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The Geological Significance of the Deformation and Geochronology of the Xiaotian–Mozitan Shear Zone in the Dabie Orogenic Belt(East-Central China)

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Acta Geologica Sinica(English Edition) 2021年第2期95卷 370-392页

作者： HUANG Peng SONG Chuanzhong XIAO Wenjiao li Jiahao ZHOU Kefa WANG Jinlin NIJIATI Abuduxun li zhenwei Slate Key Laboratory of Desert and Oasis Ecology Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUramqi 830011China Xinjiang Research Center for Mineral Resources Chinese Academy of SciencesUrwnqi 830011China Xinjiang Key Laboratory of Mineral Resources and Digital Geology Urumqi 830011China School of Resources arid Environmental Engineering Hefei University of TechnologyHefei 230009China State Key Laboratory of lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100049China College of Earth and Planetary Sciences University of the Chinese Academy of SciencesBeijing 100049China Chinese Academy of Sciences Center for Excellence in Tibetan Plateau Earth Science Chinese Academy of SciencesBeijing 100101China Xinjiang Key Laboratory for Geodynamic Processes and Metallogenic Prognosis of the Central Asian Orogenic Belt School of Geology and Mining EngineeringXinjiang UniversityUrumqi 830046China

The Xiaotian–Mozitan Shear Zone(XMSZ)is the boundary of the Dabie High-grade Metamorphic Complex(DHMC)and the North Huaiyang Tectonic *** was deformed in ductile conditions with a top-to-NW/WNW *** applied to mineral parageneses in mylonites of the shear zone give a temperature range of 623–691°C for the predeformation and 515–568°C for the syndeformation,respectively,which indicates a retrograde process of evolution.A few groups of zircon U-Pb ages were obtained from undeformed granitic veins and different types of deformed rocks in the *** from the felsic ultramylonites are all magmatic,producing a weighted mean 206Pb/238U age of 754±8.1 Ma,which indicates the time of magmatic activities caused by rifting in the *** from the granitic veins,cutting into the mylonites,are also of magmatic origin,producing a weighted mean 206 Pb/238 U age of 130±2.5 Ma,which represents the time of regional magmatic activity in the *** from the mylonitic gneisses are of anatectic-metamorphic origins and are characterized by a core-mantle interior texture,which yielded several populations of ages including the Neoproterozoic ages with a weighted mean 206 Pb/238 U age of 762±18 Ma,similar to that of the felsic ultramylonites and the Early Cretaceous ages with a weighted mean 206Pb/238U age of 143±1.8 Ma,indicating the anatectic metamorphism in the Dabie Orogenic Belt(DOB).Based on integrated analysis of the structure,thermal conditions of ductile deformation and the contact relations of the dated rocks,the activation time of the Xiaotian–Mozitan Shear Zone is constrained between~143 Ma and 130 Ma,during which the DOB was undergoing a transition in tectonic regime from compression to ***,the deformation and evolution of this shear zone plays an instrumental role in fully understanding this *** research also inclines us to the interpretation of it as an extensional detachment,with regard to the te

关键词： syndeformation temperature zircon U-Pb dating tectonic regime transition Xiaotian-Mozitan Shear Zone Dabie Orogenic Belt

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Characterization of natural peptides in Pheretima by integrating proteogenomics and label-free peptidomics

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Journal of Pharmaceutical Analysis 2023年第9期13卷 1070-1079页

作者： Xiaoxiao Luo Qirui Bi Dongdong Huang Yun li Changliang Yao Jianqing Zhang Wenlong Wei Jiayuan li zhenwei li Jingxian Zhang Shen Ji Yurong Wang De-an Guo School of Basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjing211198China Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Research Center of TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of Sciences Beijing100049China NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China

Pheretima,also called“earthworms”,is a well-known animal-derived traditional Chinese medicine that is extensively used in over 50 Chinese patent medicines(CPMs)in Chinese Pharmacopoeia(2020 edition).However,its zoological origin is unclear,both in the herbal market and *** this study,a strategy for integrating in-house annotated protein databases constructed from close evolutionary relationship-sourced RNA sequencing data from public archival resources and various sequencing algorithms(restricted search,open search,and de novo)was developed to characterize the phenotype of natural peptides of three major commercial species of Pheretima,including Pheretima aspergillum(PA),Pheretima vulgaris(PV),and Metaphire magna(MM).We identified 10,477 natural peptides in the PA,7,451 in PV,and 5,896 in MM *** specific signature peptides were screened and then validated using synthetic peptides;these demonstrated robust specificity for the authentication of PA,PV,and ***,all marker peptides were successfully applied to identify the zoological origins of Brain Heart capsules and Xiaohuoluo pills,revealing the inconsistent Pheretima species used in these *** conclusion,our integrated strategy could be used for the in-depth characterization of natural peptides of other animal-derived traditional Chinese medicines,especially non-model species with poorly annotated protein databases.

关键词： Pheretima Natural peptides Label-free peptidomics Proteogenomics Animal derived medicine

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纳米Cr_2O_3微粒对2024-T4铝合金微弧氧化膜结构及耐磨性能的影响

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稀有金属材料与工程 2017年第7期46卷 2022-2027页

作者：李振伟狄士春哈尔滨工业大学黑龙江哈尔滨150001

在含有不同浓度纳米Cr_2O_3微粒的硅酸盐体系电解液中对2024-T4铝合金进行微弧氧化处理,使用SEM观察陶瓷膜的表面形貌、截面形貌、磨痕形貌。使用EDS能谱仪分析膜层中各主要成分沿截面方向的分布,使用XRD分析陶瓷膜的相结构,使用纳米压... 详细信息

在含有不同浓度纳米Cr_2O_3微粒的硅酸盐体系电解液中对2024-T4铝合金进行微弧氧化处理,使用SEM观察陶瓷膜的表面形貌、截面形貌、磨痕形貌。使用EDS能谱仪分析膜层中各主要成分沿截面方向的分布,使用XRD分析陶瓷膜的相结构,使用纳米压痕硬度计测量陶瓷膜的硬度,使用粗糙度仪测量陶瓷膜的表面粗糙度,使用摩擦磨损试验机测量陶瓷膜的摩擦系数,使用激光共聚焦显微镜测量磨痕体积,评估磨损率。结果表明:在电解液中加入纳米Cr_2O_3微粒后,制备的陶瓷膜中出现了Cr_2O_3相,电解液中纳米Cr_2O_3微粒浓度达到2.4 g/L时,陶瓷膜的硬度最高,摩擦系数最小,磨损率最低,耐磨性最好。

关键词： 2024-T4铝合金微弧氧化纳米Cr2O3 耐磨性能

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纳米TiO_2微粒对2214铝合金微弧氧化膜微观结构及耐磨性能的影响

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材料导报 2018年第8期32卷 1294-1299页

作者：李振伟狄士春哈尔滨工业大学机电工程学院哈尔滨150001

在含有不同浓度纳米TiO_2微粒的硅酸盐体系电解液中对2214铝合金进行微弧氧化处理,以在2214铝合金表面制备包含TiO_2的复合陶瓷膜。分别使用SEM、EDS、激光共聚焦显微镜、XRD、维氏硬度计、划痕仪和球盘式摩擦磨损试验机对复合陶瓷膜的... 详细信息

在含有不同浓度纳米TiO_2微粒的硅酸盐体系电解液中对2214铝合金进行微弧氧化处理,以在2214铝合金表面制备包含TiO_2的复合陶瓷膜。分别使用SEM、EDS、激光共聚焦显微镜、XRD、维氏硬度计、划痕仪和球盘式摩擦磨损试验机对复合陶瓷膜的微观结构、表面粗糙度、相成分、硬度、粘结强度、耐磨性能进行分析。结果表明:复合陶瓷膜主要由γ-Al_2O_3、α-Al_2O_3、莫来石、锐钛矿型TiO_2和金红石型TiO_2组成,且随着电解液中TiO_2微粒浓度的增加,复合陶瓷膜表面的微孔数量显著减少,微孔尺寸显著减小。与不含TiO_2成分的微弧氧化陶瓷膜相比,复合陶瓷膜通过更低的摩擦系数和更小的磨损率展示了更好的耐磨性能。

关键词： 2214铝合金微弧氧化纳米TiO2微粒粘结强度耐磨性能

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CMOS-compatible all-optical modulator based on the saturable absorption of graphene

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Photonics Research 2020年第4期8卷 468-474页

作者： HONG WANG NINGNING YANG liMIN CHANG CHAOBIAO ZHOU SHIYU li MENG DENG zhenwei li QIANG liU CHI ZHANG ZHIYONG li YI WANG Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Institute of Semiconductors Chinese Academy of SciencesBeijing 100038China

Graphene resting on a silicon-on-insulator platform offers great potential for optoelectronic *** the paper,we demonstrate all-optical modulation on the graphene-silicon hybrid waveguides(GSHWs)with tens of micrometers in *** to strong interaction between graphene and silicon strip waveguides with compact light confinement,the modulation depth reaches 22.7%with a saturation threshold down to 1.38 pJ per pulse and a 30-μm-long graphene pad.A response time of 1.65 ps is verified by a pump-probe measurement with an energy consumption of 2.1 *** complementary metal-oxide semiconductor compatible GSHWs with the strip configuration exhibit great potential for ultrafast and broadband all-optical modulation,indicating that employing two-dimensional materials has become a complementary technology to promote the silicon photonic platform.

关键词： CMOS-compatible all-optical modulator saturable absorption graphene

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Key technological innovations in the construction of the main terminal of Beijing Daxing International Airport

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Frontiers of Engineering Management 2022年第4期9卷 689-694页

作者： Jianhua li Xianjun DUAN Hanchao liU Susu LEI Zheng ZHANG zhenwei li Tsinghua University Beijing 100091China Beijing Urban Construction Group Co. Ltd.Beijing 100088China

Beijing Daxing International Airport,a major landmark project in China and a new driver for national development,will represent the direction for the development of civil aviation airports in *** airport,situated in the junction of Nangezhuang,Daxing District,Beijing City and Gu’an County,Hebei Province,has seen its north terminal area and north terminal built in the first phase,covering a total construction area of about 1.4 million *** north terminal area is designed to have an annual throughput of 45 million passengers.

关键词： Beijing Daxing International Airport main terminal architectural technology innovation

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No association of the matrix metalloproteinase 1 promoter polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in northern China

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World Journal of Gastroenterology 2005年第16期11卷 2385-2389页

作者： XiaJin GangKuang li-zhenwei Yanli RuiWang WeiGuo NaWang Shu-MeiFang Zhi-FengChen Jian-HuiZhang HebeiCancerInstitute HebeiMedicalUniversityShijiazhuang050011HebeiProvinceChina TheFourthAffiliatedHospital HebeiMedicalUniversityShijiazhuang050011HebeiProvinceChina

AIM: To investigate association of the 2Gor1Gsingle nudeotide polymorphism (SNP) in matrix metalloproteinase 1 (MMP1) promoter with susceptibility to esophageal squam-ous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) in a population of North China. METHODS: MMP1 promoter SNP was genotyped by polymerase-chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis in 417 cancer patients (234 ESCC and 183 GCA) and 350 healthy controls. RESULTS: The genotype frequencies of the MMP1 promoter SNP in healthy controls were 55.4% (2G/2G), 30% (1G/2G) and 14.6% (1G/1G), respectively. The genotype and allelotype distribution in ESCC and GCA patients was not significantly different from that in healthy controls (all lvalues were above 0.05). Compared with the 1G/1Ggenotype, neither the 2G/2Gnor in combination with the 1G/2G genotype significantly modified the risk of developing ESCC and GCA, the adjusted odds ratio was 1.28 (95%CI = 0.78-2.09), 1.23 (95%CI = 0.38-2.05) in ESCC and 1.39 (95%CI = 0.80-2.41), 1.34 (95%CI = 0.74-2.40) in GCA, respectively. When stratified by smoking status and family history of upper gastrointestinal cancer, the 2G/2Ggenotype alone or in combination with the 1G/2G genotype also did not show any significant influence on the risk of ESCC and GCA development. In addition, influence of the MMP1 SNP on lymphatic metastasis in ESCC and GCA was also not obs-erved. CONCLUSION: The 2Gor 1GSNP in the MMP1 promoter might not modify the risk of ESCC and GCA development and might not be used as a stratification marker to predict the potential of lymphatic metastasis in these two tumor types.

关键词： SNP ESCC GCA

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Characterization of a small-molecule inhibitor targeting NEMO/IKKβto suppress colorectal cancer growth

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1219-1231页

作者： Zhenlong Yu Jian Gao Xiaolei Zhang Yulin Peng Wenlong Wei Jianrong Xu zhenwei li Chao Wang Meirong Zhou Xiangge Tian Lei Feng Xiaokui Huo Min liu Mingliang Ye De-an Guo Xiaochi Ma Pharmaceutical Research Center Second Affiliated HospitalDalian Medical UniversityDalian 116000China College of Pharmacy College(Institute)of Integrative MedicineDalian Medical UniversityDalian 116044China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhou 221004China CAS Key Laboratory of Separation Sciences for Analytical Chemistry National Chromatographic R&A CenterDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Research Center for TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Academy of Integrative Medicine Shanghai University of Traditional Chinese Medicine1200 Cailun RoadShanghai 201203China Neurology Department Dalian University Affiliated Xinhua HospitalDalian 116021China

NEMO/IKKβcomplex is a central regulator of NF-κB signaling pathway,its dissociation has been considered to be an attractive therapeutic ***,using a combined strategy of molecular pharmacological phenotyping,proteomics and bioinformatics analysis,Shikonin(SHK)is identified as a potential inhibitor of the IKKβ/NEMO *** destabilizes IKKβ/NEMO complex with IC_(50) of 174 nM,thereby significantly impairing the proliferation of colorectal cancer cells by suppressing the NF-κB pathway in vitro and in *** addition,we also elucidated the potential target sites of SHK in the NEMO/IKKβ*** study provides some new insights for the development of potent small-molecule PPI inhibitors.

关键词： IKKβ colorectal cancer

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Synchronization for Complex Networks with Randomly Occurring Coupling Delays via Passivity

Synchronization for Complex Networks with Randomly Occurring...

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第30届中国控制与决策会议

作者： Dongliang Wu zhenwei li Tao liao Jing Wang Beijing Institute of Spacecraft Environment Engineering

This paper deals with the synchronization problem for complex networks under the passivity *** particular,the randomly occurring coupling delays are taken into account to describe more complicated dynamics in the real *** means of stochastic analysis,delay-dependent sufficient synchronization criteria can be given for ensuring the desired passivity performance by matrix *** the established conditions being satisfied,the designing procedure for the synchronization controller is ***,we give an illustrative example for illustrating the efficiency of our synchronization strategy.

关键词： Synchronization Complex networks Randomly occurring coupling delays Passivity

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Epoxide hydrolase Tyr113 His polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma in population of North China

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World Journal of Gastroenterology 2003年第12期9卷 2654-2657页

作者： Jian-HuiZhang XiaJin Yanli RuiWang WeiGuo NaWang Deng-GuiWen Zhi-FengChen GangKuang li-zhenwei Shi-JieWang HebeiCancerInstitute HebeiMedicalUniversityShijiazhuang050011HebeiProvinceChina TheFourthAffiliatedHospital HebeiMedicalUniversityShijiazhuang05001lHebeiProvinceChina

AIM: To investigate the possible association of microsomal epoxide hydrolase ( mEH) Tyr113 His polymorphism with susceptibility to esophageal squamous cell carcinoma (ESCC) in a population of North ***: The mEH-Tyr113 His genotypes were determined by polymerase-chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis in 257 patients with esophageal squamous cell carcinoma (ESCC) and 252 healthy subjects as a control ***: The frequencies for Tyr and His alleles were 44.2 %, 55.8 % in ESCC patients, and 44.0 % and 56.0 %in healthy subjects, respectively. No statistic difference in allele distribution was observed between ESCC patients and controls (x2=0.008, P=0.929). The overall genotype distribution difference was not observed between cancer cases and controls (x2=2.116, P=-0.347). Compared with Tyr/Tyr genotype, neither His/His genotype nor in combination with Tyr/His genotype significantly modified the risk of the development of ESCC, the adjusted odds ratio was 1.076 (95 % CI=0.850-1.361) and 0.756 (95 % CI=0.493-1.157),respectively. When stratified for sex, age, smoking status and family history of upper gastrointestinal cancer, His/His genotype alone or in combination with Tyr/His genotype also did not show any significant influence on the risk of developing ***: MEH Tyr113His polymorphism may not be used as a stratification marker in screening individuals at a high risk of ESCC.

关键词：食道鳞状细胞癌环氧化酶基因多态性肿瘤病理学华北地区 PCR RFLP Tyr113His

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