomedicine 2024年第7期14卷 307-318页

作者： Lu Xu zhi-Hao Xie Jun Li Shi Tao Fang-Li Ren Yin-Yin Wang zhi-Jie chang Xin-Bao Hao Department of Hematology The First Affiliated Hospital of Hainan Medical UniversityHaikou570102China State Key Laboratory of Membrane Biology School of MedicineTsinghua UniversityBeijing 100084China Heya Beijing Med-Biotech Inc. Beijing 100084China Department of Hematology Roswell Park Comprehensive Cancer CenterNY 14263USA

Objective:To investigate the role of RPRD1B in the progression of diffuse large B-cell lymphoma(DLBCL)and its potential as a therapeutic ***:This study analyzed RPRD1B expression in DLBCL and normal tissues using public databases and assessed its prognostic impact through survival *** vitro and in vivo experiments were conducted to explore the mechanisms by which RPRD1B influences tumor growth and ***:RPRD1B expression was significantly elevated in DLBCL compared to normal tissues and was associated with poor *** vitro and in vivo experiments demonstrated that RPRD1B promoted lymphoma cell proliferation and inhibited apoptosis through the NF-κB signaling ***:RPRD1B plays a critical role in the progression of DLBCL by modulating apoptosis and cellular *** RPRD1B may offer a novel therapeutic strategy for DLBCL,suggesting its potential as a prognostic marker and therapeutic target in hematological malignancies.

关键词： RPRD1B RNAPⅡ Diffuse large B-cell lymphoma NF-κB Apoptosis

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Synthesis of Long-Chain Oligomeric Donor and Acceptors via Direct Arylation for Organic Solar Cells

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Chinese Journal of Chemistry 2024年第5期42卷 523-532页

作者： Yu Wu Xin-Yu He Xu-Min Huang Ling-Jun Yang Peng Liu Na Chen chang-zhi Li Shi-Yong Liu Jiangxi Provincial Key Laboratory of Functional Molecular Materials Chemistry College of MaterialsMetallurgical and ChemistryJiangxi University of Science and TechnologyGanzhouJiangxi341000 China Department of Polymer Science and Engineering Zhejiang UniversityHangzhouZhejiang310027 China

The rapid synthesis of structurally complicated electron donors&acceptors still remains a major challenge in organic solar cells(OSC).In this work,we developed a highly efficient strategy to access long-chain oligomeric donor and acceptors for OSC applications.A series of cyclopentadithiophene(CPDT)and benzothiadiazole(BT)-basedπ-conjugated oligomers,i.e.,three oligomeric acceptors(BTDT)n-IC(n=1—3)and one long-chain oligomeric donor(BTDT)4-RD,are facilely synthesized by an atom-and step-economical,and labor-saving direct C—H arylation(DACH)reaction(i.e.,C—H/C—Br cross coupling).Note that(BTDT)4-RD involving five CPDT,four BT and two rhodamine(RD)building blocks is the longest oligomeric donor in the fullerene-free OSC devices ever *** dependence of the structure-property-performance correlation of(BTDT)n-IC(n=1—3)and(BTDT)4-RD on theπ-conjugation lengths is thoroughly investigated by opto-electrochemical measurements,bulk heterojunction(BHJ)OSC devices and ***(BTDT)1-IC:PBDB-T and(BTDT)4-RD:Y6 BHJs achieve power conversion efficiencies of 9.14%and 4.51%,*** findings demonstrate that DACH reaction is a powerful tool to tune the opto-electronic properties and device performances by regulating the lengths ofπ-conjugated oligomers with varied numbers of repeating units.

关键词： Long-chainπ-conjugated oligomer Organic solar cells Direct arylation Atom-economical synthesis Cyclopentadithiophene Benzothiadiazole C—H activation Conjugation Oligomers

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Verteporfin fluorescence in antineoplastic-treated pancreatic cancer cells found concentrated in mitochondria

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 968-978页

作者： Ying-Qiao Zhang Qing-Hao Liu Lu Liu Peng-Yu Guo Run-Ze Wang zhi-chang Ba Department of Radiology Harbin Medical University Cancer HospitalHarbin 150010Heilongjiang ProvinceChina Department of Digestive Internal Medicine Harbin Medical University Cancer HospitalHarbin 150010Heilongjiang ProvinceChina

BACKGROUND Traditional treatments for pancreatic cancer(PC)are *** therapy(PDT)is non-invasive,and proven safe to kill cancer cells,including ***,the mitochondrial concentration of the photosensitizer,such as verteporfin,is *** To investigate the distribution of fluorescence of verteporfin in PC cells treated with antitumor drugs,*** Workable survival rates of PC cells(AsPC-1,BxPC-3)were determined with chemotherapy[doxorubicin(DOX)and gemcitabine(GEM)]and non-chemotherapy[sirolimus(SRL)and cetuximab(CTX)]drugs in vitro,with or without verteporfin,as measured via MTT,flow cytometry,and laser confocal *** cell proliferation was associated with GEM that was more enduring compared with *** laser microscopy allowed observation of GEM-and verteporfin-treated PC cells co-stained with 4’,6-diamidino-2-phenylindole and MitoTracker Green to differentiate living and dead cells and subcellular localization of verteporfin,*** Cell survival significantly dropped upon exposure to either chemotherapy drug,but not to SRL or *** cell lines responded similarly to *** intensity of fluorescence was associated with the concentration of *** experiments using GEM showed that survival rates of the PC cells treated with 10μmol/L verteporfin(but not less)were significantly lower relative to nil *** and dead stained cells treated with GEM were *** GEM treatment,verteporfin was observed primarily in the *** Verteporfin was observed in living *** GEM-treated human PC cells,verteporfin was particularly prevalent in the *** study supports further study of PDT for the treatment of PC after neoadjuvant chemotherapy.

关键词： Photodynamic therapy Pancreatic cancer Verteporfin Mitochondria Chemotherapy Gemcitabine

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Inhibition of Bcl-6 Expression Ameliorates Asthmatic Characteristics in Mice

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Current Medical Science 2024年第1期44卷 110-120页

作者： chang-zhi ZHOU Xiong XIONG Wei-jun TAN Ya-fei WANG Zhen YANG Xue-ying LI Xiu-wen YANG Xiao-fan LIU Sun-feng YU Liang-chao WANG Shuang GENG Department of Respiratory and Critical Care Medicine The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Department of General Surgery Wuhan Wuchang HospitalWuhan University of Science and TechnologyWuhan 430063China

Objective The function of Bcl-6 in T follicular helper(Tfh)cell maturation is indispensable,and Tfh cells play a pivotal role in *** study investigated the impact of Bcl-6 on asthmatic *** The microscopic pathological alterations,airway resistance(AR),and lung compliance(LC)were determined in asthmatic mice and Bcl-6 interference *** surface molecular markers of Tfh cells and the Bcl-6 mRNA and protein expression were determined by flow cytometry,RT-qPCR,and Western blotting,*** relationships between the Tfh cell ratio and the IgE and IgG1 concentrations in peripheral blood mononuclear cells(PBMCs)and bronchoalveolar lavage fluid(BALF)were *** Asthmatic inflammatory changes were observed in the lung tissue and were attenuated by Bcl-6 siRNA and dexamethasone(DXM).Asthmatic mice exhibited an increased AR and a decreased LC,while Bcl-6 siRNA or DXM mitigated these *** percentages of Tfh cells and eosinophils were significantly increased in the asthmatic mice,and they significantly decreased after Bcl-6 inhibition or DXM ***-qPCR and Western blotting analyses revealed that the Bcl-6 expression level in PBMCs was significantly higher in asthmatic mice,and it decreased following Bcl-6 inhibition or DXM *** IgE expression in the serum and BALF and the B cell expression in PBMCs exhibited a similar *** asthmatic mice,the ratio of Tfh cells in the peripheral blood showed a strong positive correlation with the IgE levels in the serum and BALF,but not with the IgG1 *** The amelioration of airway inflammation and airway hyper-responsiveness is achieved through Bcl-6 suppression,which effectively hinders Tfh cell differentiation,ultimately resulting in a concurrent reduction in IgE production.

关键词： Bcl-6 Tfh asthma airway hyper-responsiveness mouse model

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Constructing Hopf Insulator from Geometric Perspective of Hopf Invariant

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Chinese Physics Letters 2024年第3期41卷 121-126页

作者：常治文郝维昌 Miguel Bustamante 刘鑫 Institute of Theoretical Physics School of Physics and Optoelectronic EngineeringBeijing University of TechnologyBeijing 100124China School of Physics Beihang UniversityBeijing 100191China Complex and Adaptive Systems Laboratory School of Mathematics and StatisticsUniversity College DublinBelfield4DublinIreland

We propose a method to construct Hopf insulators based on the study of topological defects from the geometric perspective of Hopf invariant ***,we prove two types of topological defects naturally inhering in the inner... 详细信息

关键词： Hopf topological invariant

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